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Datasheet of NS-398
Description: NS-398 is a COX-2 inhibitor. The COX-1 activity is completely unaffected by 100 μM NS-398, whereas the COX-2 activity was concentration-dependently inhibited, the IC50 value being 3.8 μM. in vitro: NS-398 suppresses DOX-Induced Cytotoxicity and p53 Accumulation in U2OS and MCF-7 Cell Lines. NS-398 pre-treatment significantly reduces DOX-induced cytotoxicity in both cell lines. NS-398 reduces doxorubicin (DOX)-induced p53 accumulation and cytotoxicity. in vivo: NS-398 attenuates subretinal fibrosis, in an experimental model of subretinal scarring observed in neovascular AMD, by down-regulation of TGF-β2 in the retinal pigment epithelium-choroid complex. NS-398 can attenuate CNV and subretinal fibrosis lesions by suppressing macrophage infiltration and downregulating VEGF and TGF-β2, respectively.
Chemical Information Catalog
DC8806
Purity of current batch:
>98%
Molecular Weight (MW)
314.4
Molecular Formula
C13H18N2O5S
CAS No.
123653-11-2
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.