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Datasheet of BI-9564
Description: BI-9564 (MW 353.4) is a BRD9 / 7 specific inhibitor that has been developed in collaboration with Boehringer Ingelheim. This probe was discovered through fragment-based screening and optimized by structure guided design. BI-9564 binds to BRD9 with a higher affinity (Kd=14 nM, ITC) than to BRD7 (Kd=239nM, ITC), is completely negative on BET family members (>100 μ M by AlphaScreen) and demonstrates cellular activity by FRAP on BRD9 and BRD7 at 0.1 μM and 1 μM, respectively. BI-9564 shows off-target selectivity to CECR2 in vitro (258 nM, ITC), but not in cells (at 1 μM, FRAP).
Chemical Information Catalog
DC9888
Purity of current batch:
>98%
Molecular Weight (MW)
353.41
Molecular Formula
C20H23N3O3
CAS No.
1883429-22-8
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.