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Datasheet of NVP-BEZ235 Tosylate
Description: Description of BEZ235: BEZ235 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of NVP-BEZ235 in water, the solubility of NVP-BEZ235 in DMSO, the solubility of NVP-BEZ235 in PBS buffer, the animal experiment（test） of NVP-BEZ235,the in vivo,in vitro and clinical trial test of NVP-BEZ235,the cell experiment（test） of NVP-BEZ235,the IC50, EC50 and Affinity of NVP-BEZ235, please contact DC Chemicals..
Chemical Information Catalog
DC8786
Purity of current batch:
>98%
Molecular Weight (MW)
641.74
Molecular Formula
C37H31N5O4S
CAS No.
1028385-32-1
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.