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Datasheet of SHR-1977
. Description: SHR-1977 (ROMK IC50 = 44 nM, hERG IC50 = >100,000 nM) displayed a linear exposure relationship with dose in rats and dogs. SHR-1977 also showed selectivity for ROMK over other inward-rectifier potassium ion channels. In rats, diuresis and natriuresis were increased with oral doses of 0.3 mg/kg (3.88- and 3.25-fold, respectively, compared to vehicle) and 1.0 mg/kg (4.77- and 2.92-fold, respectively, compared to vehicle). In spontaneously hypertensive rats, daily mean systolic blood pressure was significantly reduced by these doses given for 3 days.
Chemical Information Catalog
DC9767
Purity of current batch:
>98%
Molecular Weight (MW)
419.44
Molecular Formula
C21H21N7O3
CAS No.
N/A
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.