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Datasheet of AL 082D06(D-06)
Description: AL 082D06(D-06) is the first selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM, exhibits excellent selectivity against AR, PR, MR and ER(Ki > 10 uM).The antagonists NET, DO6 and UDCA, as well as the dissociated GC ligand CpdA (14%) resulted in little to no increase in S226 phosphorylation. The antagonists NET, DO6 and UDCA (13%, 8% and 21%), as well as the dissociated GC ligand CpdA (24%) resulted in little increase in S211 phosphorylation. D06 competes with 3H-Dex for baculovirus-expressed GR with nanomolar affinity. Other intracellular receptors (AR, ER, PR, and MR) have no affinity for D06 in a similarly structured binding assay with the appropriate receptor and tritiated ligand (>2500 nM). D06 can antagonize steroid-mediated induction of glutamine synthetase RNA in MG63 cells (data not shown) and TAT enzyme in human skin fibroblasts. \Chemical
Information
Catalog
DC9677
Purity of current batch:
>98%
Molecular Weight (MW)
409.91
Molecular Formula
C23H24ClN3O2
CAS No.
256925-03-8
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.