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Datasheet of AKR1C3 Inhibitor 5f
Description: A cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 2.65μM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 2.65μM, 84.4μM, for AKR1C3, AKR1C2, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 μM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells.
Chemical Information Catalog
DC9843
Purity of current batch:
>98%
Molecular Weight (MW)
243.26
Molecular Formula
C14H13NO3
CAS No.
1275482-57-9
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.