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Datasheet of Sirtinol
Description: Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. Sirtinol has been shown to inhibit yeast Sir2 (IC50 = 70 μM), human SIRT2 (IC50 = 40 μM), and human SIRT1 (IC50 = 131 μM), yet has shown no effect on human HDAC1. In Arabidopsis, sirtinol strongly affected root and vascular tissue development by activating the auxin signaling pathway. Sirtinol has also been shown to induce senescence-like growth arrest in human breast cancer MCF-7 and lung cancer H1299 cells by impaired activation of MAPK.
Chemical Information Catalog
DC8721
Purity of current batch:
>98%
Molecular Weight (MW)
394.47
Molecular Formula
C26H22N2O2
CAS No.
410536-97-9
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.