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Datasheet of UNC2025
Description:. UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome pro?ling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined. For the detailed information of UNC2025, the solubility of UNC2025 in water, the solubility of UNC2025 in DMSO, the solubility of UNC2025 in PBS buffer, the animal experiment (test) of UNC2025, the cell expriment (test) of UNC2025, the in vivo, in vitro and clinical trial test of UNC2025, the EC50, IC50,and affinity,of UNC2025, Please contact DC Chemicals.
Chemical Information Catalog
DC7931
Purity of current batch:
>98%
Molecular Weight (MW)
476.66
Molecular Formula
C28H40N6O
CAS No.
1429881-91-3
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.