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Datasheet of HPOB
Description:. HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).1 It is at least 30-fold less effective against other HDACs.1 Through its effects on HDAC6, HPOB induces acetylation of α-tubulin but not histones.1 HPOB reduces the growth, but not the viability, of normal and transformed cells.1 It enhances the death of transformed cells as triggered by the topoisomerase II inhibitors etoposide and doxorubicin.1 HPOB enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA (Item No. 10009929) against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft. For the detailed information of HPOB, the solubility of HPOB in water, the solubility of HPOB in DMSO, the solubility of HPOB in PBS buffer, the animal experiment (test) of HPOB, the cell expriment (test) of HPOB, the in vivo, in vitro and clinical trial test of HPOB, the EC50, IC50,and affinity,of HPOB, Please contact DC Chemicals..
Chemical Information Catalog
DC7962
Purity of current batch:
>98%
Molecular Weight (MW)
314.34
Molecular Formula
C17H18N2O4
CAS No.
1429651-50-2
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.