meetings & awakenings the coevolution of plants and people
some sort of blurb about Gaia about Gaia the company or the philosophy? or a blurb about what the book is?about Gaia the company or the philosophy? or a blurb about what the book is?
Ric Scalzo and Greg Cumberford
meetings & awakenings the coevolution of plants and people by Ric Scalzo and Greg Cumberford
Š 2010 Herbal Research Publications Brevard, North Carolina
There is a Field of Infinite Correlation that connects all life. Within this field there is perfect order, unbounded energy, and supreme knowledge that guides the organized expressions found within the bounty of nature. It is from this vast dark, underlying canopy found at the core within this field, that all life is manifested. From this vastness within the unmanifest, emerges an equally vast diversity of creation. These expressions of nature spiral forth and interact in a coherent and dynamic manner.
There is no distinction between time and space in this field of infinite correlation. It is at this core of all life where we meet the unmanifest source of our diversity. The journey of the meetings that we observe in nature begins at the junction point where the unmanifest begins to express itself. So much awareness and so many awakenings are born here and a pattern of organized intelligence begins to take shape.
The Wisdom and Intelligence imbibed in every seed expresses itself into a endless pattern of diversity. With each phase of growth of the plant more and more of the unmanifest intelligence begins to become manifest. We begin to witness the expression of order, of sequence, of conviction and of reverence. And when we observe the pattern of flowers aligning to the energy and movement of the sunlight we begin to see the coherent coupling within these intelligent expressions of nature.
Coherent coupling can begin to be seen in many forms—the pistils and stamens interacting with the forces of sunlight, the morning dew finding a purposeful home on the tender petals ,the flowers aligning to the rays of the sun for their journey through the day, and the young roots beginning to seek out growth promoting nutrients from the fertile soil that they nest within. As this blossoming of creative intelligence shapes these relationships, we begin to realize that we are part of a vast network of meetings that shape our plant medicines that restore our memory of this wholeness born within the core of nature.
Meetings‌.. We are all part of one body seeking harmony. We remember our instinctual connection to the earth and all its inhabitants. Each individual longs to rekindle this connection, this partnership. Therefore, we must act in accordance with nature. There is no action more responsible.
reverence Every plant, in its true form, has the extraordinary ability to restore our bodies’ natural vitality through a symbiotic chemical interaction. It is our deepest belief, our duty, to help others return to a state of harmony by stewarding the coevolution of plants and people—
encouraging each indivdualto meet the herbs that will work for them.
Stewardship‌.. We assume our role as stewards of this life cycle. Plants bring forth their wisdom and intelligence through endless interactions with the formative forces of nature. We create fertile soils to nurture this expression of plant intelligence. Our meetings at this moment are very special as we recognize that we hold responsibility for the free and full development of this fertile and vibrant expression of nature.
a symbiotic relationship Partnership with the earth is our passion and commitment. We serve as dedicated stewards of this bond. We nourish the plants and the land, and they give vitality to all of us in equal measure.
Symbiotic Relationships…… we all are part of a life cycle… a journey together with relations that are both seen and unseen. Just as the wasp and the grub are connected together in their life path so are we connected with the soil, the plants, the insects, the cycles of day and night, the changing of the seasons. All these connections, all these relationships remind us how we are intimately woven together into a fabric of wholeness that sustains the very life that we live.
Nature heals when given the opportunity to do so‌.. we work diligently within the construct of nature to restore balance to our soils and attract elements that assist in maintaining that balance. Within nature are the remedies for any state of dis-ease‌. We simply subscribe to this truth as self evident and allow this intelligence that connects us to fully express itself so that we can meet our medicines in their purest form.
Within the very core of our existence is a mosaic of shapes and forms and relations.Our very existence depends upon our ability to sustain the fertility and vitality inherent within nature. The meetings that take place with our medicines should not be taken for granted. These meetings offer a promise that the cycle of life will not be broken. These meetings offer a promise that there will always remain a continuity of relations that will, if given the opportunity, provide us with the ability to achieve true health and wellness.
The web and the weaver‌‌ we stop for a moment in our work to witness the energy, the effort of those forces of nature that are always working for our benefit, our growth, our sustenance. Just as we take a moment to reflect on these relations, the sun carves out a moment in time to remind us that our medicines are being woven for us together within these meetings at every moment through the life cycle of plants.
Gratitude and humility‌‌ in the process of giving, we receive. We are humble servants of these formative forces of nature and pride ourselves knowing that we may not meet all that take our medicines but we still own the responsibility to maintain the purity and integrity throughout every phase of this life cycle that we are intimately woven into.
Order and coherence‌. there is a sequence and harmony that emerges from the vast unity in nature. So much diversity yet so much underlying harmony to connect these diverse elements of nature. In this field of infinite correlation we are connected at the core. Our work with plants remind us of the importance of nourishing the stillness that connects us all.
Stillness and dynamism‌.. two opposing forces of nature harmonized together become the building blocks of all life and wellness.
Honoring our present…. Nurturing our future….. We are reverent stewards of what surrounds us and what is within us….Every day we awake to these relations and honor our role in the co-creation of this evolutionary process. We must always improve the tilth of the earth we walk upon so that those that follow us can also share fully in these relations we nurture.
the choices we make The coevolution of plants and people is a harmonious continuum. Plants revitalize us, and we must nurture them in return it is this reciprocity that sustains the well-being of everything on the planet, and brings a renewed sense of wholeness to all the earth.
Observation within our sacred medicinary. We remain awake to our relations…. we observe and we serve….. we respect and we respond. We continuously take note of these ever changing cycles of nature with the intent to capture the full potential of nature’s vital energies. Our intent is purely to act in harmony with these formative forces. Our interactions must be timed perfectly.
Intention‌.. every thought, every feeling, and every emotion becomes part of our medicine. We harvest and prepare our medicine as reverent servants knowing that our being, our consciousness becomes a part of every plant medicine that we steward.
Conviction‌ as plants nourish us we in turn nourish and cultivate them organically, tending to them largely by hand, maintaining their purity. Only the truest expression of the herb must be brought forward. We must harvest gently at the optimal moment, to ensure the greatest potency. We must process carefully to deliver these gifts with integrity.
Respect for nature‌.. the formative forces of nature that guide us towards peak performances in our lives also guide the medicinal plants and trees to their peak performance. We remain patient, willing to observe their changing appearances and chemistries. Only at the precise time do we harvest these plants with deep respect for this co-evolutionary process that we share. We come to meet our medicines as they have evolved to meet us. These formative forces of nature that the plants have metabolized deepen our connection to a vital process that nurtures us endlessly.
As we share our passion, communicate our deep knowledge, and faclitate a personal connection between plants and people, coevolution grows stronger. We commit to responsible sourcing through our relationships with Family Farmers and Certified Partners, all upholding the Gaia Standards of Excellence. The influence of our carefully tended acres continues to grow, as both a trusted source and a model of organic farming and plant preservation.
co-creation with passion...... there is a small window of time in this process for us to be awake to the peak and total potential of nature. We come to this window with a passion for this meeting, with a purpose for this meeting, and a deep appreciation for the outcomes of this meeting.
Fresh and vital…… this is how we relate to our medicines. Nature is our pharmacy and we harvest this pharmacy while in it’s freshest and most vibrant state. We do not alter what nature has so perfectly created rather we look through the window of science to confirm our conviction that as long as we preserve freshness we preserve the healing power of nature.
The soil nurtures us with its vitality‌‌ we come forward to meet this fabric of fresh and vibrant life. It awakens us to the knowledge of our purpose as stewards of these medicines.
A medicine for all seasons…. Whether floral bud or flower; whether seed or root…. In every stage of development nature creates a pharmacy that determines it’s use…. For every phyto-chemical in nature there is a corresponding and complementary receptor in our body. What resides within the body and mind of nature nourishes our body and mind to make us whole and vital.
The fruits of our labor….. we’ve waited all season for this moment… the ripening of such perfectly woven plant intelligence. This ripening represents the closure of a cycle….but within each ending there are also new beginnings… these are the seeds that keep the memory of wholeness within every cell in our hearts awake to all possibilities.
Our hearts are filled with joy and gratitude‌. So many forces, so many elements, so much patience has come to this moment in time where we hold the conviction in our heart that we have truly been a part of cultivating pure plant medicine.
the roots that connect us in making transparent and traceable the history of every herb in every jar, bottle, and capsule, we empower individuals to reclaim control of their own well-being, share their knowledge with others, and participate more fully in an exchange that advances the coevlution of
plants and people.
Confidence‌ we have nothing to hide and everything to gain. We must remain open and allow the world to share our experience at every level so that others can meet and know us—and meet and know their herbs. To enable this exchange we invite each person to see where their herbal medicines come from, how it was grown, harvested, extracted, and validated for purity, integrity, and potency.
Purity‌Nature is pure. We must hold ourselves to nature’s standards above all others. Each herb must be cultivated according to how nature intended. Chosen from heirloom seeds, grown organically, harvested with care at the perfect moment of maturity with reverence—each herb realizing its potential to grow, to develop, to bring forth vitality.
SCREEN SHOT
Integrity—through the window of science we validate the intelligence of nature. We hold a keen awareness that every plant, and only the correct plant, will deliver it’s vitality and healing properties with selectivity. Validation of integrity and identity assures that a true partnership will be born between the body and mind of nature and our body and mind.
SCREEN SHOT
Validations‌.. we evaluate identity on a macroscopic level and recognize the wisdom of the plant is expressed in both seen and unseen ways. Plants reveal their intelligence in many ways‌ we must take time and honor the meeting between what is truly scientific with what is truly reverent.
SCREEN SHOT
Potency—colors and waves—a reflection of the strength that lies within……. interactive meetings between plants and sunlight are observed in absorbance and wave lengths. These meetings take place in the sacred laboratory of nature and validated within our own laboratories. We measure what nature has created and confirm with confidence the potency of our herbal medicine.
Awakenings…… the co-evolution of plants and people….. meeting our herbs as our herbs meet us… we meet our full potential as servant leaders with one simple intention……. to awaken the full potential of these meetings in their purest form……. to encapsulate the Vis Medicatrix Naturae, the healing power of nature,……. and to guide the awakening of this wisdom of nature within every cell of our body and mind.
meetings & awakenings...
Chapter 1: Co-Evolution
As you read these words, you are, presumably, breathing. But you may not fully realize what you are
As your supple diaphragm draws in and slowly
this. We may no doubt feel or believe that we are sepa-
expels air, sustaining your capacity to exist, consider
rate, that we are alone—existentially or physically—
this: that you and I can breathe at all signifies a pre-
in this life, but our very breath tells us otherwise when
breathing. The fact that your nostrils, trachea, alveoli,
cious and infinitely diverse interplay between animals,
we apprehend its significance. The humility in this
and approximately 600 miles of lung capillaries are
plants, and our living earth. Fundamentally, that all
apprehension carries us to one tenet of ecological
respiring a stable balance of atmospheric gases
cellular life respires in order to live ties us all into a
consciousness.
embeds you in a story whose origins lie at the very
responsive and empowered relationship to our own
beginning of life: the story of co-evolution. In this
bodies and to the ecology of the place in which we live.
perhaps 100 million years to our emergence, we
story, something so basic to being here—breathing—
At a cellular level, the living biosphere in which we are
mammals have shared one common, vital need in
connects you and me physically to the most ancient
intimately embedded records our existence—from at
whatever environments we’ve lived. We’ve all needed
roots of life on earth.
least the moment of our conception to the last meta-
to continuously respire an acceptable, tolerable,
bolic assimilation of our organic residue by the environ-
chemically stable quality of air. This is a precondition
ment—and responds instantaneously to our every act.
for any mammalian life form to exist, to proliferate,
Close your eyes and slowly take in one full, conscious breath, hold it briefly, then slowly release it.
In this way we are not ever, in our earthly existence, alone. Our shared biological provenance guarantees
Another is that we are all mammals. Going back
and to evolve. What assures us that this most basic need will be fulfilled?
75
At any given moment in earth’s history, the content
76
sugars, and proteins to metabolize and maintain a
primarily. (And largely still does inside our gassy GI
of our atmosphere has varied quite dramatically.
bacteria make it possible for us to metabolize our
remarkably constant physio-chemical environment
tracts, where sunlight never goes.) But once photosyn-
Indeed, the atmospheric content at the time of bacte-
food. Without them, our foods would putrefy inside us
inside us that mimics some key conditions for life on
thesis emerged, free and abundant sunlight was con-
rial life’s emergence on earth some 3.5 billion years
and we would auto-toxify in short order. Hence the
earth that predominated at their emergence.
verted by these “green” bacteria directly into sugars
ago was a methane and ammonia steam bath in
crucial importance of bacteroides, lactobacillus, and
which we would perish nearly instantly. The conditions
other beneficial gut probiotics to our own health. We
mutually beneficial relationship that trains our
cell structures while also liberating oxygen and water
for life at the beginning of life were completely incom-
can’t live without them.
immune systems, provides us metabolic energy, and
vapor into the atmosphere.
patible with the conditions we require today—and
This is a good thing, for those primordial, ancient
Yet many of our friendly gut bacteria can’t live in
Unlike a host-parasite relationship, this is a truly
kills unfriendly pathogens. This relationship signifies
that sequester atmospheric carbon dioxide into their
Paleoecologists recognize this stunning event,
that have been available reliably since at least the
what is now, for them, a toxic, nitrogen- and oxygen-
a true co-evolutionary adaptation of highly interde-
some 3 billion years ago, as the beginning of the
emergence of mammalian life. Quite interestingly,
rich atmosphere—which nearly all animals and plants
pendent cellular structures. It is rooted in continuous
proliferation of life beyond the “simple” organisms.
however, the genetic descendants of the earliest
today require to live. So they live symbiotically within
interactions that began hundreds of millions of years
This makes sense, because once the free and contin-
anaerobes, which paleobiology has determined were
us, ensuring that we can experience a long measure of
ago, but—crucially—required another evolutionary
uous energy of the sun could fuel an organism’s vital
the first living organisms on earth, live on today inside
years so long as we feed ourselves, stay clean enough,
innovation in order to occur at all: photosynthesis.
activities, a whole new world of ecological niches
the warm, mobile, flatulent digesters we maintain
and avoid fatal incidents. In exchange, we provide
for them: our stomachs.
them a regular “diet” of fluids, carbohydrates, fats,
Prior to the emergence of photosynthesis, bacterial respiration produced methane and carbon dioxide
emerged for life forms to colonize. Yet an interesting and perhaps ironic evolutionary trade-off occurred.
77
Photosynthetic organisms have remained sessile—
6
Yet at some early stage in the Paleozoic atmos-
Of course, we partake in this co-evolutionary
respire what they require (carbon dioxide) to live.
incapable of purposive mobility or mass migration.
phere’s transformation to its present composition,
symbiosis for the most part unconsciously since, like
Many non-photosynthetic organisms, including nearly
some anaerobic bacteria co-evolved metabolic
breathing, digestion is something most of us take
us and maintained over hundreds of millions of years…
all animalia, developed mobility as the means to feed
systems inside the earliest multi-cellular organisms
for granted. Yet in our exchange with the hundreds of
by plants.
and to avoid being fed on. And as our atmosphere
that would eventually allow the earliest forms of
anaerobic bacteria species and trillions of bacterial
As we breathe, so do we collectively nourish and
became more and more oxygenated over billions of
mobile animals (arthropods) to emerge. In this way,
organisms in our guts, we each ensure the other’s
feed one another continuously across the plant-animal
years by the earliest photosynthesizing bacteria, algal
the earliest ancestors of plants caused a global envi-
genetic continuity. It’s an excellent trade, especially
“divide,” which reveals from a cellular metabolic
mats, and ultimately plants, the archaic ancestors
ronmental transformation that, in turn, created the
since, had they not emerged, it’s a safe bet that
standpoint that we are in fact bound to each other
of all of today’s animals developed larger, faster, and
conditions for all animal life to flourish. But like mol-
higher plants and animals (to say nothing of mam-
through the respiratory and digestive cycles that
more complex body structures. They could do so
lusks that would emerge eons later, these anaerobic
mals) could never have emerged.
sustain us. Each “kin-dom” literally could not have
because they could derive energy from their food far
bacteria had to adapt to their changing environment to
Today we collectively breathe from a singular van-
more efficiently in the presence of increasing oxygen.
survive. They had to grow protective layers. They had
tage point—or precipice—in our living earth’s history.
even though each individual animal and plant species
And so the “botany of desire” among plants and
to go somewhere. Luckily for us, this symbiotic
Not only do plants form the basis of our nutrition
is never relieved from remaining relevant—either
animals, as Michael Pollan has brilliantly surveyed it
digestive dance with the anaerobes led to our being—
and our global medicinary, they also respire what we
adapting or failing to adapt in response to the ever
among plants and people, came into play.
or more precisely, our continual becoming.
require (oxygen and water) to live and we, in turn,
unfolding co-evolutionary paradigm of this biosphere.
We have received an atmosphere bequeathed to
proliferated over geological time without the other,
7
No individual species is inherently privileged, but
8
been relatively regular and relatively benign. But
ago and eliminated more than 80% of all terrestrial
Our species’ predilection to feed from, cultivate, and
every species expresses a particular, coherent, and
when we delve down into the world of bacteria, myc-
and marine life, most likely due to an asteroid impact
in so many ways co-create our world with plants
successful adaptive vector in relationship to its eco-
orrhizae, and endophytes, we see remarkable mor-
that altered earth’s atmosphere. This was an infinitely
that form our food and medicines expresses and vali-
logical matrix. A living or thriving species embodies
phological adaptation and phenotypic plasticity. We
long time ago in terms of conscious memory, but
dates what our DNA “knows” are highly successful
a co-evolutionary success story within a functioning
see into the co-evolutionary fire by which certain
relatively recently in terms of the genetic and cellular
strategies for surviving the most dramatic geochemical
habitat. A dying or recently extinct species embodies
assemblages and clades persist through successful
“memory” shared between the mammal and plant
upheavals possible on this planet. This knowledge
a failure to respond adequately to co-evolutionary
adaptation, and others die out. During the recent past
genera that (re)inhabited and co-evolved in the
lies latently within us, even when we have no conscious
challenges and opportunities.
2–3 million years of human proliferation on earth, a
postapocalyptic new world they inherited from the
or cultural referents to it. Even when we now appear
fairly stable phylogenetic array of animals and plants
dinosaurs and the gymnosperms.
to be the upheaval.
In this light, there can be no evolution outside coevolution. That all life forms, including humans and
has prevailed. Our atmospheric composition and
plants, inextricably interpenetrate each other’s cells
temperatures have been for the most part quite com-
beneficial, appropriative history between humans
the air, and to the magnificent story of how that air
means that we are always reciprocally co-evolving.
fortable and conducive to plant and, certainly,
and thousands of nutritive and medicinal plants is
came to be, we can feel profound hope. The several-
We only perceive taxonomic species and genotypes
mammal development. The narrative of earth history,
encoded into our DNA. Our cellular biology comes
billion-year-long story of phylogenesis on earth—
as immutable because we take a relatively short-
however, is punctuated by cataclysm.
straight from the womb and crucible of that last
the determined co-evolutionary force driving all life
great awakening among earth’s surviving species.
forward—will never finish so long as living organisms
term perspective, where climatic oscillations have
The last Great Extinction occurred 65 million years
A shared adaptive “memory” and a mutually
By reorienting our awareness (and our breath) to
9
can interact within local habitats and so long as the
what could be a more plain form of interspecies
sun sustains photosynthetic life. But due to our sheer
interaction—or cause for phylogenetic adaptation—
numbers and technology, we humans bear far more
than eating? Or being eaten? All organisms are
responsibility for outcomes now than ever before in
programmed by their shared DNA to learn from each
our cultural or biological memory.
close encounter at the threshold between life and
A dynamic, atmospheric equilibrium between 10
death, to adapt as efficiently as possible to ensure
plants and animals is a fundamental precondition for
continuity of their kind. Co-evolution is what life forms
our joint proliferation across the eons into countless
do and how they assert their relevance over geological
morphologies and habitats. Our every breath is owed
time within a biosphere that has proven remarkably
to a basic co-evolutionary process that connects our
capable of maintaining a dynamic, pulsing equilibrium
breathing to the origins of life itself.
for life’s proliferation as its only directive.
What is the simple act of breathing but the outcome of a vastly intricate and complex interaction, mediated by bacteria and mycorrhizae, among plant and animal species over millennia? For that matter,
Today more than ever, aligning with that directive is our most pressing imperative.
11
Chapter 2: Sustainable Wellness From Plant Intelligence
Many of us believe that within our lifetimes we will
our wellness within the wider and wilder realms of
and phyto-medicinal gardens of indigenous peoples,
experience a global convergence of science, eco-
phyto-medicines, we can also build a very pragmatic
yet which must be scaled up to accommodate 8–10
nomics, and earth-honoring spirituality that will cause
and sustainable platform of solutions to our wellness
billion people’s basic wellness needs by the year 2050.
humanity to embrace holistic and integrative wellness
challenges. To enter into the realms in which our
Implications for urban ecology and all related land-
as the dominant mode of primary health care. Not
neuro-physio-chemistry will meet and be enlivened
scape and energy design professions could be pro-
only do our macroeconomics compel this, but our most
by intelligent phyto-medicines, we should first ask
found. We are at an important threshold requiring
incisive sciences and our most profoundly resonant
what will form the basis of a truly sustainable and
all our healing disciplines to align within a biospheric
spiritual traditions are converging to pass humanity
regenerative phyto-medicinary? For without a robust,
mandate that has never altered over the eons.
over a threshold, through a sort of Deep Remembering,
diverse, and accessible phyto-medicinary, we cannot
into a rhizomatic awareness of our own embeddedness
experience the meetings and awakenings with plants
indicate, people hunger for real nutrition that is mean-
in a regenerative, health-giving biosphere.
that our bodies have co-evolved to expect.
ingfully connected to place: there really is no practical
The most patient denizens on our home planet—
The answers are truly fascinating and deeply reas-
As the organic farming and local foods revolutions
limit on society’s ability to promote sustainable
the algae, fungi, and plants—form the real basis of
suring, because they point to the resolution lying in a
nutrition once the preventive and wellness benefits of
human and animal wellness today, as always. By
globally regenerative ecological agriculture, one that
healthy and natural foods reduce society’s health care
remembering our human natures, and the basis of
mimics the sophisticated pharm-ecological forestries
costs. Billions of dollars spent managing avoidable,
13
14
preventable disease states can be redeployed to
roughly one-sixth of America’s GDP—to say nothing
to the “BRIC nations take over” narrative that we’re
self-care strategies. Two diagrams may help draw
supporting our inherent capacity to stay healthy when
of “big agra”—a certified organic phyto-medicinary
hearing so much lately, since America enjoys a lead in
this contrast. The first captures the conventional
we facilitate routine cellular interactions with benefi-
supply chain could actually rival biofuels and bioplas-
superior academic research infrastructure, environ-
processes and costs associated with our dominant
cial plants, and make whole plant nutrition plentiful
tics as the Next Big Thing that revives the American
mental and ecological bio-diversity protections, entre-
pharmaceutical development and delivery paradigm.
and affordable. When a society starts realizing tangible
economy and turns our society away from climate-
preneurship and financing networks, vast agricultural
The second depicts a natural phyto-medicinary
wellness dividends, through prevented managed care
change-inducing fossil fuels. If we recognize the co-
support and production systems, and legal property
development paradigm.
costs and high-tech interventions (particularly for
evolutionary power of plant intelligence to feed us and
and patent rights guarantees. Throw in its break-
low-income people and elders), then all the financial
make us healthier, and if we align our society with co-
throughs in bio-fuels and bio-plastics, and America
resources necessary to realize a renewable-energy-
evolution, we can see a very compelling economic path
is uniquely situated to rev up a new economic engine
than the pharmaceutical paradigm because it is
driven, bioregionally diverse phyto-medicinary
forward that requires a balance of university- and gov-
delivering the world a robust, safe, and scientifically
rooted in the inherent co-evolutionary symbiosis
agriculture will be freed up. Farming will also become
ernment-sponsored technological innovation, respect
verifiable phyto-medicinary supply chain.
between humans and plants, while at the same time
a much more sustainable enterprise, because of the
for indigenous wisdom traditions, and entrepreneurial
inherent needs our bodies have for phyto-medicines
ventures responsive to particular societal wellness,
the naturopathic and integrative medical professions
the keepers and communicators of medical wisdom
free of herbicides, pesticides, and fungicides.
energy, and nutritional needs.
while keeping millions of people out of the medical
traditions embodied in plants.
With health care and “big pharma” representing
Such a path also offers a substantial alternative
Imagine the societal benefits of greatly expanding
claims nightmare through responsive and natural
This second system is vastly more sustainable
honoring the pivotal role played by practitioners as
We believe that a sustainable phyto-medicinary
15
Figure 2
Figure 1 Conventional Pharmacutical Supply Chain Paradigm biotech designer ACCEPTED compounds & compounds molecultes
pharma mfg
prescrip plans
physician
IND basic research
16
target ID
translation of research target DEV lead ID
synthesis
natural phytochemistry
pre-clinical DEV lead DEV
patient
NDA clinical research
phase I
phase II
phase III
lead OPT
supply chain belongs at the base of our wellness,
research in pharmacology and systems biology has
along with seasonally diverse, regionally or locally
expressed our personal beliefs and experiences
grown foods providing for our nutritional needs. When
through observed science. These observations cer-
this approach is pursued as an ethos, as an outcome
tainly validate the naturopathic approach, while at the
of a regenerative ethical relationship to place, to family,
same time reinforcing our deeper genomic ties to a
and to our bodies, the need for nearly all of society’s
rich, biologically-diverse ancestry upon which true
best-selling pharmaceutical “lifestyle” drugs simply
human wellness was always sustained prior to the
falls away, as do nearly all of the attendant costs that
advent of chemo-pharmaceuticals.
seem to be driving our governments into prolonged
A leading voice in this area is Kevin Spelman, a
• Only 1:20,000 odds from target ID to NDA
insolvency. Not surprisingly, our physiology, our social
doctoral researcher and scientist with ties to UNC-
• 92% of drugs rejected in clinical trials
economy, and the biosphere are all signaling to us that
Greensboro, Tai Sophia Institute, and the NIH National
something has to give.
Institute on Aging. We find Spelman’s research and
• Only 1 in 3 drugs make back R&D costs
REJECTED
• DD pipeline cost per product: $1 billion
compounds
Do we need to rethink drug development?
(Modified with permission from Dr. Jeffrey Schmitt, Wake Forest University)
Perhaps we wouldn’t believe this so fervently if
writing highly compelling, because he is elevating and
we had not experienced this degree of wellness our-
articulating the paradigm-upending biological concept
selves. But more recently, an emerging field of
of “coherent coupling” and its expression between
Sustainable Phyto-Medicinary Paradigm
natural phytochemistry
biosphere & ecosystem
community natural products retail
traditional use history & clinical observation
family bio-regional agriculture & ecological harvesting
COG manufacture & GMP quality validation
patient physician: advisor & apothecary
17
18
phyto-chemical ligands and matrices of cellular
metaphoric levels of the cell, the body, and the bios-
grade biology class, this is a highly disruptive notion!
ments. Now we’re starting to see tantalizing evidence
receptors. Spelman has helped us enormously by
phere, deftly weaving together molecular-genomic
Yet we find its implications both cosmological and
in the cellular makeup of plants and humans.
surveying an international body of scientific literature
exchange processes and species-biospheric exchange
comforting at the same time.
in the fields of evolutionary medicine, molecular nutri-
processes. We believe his work and that of his col-
tion, proteomics, and metabolomics, and what he calls
leagues will form the scientific foundation for clinical
be far more flexible, adaptable, and plastic than can be
organisms are inexorably interwoven into their envi-
ecological pharmacology operating at the cellular level
research in integrative medicine for the next 20 years.
Put another way, a species’ genome is proving to
It starts with the self-evident notion that all living
accounted for by simple random genetic mutations
ronments since they all start as single-celled entities,
In essence, a central dogma of biology—namely,
and natural selection alone, and our ability to “pheno-
and that it is not really possible at the cellular level to
exploring and bringing home fascinating stories of his
that genetic information flows only in one direction,
typically shift” based on either health-inducing experi-
speak of environment and organism as separate enti-
encounters along this margin.
from our DNA to RNA to protein and onward to the
ences or harm-inducing experiences at the cellular
ties—and probably not at the level of species and envi-
cell, multicellular systems, organs, organ systems,
level is more latent to a species’ genome than clas-
ronment, either. The term first coined in the 1980s by
encapsulated in a chapter titled “Ecological Pharma-
and the body—captures only part of the story. It is
sical evolutionary theory permitted. As an example, we
systems biologists Maturana and Varela to account for
cology: Pharmacology Informed by Evolution” in the
emerging through science that our cellular experi-
already have evidence of phenotypic plasticity in how
DNA shifting is “structural coupling,” which is defined
forthcoming book Fundamentals of Complementary and
ence through environmental interactions can affect
individual Pacific tree frog tadpoles metamorphose
as “a history of recurrent interactions leading to struc-
Integrative Medicine, 4th edition (Elsevier, 2010). He flu-
our DNA. In effect, this means that DNA can “learn”
differentially due to differing predatory pressures from
tural congruence between two or more self-organizing
idly connects information exchange processes at the
directly from the environment. Going back to 8th
fish or diving beetles in their natural pond environ-
systems.” Thus, living systems can and do undergo
of the human-plant interface. Spelman is intrepidly
Spelman’s research of the past 20 years is nicely
19
“coupled histories” of structural change due to their
sions of the basic observation that mutually adaptive
chemistries, we will see, show significant bio-activity
all species—and perhaps uniquely to humanity, which
consistent and constant interactions. Anyone who has
morphologies occur among plants and animals.
in animals in vivo, but purified or synthesized fractions
is capable of perceiving and realizing our interactive
of the same chemistries do not perform as well.
nature in the biosphere. It also places a special
been married for decades can visualize how coupled histories cause structural coupling in our own lives. Among humans and plants, this means that for
20
Certain species of hummingbirds have co-evolved bills for extracting nectar from flowers whose shape is
But these relationships don’t only happen over
responsibility on us to facilitate wellness and natural
uniquely suited to allow the hummingbird optimal
geological time. They are happening right now in ways
every cellular receptor in the human body, there is
access that assures the hummingbird departs with the
we can observe in cellular structures. As an explana-
Environmentally induced genetic change under
already a corresponding and complementary phyto-
plant’s pollen and/or seeds. The same is true with cer-
tory framework, coherent coupling gets radical when
coherent coupling means that sciences capable of
medicinal expression in nature. This co-evolutionary
tain milk thistles and butterflies with specially adapted
we move to the cellular and genomic level—where
characterizing genetic change due to metabolic
work is already massively correlated inside our
mouthparts. The December 2009 National Geographic
science is showing that the environment (via metabo-
interfacing can finally validate and authenticate why
human physiology and that of plants. How ingenious…
features an article showing in micrographic detail
lism, among other exchanges), and even an
ancient nutritional protocols like the Okinawan or
and how reassuring. Yet, as we’ve seen over geolog-
how individual pollen morphologies from flowering
organism’s perception of the environment, can induce
Mediterranean or Costa Rican diet and lifestyles tend
ical time in our atmosphere, each system is slowly
plants have adapted extensively and optimally to the
genetic adaptation and rewrite sections of DNA code.
to yield markedly higher longevity. Coherent coupling
transformed by the other due to their recurrent inter-
morphologies of their animal carriers, the better
This moves us well beyond random mutation and
as an explanatory model can also move the medical
actions. Life is always in flux. We can look around the
to increase the odds of successful coupling between
natural selection guiding epigenesis. It confers a far
sciences away from disease-driven single-vector inves-
genera of plants and animals and see myriad expres-
sperm and ovum. Many whole-plant extract phyto-
more profound evolutionary legacy and resilience on
tigations toward truly wellness-driven investigations
biodiversity among all species.
21
explaining what appear to be the underlying genomic
nutritional and therapeutic plants, through metabo-
hundredth? A thousandth? What are the consequences
notes that CYP 450 genes, which allow animals to
adaptations and adaptive proclivities that result in
lizing phyto-chemistry, shows us the way. . . . It’s not
of any protracted illiteracy over a generation or two?
generate a metabolic resistance to plant compounds
sustained vitality and greater longevity. Key to this
a one-way street.
Many conventional clinical doctors, nurses, and practi-
designed to dissuade herbivory, “follow an unusual
tioners are finding out!
ability to evolve rapidly.” The large family of genes in
whole framework is the notion that our DNA in some
22
All higher primates, while considered omnivores,
sense “expects” to be perturbed by our environment
are nevertheless primarily herbivores. Nutritional
and is able to “leap” adaptively when conditions are
paleontology estimates conservatively that over the
phological and biochemical modifications in plants
which to metabolize novel, never-before-digested
favorable—like Atacama desert flora waiting cen-
past 5–7 million years, Homo sapiens and our imme-
only requires looking at our agricultural and horticul-
plant compounds. Not only do novel plant com-
turies for rain.
diate ancestral forebears have accumulated dietary
tural history. Practically every plant-based staple
pounds—themselves adaptive phyto-chemical
In this way, environment and organism and DNA
Evidence that humans have caused genetic mor-
CYP 450 supply a cache of available proteins from
exposure to a conservative estimate of 80,000 to
or starch has already been bred and/or genetically
expressions in response to environmental perturba-
are constantly shaping and transforming each other
220,000 phyto-chemicals, a vast library of secondary
altered by humans to produce the results we desire.
tions—cause human physiological changes that
to mutual benefit or, at least, to potential benefit to
metabolitic repellants and attractants, nutrients,
But Spelman gives examples of how plants are
affect and potentiate differential advantages. Those
the most adaptive organisms undergoing environ-
immuno-modulators, anti-inflammatories, toxins, etc.,
causing changes in human DNA and protein.
novel compounds also trigger CYP 450 genes to write
mental perturbation. So how do we maximize adap-
that have shaped our genomic conditions for optimal
tivity to perturbation in the system? We believe that
wellness. How much of that dietary library do our
in cytochrome P450, which are an ancient set of liver
of detoxifying the novel plant compounds. This is a
our co-evolutionary history of coherent coupling with
bodies “read” today? Perhaps a tenth? A twentieth? A
enzymes shared by all vertebrate animals. Spelman
co-evolutionary process happening in real time, in our
First to the witness stand is the shaping of genes
new RNA code to create new enzyme isoforms capable
23
bodies due to environmental “experience” in the form
tion and mortality certainly drive genomic adaptation,
lular communication regulating human cell growth.
elicit compelling explanations, but we firmly believe
of ingestion.
something deeper is going on. Further investigation
Further, soil fungi molecular messengers have been
that mounting evidence of such structural correspon-
Such a rich history of recurrent interactions
24
inside the “omics” revolutions will tell. Spelman’s
shown to bind with the human estrogen receptor
dences at the level of cellular receptors across
between our Pleistocene forebears and a rich, biodi-
second “star witness” is the steroid receptors. He
and influence gene expression, as have plant steroids
phylogenetic kingdoms argues strongly for coherent
verse array of plant compounds argues strongly that
describes in particular how the estrogen receptor,
and flavonoids. This suggests to us, at minimum, a
coupling as an operating paradigm among humans
human CYP 450 genes have engaged for millennia
whose gene structure and ligand-binding properties
common communication strategy among fungi,
and plants.
in a mutually convergent evolutionary dance with the
have been conserved in fish, amphibians, reptiles,
plants, and animals involving molecules with similar
very same phytochemicals—themselves metabolites
birds, and mammals for 300 million years of
shape and electronegativity as estrogen.
designed to confer adaptive preference in plants—
vertebrate evolution, have a high degree of genetic
that we now recognize for their specific medicinal
homology to a receptor on the cells of fungal mycor-
disparate evolutionary forms as fungi, plants, and
properties.
rhizae in plant roots. These fungi perform functions
animals could result from mere chance… or from a
is stimulated and potentiated not only by high-affinity
involving mineral and other nutrient metabolism that
shared phenotypic adaptivity derived from a rooted
single-ligand agonists or antagonists targeted to a
genes in CYP 450 resulted, even over millennia, from
are absolutely essential to plant cell growth. These
genomic mutability, expressed as a messenger-
single, well-characterized receptor. Rather, the body’s
random mutation and selective pressure alone?
fungi possess a receptor that is homologous to the
receptor homologies, to shared or common environ-
wellness response is optimally stimulated and poten-
Coherent coupling suggests that while random muta-
human estrogen receptor, itself a key gateway in cel-
mental influences. Further research will no doubt
tiated by repeatedly digesting and metabolizing high-
How likely is it that this storehouse of adaptive
We wonder whether such coherence among such
A final, critical “witness” in the emerging ecological pharmacology is highly compelling. Spelman’s personal research in phyto-pharmacology has led him to propose that the body’s overall wellness response
25
volume, low-dose phyto-complexes with recognized
optimally activated or, indeed, fail to be activated at
molecules targeted to single receptors—aside from
fruitful outcomes by pursuing “magic shotguns”
broad-based affinities within whole organ systems.
all in certain people. His work is showing that both
accommodating business concerns—was the method-
instead of conventional “magic bullets.”
To an herbalist, this sounds very familiar.
high- and low-affinity ligands must be present to
ological and technology limits against characterizing
optimally stimulate receptor mosaics. This partly
activity across cooperating matrices of receptors. It was
corridor in the investigative mandate of 21st-century
Spelman’s hypothesis extends a self-regulatory
26
The implications of all this opens up a whole new
cooperativity in multimeric proteins to receptor
explains why oftentimes a purified drug or bioactive
never because phyto-complexes were not known to
pharmacology, especially if coherent coupling among
mosaics. Perhaps in the same way that receptor
molecule fails to work in certain individuals and
be biologically active—just that they were too complex
plants and humans is the norm, and our organ sys-
mosaics synergistically integrate colors in the fovea
sometimes triggers only undesirable side effects.
to characterize within typical business investment
tems actually require phyto-complex inputs to adapt
of the human eye, Spelman’s cellular research is
Spelman proposes other supportive mechanisms
constraints, a reductionistic scientific model, and the
to changing environmental conditions. If coherent
showing how superior therapeutic responses are
like plasma membrane morphology shifts, but the
technology of the day. But that is now changing.
coupling demonstrates that it is the “other” basis by
achieved in the presence of complementary (suppos-
key point is that whole phyto-complexes deserve
edly “non-active” or “low-activity”) phyto-constituent
pharmacodynamic characterization as much as high-
diseases, including AIDS and Alzheimer’s, that are
found implications for what constitutes a sustainable
complexes. His proposed mechanism is the stimula-
affinity ligand drug molecules do.
now shown to be treated far more effectively with
medicinary and how society achieves optimal well-
combinatorial therapies acting on multiple receptor
ness via the medical professions.
tion of cooperative and synergistically interacting
Tellingly, the main reason 20th-century pharma-
Even within traditional allopathy, there are many
matrices of cellular receptors that, if triggered solely
cology and the ensuing pharmaceutical drug develop-
sites simultaneously. Leading researchers now pro-
by a single high-affinity ligand drug may fail to be
ment model focused on isolating high-affinity ligand
pose that research investment dollars will yield more
which cellular biology functions, then it also has pro-
It certainly argues against a pharm-agra industrial complex, which systematically simplifies and
27
28
artificially fortifies our food to suit the dictates of
consciously extending Michael Pollan’s brilliant co-
capital efficiency and mass distribution. It also argues
evolutionary thesis in the magnificent Botany of Desire
and thus any species’ genome, has a vast reservoir of
against heavy governmental investment in single-
(Random House, 2001) to include adaptive mutualism
accessible yet latent phenotypic adaptiveness open
we must remember the rich herbivory upon which our
vector drug development (and towards combinatorial
among the human genome and entire plant communi-
to influence at the cellular interface. Why? Because
species has always relied and which our living bios-
approaches), since under the paradigm of coherent
ties in one direction, and adaptive mutualism among
it means that abiding wellness is our biological
phere still makes readily available. We must meet our
coupling, more affordable and sustainable medical
specific plant genomes and human DNA/receptor
birthright. It means that life is not an endless battle
healing herbs—whether by cultivating them in plant
interventions would derive from influencing a
matrices in the other.
against disease states until we die. And abundant
pots or garden beds, using them in our cooking and
wellness is not something scarce to be rationed and
salads, collecting seeds, or fortifying ourselves with
patient’s entire ambient experience through dietary,
Such holistic, transpersonal, and integrative
We find comfort in this idea that our genome,
The more diverse experiences, the better. To regain abundant wellness as our natural state,
lifestyle, and attitudinal changes—guided by our
approaches would greatly increase the likelihood that
mediated through a medical/insurance/pharma
them in medicinal preparations. As the poet Rumi
knowledge of our prehistoric ancestors’ diets. If you
balance and natural vitality return to a distressed
complex, like Pell Grants or food stamps or carbon
wrote, “There are a thousand ways to kneel and kiss
wish to go deeper into this realm, we highly suggest
or diseased individual, precisely because the human
credits. Abundant wellness is abundantly available to
the Earth.” Our challenge is to find our own ways to
reading Paul Shepard, the human ecologist who
genome is biologically inseparable from its environ-
anyone who consistently supplies his or her phenome
allow such coherent couplings to occur. When we do
wrote Coming Home to the Pleistocene (Island Press,
ment and each individual’s genome awaits gentle or,
with cellular experience that our genome expects
this, we are stewarding a wellness revolution whose
1998) and Traces of an Omnivore (Island Press,
at times, robust interventions to stimulate healing
based on millions of years of iterative physiochemical
utmost consequence is a determined co-evolution
1996), among his many classics. We are also very
and regain balance.
and psychological interactions, primarily with plants.
that transforms our species’ future.
29
Chapter 3: Conviction
If all this is scientifically reasonable, then our real
heartfelt passion is to build a certified organic foun-
turn the tide against our amazingly dysfunctional
challenge is to sustainably provide people with the very
dation for medicinal herbs so that people will taste
health care system. Herein lies the power of our
best organic nutrition and botanical preparations that
and feel the difference in their quests for radiant
shared conviction, one that rests on solid science.
support convergence with their evolutionary potential.
health. Thankfully, a cadre of botanical medicine
It is up to us—we must create the opportunity for
Recent peer-reviewed scientific studies confirm
manufacturers is on this same quest. Many, if not
the interesting ways in which complex plant extracts
informed practitioners to help their patients “meet
most, of you reading these words would make botan-
exert a more “intelligent” therapeutic synergism than
the herbs” and accelerate the transformative power
ical preparations lovingly by hand if you could spare
isolated phytochemical fractions or their synthetic
of coherent coupling. We want practitioners and
the time. No doubt some of you do! For the rest,
counterparts alone. For example, in 2009 the journal
patients to feel undeniably better through a visceral
we’re here to help you convey your love of the healing
Phytomedicine published a review of recent pharma-
experience of coherent coupling with the most lov-
power of phyto-medicines directly to your body,
cological literature on this topic. Authors Wagner
ingly and caringly produced botanical medicines. It is
mind, and spirit. If you believe in what we’re sharing,
and Ulrich-Merzenich (J. Phytomedicine 16: 97–110)
then only up to you to meet the herbs that have been
then together we can move many more of our
survey the main mechanisms through which recent
stewarded by medicinal herbal partners who adhere
friends, relations, and colleagues to embrace a path
molecular medical science is discovering how
with conviction to deeply sustainable practices.
that not only sustains, but also regenerates our
complex botanical extracts oftentimes show a supe-
bodies, communities, and ecosystems even as we
rior therapeutic effect compared with isolated single
Organic foods have legions of advocates, but our
31
constituents. They define a synergistic effect when-
32
pounds that are naturally present in the whole-plant
involving the Ayurvedic herb Ammi visnaga as an
ever it can be shown that two or more constituents
target effects occurring in Saint-John’s wort (Hyper-
Hypericum extract “meet” a particular individual’s neu-
example, in which Khellin, the bioactive agent from the
The authors give an example of synergistic multi-
interact within in vitro or in vivo models in such a way
icum perforatum), in which multiple phytochemical
rophysiology and exert a definite antidepressant effect
whole-herb extract, is fully bioavailable in 10 minutes,
as to reduce the total amount of “actives” required to
constituents in this extract—hypericins, hyperforin,
that is customized intelligently to that person’s neuro-
as compared with the purified equimolar Khellin that
achieve a given dose-dependent effect than would
rutin, xanthones, etc.—are evidently “cooperating”
chemistry. Notably, the preponderance of over 40
is not fully bioavailable until 60 minutes. They also cite
be required using any single constituent. Put another
in achieving a beneficial antidepressant action at
placebo-controlled clinical studies cited by the authors
a compelling animal studies involving Hypericum
way, the total effect achieved in a truly synergistic
multiple receptor sites that is comparable or favorable
show little or no side effects, although certain herb-
showing that pure hypericin exerts only a weak antide-
therapy is greater than what could be achieved by
to synthetic drugs. They cite a study by Simmen et al.
drug interactions and increased photosensitivity are
pressant effect, but when combined with other con-
merely adding up the separate effects.
in J. Pharmacopsychiatry (2001) that showed affinities
well-known factors to consider when using Hypericum
stituents normally present in a whole-plant extract,
among these compounds at presynaptic neurons,
for mild to moderate depression.
“the plasma level of hypericin is clearly enhanced and
The three main mechanisms the authors find are:
Enhanced pharmacokinetic benefits occur when
a strong antidepressant effect is obtained….” These
•
Synergistic multitarget effects
postsynaptic neurons, the hypothalamus, and the
•
Pharmacokinetic effects
pituitary gland, and they further cite beneficial binding
“minor” or supposedly “non-active” constituents
studies underscore how important it is to prepare
(e.g., improved solubility, bioavailability)
inhibitions for serotonin, histamine, and H-estradiol,
increase the solubility or resorption rate of the sup-
phyto-medicines in a manner that preserves the nat-
Influencing bacterial resistance mechanisms
among other known depressant compounds. This is
posedly “active” compound(s), thus improving overall
ural array of phyto-constituents contained in the
a classic example of how differing bioavailable com-
bioavailability. The authors cite a 2000 German study
useful plant part. Just because science has not yet
•
33
34
parsed out exactly how a traditionally used botanical
cocus aureus, potentiating the antimicrobial effective-
Along these lines, they discuss research into many
such as Fiji, Vanuatu, and Western Samoa have
medicine works does not mean that the traditional
ness of berberine, and consequently shutting down the
different essential oils, including those from oregano
exceptionally low incidences of cancer, including lung
preparation methods, which preserve the natural array
multidrug-resistance capacity in the bacterium. They
and tea tree, and show many promising examples
cancer, despite not having smoking rates or cancer
of compounds, should not be respected. The minor
also cite studies involving thymol and carvacrol,
whereby their use in combination with antibiotic drugs
registration systems much different from other
compounds may hold the key to the medicine’s syner-
essential oil compounds commonly found in thyme,
significantly reduces the antibiotic dosage required
countries. This led them to suppose that kava con-
getic and coherent coupling potential.
cloves, and holy basil, which synergistically facilitate
to achieve the same effect. They state “…in all cases
sumption may have a chemopreventive effect, since
the permeation and penetration of antibiotic com-
real synergy effects could be measured.”
their epidemiological study showed that the more
A fascinating third synergistic mechanism exhibited by many botanical extracts is bacterial resistance
pounds into gram-negative bacteria. They further cite
Another highly compelling study recently con-
inhibition. The authors highlight many examples,
the remarkable effectiveness of grape seed extract
ducted by researchers at the University of Minnesota
their cancer incidence rates. One key outcome of this
including the well-known antimicrobial effect that
(Vitis vinifera) to potentiate the anti-candidiasis effect of
(J. Cancer Prevention Research, 2008, 1(6): 430–438)
study was that whole kava extract given at 10
Oregon grape root (Berberis aquifolia) has, despite the
amphotericin B in mice. When used in combination
showed a statistically significant chemopreventive
mg/gram of diet reduced lung tumorgenesis by 56%
fact that pure berberine is only weakly antibiotic.
with grape seed extract, half the dose (by body weight)
effect from kava root (Piper methysticum) extract
vs. controls, yet showed no liver toxicity at this
This occurs because a non-antimicrobial phenolic
of amphotericin B resulted in mean survival times
against induced lung cancer in mice. The researchers
relatively high dose. The authors concluded, “These
compound (MHC) in the plant extract has been shown
nearly three times as long as in control groups
in this study followed up on epidemiological evidence
results clearly show a chemopreventive effect of kava
somehow to shut down the “efflux pump” in Staphyloc-
receiving the full dose of amphotericin B by itself.
showing that people in certain Pacific island nations
against lung tumorgenesis in the A/J mouse model…
kava these nations consumed per capita, the lower
35
36
Its chemopreventive efficacy compares fairly favor-
ering how the unifying field at the deepest level of
botanical medicines work now represents the cutting
ably over other chemopreventive candidates…” We
nature expresses itself through medicinal plants.
edge on which our wellness may very well rest. For
find outcomes from rigorous scientific investigations
Ancient cultures have known of this formative force in
these reasons, we feel even greater conviction that, as
highly compelling because they verify that modern
nature for thousands of years. Modern pharmacolog-
makers of herbal medicines, we are helping usher
21st-century pharmacological and toxicological
ical sciences are just recently developing the capacity
humanity over an important biospheric proving ground.
investigations are capable of fully validating the var-
to evaluate and characterize the synergetics of tradi-
ious efficacies of traditionally used and traditionally
tional Chinese, Ayurvedic, and Native American for-
prepared botanical medicines, both for their past co-
mulas—some of humanity’s most ancient medical
evolved expressions of the infinite correlation
systems. They regard medicinal plants as particular
between humans and plants and for their future syn-
embodiments or expressions from the wellspring of
ergistic expressions as botanical drugs. Science is
intelligence within nature that coherently nourishes
finally catching up and converging with the traditional
and fortifies the infinite diversity of life. A “natural
medicinal arts. This is part of the Deep Remem-
biotechnology” that respects these ancient cultural
bering we are now inside.
systems and deploys 21st-century analytical
Modern medicine is just now on the verge of discov-
approaches to understand how and why traditional
37
Chapter 4: Confidence
Of the early 20th century’s many memorable insights,
be done—then it is done and all the world wonders
vate, make, package, and distribute herbal medicines
an especially compelling one to those who make
why it was not done centuries ago.
with a heartfelt confidence—an indwelling knowing—
whole plant phyto-medicines in the early 21st century came from The Secret Garden, a children’s book by
that we are doing our utmost to preserve the integrity In our lives, once we know something to be true—
of the plant intelligence expressed in each herb.
Frances Hodgson Burnett, which was published in
especially when it is something that bears moral depth
the spring of 1910, exactly 100 years ago:
and captures our hearts—we can no longer avoid it.
the United States, besides conferring certain undis-
You probably know that Certified Organic status in
We can uphold it, share it, and humbly follow its conse-
putable quality benefits to foods and medicinal plants
In each century since the beginning of the world,
quences. Its truth transcends our individuality even as
alike, also explicitly creates lot traceability to the orig-
wonderful things have been discovered. In the last
our lives feel more significant as we join with others
inal agricultural source (the grower) and oftentimes to
century, more amazing things were found out than
who understand its meaning.
a particular field on a particular farm. This is true at
in any century before. In this new century hun-
Yet our conviction must move beyond the scientific
dreds of things still more astounding will be
validity of traditional whole-plant medicines. So much
Gaia Herbs: we are Certified Organic on our farm and our manufacturing facility by Oregon Tilth, the strictest
brought to light. At first, people refuse to believe
of the synergism our bodies seek from medicinal
USDA organic certifying agent. Under annual audit,
that a strange new thing can be done, then they
herbs can be harmed, or at least attenuated, inside
products must not only prove the absence of toxic and
begin to hope it can be done, then they see it can
the supply chain from seed to shelf. We must culti-
synthetic agricultural inputs, they must also rigorously
39
40
demonstrate an unbroken chain of custody for all their
benefits it delivers, but also because of the third-party-
chain parties source only from wildcrafters who follow
fair trade certification agencies now exist to assure the
allowed inputs, yielding up a complete geographical
audited accountability it imposes on the entire supply
ethical, legal, and ecologically sustainable harvest
socioeconomic sustainability of a particular botanical’s
and chronological characterization of the provenance
chain. Certified Organic, as we have seen in the food
practices, who provide full and complete authentica-
uptake into the phyto-medicinal supply chain.
of each botanical. An industry movement in “radically
industry, also tends to support the growth and prolifer-
tion of their location, timing, and methods of harvest,
transparent” disclosures of sources is beginning,
ation of family-owned and -operated farm supply
and who submit willingly to site visits by their buyers.
farther and assure that a premium on the price they
and we’re among the companies at the headwaters.
networks, even when a nationally branded distributor
For their part, the buyers must respect international
pay for a given botanical goes directly into educational
Failure to prove a continuous chain of custody is
becomes the end consumer’s trusted trademark—for
and national laws prohibiting trade in CITES-listed
and community-supportive infrastructure in the
grounds for loss of certification for that herb or even
example, Earthbound Farms, Organic Valley, Stonyfield
botanicals, must assure that properly identified botan-
source villages. Gaia Herbs and other cohort compa-
that grower. Gaia Herbs’ farm has been Oregon Tilth
Farms, Cascadian Farms, and Seeds of Change. This
ical species are in fact being harvested (and not com-
nies in the United States have for decades directly
certified organic for 13 years as of 2010.
trend reinforces bioregional economic resilience and
mingled with other species), and must assure that
supported local and indigenous communities through
undercuts the proliferation of GMO foods and medicinal
fair trade practices are employed, preferably under fair
direct financial or in-kind sponsorship of school con-
plant crops, which is all to the good.
trade certification. This is particularly important when
struction, agro-ecology education, forest academies,
the botanical in question is endemic to the tropics
and wellness clinics in places as diverse as Vanuatu,
Potential loss of certification is true both at the level of the grower and the manufacturer of a phytomedicine. So one critical element of a sustainable
The next stepping-stone in a “green” phyto-medic-
The best medicinal herb companies take it a step
phyto-medicinary is organic certification, not only
inary covers botanicals that fall outside the Certified
and is being harvested by indigenous people who are
Jamaica, Costa Rica, Indonesia, and West Africa. Fur-
because of all the ecosystem and topsoil conservation
Organic framework. Here, the truly sustainable supply
themselves susceptible to exploitation. A number of
ther, Gaia Herbs in recent years has donated over a
41
quarter of our corporate profits to charitable or educa-
Organic brands in neighboring channels like medicinal
this, we set aside crude dried herbs that can be taken
delivery systems are well respected and well tolerated
tional causes like United Plant Savers, the American
teas and body care products. Bottom line: It makes no
in capsule, tablet, or tea form. Many have a fully legiti-
and oftentimes the least-cost way of ingesting medic-
Herbal Pharmacopoeia, naturopathic college endow-
sense if the systems from which we derive our health
mate role inside the materia medicae of the world’s
inal herbs. Certainly this is true for all culinary spices.
ments, and state naturopathic licensure efforts. This
and livelihood are in turn degraded. That’s just a for-
most venerated traditional medical systems, including
is actually another mode of coherent coupling.
mula for system-wide collapse, a possibility if we fail
traditional Chinese medicine and Ayurveda. However,
herbs because they want to consume a higher
Bringing ecological and socioeconomic sustain42
People take botanical extracts rather than crude
to coordinate our vision and let misguided convictions
crude herbs used in these systems present a number
amount of a given herb or herbal complex, beyond
ability full circle, the very best companies are now
run our manufacturing companies whose work trans-
of therapeutic challenges ranging from dosage vari-
daily levels that a crude herbal delivery system can
engaging in efforts to coordinate their botanical pro-
forms the economic and ecological nexus between
ability and patient aversion to supplier quality variability,
practically or palatably deliver. However, a wide quality
curement as part of a global supply chain integrity net-
humans and medicinal plants.
microbial and heavy metals concerns, and oxidative
spectrum exists within botanical extract manufac-
degradation. While there are certainly management
turing. There are many extract manufacturers that
work, assuring that botanical and human communities
Let’s now take up the manufacturing process, once
that supply the phyto-medicinal benefits that we all
a given bark, berry, leaf, root, flower, seed, aril, nut, or
systems and companies devoted to assuring premium
sacrifice the natural balance and array of phyto-
prize in turn realize long-term and systemic health
vine arrives to be made into a phyto-medicine. As you
quality in crude herbs, this delivery system presents
constituents in a crude herbal material for the sake
benefits. Such companies will assure that horticultural
may know, there are many ways to make a botanical
more unknowns and quality validation challenges to
of process efficiency, cost-cutting, or fraudulent profi-
and ethical protocols reach beyond direct supply chain
extract. Not all of them are completely nontoxic, and
the practitioner and the end user from a scientific
teering. This is some of our industry’s dirty laundry,
involvements to include some of the largest Certified
not all of them result in a therapeutic product. In saying
standpoint. Even with those constraints, crude herbal
but denying it won’t foster necessary system-wide
43
improvements. And from a health standpoint, practi-
safety regulations and widely varied capacities to
the body to receive a more consistently therapeutic
packaging applications in the natural products
tioners and consumers need to learn that many
enforce the rules they’ve enacted. Country of Origin
concentration of the plant’s full-spectrum of con-
industry. It is called the EarthBottle, and you will
botanical extracts today are primarily extracted in
labeling therefore is something we will see coming
stituents. And there is no need to isolate, purify, or
start seeing it used by more companies in the natural
industrial solvents like acetone, hexane, methanol,
forward to improve supply chain transparency.
“spike” the extract for the sake of hitting a certain bio-
products industry. Soon we will have a real alterna-
marker concentration: it is simply a matter of meas-
tive to petroleum-based plastics and the associated
certainly from the biology within the coherent coupling
uring the primarily active constituents using validated
risks of low-level endocrine disruption from the con-
model, Certified Organic botanical extracts made
analytical methods, assuring they are present at a
tainers for our bottled water, foods, and dietary sup-
the cumulative effects of consuming legally permis-
from water, vegetable alcohols, and/or supercritical
required level, and presenting this outcome on the
plements. There is a whole movement underway
sible trace industrial solvents in the finished products.
CO2 deliver the best overall wellness solutions from a
product’s label alongside the phyto-chemical array.
right now in sustainable packaging. Suffice it to say
Needless to say, sustainable companies use only
personal and planetary perspective. That is Gaia
ingestible and organically-certifiable solvents to make
Herbs’ choice. Companies that follow these extraction
ished botanical product, leading “green” phyto-medi-
away from packaging that causes unnecessary cli-
their extracts. It is up to each company to decide how
systems get extra points if they are already powering
cinary companies are now committing to sustainable
mate or solid-waste-stream impacts and towards
harshly or gently they wish to make their extracts, and
their manufacturing plants with renewable energy
packaging. Gaia Herbs is proud of our efforts to
packaging that poses no harm to the environment or,
which national quality standards to abide by. Different
systems. The resulting extracts retain the natural
develop and introduce a renewable, all-natural, and
in the best cases, can actually enhance soil nutrition
countries have different environmental health and
array of the crude herb’s phyto-chemistry yet allow
industrially compostable biopolymer resin for rigid
in managed composting systems.
and denatured alcohol—and must then be purified to remove the toxic solvents prior to final formulation. 44
This common practice leaves open the question of
From a “green” phyto-medicinary standpoint, and
Beyond the sustainable manufacture of the fin-
that the most forward-looking companies are moving
45
The final realm in which truly sustainable initiatives
46
Unless each generation keeps alive the world’s
moment we first felt “held” in a still place in nature,
are underway in phyto-medicines pertains to practi-
herbal traditions and delves deeper into the seemingly
perhaps at the first whisper of dawn against a gull’s or
tioner and consumer education. The actual point of
infinite mystery of phyto-therapy at the human-plant
a loon’s cry, or perhaps under a liquid canopy of stars
all this effort at sustainability and wellness is not truly
nexus, we will progressively lose access to our living
against a primordial night din of cicadas, or at the lap
fulfilled unless practitioner and patient alike under-
biosphere’s greatest and most plentiful source of well-
of a pristine lakeshore or lagoon, revealing a knowing
stand the principles of medical herbalism and can
ness and renewal: medicinal plants. Education and
to our depths that we are not alone—we were never
trust wholeheartedly in their supplier’s transparency in
use must go hand in hand—another type of coherent
alone—and the beating pulse of our earth mother’s
delivering full-cycle value to them. Gaia Herbs has
coupling—so that botanical communities and their
heart is waiting patiently, through her plants, throug-
traditionally taken a leading role in botanical education,
human collaborators around the globe can renew
hout the seasons, for us to hear her once again.
through our sponsorship of the annual Medicines from
themselves each season, in a never-ending dance that
the Earth symposium in Black Mountain, NC, our on-
yields greater and more sustainable wellness out-
site residential naturopathic education seminars each
comes for our soils, our ecosystems, and the biodiver-
summer, our financial support of naturopathic college
sity of our only home.
endowments, and our development of path-breaking online botanical-protocol support tools.
The biosciences are finally starting to confirm what many of us have known and felt intuitively, from the
47
Chapter 5: Reverence
Reverence for anything we do in our lives with
In making herbal medicines reverently and
help us remember our gifts and understand the true
conviction and confidence requires insight, perhaps
humbly before the great arc of our co-evolutionary
to the point of revelation, into what we’re really
story on this earth, our object is at once the plants
doing. Prayer and meditation express reverence most
themselves and the wider ecology in which we are
first generation to assimilate a detailed scientific
directly, of course. So could eating, or preparing
embedded. In offering herbal medicines to people
portrait of humanity’s impacts on global biodiversity,
a meal, or making love, or singing, or teaching
and other animals, we realize how crucial it is that
climate, and myriad fragile habitats and threatened
someone an art or craft or skill—like stringing a
our actions express our relevance to the infinitely
species, we are likely the last generation with the
bow or fletching an arrow or making fire. Traditional
complex co-evolutionary process by which life
means to do anything pivotal to prevent our bios-
hunters know this, too. We take reverence to mean
unfolds. Such relevance, as we have seen, is not
phere’s increasingly turbulent responses to humanity’s
“enacting consciously with utmost humility and
guaranteed to any species. At this time, through a
excrescence. As translators of archaic cultural and
respect” for the object of one’s actions and for the
global convergence of our sciences, our cultural and
physiological memory through the intelligences of
process itself. Reverence occurs when we realize
spiritual traditions, and the economics of 6.7 billion
the plants, we see that in order to achieve any of our
we are encountering the divine, enacting the sacred,
people seeking meaning in this world, we are called
aspirations to love, to family, to God, to self-realization,
and extending our awareness through the limits of
to understand what it means to remain relevant
to influence or legacy in the world, or to service unto
our normal everyday senses.
within that great arc. Surely the medicinal plants can
others, we must each signify ourselves ultimately as
syntax mediating our wellness. The message is quite humbling. As perhaps the
49
beings whose lives reinforce the whole of life that the
maintain balance. We have settled for medicating our
play, and knowledge. Is it working? More of us each
how many of us are seeking relief and even perhaps
plants initially created and bequeathed to us. We see
inflammation, stress, and anxieties. We have entrusted
day are drawn into this vortex of smart phones, social
freedom, ultimately, from stress? Most of us, to be
that we cannot systematically conserve and lay waste
our wellness to institutional experts and yielded to the
media, and digital simulation, but with unknown and
sure. At Gaia Herbs, we know that we certainly want
to our biological provenance. Paraphrasing Einstein’s
succor of conglomerate-produced surrogates for real,
largely unaddressed consequences to our health. We
this freedom—it was this yearning that led us to rec-
observation on the harrowing specter of nuclear
abiding satisfaction.
are undoubtedly more connected to one another glob-
ognize the profound ways in which our medicinal
ally. Many of us, however, are not healthier—only more
plants humbly meet us and can awaken a reverence with the power to resolve our stresses.
armageddon: you cannot simultaneously prevent and 50
So many of us excuse ourselves from the most
foment biospheric extinction. We must choose. We
basic responsibility that our bodies expect from us and
obligated, fractured, and oversubscribed. Hence the
must remake our lives, our commerce, and our cul-
which our biosphere makes available to us—to sustain
adoption of avatars, virtual beings in cyberspace
tures so that they proceed with reverence towards the
ourselves in vibrant health so that we may experience
whose lives we can live vicariously while our actual
as historically exceptional—as if no time prior to ours
source of our wellness. Inevitably this returns us to
joy, vitality, and fulfillment in relationship with others.
biological being languishes. Hence the proliferation of
could possibly have been this overwhelming or fraught
encounters with the healing and nutritious plants.
Very little, if any, technology is needed to come into the
virtual media and nanotechnologies into our very cells.
with stressful triggers. Think again. The 20th century
Of course, many of us already feel that we have no
We may feel tempted to regard our current stress
intimacy of God, love, nature, or health in our lives. Yet
Stressful responses and fantasized reactions
option but to sequester ourselves away from healthy
we are pitched headlong as a global society immersed
are the opposite of reverence, the antithesis of con-
global fascism, genocide, and then nuclear annihilation.
relationships, healthy lifestyles, and healthy consump-
in ever more ingenious technological interventions
sciously enacted rituals that reinforce our grounded,
The 19th century bore humanity through the Industrial
tion patterns. We feel our lives are moving too fast to
designed to “facilitate” communication, enjoyment,
natural feeling of belonging within the webs of life. Yet
Revolution, which, despite tremendous technological
brought humanity face to face with the real threat of
51
52
advances in almost all aspects of human commerce
human history is useful when we realize that despite
and science, was built upon the depredations of child
all our excesses—our global population has more
nized and recorded the basic ecological truth that we
Rachel Carson, who is credited widely as the awak-
and slave labor in the most “advanced” societies, let
than tripled in just the last century—the medicinal
humans are, in essence, expressions of plant intelli-
ener of the modern environmental movement through
alone aboriginal ones. The 18th and 17th centuries,
plants are still with us, still capable of offering the
gence. They saw further that plants are, in essence,
her 1962 classic Silent Spring, herself credited Henry
albeit an era of an ascending rationalist and scientific
same supportive benefits that they did thousands of
expressions of the interplay of water and earth (in a
Beston as her only literary influence. Beston stood at
enlightenment, witnessed the ascension of the first
years ago, before all written history even began.
cosmic field of light). The wisdom we seek to help us
the beginning of our technological age and, because
truly global empire—Great Britain—out of the previous
Musing on humanity’s basis in plant wisdom, the
move through and beyond the debilitating stresses
of his descent into shattering horror in places like
hegemonic reigns of France, Spain, and Holland, all
Chandogya Upanishad, one of humanity’s most
of our lives, therefore, is literally under our feet,
Verdun, sought personal renewal and solace with his
of whom had achieved their grandeur by laying waste
ancient sacred texts from the middle of the first mil-
beckoning us back to the garden.
young family in a small herb garden at his farmhouse
to indigenous cultures and native peoples the world
lennium BCE, observes:
over while capitalizing on the addictive power of
Vedic philosophers 2,500 years ago already recog-
Writing in the 1930s after experiencing directly the
by the simple interplay of the gardener and herbs.
in Maine. Luckily for us, his writing summoned well-
mechanized human slaughter of World War I, the
springs of reverence for the herbs full enough to span
opium, sugar, cacao, and coffee among other drugs.
The essence of all beings is Earth.
American naturalist Henry Beston, in his little-known
well into our 21st century and beyond if we can yet
Each time and century in the modern era has provoked
The essence of the Earth is water.
gardening diary Herbs and the Earth (now reprinted by
share in the delight, wonder, and yearning for (re)con-
and distributed its own stressors.
The essence of water is plants.
David R. Godine, Publishers, 2002) saw clearly how
nection to life that he expressed so lucidly as he
The essence of plants is the human being.
human alienation from the natural world is corrected
sought to heal from the psychological trauma of war.
Seeing today’s stress triggers in light of recent
53
Since Beston’s words are so highly relevant today,
the sun‌ the slow murmur and the long crying of
In describing a plant as powerful, ancient, and
the seas are in his veins, the influences of the
ubiquitous as basil, Beston shows us what happens
attack and disaster, if they can but lift one flower
rent societal debate on preventing climate change-
moon, and the sound of rain beginning. Torn from
when we allow ourselves the time and space to meet
from the ruin.
induced impacts on humanity, Beston wrote:
earth and unaware, without the beauty and the
a particular herb as it reveals itself to us: In Herbs and the Earth, Beston offers us rich
terror, the mystery and ecstasy so rightfully his,
54
bear, not surmount of caprice and outrage, of
it is worth quoting him at length. Presaging our cur-
What winds shall blow, fall what lustral rains that
man is a vagrant in space, desperate for the
Pivoted upon its share of soil, potent with its inten-
and poignant declarations of his love for the healing
the ancient sense of the beauty and integrity of
inhuman meaninglessness which has opened
sity of living, symmetrical and predetermined to
plants, and he perhaps uniquely understood the
the earth shall presently reawaken in the indif-
about him, and with his every step becoming
symmetry, a fine plant of Basil is a form, a gath-
contours of the precipitous escarpment along which
ferent blood? Or must some great and furious
something less than man.
ering together of that mysterious vitality of green
technological man stood, even before agricultural
storm (and such storms come) sweep clear the
Peace with the earth is the first peace. Unto
whose veins draw up the earth itself, and whose
chemicals, pharmaceutical drugs, and nuclear war-
whole coast of the soul of man and restore him
so great a mystery‌no one path leads, but many
impulse of life is the other side of that rhythm of
fare. Beston saw into our present age with historical
thus to his humanity? For man is of a quickening
paths. What pleasant paths begin in gardens,
life stirring with us in our blood. What a passion
foreboding, certainly, but also with an almost childlike
spirit and the earth, the strong, incoming tides
leading beside the other great mystery of nature,
for life plants reveal, what a body and desire of life
delight for the wonder and pleasure that healing
and rhythms of nature move in his blood and
the mystery of the growing green thing with its
dwell in the dark of roots and the hunger under
herbs would render to anyone who takes time to slow
being; he is an emanation of that journeying god
mute passion and green will.
the earth! What will they not endure to live and
down and meet them.
55
FPO need 1 color logo
Henry Beston saw, as we do still, that our own
themselves to you. They are always available to meet
humanity continues when we maintain some real
you, as you are, wherever you are, and to awaken you
connection to the herbs—and that we descend at our
to your highest potential under this sun, within this
own peril when we decide to “go it alone” outside the
majestic biosphere that they in fact created for us.
garden, outside what all indigenous peoples recog-
They are waiting patiently to bring you back home.
nize as our proper place among—not above—the 56
plants, the animals, and the rhizomatic tendrils of life force that tie us all together, in our innumerable diversity, as one. As you breathe in each moment, as you proceed over the terrain that is uniquely yours to cover in the time you have, save a part of yourself for the wondrous encounters that are also uniquely yours to experience with the plant-beings who show
Photographs by Stacey Haines Book design by Katie Craig