Healthy Living Could Be So Easy
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Orthomolecular Medicine 1.
Recommendations of the DGE (Deutsche Gesellschaft für Ernährung e.V. – German Nutrition Society)
2.
Our nutritional situation in Germany
3.
Reasons for an increased need for nutrients
4.
Linus Pauling – founder of orthomolecular nutritional medicine
5.
Orthomol products – the dietary advantage 2
Orthomolecular Medicine 1.
Recommendations of the DGE (Deutsche Gesellschaft für Ernährung e.V. – German Nutrition Society)
2.
Our nutritional situation in Germany
3.
Reasons for an increased need for nutrients
4.
Linus Pauling – founder of orthomolecular nutritional medicine
5.
Orthomol products – the dietary advantage 3
1. Recommendations of the DGE
Dietary reference intakes (DRIs) according to D-A-CH* In March 2000, the following Nutrition Societies agreed on common dietary reference intakes (DRIs): • DGE (German Nutrition Society) • ÖGE (Austrian Nutrition Society) • SGE (Swiss Society for Nutritional Research) • SVE (Swiss Association for Nutrition) The objective of these DRIs is the maintenance and promotion of good health, and thus the quality of life. * Nutrition Societies of Germany, Austria, Switzerland DGE/ÖGE/SGE/SVE. D-A-CH Referenzwerte für die Nährstoffzufuhr [D-A-CH dietary reference intakes (DRIs)]. 1st Edition, Frankfurt a.M., Germany: Umschau/Braus; 2000.
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1. Recommendations of the DGE
DRIs according to D-A-CH* • As defined by the FAO** and WHO, these intakes should be able to maintain essential metabolic, physical and psychological functions in almost all healthy individuals in the general population. • The dietary reference intakes should prevent diet-related deficiency diseases (rickets, scurvy, pellagra) and symptoms of deficiencies (dermatitis, ophthalmological and cerebral disorders).
* Nutrition Societies of Germany, Austria, Switzerland ** Food and Agriculture Organization of the United Nations DGE/ÖGE/SGE/SVE. D-A-CH Referenzwerte für die Nährstoffzufuhr [D-A-CH dietary reference intakes (DRIs)]. 1st Edition, Frankfurt a.M., Germany: Umschau/Braus; 2000.
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1. Recommendations of the DGE
DRIs according to D-A-CH* The established DRIs are not valid for patients who are suffering from diseases or those who are recovering from illness. Also, with the exception of iodine, they are inadequate for refilling the depleted reserves of people with nutrient deficiencies. Nor are they meant for people with digestive or metabolic disorders, or individuals who have a burden from stimulants (alcohol, nicotine) or from regular drug therapy. * Nutrition Societies of Germany, Austria, Switzerland DGE/ÖGE/SGE/SVE. D-A-CH Referenzwerte für die Nährstoffzufuhr [D-A-CH dietary reference intakes (DRIs)]. 1st Edition, Frankfurt a.M., Germany: Umschau/Braus; 2000.
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1. Recommendations of the DGE
DRIs according to D-A-CH*
These people need individual consultation and supervision on a nutritional and medical basis. This is also true for late sequelae and long-term damage after the manifestation and progression of diseases.
* Nutrition Societies of Germany, Austria, Switzerland DGE/ÖGE/SGE/SVE. D-A-CH Referenzwerte für die Nährstoffzufuhr [D-A-CH dietary reference intakes (DRIs)]. 1st Edition, Frankfurt a.M., Germany: Umschau/Braus; 2000.
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Orthomolecular Medicine 1.
Recommendations of the DGE (Deutsche Gesellschaft für Ernährung e.V. – German Nutrition Society)
2.
Our nutritional situation in Germany
3.
Reasons for an increased need for nutrients
4.
Linus Pauling – founder of orthomolecular nutritional medicine
5.
Orthomol products – the dietary advantage 8
Germany: The Melander family from Bargtheide a town in the north. Eating expense per week: 375.39 Euro
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2. Our nutritional situation in Germany
Many people have an imbalanced diet Actual Alcohol 4% Sugar* 20% Complex carbohydrates 27% Protein 13% Fat 36% * mono- and disaccharides (according to DGE)
Target Sugar* 10% Complex carbohydrates 48 % Protein 12% Fat 30% DGE. Ern채hrungsbericht 2004 [Nutrition Report]. Frankfurt a.M., Germany: DGE; 2004.
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2. Our nutritional situation in Germany
Dietary habits Vegetables
Fruit
We should eat per day:*
Women eat per day:**
Men eat per day:**
approx. 300 g = 100%
approx. 400 g = 100%
172 g = 57.3%
175 g = 43.8%
137.5 g = 45.8%
132 g = 33.0%
* Quantities according to the recommendations of the German Nutrition Society (DGE): 5-a-day campaign ** Average intake of adults: DGE. Ern채hrungsbericht 2004 [Nutrition Report]. Frankfurt a.M., Germany: DGE; 2004.
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2. Our nutritional situation in Germany
Micronutrient intake according to DGE* Nutrition survey in Germany (percentages achieved)
Women Men
Calcium
Iodine
85.0% 85.5%
46.5% 52.0%
Vitamin D3
Folic acid
49.0% 66.5%
55.0% 54.5%
Pantothenic acid
79.0% 86.5%
The intake of calcium, iodine, vitamin D3, folic acid and pantothenic acid is still below the recommended dietary reference intakes of the DGE.
* German Nutrition Society DGE. Ern채hrungsbericht 2004. [Nutrition Report.] Frankfurt a.M., Germany: DGE; 2004.
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Orthomolecular Medicine 1.
Recommendations of the DGE (Deutsche Gesellschaft für Ernährung e.V. – German Nutrition Society)
2.
Our nutritional situation in Germany
3.
Reasons for an increased need for nutrients
4.
Linus Pauling – founder of orthomolecular nutritional medicine
5.
Orthomol products – the dietary advantage 13
3. Reasons for an increased need for nutrients
Losses of micronutrients • Due to long-distance transportation • Due to long storage periods (with poor temperature/air conditions and excessive light exposure)
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3. Reasons for an increased need for nutrients
Processing and preparation Losses due to: - Conservation (e.g. freezing, processing) - Preparation (e.g. washing, peeling)
- Processing (e.g. mincing, heating) - Keeping warm, heating up
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3. Reasons for an increased need for nutrients
Losses of micronutrients Example: cauliflower  vitamin C 100 g cauliflower contains when harvested 70 mg of vitamin C
70.0 mg
2-day transportation/storage with 20 °C, Â loss of approx. 26%
52.0 mg
Preparation (washing, cooking) Â loss of approx. 45%
28.6 mg
Keeping warm, heating up  loss of approx. 10%
25.7 mg
After this “treatment” 100 g cauliflower contains only 1/3 of the original content of vitamin C. Modified after Bognár A. Vitaminverluste bei der Lagerung und Zubereitung von Lebensmitteln [Loss of vitamins during storage and preparation of food]. Ernährung/Nutrition 1995;19 (9/10/11): 411-416, 478-483, 551-554.
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3. Reasons for an increased need for nutrients
What is the impact of pharmaceuticals?
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Pharmaceuticals as "micronutrient robbers" Pharmaceutical
Effect on
Due to
ACE inhibitors
Zinc
• Increased renal excretion
Acetylsalicylic acid (ASA)
Vitamin C
• Impaired absorption • Increased renal excretion
Antibiotics, such as - Neomycin - Tetracyclines
Intestinal synthesis of vitamins B12 and K; tetracyclines Æ vitamin C
Anticonvulsants, such as - Phenytoin - Carbamazepine - Valproate
• Folate antagonists, reduction of folate Carnitine, folic acid, vitamins D and K, calcium absorption
CSE inhibitors (statins)
Coenzyme Q10
• Inhibition of synthesis of mevalonic acid, and thus also decrease in the body’s coenzyme Q10
Sulfonamides
Folic acid
• Disturbance of the enteric metabolism • Folate antagonists
Methotrexate, sulfasalazine
Folic acid
• Folate antagonists
• Destruction of intestinal microflora • Increased excretion of vitamin
Gröber U. Arzneimittel und Mikronährstoffe [Pharmaceuticals and micronutrients]. Dtsch Apoth Ztg 2005;14:44-56. Biesalski HK, Schrezenmeir J, Weber P, et al. Vitamine [Vitamins]. Stuttgart, Germany: Georg Thieme; 1997. Hahn A, Ströhle A, Wolters M. Ernährung [Nutrition]. Stuttgart, Germany: Wissenschaftliche Verlagsgesellschaft; 2005.
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Pharmaceuticals as "micronutrient robbers" Pharmaceutical
Effect on
Diuretics, such as - Thiazides - Furosemide
Magnesium, potassium, • Increased renal excretion of all micronutrients vitamin B1, folic acid, mentioned potassium, vitamin B1, zinc
Glucocorticoids
Calcium, vitamin D
• Anti-vitamin D effect, absorption of calcium is decreased, renal excretion is increased
Cardiac glycosides
Magnesium, potassium, vitamin B1
• Decrease in magnesium-dependent NA/K-ATPase • Reduction in the uptake of vitamin B1 into the cardiocytes
Laxatives, antibiotics
Several micronutrients, • Alteration of gastrointestinal especially minerals, e.g. magnesium and potassium motility/diarrhea
Oral contraceptives
Vitamin C Folic acid Vitamin B6 Vitamin B12
Due to
• Increased oxidation of vitamin C • Inhibition/inactivation of digestive enzymes • Activation of pyridoxine phosphate-dependent enzymes • Impaired absorption
Gröber U. Arzneimittel und Mikronährstoffe [Pharmaceuticals and micronutrients]. Dtsch Apoth Ztg 2005;14:44-56. Biesalski HK, Schrezenmeir J, Weber P, et al. Vitamine [Vitamins]. Stuttgart, Germany: Georg Thieme; 1997. Hahn A, Ströhle A, Wolters M. Ernährung [Nutrition]. Stuttgart, Germany: Wissenschaftliche Verlagsgesellschaft; 2005.
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Answer 1
Answer 2
Question 1. What does the abbreviation DGE mean?
German society for eating education
German society for nutrition
individually
through mass media
scurvy
neurodermitis
6%
4%
5. Which foods do germans eat too much?
sugar, fat, vegtables
fat, alcohol, sugar
6. How does a loss of micronutrients develop?
too warm storage
too fine chewing
free radicals
more energie
8. What is better for your metabolism?
potatoes boiled in their skins
boiled potatoes
9. How many vegetables do men eat?
about 40% of the recommendation
about 30% of the recommendation
2. How should the nutrition consultation be done? 3. What is a typical diet related definciency? 4. How many percent of the Germans eat fruit and vegtables five times per day?
7. What develops in your body through a breakdown of medicine?
20 Obst
3. Reasons for an increased need for nutrients
Increased need for nutrients WITHOUT concurrent disease • • • • • •
Hobby sports enthusiasts People suffering from major stress Sun worshippers People on a weight-reduction diet People on a vegetarian diet Environmental strain
• • • • • •
Elderly people Adolescents Women taking a contraceptive pill Smokers People drinking alcoholic beverages Pregnant women
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3. Reasons for an increased need for nutrients
Increased need for nutrients WITH concurrent disease • • • • • • •
Heart failure Coronary heart disease After infarction/stroke Elevated blood lipids Diabetes Hypertension Rheumatoid arthritis
• • • • • • • •
Osteoarthritis Age-related eye diseases Cancer High drug use Asthma Allergies Bowel diseases Neurodegenerative diseases
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5. Der Nährstoffbedarf
Who doesn´t need any micronutrients
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Key role of free radicals
Why are free radicals so harmful? Preferably attack lipids in cell walls
Change of body structures
Dysfunction
Damage to function, and degradation
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Key role of free radicals
How are free radicals formed? Endogenous factors
Exogenous factors
– In metabolic
Smoking –
processes
–
Burden from environmental pollutants – (e.g. car exhaust, smog, In energy-supplying respiratory ozone, fine dust particles) activity
– Inflammatory processes or diseases
– Increased physical stress
Use of pharmaceuticals – Burden from UV radiation – (intensive sun exposure)
Excessive formation of free radicals 25
3. Reasons for an increased need for nutrients
Protection against free radicals Natural radical scavengers: Â Vitamin C
 Phytonutrients
 Vitamin E
 Zinc, manganese, copper, selenium (as components of antioxidant enzymes)
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zinc
support
copper
sup
por t
t por
sup
Vitamin C pr
t c e ot
selenium s
t ec
su pp
prot e
up p o rt
t pro
Coenzym Q10 ct
ort
Betasupport Carotene
Vitamin E 27
Orthomolecular Medicine 1.
Recommendations of the DGE (Deutsche Gesellschaft für Ernährung e.V. – German Nutrition Society)
2.
Our nutritional situation in Germany
3.
Reasons for an increased need for nutrients
4.
Linus Pauling – founder of orthomolecular nutritional medicine
5.
Orthomol products – the dietary advantage 28
4. Linus Pauling – founder of orthomolecular nutritional medicine
Orthomolecular nutritional medicine “Orthomolecular medicine is the preservation of good health and the treatment of disease by varying the concentrations in the human body of substances that are normally present in the body and are required for health.”*
Linus Pauling Twice winner of the Nobel Prize and founder of orthomolecular medicine
* Pauling L. Orthomolecular somatic and psychiatric medicine. Z Vitalst Zivilisationskr 1968; 12(1): 3-5. See also: Pauling L. Orthomolecular psychiatry. Science 1968; 160(825): 265-71. www.orst.edu/dept/lpi/
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4. Linus Pauling – founder of orthomolecular nutritional medicine
The synergy of micronutrients is critical Vitamins
Minerals
Trace elements
Probiotics and prebiotics
Phytonutrients
Amino acids
Fatty acids
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Orthomolecular Medicine 1. Recommendations of the DGE (Deutsche Gesellschaft für Ernährung e.V. – German Nutrition Society) 2. Our nutritional situation in Germany 3. Reasons for an increased need for nutrients 4. Linus Pauling – founder of orthomolecular nutritional medicine 5. Orthomol products – the dietary advantage 31
5. Orthomol products – the dietary advantage
Established Orthomol micronutrient combinations  Based on the knowledge of orthomolecular nutritional medicine  Balanced dosage  Combination related to a special need  Innovative, user-friendly forms of administration  Practical daily servings  Premium products according to the high international standard for quality assurance ISO 22000/GMP/HACCP
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5. Orthomol products – the dietary advantage
What is it that makes Orthomol so unique?
Complexity
Dosage
Quality/ Certification
Uses
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5. Orthomol products – the dietary advantage
Complexity
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5. Orthomol products – the dietary advantage
Dosage Using the example of the vitamin C content
Market leader for multivitamins
1 small orange * Based on the average weight of one orange of 120–150 g
2 kg oranges* 35
5. Orthomol products – the dietary advantage
Differentiating food supplements and foods for special medical purposes Food supplements (German: NEM)
Foods for special medical purposes (EBD)
Laws
NemV (Nahrungsergänzungsmittelverordnung; ordinance on dietary supplements)
DiätV (Diätverordnung; ordinance on foods for special medical purposes)
Uses
Foods that shall supplement the normal diet, especially in certain phases of life associated with increased requirements, e.g. pregnancy, sports
Foods that shall serve as a specific form of diet, for the dietary management of diseases, symptoms or disturbances
Target group
Healthy individuals
Patients with diseases, symptoms or disturbances
Ingredients Exclusive use of compounds that are listed in the NemV
Ingredients according to the directive 2001/15/EC / Appendix (PARNUTS), exceptions are allowed in case of special nutritional requirements
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5. Orthomol products – the dietary advantage
Quality Orthomol is the first company to fulfill the requirements of the global standard ISO 22000:2005 in the segment micronutrients/foods. 2001 Implementation and certification of the HACCP system (Danish Standard). Annual checks performed by representatives of the TĂœV (Technical Inspection Authority) 2005 Additional compliance to GMP requirements. Orthomol received GMP certification in addition to the HACCP certificate. 2006 Implementation of the quality management system for food safety DIN EN ISO 22000:2005 at Orthomol.
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5. Orthomol products – the dietary advantage
These points makes Orthomol unique!
Complexity
Dosage
Quality/ Certification
Uses
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answer 1
answer 2
question aggressive molecules
free components of cells
2. How do free radicals develops?
through smog, singing
through smoking, physical exercise
3. Which are natural antioxidants?
Vitamin A, Vitamin E
L-Carnitin, ASA
hair and nails
fats of the cell wall
1. What are free radicals?
4. Which tissue do attack free radicals in particular?
they protect and 5. Why do we need various antioxidants? support each other hobby sports enthusiasts, elderly 6. Who needs more micronutrients? people 7. Do people with cardiovascular diseases need more micronutrients? 8. Which Vitamins can reduce Homocystein? 9. What happens with a combination of Vitamin C and iron?
it´s try and error late riser, coach potatoes
yes Vitamin B6, B12 and folic acid
no Vitamin B6, B12 and E
Vitamin C will be decomposed
iron will be better absorbed 39