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Datasheet of Vacquinol-1
Description: Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture.A key effector of vacquinols is MAPK kinase 4 (MKK4).1 Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells.It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μ M at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics.Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.
Chemical Information Catalog
DC8473
Purity of current batch:
>98%
Molecular Weight (MW)
352.9
Molecular Formula
C21H21ClN2O
CAS No.
5428-80-8
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.