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Datasheet of calpeptin
Description:. Calpeptin is a cell permeable calpain inhibitor. Research shows that Calpeptin is an effective inhibitor of calpain 2 and can fully block cleavage of PLC-β 3 enzymes. Additionally, Calpeptin has demonstrated the ability to inhibit the activities of cathepsin L and calpain-1. In muscle cell studies Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. Pulmonary fibrosis research in mice have reported that Calpeptin can decrease expression of TGF-β1, IL-6, collage type Iα1, and angiopoietin-1 mRNA. Calpeptin is an inhibitor of Calpain 1, cathepsin K, cathepsin L and PTP. Calpeptin is an activator of Rock. For the detailed information of calpeptin, the solubility of calpeptin in water, the solubility of calpeptin in DMSO, the solubility of calpeptin in PBS buffer, the animal experiment (test) of calpeptin, the cell expriment (test) of calpeptin, the in vivo, in vitro and clinical trial test of calpeptin, the EC50, IC50,and affinity,of calpeptin, Please contact DC Chemicals.
Chemical Information Catalog
DC7967
Purity of current batch:
>98%
Molecular Weight (MW)
362.46
Molecular Formula
C20H30N2O4
CAS No.
117591-20-5
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.