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Datasheet of TM5275 sodium salt
Description:. "Selective, orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 value 6.95 µM in tissue plasminoge n activator-dependent peptide hydrolysis essay) with antithrombotic benefits devoid of bleeding effect in rodents and no nhuman primates, and with impressive bioavailability.TM 5275 prolongs tPA retention and enhances plasmin generation on the vascular endothelial cell (VEC) surface as a result of PAI-1 inhibition.
Additionally, TM 5275 represents a novel class of anti-inflammatory agents targeting macrophage migration by the inhi bition of the interaction of PAI-1 with low-density lipoprotein receptor–related protein (IC50 values 3.13 µM and 3.02 µM for LRP1 protein Cl II and Cl IV, respectively)."
Chemical Information Catalog
DC10149
Purity of current batch:
>98%
Molecular Weight (MW)
543.97
Molecular Formula
C28H27ClN3NaO5
CAS No.
1103926-82-4
Solubility (25°C)
DMSO
Storage
Store at -20°C (desiccating conditions).
Handling: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.