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Datasheet of E-64c
Description:. E-64c is a synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor isolated from Aspergillus japonicus.E-64c inhibits the cysteine proteases cathepsin B and cathepsin L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.The ethyl ester of E-64c, E-64d, is cell permeable and hydrolyzed in cell culture to E-64c. E-64d arrests the growth of A431 cells in metaphase at concentrations between 20-200 µg/ml. Chemical Information Catalog
DC10126
Purity of current batch:
>98%
Molecular Weight (MW)
314.4
Molecular Formula
C15H26N2O5
CAS No.
76684-89-4
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.