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Datasheet of BRD73954
Description:. HDACs are a family of proteins with diverse roles. HDAC6 is a class IIb histone that deacetylates cytoplasmic proteins, including tubulin, heat shock protein 90, and cortactin, and has roles in cell adhesion and motility.1 HDAC8, on the other hand, is a class I histone that primarily targets nuclear proteins, including histones and cohesins, and regulates gene expression.2,3 BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).4 It is at least 75-fold less effective against other HDAC isoforms.4 At 10 μM, BRD73954 treatment results in a robust increase in acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, 2, and 3, in HeLa cells. For the detailed information of BRD73954, the solubility of BRD73954 in water, the solubility of BRD73954 in DMSO, the solubility of BRD73954 in PBS buffer, the animal experiment (test) of BRD73954, the cell expriment (test) of BRD73954, the in vivo, in vitro and clinical trial test of BRD73954, the EC50, IC50,and affinity,of BRD73954, Please contact DC Chemicals.
Chemical Information Catalog
DC7936
Purity of current batch:
>98%
Molecular Weight (MW)
284.3
Molecular Formula
C16H16N2O3
CAS No.
1440209-96-0
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.