Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:12 Page 1
Becel pro.activ with plant sterols. Clinically proven to lower cholesterol.
Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:12 Page 2
Contents 02 Introduction 03 Diet and lifestyle play a key role in reducing risk of cardiovascular disease 04 International dietary guidelines recommend plant sterol 05 Plant sterols - occur naturally in everyday foods 06 Plant sterols - proven doseresponse reduction of LDL cholesterol 07 Plant sterols - reducing cholesterol absorption in the gut 08 Plant sterols - effective in combination with Statins 09 Plant sterols - effective across populations 10 Actively Lowering Cholesterol 11 Optimum Intake of 2g/day 12 Every day consumption of plant sterols delivers sustained beneďŹ t 13 Plant Sterols Safety 14 A cost effective solution XXX 15 Supporting Patient Compliance 16 FAQs 17 References 18 Facts about Becel pro.activ foods
Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:13 Page 4
Introduction
Diet and lifestyle play a key role in reducing risk of cardiovascular disease
Globally, cardiovascular disease is the leading cause of morbidity and mortality, yet about 80% of heart disease and stroke could be prevented by positive lifestyle changes, such as eating a healthy diet, exercise and abstinence from smoking1.
Elevated LDL-cholesterol is widely accepted as a key modifiable risk factor for coronary heart disease (CHD), the main form of CVD, yet more than half the population in most Western countries has cholesterol levels higher than desirable5.
Elevated LDL-cholesterol is widely accepted as one of the major modifiable risk factors. Both lipid-lowering drugs as well as diet have been shown to be effective in reducing CHD risk.
Many dietary factors affect LDL-cholesterol levels. Making positive dietary changes including replacing saturated fats with polyunsaturated fats and keeping intakes of trans fats to a minimum are well known to lower LDL-cholesterol6.
There are many diet and lifestyle changes that may help control elevated LDL-cholesterol and therefore help in reducing the risk of CHD. Dietary recommendations highlight the need to lower serum cholesterol and the important role that diet and lifestyle change must play. They include recommendations for the use of specific foods with cholesterol-lowering benefits such as plant sterols. These additional options can enhance the effectiveness of a typical healthy diet low in saturated fat and controlled in energy intake. Becel pro.activ foods contain plant sterol in many human studies it has been shown that plant sterols significantly lower total and LDL-cholesterol. Combined with other diet and lifestyle changes plant sterolenriched foods can contribute to increasing the effectiveness of diet in lowering cholesterol and offer a valuable addition to reduce CHD risk. This brochure contains information on plant sterols and Becel pro.activ for health care professionals.
However, the single most effective way to lower LDLcholesterol with dietary change7 is to include plant sterols or stanols. Eating 2-2.5 g of plant sterols daily can lower LDLcholesterol by up to 15% when combined with the move to a healthy diet and lifestyle†. As heart disease has multiple risk factors, more than one may need to be improved to reduce the overall risk. † Consumption of plant sterols in the range of 1.5-2.4g per day can lower LDL-cholesterol from 7-10% in 2-3 weeks. The effect can be increased to 15% when combined with the move to a healthy diet and lifestyle.
Diet and lifestyle factors and their effect on LDL-cholesterol levels Component
Dose or change in intake/habit
Approximate reduction in LDL-cholesterol levels
Recommendation in case of elevated LDL-C levels/increased CVD risk
Plant sterols
-2g per day
-10%
consume 2g per day
Saturated fatty acids (SAFA) (reduction in intake)
-5% of total energy intake
-5%*
reduce intake to <7% of total energy
Dietary cholesterol (reduction in intake)
Reduce intake to <200mg a day
-5%
reduce intake to <200mg a day
Body weight (loss)**
-5 kg
Viscous dietary fibres
5-10g per day
-5%
+5% of total energy intake
-3%***
PUFA
-5%**
lose~10% body weight** increase intake to 10g per day consume up to 10% of total energy
* Calculated assuming a baseline LDL-cholesterol level of 3.5 mmol/L and assuming that 5 energy% from saturated fatty acids are replaced by an isocaloric amount of carbohydrates (Mensink et al, Am J Clin Nutr 2003)12 ** In case of overweight or obesity ***Calculated assuming a baseline LDL-cholesterol level of 3.5 mmol/L and assuming that 5 energy% from carbohydrates are replaced by an isocaloric amount of polyunsaturated fatty acids (Mensink et al, Am J Clin Nutr 2003)12
02
03
Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:13 Page 6
Plant sterols proven dose-response reduction of LDL cholesterol
Plant sterols reducing cholesterol absorption in the gut
There is a continuous dose-response relationship between the intake of plant sterols and their effect on LDL-cholesterol levels21,22. The more plant sterol consumed, the greater the reduction in LDL-cholesterol up to about 2-2.5g plant sterol per day. Intakes above 2.5g/day are not recommended as this provides little further benefit7.
Since the late 1980s, Unilever, in collaboration with many independent scientific investigators, has extensively researched the cholesterol-lowering properties of plant sterols. There are over 40 clinical studies published in peer reviewed journals, proving the cholesterol-lowering efficacy of Becel pro.activ foods.
The effect of plant sterols on LDL-cholesterol levels7
For more information about specific studies and products see www.proactivscience.com [Insert new HCP website address when launched]
The key benefit of plant sterols lies in their ability to reduce the absorption of cholesterol from the gut into the blood stream. Cholesterol is an essential building block in the human body and plays a key role in maintaining cell membranes. It is naturally produced in the liver but is also delivered through foods containing cholesterol in the diet. As a part of normal metabolism, cholesterol in the gut mixes with bile salts, lecithin and triglycerides to form micelles. Micelles then deliver cholesterol to the cells lining the gut wall where the cholesterol is re-packaged and released into the bloodstream.
Plant sterols should be consumed as part of a healthy diet.
Plant sterols have a similar chemical structure to cholesterol. It
plant sterols (grams per day) 0.5
1
1.5
2
2.5
3
3.5
LDL-cholesterol lowering % reduction
0
is thought that when plant sterols reach the gut they displace cholesterol from the micelles23. In this way, less cholesterol reaches the lining of the gut wall in a form that can be absorbed. Consuming 2g of plant sterols a day reduces the absorption of cholesterol by 30-40%24. The cholesterol that is not incorporated into the micelles is then excreted (along with virtually all the plant sterols). In this way, cholesterol is removed from the body. Subsequently, levels of LDL cholesterol are lowered but HDL-cholesterol and triglyceride levels remain unaffected.
The effects of plant sterols on cholesterol absorption -5
Without plant sterols
With plant sterols
-10
-15
Optimal Little further intake benefit 95% confidence interval
Cholesterol
Plant Sterols Less cholesterol absorbed = lower cholesterol levels
More cholesterol absorbed = higher blood cholesterol levels
Plant sterols partially block the absorption of cholesterol from the gut, significantly lowering blood cholesterol levels 04
05
Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:13 Page 8
Plant sterols occur naturally in everyday foods
Optimum Intake of 2g/day
The optimal intake of plant sterols for significant cholesterol lowering is 2-2.5g/day. To reach this recommended intake, very large quantities of regular foods would need to be consumed.
The quantity of regular foods required to provide 2g plant sterols18,19,20
2g plant sterols = 150
83
apples*
oranges*
425
210
tomatoes*
carrots*
70 slices of wholemeal bread*
The optimum intake of plant sterols is 2-2.5g daily. This can be achieved by either eating three portions from a combination of the Becel pro.activ spreads, milk drink or yoghurt, or with the ‘one-a-day’ yoghurt mini-drink (3 portions in one). Consuming more than this doesn’t provide an additional cholesterollowering benefit. For optimum benefit, Becel pro.activ foods should be consumed as part of a healthy diet and lifestyle. It is recommended that plant sterols are consumed every day for continued cholesterol-lowering effects; if plant sterolenriched foods are not consumed, the cholesterol-lowering effect is lost.
Continued use of Becel pro.activ 0% Cholesterol reduction
Plant sterols are found naturally in everyday foods like vegetable oils, nuts,seeds, grain products, fruit and vegetables. The average daily intake of plant sterols from regular foods is about 0.3g per day. Western populations consume 0.15-0.31g plant sterols perday14,15,16. Diets that contain plant sterol-rich foods in abundance, such as vegetarian diets, provide 0.6g plant sterols per day17.
stop using pro.activ
continued use of pro.activ
10% TIME
3 weeks 6 weeks
Each portion of becel pro.activ contains plant sterols to actively lower cholesterol. To get the best effect, continue eating the recommended amount of Becel pro.activ everyday to keep your cholesterol level down.
Plant sterol-enriched foods significantly lower cholesterol whether they are consumed once a day or over a number of occasions throughout the day. For maximum effect, Becel pro.activ foods should be consumed with a meal.
11 cups of peanuts*
*where each individual item weighs 100g.
07
08
Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:13 Page 10
International dietary guidelines recommend plant sterols The International Atherosclerosis Society2, the US National Cholesterol Education Program (NCEP), and many national organisations including American Heart Association, Heart Foundation Australia, Dutch Heart Foundation, Finnish Nutrition Association, Finnish Medical Society, Spanish Atherosclerosis Society and Nutrition Foundation of Italy have all included plant sterols in their dietary recommendations for cholesterol management. Both national and international dietary guidelines for the prevention of CHD now recommend the inclusion of 2g plant sterols per day for cholesterol lowering.
Plant Sterols Safety Consuming plant sterol-enriched foods could reduce healthcare costs. Plant sterol-enriched foods significantly lower cholesterol and have the potential to provide substantial savings in healthcare costs. Estimates based on the cost and outcomes associated with suffering from a myocardial infarction in the UK predicted annual savings of approximately £87 million / €130 million13.
International Atherosclerosis Society guidelines for prevention of heart disease Therapeutic modifications towards a heart healthy diet l l l
l l l l l
l
reduce saturated fats to <7% of total energy keep intakes of trans fatty acids low maintain intake of omega-3 fatty acids - linolenic acid to at least 1% of total energy [2-3 g/day] - fish oil supplements for high risk patients optional [EPA+DHA of 1 g/day reduce dietary cholesterol to <200 mg/day increase viscous fibre, if possible to 10 g/day consume at least 5 servings of fruits and vegetables daily ensure adequate intake of folic acid (400-1000 mg/day) avoid excess intake of alcohol: no more than 20-30 g/day (men) or 10-20 g/day (women) consider adding plant stanol/sterols (2 g/day) for elevated LDL-cholesterol
Plant sterols are natural components of a normal diet. The safety of consuming high intakes of plant sterols to lower cholesterol has been studied extensively since the 1950s and reviewed by independent experts and regulatory authorities internationally. In 2000, Becel pro.activ was the first spread to fully comply with the European Union Novel Foods legislation. It has been approved as safe by independent authorities in The European Union, Norway, Switzerland, The United States, Australia, New Zealand, South Africa, Brazil, Israel, Iceland and Japan. In 2004, the Becel range was extended following European Union Novel Foods approval of plant sterol-enriched milk drink, yoghurt and ‘one-a-day’ yoghurt mini-drink. Unilever’s continuing post-launch monitoring programme confirms that Becel pro.activ is being consumed by the correct target group and there is no evidence of over-consumption or adverse health effects34.
Ref: International Athersclerosis Society Executive Board Harmonised Clinical Guidelines on Prevention of Athersclerosis Vascular disease, March 2003
09
10
Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:13 Page 12
Plant sterols effective in combination with Statins Plant sterol-enriched foods significantly lower cholesterol in people: • following both ‘typical’ and low fat diets • on lipid-lowering medications such as statins and fibrates • with elevated blood cholesterol levels • with type II diabetes • with familial hypercholesterolaemia
People with type II diabetes and familial hypercholesterolaemia (FH) It has been shown that plant sterols lower LDL-cholesterol levels in people with type II diabetes28 and in children and adults with FH29.
Suitability of Becel pro.activ for specific dietary needs (adapt locally) Becel pro.activ suitable for:
Spreads (all variants)
Milk drink
Yoghurt
‘One-a-day’ yoghurt mini-drink
Low fat diet Ovo-lacto vegetarians Vegans Diabetic Diet Dairy/ milk free Coeliac/ gluten free Lactose intolerance Nut free Halal diet Kosher diet
Yes
Yes
Yes
Yes
Yes
Yes
Yes
Yes
No Yes
No Yes
No Yes**
No Yes**
No
No
No
No
Yes
Yes
Yes
Yes
No
No
No
No
Yes No No
Yes No No
Yes No No
Yes No No
Complementary cholesterol lowering effects of plant sterols with statins
Clinical evidence shows that eating plant sterol-enriched foods, in combination with statins, can have a greater cholesterollowering effect than statins alone1.
Cumulative benefits A combination of statins, plant sterols and diet and lifestyle changes can work together to help patients achieve targets for cholesterol reduction3. They work in different ways and therefore the effect of each is additive: • Statins reduce LDL cholesterol levels by an average of 25%4. • Moving to a healthy diet and lifestyle can lower cholesterol by 5%; and • Including a plant sterol-enriched spread can help lower it by a further 7-10%* This combination of statins and plant sterols can lead to a greater reduction in cholesterol levels than doubling the statin dose which has been shown to achieve just a 6% further reduction6.
0
% LDL cholesterol lowering
Plant sterols effective across populations
10
Statins
Statins
20
Diet and lifestyle 30
Plant Sterols 40 Scholle et al, 2009
Becel pro.activ may be a useful adjunct to statins and fibrates, offering additional cholesterol-lowering benefits27. However, dietary approaches should not be a substitute for lipid-lowering medications and vice versa. If people are taking statins and/or fibrates and consuming plant sterol-enriched foods as part of a heart healthy diet, the dosage of medication may need to be adjusted.
** contains artificial sweeteners: yoghurt contains sucralose and acesulfame K, and mini-drink contains sucralose.
11
12
Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:13 Page 14
Real People, Real Results
Supporting Patient Compliance A powerful clinical evidence base for plant sterols is the cornerstone for the becel pro.activ product range, but we all know that it’s real results in the real world for your patients that count. 1000s of real people have successfully lowered their cholesterol with becel pro.activ, Their stories are available on the becel website, as a source of inspiration for others who are looking to make dietary changes to reduce cholesterol.
13
One of the biggest challenges facing any health intervention requiring individual behaviour change is the waning of individual commitment and enthusiasm, leading to relapse. The expert team behind Flora pro.activ recognise the need for ongoing support for patients aiming to lower cholesterol through diet and lifestyle modifications. As well as a range of patient materials available to kick-start the intervention, we have therefore launched a cutting-edge new consumer website committed to giving inspiration and encouragement to stick with a cholesterol-lowering regime, in a way that’s friendly and accessible for consumers. Using real people’s stories as a basis, it makes it easier for your patients to see how they can make a long-term change that’s good for their cholesterol. Visit our pro.activ website to see inspiring stories, recipes, and exercise and diet tips from people who have seen great results with flora pro.activ.
14
Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:13 Page 16
Facts about Becel References
FAQs What are plant sterols? Plant sterols are naturally occurring substances that are found in everyday foods like fruits and vegetables, vegetable oils and nuts and grains. Plant sterols have a chemical structure similar to that of cholesterol. They play the same stabilising role in plant cell membranes as cholesterol does in our cells’ membranes.
How do plant sterols lower cholesterol? Plant sterols partly block (inhibit) the absorption/uptake of cholesterol from the gut. This results in a reduction in blood LDL cholesterol with no effect on HDL cholesterol or triglycerides.
What is the difference between plant sterols and plant stanols (found in Benecol)? Both have similar chemical structures and differ by only one chemical bond. Plant stanols are the hydrogenated form of sterols, lacking the double bond. Plant sterols are naturally occurring substances that are found in everyday foods like fruits and vegetables, vegetable oils, nuts and grains. We use plant sterols extracted from vegetable oils, such as sunflower seed, rape seed or soy bean and tall oil from pine trees. Independent clinical studies demonstrate that sterols and stanols are equally effective in terms of their cholesterollowering potential and play an important role in foods providing heart health benefits.
How safe are plant sterols? Plant sterols are safe – they are naturally occurring in the diet at low levels. To achieve substantial reduction in cholesterol levels we have increased the daily intake of plant sterols by around five times. We are satisfied that they are safe at this 15
level too. Their safety has been supported by a large amount of data, including high dosage studies in different groups and long-term studies which measured the key safety parameters. In addition, the safety of plant sterols has been reviewed by many regulatory bodies around the world including the European Union.
1
2 3
4
Are plant sterol enriched foods suitable for pregnant and breastfeeding women, and children under five? Plant sterols are considered as safe cholesterol-lowering ingredients. However, we do not recommend plant sterol enriched foods for children and breast-feeding or pregnant women, as these groups have specific nutritional needs and lowering cholesterol is not normally a priority for them. The nutritional needs of children, breast-feeding or pregnant women are better met by regular Becel or regular milk and yoghurt.
5
6 7
8
9 10
How is pro.activ different from other Becel products? Becel pro.activ cholesterol products are specifically designed for people who want to actively lower their LDL cholesterol through dietary change. All Becel pro.activ cholesterol foods are enriched with plant sterols which are clinically proven to significantly lower cholesterol as part of a healthy diet and lifestyle. Other products in the Becel range are not enriched with plant sterols and are not intended to actively lower cholesterol, rather they are designed to contribute to a heart healthy diet because they are high in polyunsaturated fat, significantly lower in saturated fat than butter and less than 1% trans fat.
11
12
13 14
15
16
World Health Organisation (WHO). Diet, nutrition and the prevention of chronic diseases. Report of a joint WHO/FAO Expert Consultation. WHO Technical Report Series 916. Geneva, 2003. International Atherosclerosis Society Executive Board, Harmonised Clinical Guidelines on Prevention of Atherosclerotic Vascular Disease. March 2003. National Cholesterol Education Program. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001; 285: 2486-2497. Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC, Smith SC Jr, Stone NJ; for the Coordinating Committee of the National Cholesterol Education Program. Implication of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004; 110: 227239. Tolonen H, Keil U, Ferrario M, Evans A. Prevalence, awareness and treatment of hypercholesterolaemia in 32 populations: results from the WHO MONICA Project. Int J Epidemiol 2005; 34(1): 181-192. Clarke R, Frost C, Collins R, Appleby P, Peto R. Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. BMJ 1997; 314(7074): 112-117. Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R; Stresa Workshop Participants. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 2003 Aug; 78(8): 965-978. Review. Recommendations from the International Atherosclerosis Society, 2003, and NCEP ATP III, Circulation, 2002 (except for soya protein: FDA recommendation, federal register, 1999). Federal Drug Administration. Food labelling: Health Claims; Soya Protein and Coronary heart Disease; Final Rule. Federal register 1999; 64(206):57699-57733. Jenkins DJA, Kendall CWC, Axelson M, Augustin LSA, Vuksan V. Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 2000;11:49-56. Harland JI, Haffner TA. Systematic review, meta analysis and regression of randomized controlled trials reporting an association between an intake of circa 25g soya protein per day and blood cholesterol. Atherosclerosis 2008; doi:10.1016/j. atherosclerosis. 2008/04.006. Mensink RP, Zock PL, Kester ADM, Katan B. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL-cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77: 114655. Phillips C, Belsey J, Schindler J. Flora pro.activ: a clinical and financial impact analysis. J Med Econ 2000; 3: 61-76. Normen AL, Brants HA, Voorrips LE, Andersson HA, van den Brandt PA, Goldbohm RA. Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. Am J Clin Nutr 2001;74(1):141-148. Andersson SW, Skinner J, Ellegard L, Welch AA, Bingham S, Mulligan A, Andersson H, Khaw KT. Intake of dietary plant sterols is inversely related to serum cholesterol concentration in men and women in the EPIC Norfolk population: a cross-sectional study. Eur J Clin Nutr 2004;58(10):1378-1385. Valsa LM, Lemstrom A, Ovaskainen ML, Lampi AM, Toivo J, Korhonen T, Piironen V. Estimation of plant sterol and cholesterol intake in Finland: quality of new values and their effect on intake. Br J Nutr 2004;92(4):671-678(8).
17 Vuoristo M, Miettinen TA. Absorption, metabolism, and serum concentrations of cholesterol in vegetarians: effects of cholesterol feeding. Am J Clin Nutr 1994;59(6):1325-1331. 18 Normen L, Johnsson M, Andersson H, van Gameran Y, Dutta P. Plant sterols in vegetables and fruits commonly consumed in Sweden. Eur J Nutr 1999;38:84-89. 19 Normen L, Bryngelsson S, Johnsson M, Evheden P et al. They phytosterol content of some cereal foods commonly consumed in Sweden and in the Netherlands. J Food Comp Analysis 2002;15(6):693-704. 20 Weihrauch JL, Gardner JM. Sterol content of foods of plant origin. J Am Diet Assoc 1978;73(1):39-47. 21 Law M. Plant sterol and stanol margarines and health. BMJ 2000;320:861-864. 22 Hendriks HF, Weststrate JA, Van Vliet T, Meijer GW. Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1999;53:319-327. 23 Trautwein EA, Duchateau GSMJE, Lin YG, Mel’nikov SM, Molhuizen HOF, Ntanios FY. Proposed mechanisms of cholesterol-lowering action of plant sterols. Eur J Lipid Sci Tech 2003; 105: 171-185. 24 Tikkanen MJ, Hogstrom P, Tuomilehto J et al. Effect of a diet based on low-fat foods enriched with nonesterified plant sterols and mineral nutrients on serum cholesterol. Am J Cardiol 2001; 88:1157-1162. 25 Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reductions in plasma total-and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1998;52:334-343. 26 Maki KC, Davidson MH, Umporowicz DM, Schaefer EJ, Dicklin MR, Ingram KA, Chen S, McNamara JR, Gebhart BW, Ribaya-Mercado JD, Perrone G, Robins SJ, Franke WC. Lipid responses to plant-sterol-enriched reduced-fat spreads incorporated into a National Cholesterol Education Program Step I diet. Am J Clin Nutr 2001; 74: 33-43. 27 Simons LA. Additive effect of plant sterol-ester margarine and cerivastatin in lowering low-density lipoprotein cholesterol in primary hypercholesterolemia. Am J Cardiol 2002; 90:737-740. 28 Lee YM, Haastert B, Scherbaum W, Hauner H. A phytosterol-enriched spread improves the lipid profile of subjects with type 2 diabetes mellitus - a randomized controlled trial under free-living conditions. Eur J Nutr 2003; 42(2): 111-117. 29 Amundsen Å &, Ntanios F, Put N V.d, Ose L. Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread. Eur J Clin Nutr 2004; 58(12): 1612-1620. 30 The research was carried out amongst women aged 16-64 years in France, Germany, Belgium and the UK. The research was conducted by TNS via Ncompass OnLine international omnibus from 17-20 April 2008. 2,119 interviews were carried out. 31 A healthy balanced diet is defined as one that is typically low in saturated fat, high in fruit and vegetables and low in salt. 32 Consuming the optimal 2-2.5g of plant sterols daily typically lowers LDL cholesterol by 10% – Katan MB, et al. Mayo Clin Proc 2003 Aug; 78(8): 965-978. 33 Assumes daily intake of three portions of Becel pro.activ foods e.g. two teaspoons of Becel pro.activ spread, 250ml milk and one pot of yogurt, or, alternatively, one Becel pro.activ mini-drink. 34 Lea LJ and Hepburn PA. Safety evaluation of phytosterol-esters. Part 9:Results of a European post-launch monitoring programme. Food Chem Toxicol 2006;44(18):12131222.
16
Becel pro.activ HCP brochure 4_Layout 1 28/09/2011 15:13 Page 18
Becel pro.activ: Clinically proven in 45 studies
Facts about Becel pro.activ foods l
Becel pro.activ is a range of everyday foods enriched with plant sterols
l
Plant sterols lower cholesterol by partially blocking its absorption from the gut
l
Over 40 clinical studies have proven the LDL-cholesterol lowering effect of Becel pro.activ foods
l
Advice to consume 2g of plant sterols per day is now included in both international and national dietary recommendations for cholesterol management
l
17
Several international health organisations recommend an optimal daily intake of 2-2.5g plant sterols as part of a healthy diet
l
This can be achieved by consuming 3 portions of Becel pro.activ foods from spreads, milk drink and yoghurt or alternatively (3 portions in 1) with the ‘one-a-day’ yoghurt mini-drink
l
Plant sterol-enriched foods have been developed for people who want to actively lower their LDL-cholesterol through healthy diet and lifestyle
l
Proven to be a safe and effective way to lower cholesterol, Becel pro.activ foods are available in more than 30 countries worldwide
l
Becel pro.activ may be suitable for people with elevated cholesterol levels, as well as people already taking cholesterol lowering medication such as statins and fibrates, where they can be a useful addition
l
Becel pro.activ may be suitable for people with type II diabetes and familial hypercholesterolaemia, but may be nutritionally inappropriate for pregnant and breast-feeding women and children under five
For more information visit [insert new HCP website URL] August 2011
18