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Datasheet of RG-3039
Description:. RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. (Last updated: 2/5/2015) For the detailed information of PF-06687859/RG-3039 , the solubility of PF-06687859/RG-3039 in water, the solubility of PF-06687859/RG-3039 in DMSO, the solubility of PF-06687859/RG-3039 in PBS buffer, the animal experiment (test) of PF-06687859/RG-3039 , the cell expriment (test) of PF-06687859/RG-3039 , the in vivo, in vitro and clinical trial test of PF-06687859/RG-3039 , the EC50, IC50,and affinity,of PF-06687859/RG-3039 , Please contact DC Chemicals.
Chemical Information Catalog
DC7957
Purity of current batch:
>98%
Molecular Weight (MW)
431.13
Molecular Formula
C21H23Cl2N5O
CAS No.
1005504-62-0(RG3039freebase);1466525-84-7(RG3039·2HCl)
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.