Juan Ansó, May 2015
Drill integrated neuro-monitoring for minimally invasive robotic cochlear implantation Background —
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Facial nerve safety – preliminary work —
Neuromonitoring for FN protection (detect FN proximity)
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Optimal stimulation protocol determined in sheep
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Custom neuromonitoring probe detects FN (<0.1 mm)
Project Goal —
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Cathode
Drill integrated stimulation for conitinuous FN monitoring Anode 3 Anode 2 Anode 1
Proposal — — —
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Drill passes within 0.3 – 1 mm of facial nerve
Protocol verification in humans (medical grade EMG device required) (Neurosign device, 17000 CHF )
FN
Drill bit insulation coating for integrated stimulation electrodes (Student 2.5 months ~ 14,000 CHF) Total budget 31,000 CHF, project duration 6 months
Collaborators —
Marco Caversaccio, Department of ENT, Unibe
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Jorg Patscheider, Coatings department, Empa
Stimulus threshold (mA)
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Sheep 2 Trajectory 7 LD = 0
d=2 d=4 d=7 Mono
1.5 1 0.5 0.3 0.1 -1
0 Axial distance (mm)
1
1
NextStep - Scientific Collaboration 04.05.2015 - Tobia Brusa, ISTB, University Bern
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Functional anatomy of Fecal Incontinence (FI) — Characterization of continence organ’s anatomy and biomechanics in patients suffering from fecal incontinence (FI). — Prof. Dr. Med. Radu Tutuian, chief physician gastroenterology at Tiefeneau Hospital Bern — Chf: ~30’000.-
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Extension of current Nano-Tera study aiming at defining design specifications of implant based on healthy volunteers.
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Main benefit: add clinical component to the project — — — —
Comprehensive assessment of contraction and compliance Integration of imaging and functional data Establishing normal (healthy subjects vs. patients) Develop new treatment concepts 1
Digital Ultrasound Head [UltrasoundToGo] Pascal Alexander Hager largest ultrasound research unit Europe more than 20 years experience
Project Scope
Frontend HDI PCB (commercial components)
Digital Processing Digital high‐speed link
Piezoelectric Transducer Array
Backend System FPGA Board (Tablet/Smartphone)
Ultrasound Division Fraunhofer IBMT
ETHZ IIS
Conventional 2D Ultrasound System:
Goal: •
Explore new digital ultrasound head concept.
Collaboration: • •
Build two heads, collaborators provide parts Funding (30k): PCB, Components, IBMT Assistance
Time Table: Transducer head
Cable 64‐256 coax
Analog Frontend Digital Processing Backend System
• •
6 Month, 50% PhD Student IIS 10% support personnel IIS/IBMT
Image Sources: Ibmt.fraunhofer.de healthcare.philips.com www.akutron.com/products
Functional c-Si/GaAs nanowire tandem solar cell Flexible PDMS film helps to transfer GaAs nanowire forest from Si substrate to surface of c-Si solar cell
Problem with PDMS hardness – film with thickness 5 µm is very fragile Solution: perform search and analysis of different range of polymers with professional polymer chemist
Dmitry Mikulik, EPFL
1st Idea: Reliability of NW-polymer composite New polymer material – UV curable polyester. • High transparence • Low viscosity • Good adhesion • Good hardness
Main collaborator: Tommaso Nardi, Laboratory of Composite and Polymer Technology, EPFL Planning work: Work with different polymers and methods for embedding GaAs NWs on equipment of Polymer Lab in EPFL Our part: provide test samples with nanowires, analysis of experiments with SEM, OM and other techniques. Collaborator part: provide new polymer materials, expertise of methods of embedding NWs in polymer, provide equipment for experiments Funding: 5.000 chf
Sun light
Functional c-Si/GaAs nanowire tandem solar cell
ITO PDMS ITO c‐Si solar cell
2nd Idea: Reliability of GaAs NW solar cells by analyzing spectral and electrical characteristics Optical measurements: EQY – Initial measurements Reflectance — give information about surface quality IQY - depends on structure and p-n junction optical properties
GaAs p-i-n nanowires embedded in flexible PDMS film would play a role of second solar cell, placed on top of conventional c-Si solar cell Problem: Reliability of GaAs NW based solar cells Solution: To realize perspective and weak points of GaAs NW based solar cell - spectral, electric and optical measurements must be performed.
Dmitry Mikulik, EPFL
Electrical measurements: IV curves in a wide range of irradiance allows to obtain a number of important characteristics: Voc-Jsc dependence to form p-n junction IV curve resistive losses IV as a difference between p-n junction and practical IV curve
Electro-luminescence pattern determination at different temperatures: Could be applied to evaluate the uniformity of nanowires photo-electrical properties
T= 25C, J=100 mA/cm2
T= -190C, J=5 mA/cm2
T= -190C, J=5.5 mA/cm2
Main collaborator: Mikhail Mintairov, Photovoltaics Lab, Ioffe institute, Russia Planning work: Measurements and analysis of results of pilot devices in Photovoltaics lab in Ioffe institute Our part: provide pilot devices based on GaAs NWs, organize joint workshop/visit to discuss results Collaborator part: provide different measurements of solar cells, analysis of measurements Funding: 10.000 chf
PARTNERS
GOAL
Soft & dry biopotential electrodes MOTIVATION APPROACH
LBB
MNS
‐ Conductive polymers ‐ Implantables
‐ Micro & Nanofabrication ‐ Wearables
Flurin Stauffer
Moritz Thielen
FUNDING • Wearable health monitoring • Brain‐computer interfaces • Poor performance of Embedding conductive commercial systems nanostructures in soft substrates Contact: Moritz Thielen, thielenm@ethz.ch
Enobio from Neuroelectrics®
• A portable EEG system (12k) • Biocompatibility studies (8k) • Clinical evaluation (10k)
Development of an impedance setup to study electric and electrochemical bone tissue properties.
Thomas Wyss Balmer ISTB University of Berne
Facial nerve neuro‐monitoring is used to improve the safety of drilling in the bone for DCA. Bone electric properties required to predict the distance between drill bit and nerves. Electro‐chemical effects
Better characterization of these effects
Budget ~ 30’000 CHF
Contact effects Voltage/frequency dependent Affected by the type of electrolyte Collaboration with Department of Chemistry and Biochemistry at University of Bern & University of Budapest (P. Broeckmann, H. Siegenthaler) Setup for reliable measurement of the electrochemical properties (optimize stray capacitance, contact interface, signal/noise ratio, waveform…)
Cost of personnel & material Seed project towards snf proposal
Therapeu*c Drug Monitoring (TDM) Today:
???
[1] Edurant (Rilpivirine) prescribing informa*on
2
TDM of Rilpivirine (an*retroviral drug) Today:
Cmin < 44ng/mL for 40% of popula;on !
C o n c e n t r a t io n s ( n g / m L )
R ilp iv ir in e
1000
100
Target Cmin=44ng/mL
10 0
6
12
18
24
T im e a f te r d o s e [H o u r s ]
[1] Edurant (Rilpivirine) prescribing informa*on
30
36
35 000 000 HIV+ 6300 new infec;on/day 3
Therapeu*c Drug Monitoring (TDM) Tomorrow:
Today:
ü automated ü personalized
4
ü Predic*on engine (Bayesian approach) ü Ergonomic soHware
Population-based percentiles Individual concentration vs time profile dosing schedule suggestion
5
EzeCHiel light DBMS, remote data collection
Easy to integrate (Health Level 7 interface)
Ø Clinical interpretation (TDM) Ø Drug developement Ø Clinical trials Ø Ø Ø Ø
Aggregation of data for the research
Precision Predic;on modeling Time Interoperability Privacy & Security U;lity 6 User-‐friendly
Team Dr. Séverine Pe;tprez, Drug models development
Alev;na Dubovitskaya, Data mining, Interoperability
Dr. Manel Aouri, Clinical evalua8on
Advisory Board: Division of Clinical Pharmacology, CHUV Development of drug models, clinical evalua8on
Prof. T. Buclin, MD
A. Chaouch
Dr. N. Widmer
Dr. M. Guidi
Prof. C. Csajka
Dr. P. André
REDS HEIG-‐VD, HES-‐SO VS So;ware development, Interoperability
Prof. Y.Thoma
R. Hooper
Prof. M. Schumacher
Y. Su]er 7
Ac*on Plan
8
Ac*on Plan
9
SoHHytec
Solar Fuel, the smarter way.
Ready to Launch
We sell Onsite H2 production system which is cost effective, cleaner & greener, for fertilizer and chemical industries Nano-Tera Meeting, Bern| 04 May, 2015
1/09
Our Customer
Refineries 20%
Fertilizer and Chemical industries  Methanol 7%
Ammonia 53%
Other 20%
H2 Usage
Nano-Tera Meeting, Bern| 04 May, 2015
2/09
Our Opportunity Problem worth solving: Lack of cost effective onsite H2 production. 95% of current world H2 production comes from off-site steam reforming of conventional fossil fuels which is Not clean & non-renewable Downscaling the size becomes extremely expensive Costly due to specialized transportation
Lack of cost effective onsite H2 production
Faster degradation of the system
Our Solution: On site cost effective H 2 production using smart combination of concentrated solar energy during day and cheap grid electricity during night using our Integrated PEC device Cleaner & Greener Highly scalable in size (up/down) Onsite hence no costly expenses for transportation Longer and durable life span Nano-Tera Meeting, Bern| 04 May, 2015
3/09
Our Product PV+ELECTROLYZER
Night Day Operation Operation
H2 Inte
gra
PE ted
Cheap Grid Electricity During night
O2
H2O
C
Compressor Storage
CUSTOMER
Concentrator
Nano-Tera Meeting, Bern| 04 May, 2015
4/09
Business Potential 2.21 $ 1.69 $
For 50m by 50m system producing 234 Kg H2/ day
2$
Exemplary case
Our H2 Production cost (without CSD) including 15% ROI 1.69 $/Kg
1
2
3 Case
Operation Type
Price
1
Our System
1.69 $/Kg
Great combination of sunlight during day and cheap electricity during night
2
Just electrolysis using electricity (Day + Night)
2.21 $/Kg
Even just day electricity price during the lifespan makes it expensive option
3
Steam reforming requiring transportation
2 $/Kg
Transportation alone increase price of hydrogen by 1$/kg* of H2
*Hydrogen Sta.on Compression, Storage, and Dispensing Technical Status and Costs ,G. Parks, R. Boyd, J. Cornish, and R. Remick , NREL Independent Peer Review Report
Nano-Tera Meeting, Bern| 04 May, 2015
5/09
How we make Profit Strategy: 15% ROI plus yearly charges equal to 50% of customer’s saving potential for next 15 years For the installation of the size of 50m by 50m with 360k $ investment
$/Kg of H2
132k $
2
136k $
Distributed stea
m reforming
54k $
Our system
0 1
3
5
7 Years
9 11 13 15
Customer’s Saving potential
day 1
year 1-10
year 10-15
Our profits Nano-Tera Meeting, Bern| 04 May, 2015
6/09
Meet our Team
Saurabh Tembhurne CEO and co-founder
Meng Lin CTO and co-founder
Prof. Sophia Haussener Scientific Advisor
Doctoral Assistant in ENERGY Laboratory of Renewable Energy Science and Engineering (LRESE) EPFL, Lausanne
Doctoral Assistant in ENERGY Laboratory of Renewable Energy Science and Engineering (LRESE) EPFL, Lausanne
Assistant Professor Laboratory of Renewable Energy Science and Engineering (LRESE) EPFL, Lausanne
Nano-Tera Meeting, Bern| 04 May, 2015
7/09
Gives as Great Opportunity to showcase and demonstrate our product as well as would be a brilliant chance to make new connections and attract tentative investors
Nano-Tera Meeting, Bern| 04 May, 2015
8/09
THANK YOU
Nano-Tera Meeting, Bern| 04 May, 2015
9/09
Ø Wearable sensing devices will represent $47.4B market* in 2019 Ø Wearable electronics should be conformal, light weight and unno6ceable Ø However current electronic solu@ons are rigid, planar and bulky.
* Source :Onworld Wearable Technologies Consumer Survey
Ø We are a wannabe EPFL Spin-‐off -‐ Prof. S. P. Lacour:
Laboratory for soM bioelectronics interfaces
Ø Target Market: Electronic companies Ø We provide B2B technological solu6ons to help industrial partners implement systems that can conform to the human body
Ø Robustness, Cost effec6veness Design flexibility Ø Patent applica@on ongoing, backed by EPFL TTO
SolSticE
SolSticE Solar Sticker for Energy
Highest EďŹ&#x20AC;iciency Materials Flexible Adhesive
Applications
SolSticE
SolSticE
Comfort
Benchmark
Flexibility
Planar VS Nanowire
n-doped intrinsic p-doped
SolSticE
SolSticE
Status Achievements • • • •
First prototype on Si. Peeling procedure developed. The Silicon wafer can be reused. The technique is scalable independently on the wafer size.
10 µm
Status Open Challenges •
• •
Realization of high conductivity and flexible contacts. Iterative optimization of the design. Scale up.
SolSticE
SolSticE
The Team
COO
CTO
CEO
Jelena Vukajlovic-Plestina
Dmitry Mikulik
Federico Matteini
Princess
Astronaut
Wizard
November 2â&#x20AC;&#x201C;4, 2015, MIT Media Lab, Cambridge, MA
SolSticE