Study Confirms Hair Use for Long-Term Detection of Bisphosphonates

from The Florida Horse - August 2023

Industry Urged to Complete Important Survey

BY GRAYSON-JOCKEY CLUB PRESS OFFICE

LEXINGTON, KY—A new study was published on the use of hair as a matrix for the long-term detection of bisphosphonates in horses. The study was in response to a special call for bisphosphonate research by Grayson-Jockey Club Research Foundation in 2019.

“Over the past few years, bisphosphonate use has become a concern with regard to the welfare of Thoroughbred racehorses,” Grayson President Jamie Haydon said. “We are very thankful for the generous support by Vinnie and Teresa Viola’s St. Elias Stables and their ability to recognize the importance of this research in promoting equine safety and welfare.”

“Bisphosphonates are labeled for horses 4-year-olds and older to manage navicular symptoms,” A. Gary Lavin Grayson Research Chair Dr. Johnny Smith said. “Unfortunately, people were using them in young horses, which is detrimental because bisphosphonates inhibit bone resorption, can stay in a horse’s system for years, and can have long-term effects on bone.”

The new study found that hair testing can be used to consistently detect bisphosphonates for up to six months after administration. Previously published studies, including one conducted by the same group and funded under the same special call, demonstrated that in some cases bisphosphonates can be detected in blood and urine for extended periods of time, but detection using these matrices can be unpredictable and less consistent.

“Our study from 2020 showed that clodronate and tiludronate reside in the bone for extended periods,” the study’s principal investigator Dr. Heather K. Knych said. Dr. Knych is with the K.L. Maddy Equine Analytical Chemistry Lab’s Pharmacology section and the Department of Molecular Biosciences at the School of Veterinary Medicine, University of California Davis. “This can lead to lasting pharmacologic effects and increase the risks of injury to racehorses. Being able to detect bisphosphonates long term in hair benefits the athletes and increases the integrity of the sport.”

Bisphosphonates are considered a banned substance for covered horses under the Horseracing Integrity and Safety Authority’s Anti-Doping and Medication Control program. A covered horse that tests positive is subject to lifetime ineligibility.

The study was conducted by Knych; D.S. McKemie, Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis; S. Yim, K.L. Maddy Equine Analytical Pharmacology Lab, School of Veterinary Medicine, University of California, Davis; S.D. Stanley, University of Kentucky College of Agriculture, MH Gluck Equine Research Center, Lexington, Kentucky; and R.M. Arthur, School of Veterinary Medicine, University of California, Davis. TFH

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April 2023

Stakes, Allowance, Allowance Optional Claiming and Maiden Special Weight statistics below are listed for the month of April 2023 for win, place and show, alphabetically by horse name.