2021 TDDW
Section：LGI 100%), history of HCC (26/26, 100% vs. 10/10, 100%) and end-stage renal disease (22/22, 100% vs. 77/77, 100%). There was significant difference in eGFR change at the end of treatment from baseline (-2.54 ± 17.8 versus 0.54 ± 12.9 mL/ min/1.73m2, p=0.008) and at post-treatment 12 weeks from baseline (-3.31 ± 16.9 versus 0.25 ± 13.6 mL/min/1.73m2, p=0.001) between Epclusa and Maviret groups in patients with eGFR ≥30 mL/ min/1.73m2 at baseline. In patients with incomplete treatment in the groups of Epclusa (n=14) and Maviret (n=13), 11 patients discontinued treatment due to side effect of drugs (Epclusa versus Maviret: 1 versus 5) or complications of other etiologies (Epclusa versus. Maviret: 2 versus 3). Conclusions: Eight-week Maviret and 12-week Epclusa had a similar SVR12 rate in different HCV genotypes and special populations. However, Epclusa group seemed to have a worse eGFR change than Maviret group.
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TREND CHANGES OF METABOLIC RISK FACTORS OF COLORECTAL NEOPLASMS – FROM ADENOMA TO ADENOCARCINOMA Yu-Min Lin1,2,3, Tsan-Hsuan Chang1, Lee-Won Chong1,2,3, Hung-Chuen Chang1,2,3, Yu-Hwa Liu1,2, Cheuk-Kay Sun1,2,3, Kou-Ching Yang1,2 Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan1 Division of Gastroenterology and Hepatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan2 School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan3
結直腸腫瘤的代謝危險因子之變化趨 勢分析 ─ 從腺瘤到腺癌 林裕民1,2,3 張燦璿1 張麗文1,2,3 張鴻俊1,2,3 劉玉華1,2 孫灼基1,2,3 楊國卿1,2 新光吳火獅紀念醫院內科1 新光吳火獅紀念醫院胃腸肝膽科2 天主教輔仁大學醫學系3 Background: Colorectal cancer (CRC) is the third leading cause of cancer death in Taiwan. Recent reports suggest that metabolic derangements are important risk factors of colorectal neoplasm (CRN), however, the alterations of metabolic factors in the malignant transformation remain not clear. Aims: We evaluate the trend of changes of key metabolic factors in the colorectal adenomacarcinoma sequence. Methods: We enroll participants for health examination with complete colonoscopy between Jan. 2014 and Feb. 2020 in our hospital. Individuals of colorectal adenomatous neoplasms with diameter larger than 0.5cm were enrolled for analysis. We design an age and gender matched case-control study (case to control ratio: 1:2). The differences in the proportions of common chronic disorders including hepatitis B, hepatitis C, obesity, hypertension, dyslipidemia, glucose intolerance and positivity of fecal Hb (FIT) are compared between individuals with and without CRN. The associations between the histological trends of CRN and chronic disorders are determined by the
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