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Datasheet of PRT-060318
Description:. PRT-060318, also known as PRT318 or P142–76, is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monoclonal HIT-like antibody, and heparin. The experimental group received orally dosed PRT318, whereas the control group received vehicle. Nadir platelet counts of PRT318-treated mice were significantly higher than those of control mice. When examined with a novel thrombosis visualization technique, mice treated with PRT318 had significantly reduced thrombosis. The Syk inhibitor PRT318 thus prevented both HIT immune complex-induced thrombocytopenia and thrombosis in vivo, demonstrating its activity in HIT. (source: Blood. 2011 Feb 17;117(7):2241-6.) For the detailed information of PRT-060318 , the solubility of PRT-060318 in water, the solubility of PRT-060318 in DMSO, the solubility of PRT-060318 in PBS buffer, the animal experiment (test) of PRT-060318 , the cell expriment (test) of PRT-060318 , the in vivo, in vitro and clinical trial test of PRT-060318 , the EC50, IC50,and affinity,of PRT-060318 , Please contact DC Chemicals.
Chemical Information Catalog
DC7948
Purity of current batch:
>98%
Molecular Weight (MW)
340.4
Molecular Formula
C18H24N6O
CAS No.
1194961-19-7
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.