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Datasheet of OTSSP167
Description: MELK (maternal embryonic leucine zipper kinase) is a novel therapeutic target For breast cancer and also reported to be highly upregulated in multiple types of human cancer. OTSSP167 is a highly potent MELK inhibitor (IC50 of 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like). MELK inhibitor OTSSP167 should be a promising compound possibly to suppress the growth of tumor-initiating cells and be applied For treatment of a wide range of human cancer.For the detailed information of OTSSP167 HCl Salt, the solubility of OTSSP167 HCl Salt in water, the solubility of OTSSP167 HCl Salt in DMSO, the solubility of OTSSP167 HCl Salt in PBS buffer, the animal experiment (test) of OTSSP167 HCl Salt, the cell expriment (test) of OTSSP167 HCl Salt, the in vivo, in vitro and clinical trial test of OTSSP167 HCl Salt, the EC50, IC50,and Affinity of OTSSP167 HCl Salt, Please contact DC Chemicals.
Chemical Information Catalog
DC8732
Purity of current batch:
>98%
Molecular Weight (MW)
487.42
Molecular Formula
C25H28Cl2N4O2
CAS No.
1431697-89-0
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.