Understanding The Dynamics Of Biological Systems DOWNLOAD HERE
1;Understanding the Dynamics of Biological Systems;3 1.1;Preface ;5 1.2;Contents ;11 1.3;Contributors ;13 1.4;Chapter 1 Effects of Protein Quality Control Machinery on Protein Homeostasis ;15 1.4.1;1.1 Protein Folding is Catalyzed by a Complex Network of Reactions;15 1.4.1.1;1.1.1 Disruptions to the Protein Folding Network are Associated with Disease;16 1.4.1.2;1.1.2 The ER Functions as a Protein Folding Factory;17 1.4.1.3;1.1.3 Mathematical Models of Protein Quality Control Provide Novel Insights into the Regulation of Protein Assembly;18 1.4.2;1.2 Case Studies;18 1.4.2.1;1.2.1 Case Study I: Protein Folding Without Quality Control;18 1.4.2.1.1;1.2.1.1 Assumptions;18 1.4.2.1.2;1.2.1.2 Analytical Solution;19 1.4.2.1.3;1.2.1.3 Timescale Analysis;20 1.4.2.1.4;1.2.1.4 Conclusions for Case Study I;21 1.4.2.2;1.2.2 Case Study II: Protein Folding with Quality Control;21 1.4.2.2.1;1.2.2.1 Assumptions;22 1.4.2.2.2;1.2.2.2 Qualitative Dynamical Behavior and Equilibrium Points;23 1.4.2.2.3;1.2.2.3 Timescale Analysis;24 1.4.2.2.4;1.2.2.4 Parametric Sensitivity Analysis;26 1.4.2.2.5;1.2.2.5 Conclusions for Case Study II;28 1.4.3;1.3 Lessons Learned;29 1.4.4;Appendix;30 1.4.5;References;31 1.5;Chapter 2 Metabolic Network Dynamics: Properties and Principles ;32 1.5.1;2.1 Introduction;32 1.5.2;2.2 Dynamic Mass Balances and Fundamental Subspaces;33 1.5.2.1;2.2.1 Key Considerations in Networks;35 1.5.2.2;2.2.2 Properties of Dynamic Systems;36 1.5.2.2.1;2.2.2.1 Underlying Structure of the Jacobian;37 1.5.2.2.2;2.2.2.2 Structural Similarity;37 1.5.2.2.3;2.2.2.3 Flux-Concentration Duality;37 1.5.2.2.4;2.2.2.4 Hierarchical Dynamics;38 1.5.3;2.3 Dual Jacobian Matrices;38 1.5.4;2.4 Stoichiometry Versus Gradients;39 1.5.5;2.5 Example: Folate Metabolism;40 1.5.5.1;2.5.1 Constituent Matrices and Subspaces;40 1.5.5.2;2.5.2 Hierarchical Pooling of Metabolites;42 1.5.5.3;2.5.3 Environmental Perturbations;44 1.5.6;2.6 Conclusions;46 1.5.6.1;2.6.1 Future Directions: Constructing Genome-Scale Models;47 1.5.7;References;49 1.6;Chapter 3 A Deterministic, Mathematical Modelfor Hormonal Control of the Menstrual Cycle ;51 1.6.1;3.1 Introduction and Biological Background;51 1.6.2;3.2 The Pituitary and Ovarian Models;54 1.6.3;3.3 Fitting Parameters;59 1.6.4;3.4 Parameter Sensitivity and Bifurcations;64 1.6.5;3.5 Exogenous Hormone Effects;66 1.6.6;3.6 Conclusion;68 1.6.7;References;69 1.7;Chapter 4 Modeling Transport Processes and Their Implications for Chemical Disposition and Action
;71 1.7.1;4.1 Introduction;71 1.7.1.1;4.1.1 The Fate of Chemicals in the Body;71 1.7.1.1.1;4.1.1.1 Absorption;71 1.7.1.1.2;4.1.1.2 Distribution;73 1.7.1.1.3;4.1.1.3 Metabolism;73 1.7.1.1.4;4.1.1.4 Excretion;74 1.7.1.2;4.1.2 Chemical and Pathophysiological-Mediated Alterations in Drug Disposition;74 1.7.1.3;4.1.3 Extrapolation of Data Between Biological Scenarios;75 1.7.2;4.2 Traditional Pharmacokinetic Approaches to Modeling Drug Disposition;76 1.7.3;4.3 More Complex Models of Drug Movement Across Biological Membranes;77 1.7.3.1;4.3.1 The Measurement of Chemical Movement Across Biological Membranes;77 1.7.3.2;4.3.2 General Considerations for Measuring Movement of Drugs Across Biological Membranes;78 1.7.3.2.1;4.3.2.1 Simple Versus Complex Measurement Systems;79 1.7.3.2.2;4.3.2.2 Ionization Status of the Drug;79 1.7.3.2.3;4.3.2.3 Heterogeneity in Drug Dispersion;80 1.7.3.2.4;4.3.2.4 Chemical Sequestration;80 1.7.3.2.5;4.3.2.5 Physico-Chemical Characteristics of the Chemical;81 1.7.3.2.6;4.3.2.6 ATP Usage Within the Test System;82 1.7.3.3;4.3.3 Measurement of Passive Diffusion;82 1.7.3.4;4.3.4 Measurement of Active Transport;84 1.7.4;4.4 The Integration of Drug Disposition and Drug Fate into a Predictive Model of the Life Cycle of a Drug in the Body;86 1.7.4.1;4.4.1 Multiple Drug Resistance Phenotype in Cancer Treatment;87 1.7.5;4.5 Summary;91 1.7.6;References;92 1.8;Chapter 5 Systems Biology of Tuberculosis EAN/ISBN : 9781441979643 Publisher(s): Springer, Berlin, Springer Science & Business Media Format: ePub/PDF Author(s): Dubitzky, Werner - Southgate, Jenny - Fu, Henrik
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