Therapeu*c Drug Monitoring (TDM) Today:
???
[1] Edurant (Rilpivirine) prescribing informa*on
2
TDM of Rilpivirine (an*retroviral drug) Today:
Cmin < 44ng/mL for 40% of popula;on !
C o n c e n t r a t io n s ( n g / m L )
R ilp iv ir in e
1000
100
Target Cmin=44ng/mL
10 0
6
12
18
24
T im e a f te r d o s e [H o u r s ]
[1] Edurant (Rilpivirine) prescribing informa*on
30
36
35 000 000 HIV+ 6300 new infec;on/day 3
Therapeu*c Drug Monitoring (TDM) Tomorrow:
Today:
ü automated ü personalized
4
ü Predic*on engine (Bayesian approach) ü Ergonomic soHware
Population-based percentiles Individual concentration vs time profile dosing schedule suggestion
5
EzeCHiel light DBMS, remote data collection
Easy to integrate (Health Level 7 interface)
Ø Clinical interpretation (TDM) Ø Drug developement Ø Clinical trials Ø Ø Ø Ø
Aggregation of data for the research
Precision Predic;on modeling Time Interoperability Privacy & Security U;lity 6 User-‐friendly
Team Dr. Séverine Pe;tprez, Drug models development
Alev;na Dubovitskaya, Data mining, Interoperability
Dr. Manel Aouri, Clinical evalua8on
Advisory Board: Division of Clinical Pharmacology, CHUV Development of drug models, clinical evalua8on
Prof. T. Buclin, MD
A. Chaouch
Dr. N. Widmer
Dr. M. Guidi
Prof. C. Csajka
Dr. P. André
REDS HEIG-‐VD, HES-‐SO VS So;ware development, Interoperability
Prof. Y.Thoma
R. Hooper
Prof. M. Schumacher
Y. Su]er 7
Ac*on Plan
8
Ac*on Plan
9
SoHHytec
Solar Fuel, the smarter way.
Ready to Launch
We sell Onsite H2 production system which is cost effective, cleaner & greener, for fertilizer and chemical industries Nano-Tera Meeting, Bern| 04 May, 2015
1/09
Our Customer
Refineries 20%
Fertilizer and Chemical industries  Methanol 7%
Ammonia 53%
Other 20%
H2 Usage
Nano-Tera Meeting, Bern| 04 May, 2015
2/09
Our Opportunity Problem worth solving: Lack of cost effective onsite H2 production. 95% of current world H2 production comes from off-site steam reforming of conventional fossil fuels which is Not clean & non-renewable Downscaling the size becomes extremely expensive Costly due to specialized transportation
Lack of cost effective onsite H2 production
Faster degradation of the system
Our Solution: On site cost effective H 2 production using smart combination of concentrated solar energy during day and cheap grid electricity during night using our Integrated PEC device Cleaner & Greener Highly scalable in size (up/down) Onsite hence no costly expenses for transportation Longer and durable life span Nano-Tera Meeting, Bern| 04 May, 2015
3/09
Our Product PV+ELECTROLYZER
Night Day Operation Operation
H2 Inte
gra
PE ted
Cheap Grid Electricity During night
O2
H2O
C
Compressor Storage
CUSTOMER
Concentrator
Nano-Tera Meeting, Bern| 04 May, 2015
4/09
Business Potential 2.21 $ 1.69 $
For 50m by 50m system producing 234 Kg H2/ day
2$
Exemplary case
Our H2 Production cost (without CSD) including 15% ROI 1.69 $/Kg
1
2
3 Case
Operation Type
Price
1
Our System
1.69 $/Kg
Great combination of sunlight during day and cheap electricity during night
2
Just electrolysis using electricity (Day + Night)
2.21 $/Kg
Even just day electricity price during the lifespan makes it expensive option
3
Steam reforming requiring transportation
2 $/Kg
Transportation alone increase price of hydrogen by 1$/kg* of H2
*Hydrogen Sta.on Compression, Storage, and Dispensing Technical Status and Costs ,G. Parks, R. Boyd, J. Cornish, and R. Remick , NREL Independent Peer Review Report
Nano-Tera Meeting, Bern| 04 May, 2015
5/09
How we make Profit Strategy: 15% ROI plus yearly charges equal to 50% of customer’s saving potential for next 15 years For the installation of the size of 50m by 50m with 360k $ investment
$/Kg of H2
132k $
2
136k $
Distributed stea
m reforming
54k $
Our system
0 1
3
5
7 Years
9 11 13 15
Customer’s Saving potential
day 1
year 1-10
year 10-15
Our profits Nano-Tera Meeting, Bern| 04 May, 2015
6/09
Meet our Team
Saurabh Tembhurne CEO and co-founder
Meng Lin CTO and co-founder
Prof. Sophia Haussener Scientific Advisor
Doctoral Assistant in ENERGY Laboratory of Renewable Energy Science and Engineering (LRESE) EPFL, Lausanne
Doctoral Assistant in ENERGY Laboratory of Renewable Energy Science and Engineering (LRESE) EPFL, Lausanne
Assistant Professor Laboratory of Renewable Energy Science and Engineering (LRESE) EPFL, Lausanne
Nano-Tera Meeting, Bern| 04 May, 2015
7/09
Gives as Great Opportunity to showcase and demonstrate our product as well as would be a brilliant chance to make new connections and attract tentative investors
Nano-Tera Meeting, Bern| 04 May, 2015
8/09
THANK YOU
Nano-Tera Meeting, Bern| 04 May, 2015
9/09
Ø Wearable sensing devices will represent $47.4B market* in 2019 Ø Wearable electronics should be conformal, light weight and unno6ceable Ø However current electronic solu@ons are rigid, planar and bulky.
* Source :Onworld Wearable Technologies Consumer Survey
Ø We are a wannabe EPFL Spin-‐off -‐ Prof. S. P. Lacour:
Laboratory for soM bioelectronics interfaces
Ø Target Market: Electronic companies Ø We provide B2B technological solu6ons to help industrial partners implement systems that can conform to the human body
Ø Robustness, Cost effec6veness Design flexibility Ø Patent applica@on ongoing, backed by EPFL TTO
SolSticE
SolSticE Solar Sticker for Energy
Highest EďŹ&#x20AC;iciency Materials Flexible Adhesive
Applications
SolSticE
SolSticE
Comfort
Benchmark
Flexibility
Planar VS Nanowire
n-doped intrinsic p-doped
SolSticE
SolSticE
Status Achievements • • • •
First prototype on Si. Peeling procedure developed. The Silicon wafer can be reused. The technique is scalable independently on the wafer size.
10 µm
Status Open Challenges •
• •
Realization of high conductivity and flexible contacts. Iterative optimization of the design. Scale up.
SolSticE
SolSticE
The Team
COO
CTO
CEO
Jelena Vukajlovic-Plestina
Dmitry Mikulik
Federico Matteini
Princess
Astronaut
Wizard
November 2â&#x20AC;&#x201C;4, 2015, MIT Media Lab, Cambridge, MA
SolSticE