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Datasheet of Molidustat
Description: Molidustat(BAY-85-3934) is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) production and the formation of red blood cells; HIF-stabilizer. in vitro: Under standard assay conditions, in the presence of 20 μM 2-oxoglutarate, 10 μM Fe2+, and 2 mM ascorbate, the mean IC50 values of BAY 85-3934 for PHD1, PHD2, and PHD3 were 480 nM, 280 nM, and 450 nM, respectively. Exposure of HeLa cells to 5 μM BAY 85-3934 for 20 min was sufficient to induce detectable concentrations of HIF-1α. In a cellular reporter assay, BAY 85-3934 induced the expression of the firefly luciferase reporter gene under the control of a hypoxia responsive element promoter at a mean (± SD) EC50 of 8.4± 0.7 μM (n=4). in vivo: EPO was significantly induced 7 h after administration of BAY 85-3934 (1.5 mg/kg) in all animals, and showed a clear increase after the 0.5 mg/kg dose in females.
Chemical Information Catalog
DC8166
Purity of current batch:
>98%
Molecular Weight (MW)
314.12
Molecular Formula
C13H14N8O2
CAS No.
1154028-82-6
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.