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Datasheet of GK921
Description: GK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 uM in cancer cell lines. GK921 inhibited the tgase 2-induced polymerization of I-κBα and p53 in vitro in a dose-dependent manner. Oral administration of GK921 (8 mg/kg) began when tumors reached a volume of 100 mm3 and proceeded for 5 days/week. after 64 days of treatment, tumor volumes were significantly different in GK921-treated mice and vehicle-treated controls.
Chemical Information Catalog
DC9855
Purity of current batch:
>98%
Molecular Weight (MW)
344.41
Molecular Formula
C21H20N4O
CAS No.
1025015-40-0
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.