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Datasheet of GSK-481
Description: Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases. A novel benzoxazepinone (BOAz) series of RIP1 inhibitors, represented by GSK481, was discovered from a focused screen using a three-cycle amino acid core DNA-encoded library. BOAz has demonstrated outstanding in vitro potencies, excellent developability properties, and extraordinary cross-kinase selectivity.
Chemical Information Catalog
DC9312
Purity of current batch:
>98%
Molecular Weight (MW)
377.39
Molecular Formula
C21H19N3O4
CAS No.
1622849-58-4
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.