CDFormulationProvidesPharmaceuticalTestingonTablet Fragility,Dissolution,andDisintegration
Pharmaceuticaltestingisamusttoensurethatallmedicationsmeet thetopquality,safety,andperformancerequirementsbeforethey enterthemarket.CDFormulation’scGMP-compliantlaboratoryis well-equippedtoidentifyboththechemicalandstructural compositionofeachdrugsubstance.Morerecently,thecompany announcedtobroadenitsservicerangetotabletfragilitytest, dissolutiontest,anddisintegrationtest.
“Staffedwithagroupofpharmaceuticalexpertsspecializedin chemistry,biochemistry,andengineering,CDFormulationhasgrown tobeoneofthefinestcontractserviceorganizations.Ourtesting laboratorieshavebothexpertiseandexperiencetohandlethemost complexformulationproblems,”saidtheMarketingChiefofCD Formulation.“Ouranalysisandtestingserviceswillsupport pharmaceuticalcompaniesateverystepandphaseofthedrug developmentlifecycle,makingsuretheentiredrugdevelopment processcomplieswiththelatestregulatorystandardsand requirements.”
BelowaresomeofthetestingservicesnewlyintroducedbyCD Formulation:
TabletFragilityTest
Thetabletfragilitytestispurposedtodeterminetheresistanceof tabletsagainstmechanicalstress,bothshakinganderosion. Theoreticallyspeaking,thehigherthepercentageoffragility,the greaterthelossoftabletlife.Thephysicalandchemicalproperties andstabilityofAPIhaveagreatinfluenceonthefriabilityoftablets. Otherfactorssuchasexcipientsandtheproductionprocesswill influencetabletfragilityaswell.CDFormulation’sexperienced analysisexpertscanperformtabletfragilitytestsbypharmacopeia methods,helpingclientstoconductanappropriateriskassessmentof thefinisheddrug.
DissolutionTest
Drugdissolutiontestisastandardizedmethodformeasuringthe releaserateofadrugfromagivendosageform,whichhelpsto evaluatetheperformanceofadrug.CDFormulation’sdissolution testingisperformedunderspecifiedconditionsaccordingtospecific applicablepharmacopoeialstandards,suchasFourDissolution ApparatusesStandardized,USPDissolutionApparatus1–Basket
(37°C±0.5°C),USPDissolutionApparatus2–Paddle(37°C± 0.5°C),USPDissolutionApparatus3–ReciprocatingCylinder(37°C ±0.5°C),andUSPDissolutionApparatus4–Flow-ThroughCell (37°C±0.5°C).
DisintegrationTest
Thedisintegrationtestistoevaluatetheabilityofasample,mostly tablets,capsules,andenteric-coatedtablets,tobreakintosmaller particlesunderstandardconditions.Theresultswillprovidecritical safetydataonthebioavailabilityofdrugsinvivowithouttheuseofin vivomethods.AtCDFormulation,aseriesofmethodssuchasthe test-tubemethod,sievemethodwithshaker,sievemethod,and pharmacopoeialmethodareusedtotestdisintegrationfordrugs.
Please visit the website https://www.formulationbio.com/analytical.htmltolearnmore.
About
Successfullysolvingdrugformulationanddeliveryissuesforitsglobal customersisalwaysthegoalofCDFormulation.Equippedwith advancedfacilitiesthatcomplywithGMPregulations,CDFormulation isofgreathelptopharmaceuticalcompaniesduringtheprogressof formulation,frominitialpre-formulationtrialstocommercial manufacturing.Moreover,afteryearsofuntiringefforts,thecompany hasalsoextendeditsproductlinestopharmaceuticalexcipients, cosmeticingredients,foodingredients,offeringalmost1,000 excipientsorrawmaterialsacrosstheglobe.