Make your Small Molecule Drug Discovery Work Flow

Making your Small Molecule Drug Discovery Work Flow

with R&D Enterprises to Make the World Heathier, Cleaner, Safer 2M+ 10K+ Scientists Customers

Partnering

New R&D Markets and Roles for Small Molecules

Need to Make Better Candidates, Faster

• Cost to develop new drug $1.4 Bn ($1 Bn in Clinical)

• 12% increase in small molecule drug discovery costs

• Declining research productivity stabilized by CRO outsourcing

• Discovery workflows have become more complicated

• Optimize discovery and reduce downstream costs

New Informatics Ecosystem Required

• Explosion in data requires new software and capabilities

• Data and analysis is fragmented across functions

• Vendor software codes at end of life

• Increased technical debt and cost of ownership

• Lab IT sponsorship competing with digitalisation projects

Accumulation of Task Software Created Greater Lab Capabilities and Technical Debt

15 23 31 22 29 32 15 34 42 38 40 6 6 6 3 11 12 7 12 17 10 13 0 20 40 60 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 Biologics Small Molecules Small Molecule Market is Growing The Opportunity

The Challenge FDA approvals for small molecules and biologics 2010-2020 High Level Pharma Value Chain

We are building the world’s most powerful scientific R&D Platform connecting best-of-breed applications to enable collaboration, automation and analysis.

Best-of-Breed Applications Scientific Data Platform Unparalleled Insights

• Dotmatics’ Small Molecule Drug Discovery workflow supports discovery from hit and lead identification, through lead optimization, to candidate selection.

• Fully integrated laboratory informatics software captures experiments, molecules, samples and assays.

• Decision support tools enable gathering, analysis and visualization of project data.

• Together, these help project teams be more efficient and make better informed decisions, faster.

The Solution

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Small Molecule Drug Discovery Workflow

Plate Data Processing

Data Review and Curve Fitting

Configurable End-point Data Loading

Automated Data Classification

Interactive Curve Comparison

Assay Screening

Characterize Request

Registration

Purification

Library Synthesis

Compound Synthesis

Reuse Prior Chemistry

Automated Stoichiometry Table

Integrated Chemical Inventory

Accurate Procedure Capture

Data Import Compound Registration

Analytical Requests CRO Requests

Collate Data

Analyze/SAR

Hit Selection

Idea Generation

Compound Design

Connect Scientific Data

Visual Analysis

Statistical Modeling

Uncover Promising Compounds

Purpose-Built Views

R-Group Analysis

Library Enumeration

In Vitro In Vivo Analysis/QC

Save time and costs while enabling better-informed, faster decision making.

Productivity and Collaboration

• Integrate capabilities and simplify data workflows

• Increase collaboration via transparent communication

• Increase scientists’ focus on discovery

Insights and Innovation

• Real time insights to drive better discovery strategies

• Advanced, guided visualisation and data analytics tools

• Optimised planning and design capabilities

Operational Efficiency

• Reduce workflow inefficiency time and costs

• Reduce technical dept and total cost of ownership

• Reduce informatics solution implementation time

Quality and Compliance

• Standardize data and improve integrity

• Improve data governance and regulatory compliance

• Automated data capture and audit tracking

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