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Datasheet of IQ-1
Description: IQ-1 has many functions such as decreasing Wnt-stimulated phosphorylation, maintaining the pluripotency of murine ESCs, preventing PP2A/Nkd interaction and so on. 1、IQ-1 maintains the pluripotency of murine ESCs in long-term culture in a Wnt-dependent manner. 2、IQ-1 decreased Wnt-stimulated phosphorylation of p300 at Ser-89. 3、 IQ-1 binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction. 4、The binding of IQ-1 to PR72/130 leads to decreased phosphorylation of the coactivator protein p300 at Ser-89. 5、IQ-1 thereby diminishes the β-catenin/p300 interaction and prevents β-catenin coactivator switching from CBP to p300.
Chemical Information Catalog
DC9952
Purity of current batch:
>98%
Molecular Weight (MW)
362.42
Molecular Formula
C21H22N4O2
CAS No.
331001-62-8
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.