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Datasheet of DEL-22379
Description: DEL-22379 is an ERK dimerization inhibitor with IC50 of 0.5 μM. in vitro: DEL-22379 inhibits ERK dimerization without affecting its phosphorylation. DEL-22379 blocks proliferation of tumor cells harboring RASERK pathway oncogenes. Pretreating cells with DEL-22379 inhibits EGF-stimulated RSK1 phosphorylation, with estimated IC50 values of 500 nM for DEL-22379. in vivo: In animal tumor models, DEL-22379 induces apoptosis, preventing tumor progression.DEL-22379 abolishes EGF-induced co-immunoprecipitation of ectopic ERK2 molecules tagged with hemagglutinin (HA) or FLAG epitopes, with an estimated half-maximal inhibitory concentration (IC50) of 0.5 uM.
Chemical Information Catalog
DC8866
Purity of current batch:
>98%
Molecular Weight (MW)
444.53
Molecular Formula
C26H28N4O3
CAS No.
181223-80-3
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.