Website:www.dcchemicals.com Email: info@dcchemicals.com Phone:+86-21-58447131 Marketing Center: Room 610,Building 15, Jinxiang Rd 201, Shanghai, China
Datasheet of LY3177833
. Description: LY3177833 is a novel CDC7 inhibitor,CDC7/DBF4 IC50 = 3.3 nM, pMCM2 (S53) IC50 = 290 nM and IVTI TEC70 = 1.6 mcM. LY-3177833 showed MED = 5 mg/kg (p.o.) in vivo. LY-3177833 strongly impacted chromosome dynamics. In mouse xenograft models, broad antitumor activity was associated with robust dose/exposure-dependent in vivo target inhibition. In addition, the preclinical profile of LY-3177833 was different from nonselective CDC7 inhibitors and cytotoxic agents, something that supports its clinical development with a continuos dosing regime
Chemical Information Catalog
DC9766
Purity of current batch:
>98%
Molecular Weight (MW)
309.3
Molecular Formula
C16H12FN5O
CAS No.
1627696-51-8
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.