Prebiocran™ shows in vivo and ex vivo a potential prebiotic effect leading to metabolic health protection

M-SHIME® MODEL

Cattero et Lessard-Lord, unpublished

The M-SHIME® study showed that Prebiocran™ promotes not only the growth of individual bacteria, but also the growth of specific guild of bacteria, enhancing a favorable ecosystem associated with metabolic protection:

• Shift in production of short chain fatty acids (SCFAs) in favor of butyrate production

• Shift in cholesterol-derived bile acids, notably:

- Decrease of DCA (deoxycholic acid), associated with negative effects on metabolic health

- Increase of UDCA (ursodeoxycholic acid), associated with positive effects on metabolic health

Animal Studies

Anhê et al., 2015 ; Anhê et al., 2017 ; Rodríguez-Daza et al., 2020 ; Daoust et al. 2021 ; Medina-Larqué et al., 2022

In our various mouse models of obesity and type 2 diabetes, Prebiocran™ (200 mg/kg of body weight daily for 8 to 12 weeks) significantly demonstrated several metabolic health improvements:

• Prevention of body weight gain, glucose homeostasis alteration and hepatic steatosis in mice fed a high-fat high-sucrose diet

• Reversal of hepatic steatosis in obese mice

Anhê et al. are the pioneers in demonstrating the prebiotic potential of a high in polyphenols cranberry extract and its cardiometabolicassociated benefits. This reference article has been cited more than 900 times.

Metabolomics analyses were performed in the transverse colon.

On the left, short chain fatty acids (SCFAs) quantification showed that Prebiocran™ induced a shift from acetate (yellow) to butyrate (black) production since the first days of treatment.

On the right, the heatmap displays bile acids levels and shows that Prebiocran™ progressively induced an increase of UDCA concomitant to a decrease of DCA.

Our results suggest the role of Prebiocran™ at a low dose of 480 mg, in supporting gut and metabolic health.

— Our Prebiocran™ offer

Prebiocran™ is a 100% cranberry extract in powder, designed to fit most of dietary supplement applications thanks to a low dosage: only 480 mg daily!

Standardized to minimum 30% total polyphenols (Folin-Ciocalteu) Spray dried powder

Highly soluble

Sourced and extracted locally in Canada from high polyphenol cranberry varieties

Sources

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