Microfluidics Controlling and handling of liquids is in the blood of the Dutch. This is true when it comes to either huge infrastructural constructions like the Afsluitdijk or the Maeslant Storm Surge Barrier, or when it comes to the handling of very small quantities of liquid or gas. In either case, the Dutch excel in this domain. The Dutch Association for Microsystems and Nanotechnology MinacNed (www.minacned.nl) and the business cluster MicrofluidicsNL bring together, in this brochure, eleven Dutch specialist organisations in the area of microfluidics. Together they cover the complete microfluidic business chain from components to complete systems.
The companies presented are: ®
Microfluidics R&D • KIT Biomedical Research • MESA + Institute • TNO Science & Industry Microfluidics Equipment • Kryoz Technologies • MA3 Solutions Planar Microfluidic Chips • Micronit Microfluidics • Technogation Flow Chemistry • Flowid • FutureChemistry Flow Measurement and Control • Bronkhorst High-Tech • Brooks Instrument
Holland’s High Tech Entrepreneurship in Microtechnologies Dutch Design in Microtechnology, Competences of High Tech Companies from Holland Microfluidics is a hotspot in microtechnology. The technology is developing fast, and continuously. Microfluidics specifically is enabling three application areas: research laboratory, life sciences and industrial processing. Analytical lab equipment is the most basic application area for microfluidics. The importance of microfluidics for life science is growing. The most important market segment is undoubtedly point of care diagnostics, but also younger applications like encapsulation of drugs and drug delivery through micro nozzles achieve a growing interest. Many new applications are also expected to arise in the chemical industry through microreactors, flow chemistry, process intensification and fabrication of nanoparticles. In the application area of process intensification, a major contribution from microfluidics may be expected in optimizing the yield from raw materials and reducing energy use in production processes. Dramatic wins in terrains of sustainability are ahead. In the field of medical diagnostics, fast reaction times and the use of small sample sizes are both attractive features offered by microfluidics. The small size and low fabrication cost enables the transfer of diagnostics from the clinical labs closer to the patients, thereby minimising response times. In systems biology main breakthroughs are expected, enabled by microfluidics. The injection of biocells can only be adequately executed by microfluidics. Typically, microfluidic products can be divided into products to be used in production, where efficient mixing, material and heat transfer and more precise control of process are of importance, and products for more accurate measurement. The more precise measurement is needed when extremely small amounts of fluid must be detected. Examples in this domain and in this brochure are: Plug & Produce Skid by Flowid, FutureChemistry, Bronkhorst High-Tech and Micronit Microfluidics Microdispensing by MA3 Solutions DLI (Direct Liquid Injection) Vapouriser by Brooks Instrument Kryoz CryoLab© by Kryoz Technologies High-throughput experimentation in microreactor chips by MESA + Institute Unique Room Temperature Bonding Process by Technogation
As you can notice, we in the Netherlands are very fortunate to have a group of innovative companies covering the whole range of technologies required as well as an active user community. This brochure presents the Dutch microfluidic supply chain, from component suppliers to system integrators.
Business cluster MicrofluidicsNL MinacNed - mission and objectives MinacNed is the association of companies and institutes creating economic added value in the Netherlands based on joint activities among members and with relevant stakeholders in the field of microsystem and nanotechnology. The association’s ambition is to provide room for all new subsectors within the field of microsystem and nanotechnology within the association, including its scientific base and its areas of application. In addition to this, MinacNed aspires to a representative circle of affiliated members regarding the scope of the association.
Objective
The branche cluster MicrofluidicsNL has been established the first of October 2010. Fifteen high-tech enterprises initiated to set up the cluster as part of the association MinacNed, with the mission to strengthen the development of the microfluidica market in the Netherlands. The activities of the cluster cover three domains: • Joint (inter)national markets • Stimulating R&D projects in the Netherlands in the field of microfluidica and the participation of members in these projects • Promotion of members’ interests to stakeholders in the market, research institutes and government Concrete activities are: • XS2Hitek workshops to share knowledge and support cooperation, preferably organized by a (potential) user of the technology and specified to one field of application • Regular publication and (inter)national distribution of the brochure “Microfluidics: Holland’s high-tech entrepreneurship in Microtechnologies”, containing business profiles, activities and contact information of cluster members. • Collective participation in large national and international conferences and other events • Preparing collective R&D projects
Mission: “Strenghten Dutch Economic Activity based on Micro- and Nanotechnology”
Business cluster MicrofluidicsNL members are:
Within its vision, MinacNed sets itself the aim of having the Netherlands participate at international level in all fields of enabling microsystem technology and nanotechnology and become and remain an international leader in a number of more precisely defined specialisms, such as microfluidics. MinacNed aims to effect an exponential increase in the applications of microsystem and nanotechnology in the Netherlands.
MinacNed – Target Groups
MinacNed is targeted at all links in the knowledge chain. The multi-disciplinary nature of Micro- and Nanotechnology, together with the high-quality technological solutions that they provide, requires intensive cooperation between all players involved.
Activities
• member meetings to reinforce networks • workshops focussing on market development with specific groups of customers or potential customers of members / users of micro and nano technology. Such workshops could be within the framework of development of joint roadmaps, as was the case in the past for Food & Nutrition. • the annual Netherlands’ MicroNanoConference in which, besides both objectives specified, we also strive for broad reinforcement of the image of the micronano industry, nationally and internationally. During organisation of the Netherlands’ MicroNanoConference, MinacNed collaborates with related organisations wherever possible. • initiating and organising specific clusters within the association which need their own network and identity in the market, within the framework of MinacNed. Specific marketing activities can be set up for and with such clusters. When forming and running such clusters, collaboration with other industry organisations is possible, with the aim of preventing companies that fit in here having to join too many organisations at the same time. • initiating, encouraging and to a certain extent facilitating the formation of consortia between members and groups of members with other stakeholders, focussed on joint R&D and/or marketing.
Beckman Coulter Nederland B.V. www.beckmancoulter.com
ChemtriX www.chemtrix.com
FutureChemistry www.futurechemistry.com
Micronit Microfluidics B.V. www.micronit.com
For more information on this activities, please go to: www.minacned.nl
BIOS Lab-on-a-chip Group, University of Twente http://bios.ewi.utwente.nl
Delft Institute of Microsystems and Nanoelectronics www.dimes.tudelft.nl
KIT Biomedical Research www.kit.nl
Nanomi B.V. www.nanomi.com
Relationship with existing organisations
Kryoz Technologies www.kryoz.com
Philips Research Applied Chemical Technology www.research.philips.com
Bronkhorst High-Tech B.V. www.bronkhorst.com
Distrilab B.V. www.distrilab.nl
Brooks Instrument B.V. www.brooksinstrument.com
Eindhoven University of Technology www.tue.nl
CALIPER LifeSciences N.V. www.caliperls.com
enablingMNT Netherlands www.enablingmnt.com
Capilix www.capilix.com
Flowid www.flowid.nl
LioniX B.V. www.lionixbv.nl MA3 Solutions B.V. www.ma3solutions.com MESA+ Institute for Nanotechnology www.mesaplus.utwente.nl
TNO www.tno.nl Technogation www.technogation.com University of Leiden http://abs.lacdr.gorlaeus.net
In the dissemination of knowledge, MinacNed organises activities in accordance with NanoNextNL research programme. There are other Dutch organisations whose aims are similar to those of MinacNed, such as: “Sensor Technology Club” or “Development Club”, both run by the Dutch Federation of Technology Branches (FHI), the Dutch Association for Precision Technology (NVPT), and ‘Sensorplatform,’ run by the Dutch Foundation for Technical Sciences (STW). MinacNed intends to align itself with these organisations and work in partnership with them. In addition, further partnerships will be sought with other organisations working within other application areas and market sectors, including the field of genomics, biotechnology, food, fine chemistry, etc.
KIT Biomedical Research Mission: The aim of KIT Biomedical Research (KIT BR) is to improve the quality and effectiveness of health provision and services for people in low and medium income countries. We achieve this through interrelated laboratory and applied activities, including research, advice and capacity building. Our focus is on detection, management and control of infection and disease. Objectives • To develop, manufacture and implement, together with local public and private partners, diagnostics and diagnostic methods for sustainable use in resource limited situations. • To generate, evaluate and translate knowledge and evidence for improved detection, diagnosis, management and control of infectious diseases. • To build sustainable local capacity through training and collaboration in long-term partnerships. • To advise on national and international health related policies. KIT BR has been accredited according the ISO 15189 standard for medical laboratories and has fully equipped BSL3, BSL2 and BSL1 laboratories and hosts the WHO/FAO/OIE International Reference Laboratory for Leptospirosis.
KIT BR has a track record and international reputation in the field of essential diagnostics; the department is active in different aspects of the diagnostic pipeline. KIT BR’s diagnostic and research laboratory has specific microbiological, molecular, immunological and epidemiological expertise. KIT BR carries out basic and operational research focused on the diagnosis of TB, and also on MDR-TB. KIT BR is at the forefront of diagnostic development (e.g. LED-based fluorescence microscopy for TB was invented by KIT BR; rapid tests for several neglected infectious diseases developed by KIT BR have become the gold standard for field diagnosis) and provides participatory assistance to improve diagnostic test implementation in the form of workshops/trainings, monitoring and assessment visits. Our interest in Microfluidics is based on the promise that this technology will allow sophisticated but cost-effective diagnostics to be developed suitable for use where they are most needed.
Contact KIT Biomedical Research Meibergdreef 39 1105 AZ Amsterdam The Netherlands Tel.: +31 (0)20 566 54 41 Email: info@kit.nl Internet: www.kit.nl
Micro and nanofluidics at MESA+ Institute for Nanotechnology
Fluidics at the nano to micro scale is a key research area of MESA+, in which the behaviour of single and two-phase fluids in a confined environment and on nanostructured surfaces is studied.
MESA+ is one of the largest nanotechnology research institutes in the world, delivering competitive and successful high quality research. It uses a unique structure, which unites scientific disciplines, and builds fruitful international cooperation to excel in science and education. MESA+ has created a perfect habitat for start-ups in the Micro- and Nanoindustry to establish and to mature.
Physics of fluids at the nano scale The behavior and applications of droplets and bubbles on nanostructured surfaces (electrowetting, superhydrophobicity) and of liquid flow properties in micro and nanochannel (mixing, electrokinetic liquid slip, bubble cavitation for sonochemistry) are studied. High-throughput experimentation in microreactor chips Silicon-glass microreactors with microfluidic networks and integrated analysis optics and electronics are developed to generate more reaction kinetic data in less experimentation time. Performing chemical synthesis at the scale of nanoliters to microliters allows the study of chemistry under extreme conditions like high pressure, high electric field, or supercritical conditions, or with toxic or explosive reactants. Analytical microdevices for Life Science Liquid chromatography at high speed with ultimate resolution, in micro and nanostructured devices, with integrated injection and detection functionality, as well as the coupling to spectrometric methods like MS and NMR, are developed and applied to chemical, medical and biological problems.
Contact MESA+ Institute for Nanotechnology Han Gardeniers University of Twente Mesocale Chemical Systems group P.O. Box 217 7500 AE Enschede The Netherlands Tel.: +31 (0)53 489 43 56 Email: j.g.e.gardeniers@utwente.nl Internet: www.mesaplus.utwente.nl
Microfluidic technology Microfluidic technology is an important ingredient for many new technological developments. The combination of microfluidics with engineering, physics, chemistry, micro-technology, manufacturing technology and biotechnology enables the creation of innovative miniaturized analytical systems and new production concepts. TNO has more than 10 years of experience in this field and is still growing stronger. Main application areas • Instruments for physical, chemical and biological analysis TNO develops analytical equipment for process, pharmaceutical, and semiconductor industries to improve and simplify process control. By using innovative microfluidic sensor-principles, instruments are designed for in-line determination of relevant parameters. Examples of our activities in this area include the development of microfluidic flow-meters and micro gas chromatography systems. • Lab-on-a-chip for biological detection The trend in biological detection is in parallellization, miniaturization and integration of laboratory processes and development of on-site detection systems. We develop instruments for environmental, forensic, and medical industries to measure relevant biological parameters (e.g. in DNA, RNA, proteins). One of our main activities in this area is in lab-on-a-chip technology for the integration of sample preparation and biological detection for on-site applications. • Process intensification Process intensification aims at making industrial processes faster, more efficient, and environmentfriendly. We play an important role in the development and implementation of process intensification technologies in the fine-chemical and pharmaceutical industry. This involves upscaling of existing technologies and development of new technologies. Examples of our efforts include the development and scale-up of the helix mini-reactor and the development of parallel microreactor systems.
The role of TNO TNO is an independent contract research & development organization. We work on projects ranging from basic research to the development of functional models and/or prototypes. We support a large variety of customers in their research and development, ranging from small to large international companies. We offer various possibilities: - Contract R&D: TNO applies its multitude of different technology competences in different phases: research, proof-of-principle, proof-of-concept, demo/pilot or combinations. - Cooperative R&D: For this, the company and TNO will set the goal of the project together. This goal will have to fit with the long-term strategic vision of TNO. - Feasibility studies: We assess the possibilities and risks of a certain technology development. - Licensing: We offer the possibility to get a license on one of our inventions. Parallellized micro-reactor
• Printing equipment Printing is a versatile technique to produce sprays and deposit thin layers of materials. TNO explores the different high-end application areas of printing. Our main activities are in printing highly viscous materials (e.g. bio-compatible materials or highly viscous polymers), in pyrolytic metal printing, and in micro stereolithography for 3D structures for custom manufacturing. When your product or process involves small amounts of fluids or when small scale effects play an important role, please do not hesitate to contact us. We can help to find out where microfluidic technology might have a benefit, both technically and economically. When it does, we are a trustworthy partner in developing the technology for the specific application.
Contact TNO Marc van Kleef Project Manager Industrial Innovation P.O. Box 6235 5600 HE Eindhoven The Netherlands Tel.: +31 (0)888 662 415 Mob.: +31 (0)6 31 75 70 58 Email: marc.vankleef@tno.nl
Kryoz Technologies
Micro cryogenic cooling systems Kryoz Technologies is a specialised technological business in the field of cryogenics. We design, optimise and manufacture small, fully integrated cryocooler systems for specific applications. These stand-alone systems can be used to cryocool advanced electronics, such as low noise amplifiers, sensors (e.g. IR / X-ray), and superconducting circuits for various markets including:
CryoLab© By combining the micro cold tip with a base-station, which controls: cold tip temperature, gas supply, pressure safety and vacuum, we offer a plug-and-play cryocooling platform for R&D and laboratory environment. Kryoz CryoLab© system key advantages • Compact and easy to use • Fast cool-down • No cryogenic know-how required • Controllable cool-down curves • Easy exchangeable cooler units • No vibrations - no interference • Cryogen free
CryoLab©
• R&D and laboratory cryocooling • Telecom • Measurement and sensing devices • Space industry • Radio astronomy • Medical applications • Superconducting circuits
CryoCube© Using a downscaled sorption compressor and long-life vacuum chamber, we can offer an extremely small, fully integrated, stand-alone cryocooling system. A micro cryogenic refrigerator meant for in-field applications. Final system size depends on the required cooling power and temperature.
“High value at low temperatures”
Kryoz CryoCube© system key advantages • Compact and easy to use • Fully integrated and stand-alone • No cryogenic know-how required • No vibrations - no interference • Low input power - low weight • Long lifetime • Cryogen free • High volume - low cost • One compressor multiple cold tips possible
Plug-and-play micro cooling solutions Our microcooling systems contain a micro cold tip, which is fully optimised for the specific application at hand. The device to be cooled, which is supplied by our customer (e.g. an ALA, SQUID or IR-sensor), is thermally connected to the microcooler’s cold tip. Interfacing between cold tip and the device to be cooled is easy and efficient. The micro refrigerators can reach temperatures as low as 80 K (-193 Celsius). With a multi-stage microcooler it is possible to reach temperatures as low as 30 K (-243 Celsius). Cooling powers vary from a few mW to about 250 mW.
CryoCube©
Contact Kryoz Technologies BV Colosseum 15d 7521 PV Enschede The Netherlands Tel.: +31 (0)53 203 09 95 Email: info@kryoz.com Internet: www.kryoz.com
MA3 Solutions member of the TEGEMA Group
In just a couple of years since it was founded in 2003, MA3 Solutions has carved a well-defined market position for itself. Still small, with about ten employees, the company operates within a network of knowledge and skills and has established both a well-defined customer service concept and cutting edge technology. With the majority shareholding of TEGEMA Group late 2008, MA3 Solutions has found a strong strategic partner and TEGEMA can expand its activities in the area of High Tech Systems and special machines. MA3 will continue to operate independently as a process developer and system supplier, mainly at the front end of the market. The cooperation will in particular result in shared activities in, on the one side, process development and on the other side engineering and realization. The company is driven by customer demand. MA3 Solutions responds to manufacturers of micro-system products for new types of assembly processes. MA3’s own in-house R&D specialists do the development work required to achieve the target. This might involve devising new processes, machines or products. All work is carried out in close co-operation with the customer. MA3 specializes in the multi-disciplinary approach to micro assembly and micro dispensing issues. When possible, use is made of ‘proven technologies’, which results in State of the Art production equipment, including among others the production of biosensors, micro arrays, print heads and miniature lenses for mobile telephones. In this respect, the company carries out its own product development. Key products MA3 offers tailored assembly and dispensing solutions for micro systems at a range of levels, from the ‘ramp-up’ of production for one customer to an automated turnkey assembly system for another. By replacing traditional production
Market Since micro-systems are used in a variety of industries, the company operates on many, diverse markets. Life Science / Medical and ICT / Telecom are just two fields that spring to mind. In the Life Science market, MA3’s work to date has concerned actuators. Well-placed in the Southeast Netherlands, the company has been able to find international business abroad and close to home; 80% of its turnover is earned in Europe. America and Japan account for the remainder. This is a relatively new market in which MA3 has surged ahead of its competition. While no industry standards exist, MA3 is already working with de-facto standardized processes that enables it to provide tailored solutions. It is also a member of more than one body seeking industry standards.
methods with an MA3 solution, a customer can shorten the production cycle by up to half. The solution comprises a number of key stages. A Quick Scan is always the first step. This determines whether the requirements fall within MA3’s field of work and whether room for improvement can be identified. Next comes a feasibility study that focuses on the risks involved. If those are found to be acceptable a pilot series follows. This could range from 2,000 to 3,000 units and gives the customer a clear idea of the developed assembly method. During this phase rapid prototyping and standard process devices are used and once the ‘go’ decision is taken, an assembly cell will be created for volume production that could output as much as ten million units a year.
Contact MA3 Solutions BV Martin van Acht Sales Director Science Park 5080 5692 EA Son (Eindhoven) The Netherlands Tel.: +31 (0)40 296 93 30 Email: info@ma3solutions.com Internet: www.ma3solutions.com
Micronit Microfluidics Your partner for microfluidic components In many cases Micronit Microfluidics creative ideas and world-class capabilities have led to groundbreaking product innovations for our customers in analytical and diagnostic instrumentation. With this spirit Micronit Microfluidics has grown to become a leading supplier of microfluidic and lab-on-a-chip devices in life-science and chemistry. With its own cleanrooms, production and quality department Micronit Microfluidics is able to provide its customers with consistent quality from the first prototype to full scale manufacturing. Micronit Microfluidics offers a unique combination of micro structuring capabilities, glass technology, microfluidics and customer application know-how. Micronit Microfluidics has the vision to operate as a market leader in the development and manufacturing of integrated microfluidic components, by investing in quality, innovation and capacity. Microfluidics Microfluidics opens up new possibilities previous impossible on the macro-scale. Two decades of research have yielded a gold-mine of microfluidic principles, techniques and applications, including: • Continues Flow Systems • (Digital) Droplet Microfluidics • DNA Chips • Single Cell Research • Chip Electrophoresis Besides these unique features there are several trends which stimulated the ongoing adoption of microfluidic technology in modern day analytical instrumentation: • Miniaturization of Lab-equipment towards Desktop or Handheld • Integration and Simplification of Sample Handling and Analysis • Automation to Increase Data Output and Decrease Hands-on Time • Decrease costs per Analysis and/or Increase Data Quality
Markets Microfluidics is an innovative growth driver in markets such as biotechnology, medical industry, chemistry and MEMS (microelectro-mechanical systems). Customers range in size from ambitious start-up companies to some of the world’s largest analytical and diagnostic instrumentation manufacturers. Main markets include: • Molecular Diagnostics • Point-of-Care • Cell and Microbial Research • Microreactor Technology • Analytical Instrumentation
Volume manufacturing Whether you are looking for low-volume manufacturing of a precision product or high-volume manufacturing of a disposable microfluidic devices, Micronit Microfluidics is there to deliver. Micronit Microfluidics is ISO 9001:2008 certified, working towards ISO 13485 and uses statistic process control to ensure constant quality. Foundry Capabilities: • 4”, 5”, and 6” substrate processing • glass-etching (HF and DRIE) • structured MEMS wafers • bonding (glass-to-glass, glass-to-silicon) • thin glass handling • metalization (Pt, Au, Cu, etc)
• plasma deposition • surface modifications • metrology • dicing • packaging and labelling
Product development Thanks to our micromaching and microfluidics know-how we can support instrument manufacturers with their product development. By working in close cooperation with our customers time to market can be drastically reduced and the product will be designed for manufacturing. Our experience enables us to optimize the chip not only in functionality, but also in manufacturing cost. Research products The lab-on-a-chip platform Fluidic Connect offers a user-friendly way of creating your own lab-on-a-chip setup. They can easily be used with standard laboratory equipment such as syringe pumps and microscopes. The platform includes a user-friendly chip holder, connection material, a number of standard chips and the possibility to have your own designs manufactured by the Fluidic Pro prototyping service.
Contact Micronit Microfluidics Ronny van ‘t Oever Managing Director Colosseum 15 7521 PV Enschede The Netherlands Tel: +31 (0)53 850 68 50 Email: info@micronit.com Internet: www.micronit.com
FOTURAN®
Photo-Sensitive-Glass-Ceramics
Advanced microfluidics and 3D MEMS in glass Technogation is European distributor and manufacturing contractor for the Invenios group of companies, which includes Invenios (USA) and mikroglas - chemtech GmbH (Germany). Invenios is a world leader in the manufacture of gene-sequencing bio chips, microfluidic devices, microfluidic mixing and -separation systems, nano-scale motion control platforms and high volume precision micromanufacturing. With a vertically integrated manufacturing facility in the US and a fast turn prototyping/ small volume production facility in Europe, the Invenios group is able to maintain total process control of substrates from their raw form to a finished product, and can manage multiple highvolume production lines for glass based microfluidics products. Invenios’ in-house design, production and quality engineering staff enable companies to expand and expedite their prototyping and production requirements. Photo-structural deep etch capability provides straight wall (3° from the vertical) structures only possible with a higher cost DRIE or Bosch processing. Adhesive-free bonded 64 nozzle, 100 x 100µm Invenios patented print head with fully imbedded and centred nozzles
Bio chip in FOTURAN: • 2.7 mm wide channels, 0.100 mm deep, with 130µm channel wall • 350µm inlet/outlet holes in 1 mm thick glass
Unique Room Temperature Bonding Process Invenios has developed a unique room temperature bonding process (without using polymer based adhesives), which provides permanent glass-to-glass bonding solutions (other materials are possible as well, patents pending). This unique bonding process allows our customers to functionalize the substrate prior to bonding and then attach the cover slip without damaging critical micro-structures or biological treatments. This unique advantage significantly expands packaging and microfluidic design capabilities over the current high temperature bonding process, such as diffusion bonding or anodic bonding.
“What can we do for you?”
By applying UV light at certain frequencies at areas of interest on the optically clear glass surface, the native amorphous glass phase of FOTURAN is converted to a crystalline lithium silicate phase. When this phase is then ovendeveloped, the resulting substrate will etch up to 30 times faster than the surrounding substrate. This accelerated etch capability allows significantly steeper wall and port angles than other conventional wet etch methodologies. By varying the development oven profile, FOTURAN can also be ‘ceramized’ to produce various phase changes in the glass for light absorption, mechanical- or electronic purposes.
The Invenios group develops, designs and manufactures a complete range of glass products for microfluidics, microfluidic systems and sensors, from concept to production: • microreactors for separating and mixing • sensors, sensor encapsulation • DNA research • gene fracturing chips and -systems • lab-on-a-chip systems • channel- and nozzle systems, such as: inkjet print-heads (chemically inert) titerplates • 3D micro-structures (MEMS) • customer specific glass components FOTURAN PSGC FOTURAN® Photo-Sensitive-Glass-Ceramic (PSGC) is a very important tool in the toolbox for the production of a wide variety of micro-biological, -mechanical and -electrical systems. High aspect ratio microstructures can be produced relatively quickly without masks, photo-resist, DRIE or substantial up front costs. For the purpose of production, FOTURAN can be processed in high volume using masks, however, without the use of photo resist making it a very “Green Material”.
Contact Technogation Richard Bijlard Managing Director Fangorn 63 5661 AJ Geldrop The Netherlands Tel.: +31 (0)6 47 59 47 41 Email: info@technogation.com Internet: www.technogation.com
Flowid ®
Go Beyond the Standard Flowid solves mass and heat transfer limitations in the chemical industry, with process engineering solutions that go far beyond the standard. Stop wasting valuable resources by redesigning your process with Flowid’s experts.
From lab to production scale!
Over the years Flowid has implemented dedicated solutions in the fine-chemical industry and pharma. Making unique products by processes that excel in terms of safety, yield and selectivity. Successively simplifying the downstream processing as well. At Flowid we cooperate. With you as a client and your experts. With leading research groups in the field of micro flow chemistry and process technology. With the best manufactures of specialized components. And with advanced mechanical engineering firms. Securing a precise and smooth on site implementation and maintenance. Although Flowid has been awarded several times for it’s innovative and groundbreaking work. We push ourselves to go beyond our own standards. New patented reactor technology enables us to reach production capacities that will make a difference.
Plug & Produce Skid: Easy to operate, customize and transport
You are welcome at Flowid’s brand new facilities to experience how we work, learn about our technologies and what it looks like. Take back control over your whole process and go beyond your standards.
CashFlowid: Maximise value using continuous processing
Contact Flowid B.V. Wouter Stam Director Business Development De Lismortel 31 5612 AR Eindhoven Tel: +31 (0)6 24 67 97 74 Email: wouter.stam@flowid.nl Internet: www.flowid.nl
FutureChemistry “Smart, safe and clean chemistry” FutureChemistry is a worldwide technology leader in flow chemistry. With proven methodology for screening chemical reactions and synthetic routes the company develops, optimises and implements efficient flow chemistry processes. FlowStart Evo Give your flow chemistry a head start!
Flow chemistry instruments FutureChemistry develops and provides equipment and instruments required for successfully validating and operating flow chemical processes. FutureChemistry offers, combined with its instruments, a flow chemistry practical course for the implementation of flow chemistry at universities, research institutes and corporate R&D. This practical course, developed by world leading universities in collaboration with FutureChemistry, helps to understand the benefits of flow chemistry. Custom manufacturing services FutureChemistry offers flow chemistry custom manufacturing services to those companies that choose not to invest in setting up their own flow chemistry facility.
Flow process development FutureChemistry uses its expertise, know-how and experience for converting commercial chemical processes to flow chemistry, as well as for creating new flow chemistry processes starting from any R&D route to a chemical product. FutureChemistry’s research facilities include flow chemistry instruments and analysis equipment. In addition to standard analytical tools, the company has easy access to several leading research facilities in the Netherlands, enabling it to use specific equipment relevant to flow chemistry research. The company has successfully conducted its contract research services for several international blue chip customers, having created demonstrable benefits of flow chemistry processes for a range of fine and specialty chemical products.
Contact FutureChemistry Kaspar Koch Managing Director Visiting address: Toernooiveld 1 (Mercator 3) 6525 ED Nijmegen The Netherlands Tel.: +31 (0)24 711 40 29 Email: k.koch@futurechemistry.com
Microfluidic mass flow and pressure controllers Equipment manufacturers require compact solutions to monitor or control gas flow and pressure in their systems. Due to micro solid state technology (MEMS), the footprint dimensions compared to conventional mass flow and pressure controllers can be halved. Bronkhorst High-Tech B.V. has over 25 years of experience in designing and manufacturing precise and reliable measurement and control devices for mass flow and pressure. With a wide range of instruments, the company offers innovative solutions for many different applications in many different markets. These instruments can be made to a customers’ specification, in whichever style is suitable, for laboratory, industrial or even hazardous environments within such markets as semiconductor industry and analytical instrumentation. Customer specific designs A core philosophy within Bronkhorst is to form close working links and collaborations with its customers and more specifically with Original Equipment Manufacturers thereby ensuring optimised integration of our instruments. Most often, this results in bespoke designs for which various functions are combined into one microfluidic system. The IQ+FLOW range has so far offered, but is not limited to, the following functional modules: flow meter, pressure meter, control valve, shut-off valve, threeway valve and mixing chamber. A combination of these modules can be mounted on a compact manifold, in line with a customers requirement, and following open design discussions. The ”plug and play” assembly ensures space efficiency, cost reduction and minimization of potential leak points. Examples of a typical applications would include flow/pressure control in sample injection for Gas Chromatography systems and Nebulizer gas flow control in Mass Spectrometers.
Flow sensor principle of operation The actual flow sensor chip consists of a thin square membrane with two heaters and two temperature sensors (T-sensors) on its surface. The membrane is suspended by a frame around it and can withstand 200 psi (15 bar). The two heaters are raised in temperature to a T over the medium temperature by providing them with constant power. From each T-sensor, the hot side is located on the membrane, and the cold side is on the frame around the membrane. The temperature difference between the hot sides of the upstream and downstream T-sensors is proportional to, and a measure of, the flow. The combination of the patented, thermally balanced chipsensor with the digital electronics ensures high accuracy (0,8%RD + 0,2%FS), fast response (< 0.5 sec) and a very stable zero.
Conventional mass flow and pressure meters and controllers have a footprint of 1.5”, for example as specified within the NeSSI™ system. Now, and in close co-operation with LioniX and the Netherlands Organisation for Applied Scientific Research TNO, Bronkhorst High-Tech has developed the IQ+FLOW mass flow sensor. Due to micro solid state technology (MEMS), Bronkhorst has been able to halve the footprint dimension to 0.75”, thereby realising ultra compact flow controllers for flow rates from 1 to 2000 mln/min and pressure controllers for 0.3 to 100 psi. Thanks to these compact solutions the overall dimensions of the instrumentation can be downsized by 50%.
“World’s smallest mass flow and pressure controllers”
Contact Bronkhorst High-Tech B.V., Nijverheidsstraat 1A 7261 AK Ruurlo The Netherlands Tel.: +31 (0)573 458 800 Email: info@bronkhorst.com Internet: www.bronkhorst.com
Brooks Instrument
A world-leading provider of advanced flow, pressure, vacuum and level solutions Brooks Instrument is a company of highly trained specialists whose goal is to provide flow, pressure, vacuum and level solutions that exceed customer expectations. The company has a proven history of innovation including the first pressure transient insensitive (PTI) mass flow controller, the first watertight and explosion proof thermal mass flow controller (Mf Series), the first thermal mass flow controller with Foundation Fieldbus (SLA Series), the first variable area flow meter with Foundation Fieldbus (MT3809 & MT3750), and the first miniaturaized Coriolis mass flow controller (Quantim). Product portfolio Brooks Instrumentâ&#x20AC;&#x2122;s portfolio includes glass and metal tube variable area flow meters (rotameters), thermal mass flow controllers and meters, Coriolis mass flow controllers and meters, pressure control products, vacuum capacitance manometers, magnetic level instruments, and a variety of flow accessories.
Global Market Leader Brooks Instrument is a global market leader and has a large installed base in research centres, laboratories and process industries and additionally focuses in emerging markets.
Brooks Liquid Vaporizer Systems
Brooks Instrument has manufacturing locations, sales, and service offices in the Americas, Europe and Asia.
Brooks Pressure Family
European Headquarter & Support Center Our European headquarter is based in Ede - the Netherlands. We work closely with our customers to develop and deliver innovative solutions to their flow measurement needs. Our multi-lingual staff is involved in Sales, R&D, Customer Support, After Sales and Service, including start up and helpdesk functions.
Brooks TMF Family
Another important activity of Brooks Instrument relates to the verification and calibration of all flow measurement and control equipment. Our calibration tools are certified and traceable to National Standards. Brooks Instrument has a specially classified clean room for assembling and calibrating their products and is certified to ISO 9001:2000. For more information on flow solutions, products, or sales contacts please visit www.BrooksInstrument.com.
The company also owns Key Instruments which offers precision machined acrylic flow meters, molded plastic flow meters, glass tube flow meters, electronic flow meters, and flow control valves.
Brooks VA Family
Brooks Vacuum Family
Contact Brooks Instrument B.V. Neonstraat 3 671 WX Ede The Netherlands Tel: +31 (0)318 549 300 Fax: +31 (0)318 549 309 Email: brookseu@brooksinstrument.com Internet: www.brooksinstrument.com
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MinacNed Secretariat Dodeweg 6b P.O. Box 366 NL 3830 AK LEUSDEN Tel.: +31 (0)33 465 75 07 Fax: +31 (0)33 461 66 38 Email: info@minacned.nl Internet: www.minacned.nl