GW Heart & Vascular Institute 2016-2017 Report by GW Heart & Vascular Institute

GW HEART & VASCULAR I NSTITUTE

2 0 1 6 R E PO R T 2 0 1 7

OUR MISSION The mission of the GW Heart & Vascular Institute is to promote cardiac and vascular research, education, and community service with the goal of accelerating the pace of scientific discovery, reducing mortality and improving the quality of life of Americans with heart and vascular disease. To achieve these goals, the GW Heart & Vascular Institute seeks to provide an interdisciplinary structure to integrate basic and clinical investigators, clinicians, medical educators, health policy experts and community leaders. The Instituteâ&#x20AC;&#x2122;s goal is to be the leading center for heart and vascular research, education and community service â&#x20AC;&#x201D; and to do so by leveraging the enormous resources of The George Washington University.

DEAR FRIENDS OF THE GW HEART & VASCULAR INSTITUTE,

I am proud to present the many accomplishments of the GW Heart & Vascular

Letter from our Director

Institute during the 2016 – 2017 academic years. We continue to expand our mission of community service, education, and research. Locally, our fellows and faculty volunteered at Food & Friends, and internationally, Drs. Tracy and Mercader led our seventh annual medical mission to Honduras. Our educational programs include supporting advanced interventional and electrophysiology fellowship trainees and a wide range of visiting professors. In addition, we celebrated the annual P. Jacob Varghese Visiting Professorship and Alumni Reception, as well as funded cardiology fellows to attend national cardiology educational meetings. Faculty research productivity was the greatest in the Institute’s history with more than 12 0 published manuscripts, abstract presentations, and keynote scientific presentations. Furthermore, several of our faculty have been selected to serve on a wide range of national committees and medical journals providing leadership for the advances of cardiovascular disease. In addition to our physicians’ high-quality clinical care, programs of the GW Heart & Vascular Institute represent our dedicated faculty’s commitment to academic excellence. I hope this report gives you in-depth appreciation for the professional cardiovascular activities of the GW faculty. Thank you for trusting our work and supporting our mission. Sincerely,

Richard J. Katz, MD Walter A. Bloedorn Professor of Cardiology Director, Division of Cardiology Director, GW Heart & Vascular Institute 1

FACULTY &

LEADERSHIP CARDIOLOGY RICHARD J. KATZ, MD

WILLIAM BORDEN, MD

JANNET LEWIS, MD

JONATHAN REINER, MD

Director and Board Chairman, GW Heart & Vascular Institute

Associate Professor of Medicine

Professor of Medicine

Director of Healthcare Delivery Transformation

Director of Non-Invasive Cardiology

Director, Cardiac Catheterization Laboratories

Director, Division of Cardiology Walter A. Bloedorn Professor of Medicine

Director, Womenâ&#x20AC;&#x2122;s Heart Center Assistant Professor of Medicine and Radiology

LISA W. MARTIN, MD

Professor of Medicine

Associate Professor of Medicine

Director, Cardiology Fellowship

JESSICA JOHNSON

Co-Director, Cardiac CT and MR I

Director, Lipid Research Clinic

Director, CCU

Executive Director, GW Heart & Vascular Institute

BRIAN G. CHOI, MD, MBA

RAMESH MAZHARI, MD

CYNTHIA TRACY, MD

Associate Professor of Medicine and Radiology

Associate Professor of Medicine

Professor of Medicine

Director, Interventional Cardiology

Associate Director of Cardiology

MARCO MERCADER, MD

ALAN WASSERMAN, MD

Associate Professor of Medicine

Chairman of the Department of Medicine

Co-Director, Advanced Cardiac Imaging Chief Medical Information Officer, GW MFA STEVEN FARMER, MD, PhD

Associate Professor of Medicine and Public Health Associate Director, Office of Clinical Practice Innovation RICHARD J. KATZ, MD

Director and Board Chairman, GW Heart & Vascular Institute Director, Division of Cardiology Walter A. Bloedorn Professor of Medicine

ALLEN SOLOMON, MD

ANDREW D. CHOI, MD

Director, Electrophysiology Research

Director of Electrophysiology

Eugene Meyer Professor of Medicine

CHRISTIAN NAGY, MD

Assistant Professor of Medicine

WILLIAM WEGLICKI, MD

Director, Structural Heart Disease Program

Professor of Medicine

GURUSHER PANJRATH, MD

Assistant Professor of Medicine Director of Heart Failure and Mechanical Circulatory Support Program

Professor of Biochemistry & Molecular Medicine

VASCULAR SURGERY

BOARD OF DIRECTORS

ANTON SIDAWY, MD, MPH

RICHARD J. KATZ, MD

TIMOTHY MCCAFFREY, PhD

Lewis B. Saltz Chair of Surgery

Chairman

ALAN B. MILLER

JEFFREY AKMAN, MD

Chief Executive Officer and Chairman of the Board

Walter A. Bloedorn Professor of Administrative Medicine

Universal Health Services, Inc. (UHS)

Dean, GW School of Medicine and Health Sciences and Vice President for Health Affairs

ROBERT MILLER, PhD

Professor of Surgery

BASIC SCIENCES TIMOTHY MCCAFFREY, PhD

Professor of Medicine Director of Division of Genomic Medicine

ANASTASIA D. KELLY

BOARD EMERITUS

GW School of Medicine and Health Sciences

Chair, Global Governance and Compliance

JONATHAN S. REINER, MD

STEVE LONDON

Vice Chairman

(deceased 11/1/17) HARRIS N. MILLER

ANTON SIDAWY, MD, MPH CYNTHIA M. TRACY, MD

Savills Studley, Inc.

ROBERT UNDERSTEIN

JOHN MULLENHOLZ

President, GTIâ&#x20AC;&#x201C; Government Transformation Initiative

PETER A. MARINO

ALAN G. WASSERMAN, MD

Chairman, TASC

Chairman of the Department of Medicine

Private Consultant on Defense and Intelligence

FRANCIS J. DUGGAN

Senior Associate Dean of Research

Co-Managing Partner (Americas)

DLA Piper

MARY CHENEY

Eugene Meyer Professor of Medicine

COMMUNITY

OUTREACH The GW Heart & Vascular

Women’s Heart Center Supports Nutrition Education in the Community

Institute supports regional,

Dr. Jannet Lewis, director of GW Women’s Heart Center, cardiology

national, and international

nurse practitioner Helma Parikh, and registered dietitian Kelli Metzger

community service programs.

for at-risk female patients. The two-part cooking series focused on

hosted heart-healthy cooking classes at CulinAerie in Washington, DC components of the Mediterranean diet, which has shown to reduce the risk of heart disease. Supported by the Institute and the Women’s Heart Center, registered dietitian Kelli Metzger provides free heart-healthy nutrition education sessions at community health clinics in Washington, DC. Metzger partnered with AmeriHealth’s clinic at the Conway Health and Resource Center in Ward 8, to lead their Fruit and Vegetable Prescription Program’s monthly nutrition workshops. This Center is the largest healthcare facility in Ward 8. Metzger’s nutrition workshops at community clinics have served more than 500 patients since 2013.

ABOVE: DR. JANNET LEWIS, HELMA PARIKH, NP, AND KELLI METZGER, RD, HOST COOKING CLASS AT L’ACADEMIE DE CUISINE IN BETHESDA, MD. RIGHT: DR. LEWIS COOKS UP HEART-HEALTHY DISHES AT CULINAERIE IN WASHINGTON, DC.

GW CARDIOLOGY FACULTY AND FELLOWS VOLUNTEER AT FOOD & FRIENDS.

Faculty and Fellows Volunteer at Community Health Events Drs. Richard Katz, Marco Mercader, cardiology fellow Dr. Mohammed Gibreal, and physician assistant Stephen Robie volunteered at the Temple of Praise Health and Nutrition Fair and Community Food Bank in the Anacostia neighborhood in Washington, DC during the spring and fall season. The team gave a health workshop presentation to participants, checked blood pressures, and consulted on results. The health fair also provided food demonstrations and distributed fresh vegetables to participants. Dr. Allen Solomon, and cardiology fellow Dr. Sanjay Shah, provided free heart screenings to 100 high school and middle school athletes at Albert Einstein High School in Silver Spring, MD. Dr. Solomon has led annual heart screenings of young athletes in Montgomery County for more than a decade. The GW Heart & Vascular Instituteâ&#x20AC;&#x2122;s faculty, fellows, and their families volunteer annually at Food & Friends to prepare more than 200 packaged meals and

TOP: DR. MARCO MERCADER AND CARDIOLOGY

groceries for people living with life-challenging illnesses such as HIV/AIDS and

FELLOW DR. GIBREAL VOLUNTEER AT TEMPLE

cancer in the DC region. Food & Friends provides over 1 million meals per year to patients with a compromised nutritional status.

OF PRAISE HEALTH FAIR. ABOVE: DR. RICHARD KATZ CHECKS BLOOD PRESSURE AND GIVES FREE CONSULTS AT TEMPLE OF PRAISE HEALTH FAIR.

THE HONDURAS MISSION TEAM: DRS. PINA, CRUZ, TRACY, MERCADER, UMMAT, AND CHAVEZ.

Honduras by the Numbers WORKING WITH...

OUR MISSION TEAM...

Our Mission in Honduras

200

PROVIDED

CONSULTATIONS,

The GW Heart & Vascular Institute supported its Seventh Annual Medical Mission to Honduras in 2016. This brigade of five GW medical professionals

200-300 POUNDS

PERFORMED

100 223

IMPLANTED

ECHOES OVER NINE DAYS, AND

led by Drs. Cynthia Tracy and Marco Mercader has become key to providing

OF MEDICAL EQUIPMENT SHIPPED TO HONDURAS,

advanced care for patients with heart disease in Honduras, working in partner-

in Comayagua, Honduras, to identify patients in need. Since its inception, the

ship with team members from Centro Medico Comayagua Colonial Hospital GW medical team has implanted more than 230 pacemakers and defibrillators. Our 2016 Mission was a record-breaker, with 45 device implants, more than 200 consultations, and more than 100 echoes performed in just nine days.

DEVICES SINCE 2010,

AND EQUIPMENT VALUED AT

$670,000

IN 2016 ALONE.

DONATED BY INDUSTRY SPONSORS.

It was tremendously gratifying to the GW medical team to welcome back many of the device recipients from years past. Each time the GW medical team interrogated a device and found the person to be 100 percent dependent on their device, they knew the patient was alive because of our efforts! The GW medical team consisted of Dr. Cynthia Tracy, Director of Electrophysiology;

DEVICES IMPLANTED YEAR

COMAYAGUA

â&#x2014;?

DEFIBRILLATOR PACEMAKER

TOTAL

Dr. Marco Mercader, Associate Professor of Medicine; Fernando Najera, RCVT;

2010 1

18 19

Dr. Bianca Ummat, Cardiology Fellow; Ivan Pina, Medical Resident; and Maria

2011 9

16 25

2012 11

31 42

Cruz, Technical Support from Medtronic.

2013 6

33 39

Additionally, Dr. Dorys Chavez, a Honduran physician who was supported by

2014 5

15 20

2015 5

28 33

the GW Heart & Vascular Institute as a visiting cardiology intern at GW in 2016,

2016 14

31 45

joined the team. Equally important are the team members from Centro Medico Comayagua Colonial (CMCC) in Comayagua, Honduras. The Honduran medical group includes 20-30 people who dedicate time to support the GW medical team during the two week mission. Their kindness and graciousness makes being in Honduras like a trip home for the GW team!

Institute Sponsors Visiting Cardiology Intern to Support Cardiac Clinic in Honduras Planning for the annual event starts the minute the GW team returns to U.S. Acquiring medical device donations, coordinating with humanitarian groups, packing, shipping, organizing and keeping track of multiple moving parts is a major effort. The mission ships 200-300 pounds of equipment months ahead of time and personally transports another 200 pounds of equipment on the first day of travel. The estimated value of equipment is $670,000. In Honduras, colleagues at CMCC begin work months in advance within the public health system of Honduras and through word of mouth to identify patients in need. The GW Heart & Vascular Institute and GW medical team would like to thank all donors of the annual mission trip and also its sponsors: GW Hospital, Heart Beat International, Medtronic, St. Jude Medical, the University of Pennsylvania, Washington VA Medical Center, and Inova Fairfax.

TOP: DR. MERCADER AND CMCC MEDICAL TEAM EVALUATING LOCAL PATIENTS. ABOVE: DR. MERCADER INTERROGATING A PACEMAKER FOR A PATIENT.

In an effort to create a sustainable cardiac clinic for the underserved people of Honduras, the GW Heart & Vascular Institute sponsored a visiting Honduran medical graduate’s yearlong cardiology internship at GW’s Division of Cardiology. Dorys Chavez, a native Honduran who loves classical music and ballet, graduated from National Autonomous University in Honduras with a medical degree in 2015. She is the youngest of three and the daughter of two civil engineers. The support of her loving family led her to pursue this opportunity with GW. Chavez learned about the GW Heart & Vascular Institute’s mission in Honduras while she was doing medical service at the Regional Hospital of Comayagua. While interning at GW, Chavez attended weekly Cardiology conferences and classes with biomedical engineers— learning about pacemakers, ICD, and CRT and how to interrogate pacemakers.

Additionally, Chavez coedited a cardiology textbook: Essential Concepts of Cardiac Pacing and Device Therapy Case-Based Learning, with Dr. Marco Mercader. After this year of study, Chavez plans to pursue an internal medicine residency and fellowship in cardiology. Chavez is dedicated to a life of medical service and plans to return to Honduras to practice as a cardiologist. She plans to work with patients who have received care from the Institute’s medical mission and to be able to identify new patients who would benefit from advanced cardiac care.

DRS. TRACY, CHAVEZ AND MERCADER.

HONDURAN PATIENTS WAITING TO VISIT THE GW MISSION TEAM AT CMCC.

Community Health Workers Improving Outcomes of Patients with Comorbidities To meet the challenge of management of heart failure, diabetes and hypertension for inner city DC patients, Drs. Gurusher Panjrath and Richard Katz have developed two innovative programs incorporating community health workers (CHWs) into our health team to enhance patient care. With the assistance of Linda Bostrom, NP, Linda Witkin, RN, and the DC based Institute for Public Health Innovation, our GW staff has trained and deployed three full time CHWs. Our CHWs Tim Mavritt, Kim Desormeaux, and Meia Jones make home visits and telephone contacts assisting patients with both medical and social needs. In addition, the CHWs serve as “digital navigators,” supporting patients with disease-specific cell phone “apps” that further support patient self-management of chronic disease. To date our CHWs have assisted over 200 patients. Dr. Katz is working with leadership of AmeriHealth DC, Washington DC’s largest Medicaid insurer, with the hope of expanding this program across the DC metropolitan area. As part of our academic mission combining research, education and community outreach to improve outcomes in heart disease, the GW Heart & Vascular Institute sponsored its community health workers (CHWs) to attend the 14th Annual Unity Conference in Atlanta, Georgia. This conference focused on the role of CHWs in TOP, LEFT TO RIGHT: DR. KATZ, LINDA WITKIN, RN, LINDA BOSTROM, NP,

promoting healthy communities. Our CHWs presented three abstracts highlighting

AND DR. PANJRATH.

our GW team approach to improve self-management skills for patients with heart

ABOVE, LEFT TO RIGHT: MEIA JONES, TIM MAVRITT, LINDA BOSTROM, NP,

failure, hypertension, and diabetes.

AND KIM DESORMEAUX.

HIGHLIGHTS IN

EDUCATION Symposia The Institute is dedicated

Faculty and Fellows participate in Institute-sponsored

to training the next

symposia to share best practices in cardiology with clinicians

generation of cardiologists

throughout the country.

and providing continuing

Third Annual Heart Failure and Arrhythmia Conference

and professors involved in multidisciplinary cardiac care

medical education

Drs. Marco Mercader, Associate Professor of Medicine,

throughout the region.

Panjrath, Assistant Professor of Medicine, Director of Heart

Director of Electrophysiology Research, and Gurusher Failure and Mechanical Support Program, co-chaired the symposium in Washington, DC. The symposium, held at the Renaissance Hotel, provided clinicians involved in cardiac care with an update on best practices and cutting-edge care regarding heart failure, arrhythmias, valve disease, and coronary artery disease.

TOP: ANNUAL HEART FAILURE SYMPOSIUM CO-DIRECTORS DRS. PANJRATH AND MERCADER. ABOVE: SYMPOSIUM ATTENDEES AT THIRD ANNUAL HEART FAILURE AND ARRHYTHMIA SYMPOSIUM. RIGHT: DR. PANJRATH LEADING PANEL DISCUSSION: HEART FAILURE AND PULMONARY HYPERTENSION.

Visiting Professors The GW Heart & Vascular Institute enhances the educational experience of our GW medical residents and cardiology fellows by inviting renowned cardiologists and master teachers to serve as visiting professors. GW DIVISION OF CARDIOLOGY FACULTY

Understein Memorial Visiting Professor

Examples from the In-patient Service”

Patrick O’Gara, MD, MACC, Professor

trainees. The Understein Memorial

of Medicine at Harvard Medical School

Lecture Fund was established in 1978

at the Brigham and Women’s Hospital

by the family of Jack Understein, in

in Boston, MA and past president of the

gratitude for the care provided at GW.

The GW Cardiology Fellowship program, led by

American College of Cardiology, was

The Institute is grateful to the Understein

Dr. Allen Solomon, is a three-year comprehensive

the GW Heart & Vascular Institute’s 2016

family for their generous contribution

clinical cardiology training program designed

Understein Memorial Visiting Professor.

that makes this annual lectureship and

to prepare the next generations of cardiologists

Dr. O’Gara, a national leader in valvular

tribute to their father possible. Jack

for careers in clinical or academic medicine.

heart disease, delivered cardiology

Understein’s sons, Norman Understein,

Outstanding candidates may pursue a fourth

grand rounds on “The Evolution of

Robert Understein and Gary Understein,

year of advanced training to specialize in

Management of Valvular Heart Disease”

attended the lecture and joined Dr.

electrophysiology, led by Dr. Cynthia Tracy, or in

and medical grand rounds on “Decision-

O’Gara and GW’s

interventional cardiology, led by Drs. Jonathan

Making at the Interface between

cardiology fellows

Reiner, Ramesh Mazhari, and Christian Nagy. In 2016-2017, the Institute provided training to

Cardiology and Internal Medicine: Case

for dinner following

AND FELLOWS, 20162017 ACADEMIC YEAR.

Fellows Education and Training

to more than 200 GW faculty and

the event.

eight core cardiology fellows and supported one electrophysiology fellow and two interventional cardiology fellows. Fellows participate in academic research studies provided by the Institute’s Annual Young Investigator Awards.

ABOVE: DR. PATRICK O’GARA, 2016 UNDERSTEIN MEMORIAL VISITING PROFESSOR. LEFT: JACK UNDERSTEIN’S SONS: NORMAN, BOB, AND GARY UNDERSTEIN JOIN DRS. KATZ AND O’GARA AT ANNUAL MEMORIAL LECTURE.

2016 VARGHESE VISITING PROFESSOR DR. GURBEL, WITH DRS. VARGHESE, SOLOMON, KATZ, AND GW CARDIOLOGY FELLOWS ALUMNI COMMITTEE.

Bloedorn Interdisciplinary Cardiology Lecture Series

P. Jacob Varghese Visiting Professor and GW Cardiology Fellows Alumni Reception

Cardiology Grand Rounds Webinars

In 2016, the Walter A. Bloedorn

Graduates of the GW Cardiology Fellowship Program

In an effort to expand our audience and

Foundation supported an innovative

joined current cardiology faculty and fellows for the annual

impact of professional medical education

interdisciplinary cardiovascular

P. Jacob Varghese Visiting Professorships in 2016 and

to cardiologists, the Institute’s cardiology

education program, the Bloedorn

2017. Dr. Paul A. Gurbel, Director of the Inova Center for

grand rounds is broadcast live via

Interdisciplinary Cardiology Lecture

Thrombosis Research and Drug Development, served as

Webinar and is recorded and archived on

Series. These conferences bring

visiting professor in 2016, and Dr. Kim Eagle, Director of

GW’s Department of Continuing Medical

nationally recognized medical experts

Frankel Cardiovascular Center at University of Michigan,

Education Website. These lectures are

to GW’s medical campus to discuss

served as visiting professor in 2017.

available for free to cardiologists across

cross disciplinary topics including the

The alumni reception and lecture

interface of heart disease with cancer,

was hosted by the GW Cardiology

kidney disease, diabetes, and nervous

Alumni Committee: Drs. Narian

system disorders. This educational

Rajan, Hamid Taheri, and Reza

series enhances both our cardiology

Sanai, at the Westin Georgetown.

knowledge and creates a forum to better integrate colleagues across

the US, including alumni of the GW Cardiology Fellowship Program and GW School of Medicine. The Webinar series was initiated by a generous donation from Dr. Azita Moalemi, a GW Cardiology Fellowship alum. GW WOMEN’S

GW, engaging faculty and trainees

HEART CENTER

from multiple medical specialties.

VISITING PROFESSOR DR. C. NOEL

TOP: DR. JAVID MOSLEHI, BLOEDORN

BAIREY MERZ,

INTERDISCIPLINARY SPEAKER ON

WITH DR. JANNET

CARDIO-ONCOLOGY, WITH DRS.

LEWIS, CENTER

PANJRATH AND KATZ.

DIRECTOR, AND TOP RIGHT: DRS. EAGLE AND KATZ.

GW CARDIOLOGY

ABOVE: DR. KIM EAGLE.

FELLOWS.

RIGHT: 2017 VARGHESE VISITING PROFESSOR DR. EAGLE, WITH DRS. REINER, WASSERMAN, SHAH, AND SOLOMON.

CARDIOVASCULAR

RESEARCH

The GW Heart & Vascular Institute

the number one killer of people, the GW Heart & Vascular Institute has been at the forefront of cardiovascular research to closely

faculty are committed

connect research advances with the clinical practice of medicine. In

to exploring new

2016 –2017, our faculty’s research productivity was the greatest in the

innovations for the diagnosis and treatment of cardiovascular disease.

As cardiovascular disease gains a larger foothold globally as

Institute’s history, with more than 120 published manuscripts, abstract presentations, and keynote scientific presentations.

Heart Rhythm Disorders Drs. Cynthia Tracy, Allen Solomon, and Marco Mercader continue to advance knowledge of cardiac rhythm disorders, developing and testing new diagnostic and therapeutic devices, establishing national consensus guidelines, and publishing arrhythmia training monographs. Dr. Mercader, along with colleagues in the Departments of Pharmacology and Biomedical Engineering, has refined their device to monitor and target ablation treatment of atrial fibrillation and published two training monographs on electrocardiography. Dr. Solomon has provided expertise on new anticoagulation strategies for stroke prevention in patients with atrial fibrillation. Dr. Tracy has been a major contributor to the American College of Cardiology/American Heart Association/Heart Rhythm Society guidelines on atrial arrhythmias and techniques to tailor and evaluate implantable cardiac defibrillators. In addition, she has been a speaker at many national cardiology conferences.

PUBLISHED IN 2016 – 2017 HEART RHYTHM DISORDERS

Page RL, Tracy C, et al. 2015 ACC/AHA/ HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2016 Apr 5;67(13):e27-e115. Zipes DP, Tracy C, et al. 2015 ACC/ AHA/HRS Advanced Training Statement on Clinical Cardiac Electrophysiology (A Revision of the ACC/AHA 2006 Update of the Clinical Competence Statement on Invasive Electrophysiology Studies, Catheter Ablation, and Cardioversion). Heart Rhythm. 2016 Jan;13(1):e3-e37.

Tracy C, et al. 2015 HRS/EHRA/APHRS/ SOLAECE Expert Consensus Statement on Optimal Implantable CardioverterDefibrillator Programming and Testing. Europace. 2016 Feb;18(2):159-83. Mercader M. Mitigating the Risk of Microemboli Formation During Irrigated Radiofrequency Catheter Ablation. Circ Arrhythm Electrophysiol. January 13, 2016, 9. Gil DA, Swift LM, Asfour H, Muselimyan N, Mercader M, and Sarvazyan NA. Autofluorescence Hyperspectral Imaging of Radiofrequency Ablation Lesions in Porcine Cardiac Tissue. J. Biophoton. 2016. Alzahrani T, Aljishi M, Mercader M. Optical Tissue Interrogation Technology Incorporated in Irrigated Radiofrequency Ablation Provides Real-Time Monitoring of Ablation Lesion Depth. BCVS Scientific Sessions. July 2016.

Aljishi M, Afsour H, Chahbazian T, Muselimyan N, Swift L, Mercader M, and Sarvazyan N. Spectral Changes Caused by Radiofrequency Ablation of Cardiac Tissue. BCVS Scientific Sessions. July 2016. Mercader M, Armstrong KC, Ranbury T, Reddy V, Koruth J, Lasen C, Bown J, Sarvazyan N, Amirana O. Optical Tissue Interrogation that Provides Real-Time Monitoring of Catheter-Tissue Contact and Rf Lesion Progression Using NADH Fluorescence. Cardiostim. June 2016. Shams M, Sullivan A, Abudureyimu S, Hassouna B, Jayanthi V, Amdur R, Varghese PJ, Mercader M. Optimizing Electrocardiogram Interpretation and Catheterization Laboratory Activation in ST-Segment Myocardial Infarction. A

ABOVE: THE GW ELECTROPHYSIOLOGY CLINICAL AND RESEARCH FACULTY: DRS. MERCADER, SOLOMON, AND TRACY. RIGHT: ATRIAL FIBRILLATION ABLATION CT.

Teaching Module for Medical Students. American College of Cardiology Scientific Sessions. March 2016. Armstrong KC, Ransbury T, Larson C, Bowen J, Sarvazyan N, Mercader M and Amirana O. Orientation Independent Optical Tissue Interrogation for Assessment of Catheter-Tissue Contact and RF Lesion Progression. AF Symposium. January 2016, Orlando, Florida. Mercader M. New Generation of Catheters for Treatment of Atrial Fibrillation (Phase II). Nocturnal Product Development LLC. National Institutes of Health 2R41HL120511 STTR Phase II. 2016. (Completed Research)

Muselimyan N, Swift L, Asfour H, Chahbazian T, Mazhari R, Mercader M, Sarvazyan N. Seeing the Invisible: Revealing Atrial Ablation Lesions Using Hyperspectral Imaging Approach. PLOS ONE. December 2016. Alzahrani T, Satya S, Mercader M. Acute Pacing-Induced Cardiomyopathy. Case Report International. 2016; 5:48–53. Rahmani M, Peña I, Ummat B, Chavez D, Toro P, Villeda M, Tracy C, Mercader M, Chagas Heart Disease: A Comparison of Clinical and Intraoperative Pacing Parameters. American College of Cardiology Scientific Sessions, 2017. Washington DC.

Mercader M. Real Time Imaging System for Evaluation of Ablation Lesions and Gaps. Funding Agency: Allied Minds. 2016. (Completed Research)

DR. RICHARD KATZ DEMONSTRATING THE APPLICATION OF MOBILE HEALTH TO CARDIOVASCULAR DISEASE.

Drs. Richard Katz and Gurusher Panjrath lead research using mobile health (mHealth) cell phone apps and community health workers (CHWs) to engage patients with self-management of chronic diseases such as heart failure, hypertension, diabetes, and coronary artery disease. CHWs provide culturally appropriate advice on prevention, management, medications and diet; monitor weight, blood pressure, and blood glucose; and transport to clinic appointments. Our CHWs also help patients navigate “social determinants of health” such as housing,

Mobile Health & Community Health Workers in Cardiovascular Disease

food, insurance, employment, and other social services. This program lowered the 30-day re-hospitalization for our DC heart failure patients from 23 percent to 11 percent. In 2017, Dr. Katz completed a three-year, $2 million Patient Centered Outcomes Research Institute project comparing three strategies for the management of diabetes: mHealth alone, a CHW alone, and mHealth plus a CHW. All three strategies significantly improved health behaviors, and Drs. Panjrath and Katz have new funding to study mHealth/CHW strategies in heart failure patients.

Aljishi M, Afsour H, Chahbazian T, Muselimyan N, Swift L, Mercader M, Sarvazyan N. Spectral Changes Caused by Radiofrequency Ablation of Cardiac Tissue. Circulation. July 22, 2016, Volume 119, Issue Suppl 1. Abstract 430. Mercader M, Chavez D, Tiu J. Essential Concepts of Cardiac Pacing and Device Therapy Case-Based Learning. May 2017. Tracy, C. Important Technical Innovations for Ablation of Atrial Fibrillation. American Heart Association Scientific Sessions. New Orleans, LA, November 15, 2016. Tracy C. Compelling Science Within the Arrhythmias and Electrophysiology Track. American Heart Association Scientific Sessions. New Orleans, LA, November 16, 2016.

Tracy C. EP Options in Atrial Fibrillation. American College of Cardiology MidAtlantic Capital Cardiology Symposium (MACCS). Washington, D.C. November 19, 2016. Tracy C. Heart Rhythm Disorders: Today and Tomorrow. American College of Cardiology Scientific Sessions. Washington, D.C., March 17, 2017. Tracy C. Cardiology Brigade to Honduras: The Role of Medical Centers in Promoting Global Health. Heart Rhythm Society Scientific Sessions. Chicago, IL, May 10, 2017. Tracy C. EP in 2020 and Beyond — Ablation in the Future. Heart Rhythm Society Scientific Sessions. Chicago, Illinois, May 11, 2017. Tracy C. Charitable Missions in Latin America. Heart Rhythm Society Scientific Sessions. Chicago, Illinois, May 12, 2017.

MOBILE HEALTH & COMMUNITY HEALTH WORKERS IN CARDIOVASCULAR DISEASE

Katz R, Nunlee-Bland G, Magee M, Witkin L, Payne D, Nassar C. Patient Engagement and Utilization of a Diabetes Mobile Health Application: Beyond Glucose Monitoring. American Diabetes Annual Scientific Sessions. June 2016. Katz R, Nunlee-Bland G, Magee M, Witkin L, Payne D, Nassar C, Rhein M. A Structured Program Engaging Community Health Workers with Patients with Diabetes and Their Medical Team. American Diabetes Association Annual Scientific Sessions (Abstract) Diabetes Care. 2016.

Choi BG. Image-Based Mobile System for Dietary Assessment and Coaching. National Institutes of Health, Principal Investigator, 2015-2016. (Competed Research) Katz R, J Cohen, G Nunlee Bland, M Magee, A Cioletti, H Young. Changing the Healthcare Delivery Model: A Community Health Worker/Mobile Chronic Care Team Strategy. Patient Center Outcomes Research. 2016. (Competed Research) Desormeaux K, Jones M, O’Garro-Davis E, Bostrom L, Panjrath G, Katz R. Heart Failure and Community Health Workers. Unity Conference on Community Health Workers. Atlanta, GA, July 2016. Mavritte T, Witkin L, Katz R. Community Health Worker Checklist to Assist Patients with Diabetes. Unity Conference on Community Health Workers. Atlanta, GA, 2016.

Katz R, Nunlee-Bland G, Magee M, Witkin L, Cohen J. Community Health Workers, Mobile Health, or Both for the Management of Medicaid Patients with Diabetes, American Diabetes Association Scientific Sessions. San Diego, Jun 2017. Katz R. Community Health Workers and mHealth for the Treatment of Medicaid Patients. mHealth Interest Group at National Institutes of Health. Bethesda, MD, Mar 2017. Martin LW. Improving Health Care Access for Minority and High-Risk Populations —Telemedicine. Association of Black Cardiologists– American College of Cardiology Roundtable Regroup. Mar 2017.

GW Heart and Vascular Institute cardiologist Steven

Healthcare Policy

Farmer, MD, PhD and William Borden, MD, are recognized nationally for their contributions to health policy and innovations in healthcare delivery. Starting in January 2017, Dr. Farmer was selected to serve a two-year term as Senior Advisor and Medical Officer at the Center for Medicare and Medicaid innovation. Dr. Borden has been co-chair for the American Heart Association Health Policy Forum on quality of care and outcomes research on cardiovascular diseases and stroke. DRS. BORDEN AND FARMER, OUR GW LEADERS IN PROMOTING HEALTHCARE POLICY AND IMPROVING THE QUALITY OF HEALTHCARE DELIVERY.

HEALTHCARE POLICY

Alhamoud HA, Dudum R, Young HA, Choi BG. Author Self-Disclosure Compared to Pharmaceutical Company Reporting of Physician Payments. American Journal of Medicine 2016; 129(1):59-63. Dudum R, Harfouch O, Young H, Choi BG. ACC/AHA Guideline Author Self-Disclosures and the Sunshine Act: Conflicting Reports of Conflicts of Interest. Journal of the American College of Cardiology 2016; 67(13_S): 1967. Alhamoud HA, Dudum R, Young HA, Choi BG. The Limits of Sunshine as Disinfectant: Despite Improvements, Open Payments Still Lacks Systematic and Transparent Reporting. American Journal of Medicine 2016; 129(9): e195–e196. Chee TT, Ryan AM, Wasfy JH, Borden WB. Current State of Value-Based Purchasing Programs. Circulation. 2016; 133:2197-2205.

Borden WB. New Payment Models: What Does This Mean for Interventional Cardiology. American College of Cardiology Scientific Sessions. April 4, 2016; Chicago, IL. Farmer SA and Borden WB. Caution is Needed in Designing Pharmacy Coverage. Journal of the American Heart Association. 2016, 5(11). Fleming LM, Farmer SA, et al. Relationship of Provider and Practice Volume to Performance Measure Adherence for Coronary Artery Disease, Heart Failure, and Atrial Fibrillation: Results from the National Cardiovascular Data Registry. Circ Cardiovasc Qual Outcomes. 2016, 9(1): 48-54. Farmer SA. Writing Group (Co-Chair). Primary Care Cardiology Collaborative Models of Care. Washington, DC, Duke University Margolis Center for Health Policy. Jan-Dec 2016, 9. (Completed Research)

Farmer SA. The Impact of Maryland’s Capitated Hospital Payment Model on Hospital-Based and Ambulatory Surgical Center Care. Robert Wood Johnson Foundation. Sept 2016 to Jan 2017. (Completed Research) Farmer SA. Inter-Payer Agreement on Apparent Practice-Level Composite Quality Measure Performance. American College of Cardiology NCDR (PINN-123). June 2016. (Completed Research) Farmer SA. Geographic Variation in Cost, Utilization, and Prices. Health Care Service Corporation (HCSC). July 2015 to Jan 2017. (Completed Research) Farmer SA. Pricing of Hospital Cardiac Procedures: Impacts of Federal Quality Reports. Agency for Health Care Research & Quality. Oct 2014 to Sept 2016. (Completed Research)

Farmer SA. Joint Effect of Malpractice Risk and Financial Incentives on Cardiac Testing. National Heart, Lung, and Blood Institute. Aug 2013 to Jan 2017. PI (1 R01 HL113550-01A1). (Completed Research) Farmer, SA and NA Brown. Value-Based Approaches for Emergency Care in a New Era. Ann Emerg Med. 2017; 69(6): 684-686. Farmer, SA, ML Darling, M George, PN Casale, E Hagan, MB McClellan. Existing and Emerging Payment and Delivery Reforms in Cardiology. JAMA Cardiology. 2017; 2(2) 210-217. Farmer SA, J Shalowitz, M George, F McStay, K Patel, J Perrin, A Moghtaderi, M McClellan. Calculating the Fully Capitated Payment Breakeven Rate for a Mid-Size Pediatrics Practice. Pediatrics. 2016; 138(2).

Pines JM, Zocchi M, Moghtaderi A, Black BS, Farmer SA, Hufstetler G, Klauer K, Pilgrim R. Medicaid Expansion In 2014 Did Not Increase Emergency Department Use But Did Change Insurance Payer Mix. Health Affairs. 2016; 35(8): 1480-1486. Fleming LM, Jones P, Chan P, Andrei A, Maddox TM, Farmer SA. Relationship of Provider and Practice Volume to Performance Measure Adherence for Coronary Artery Disease, Heart Failure, and Atrial Fibrillation. Results from the National Cardiovascular Data Registry. Circ Cardiovasc Qual Outcomes. 2016; 9(1): 48-54. Borden WB, Nallamothu BK. Repealing the Affordable Care Act: America’s Moral Test. Circ Cardiovasc Qual Outcomes. 2017, Feb 22. doi: 10.1161/ CIRCOUTCOMES.117.003598.

Coronary Artery Disease & Structural Valve Disease Drs. Jonathan Reiner, Ramesh Mazhari, and Christian Nagy are breaking new ground in approaches to cardiac catheterization and percutaneous heart valve replacement. Dr. Mazhari is a recognized expert in radial heart catheterization techniques, as well as directing research advancing translational science understanding of coronary artery disease. Drs. Nagy, Reiner and Mazhari have created a robust structural heart disease ABOVE: OUR GW INTERVENTIONAL CARDIOLOGY CLINICAL AND RESEARCH FACULTY: DRS. REINER, MAZHARI, AND NAGY.

program and are extending application of non-surgical approaches to heart valve replacement and repair.

LEFT: VASCULAR CT

Maddox TM, Albert NM, Borden WB, Curtis LH, Ferguson TB Jr, Kao DP, Marcus GM, Peterson ED, Redberg R, Rumsfeld JS, Shah ND, Tcheng JE. The Learning Healthcare System and Cardiovascular Care: A Scientific Statement from the American Heart Association. Circulation. 2017 Apr 4. Borden WB, Dickson VV. Care Innovation: Sharing Practical Care Delivery Tools and Discoveries. Circ Cardiovasc Qual Outcomes. 2017 June 10. Farmer SA. CMS Innovation and Health Care Delivery System Reform. Centers for Medicare & Medicaid Services. 2016. Borden WB. Impact of Policy on Health Care Organizations. Substance Abuse and Mental Health Services Agency. U.S. Department of Health and Human Services. 2016.

Borden WB. Advancing Data Science and Methods for Healthcare Delivery Transformation. Guest-guided discussion. National Library of Medicine Health Services Research Information Advisory Committee. Washington, DC, 2016. Borden WB. MACRA: The Perspective of the Practicing Cardiologist. American College of Cardiology Scientific Sessions. 2017. Borden WB. The Future of Health Policy, Co-Chair. The American Heart Association Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke. 2016.â&#x20AC;&#x192;

CORONARY ARTERY DISEASE & STRUCTURAL VALVE DISEASE

Levine GN, Tracy C, et al. 2015 ACC/ AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction. J Am Coll Cardiol. 2016 Mar 15;67(10):1235-50. Hassouna B, Howard E, Reiner J. Managing Iatrogenesis Imperfecta: Percutaneous Salvage of Catastrophic Coronary Dissection. Trans Catheter Therapy (TCT), San Francisco, CA, 2015 Oct Invited Panel, Transradial Complications, Fellows Course, CRT, 2016 May.

Mazhari R. Why Transradial Incidence is Slow to Rise in the USA and Economic Implications. 2nd Annual Advanced Transradial and Complex Cardiac Interventions Symposium at UPMC Heart and Vascular Institute. April 2016. Mazhari R. Evidence of Reduced Bleeding with Transradial Approach Across All Spectrum of Patients. 2nd Annual Advanced Transradial and Complex Cardiac Interventions Symposium at UPMC Heart and Vascular Institute. 2016 April. Hynes CF, Fatemi O, Sharma AC, Nagy C, Trachiotis GD. Transapical Mitral Valve-in-Valve Replacement in Patient with Previous Complex Sternal Reconstruction. Innovations (Phila). 2016 May-Jun;11(3):222-4. Kim J, Teague H, Dey A, Silverman J, Mazhari R. A Novel Population of Neutrophils, Low Density Granulocytes,

are Upregulated in Acute ST Elevation Myocardial Infarction. American Heart Association Scientific Sessions, 2016. Dong T, Zhang M, Robie S, Najam F, Pocock E, Mazhari R, Reiner J, Choi BG, Lewis JF, Nagy C, Choi AD. Transcatheter Aortic Valve Replacement Improves Right Ventricular Hemodynamics in High Surgical Risk Patients with Aortic Stenosis. American College of Physicians Scientific Sessions, April 2017. Mazhari R. Trans-Radial Trends in Interventional Cardiology, Lessons to be Learned. ISET. Jan 2017. Mazhari R. The Role of 3-D printing in Pre-procedural Planning for Transcatheter Aortic Valve Replacement, a Conceptual Look at the Aortic Root., Abstract, Radiological Society of North America. 2016 January.

OUR CLINICAL AND RESEARCH GW CARDIAC IMAGING TEAM: DRS. JANNET LEWIS, ANDREW CHOI, AND BRIAN CHOI.

Cardiac Imaging Our GW cardiac imaging experts, Drs. Jannet Lewis, Andrew Choi, and Brian Choi have opened new vistas in viewing the heart and vascular structures using echocardiography, nuclear cardiac imaging, cardiac CT and cardiac MRI. Dr. Lewis has targeted new echocardiographic methods

TOP LEFT: 3D HEART CT.

to assess contraction and relaxation of the right and left heart chambers. Dr.

TOP: ECHOCARDIOGRAM.

Andrew Choi has gained a national reputation as a rising young investigator

ABOVE; 3D PRINT OF AORTIC ROOT.

utilizing cardiac CT to evaluate both heart muscle function and coronary artery flow characteristics. Dr. Brian Choi has collaborated with Dr. Lewis on her echo research and, in addition, he has promoted use of cardiac ultrasound for global health. Drs. Lewis, A. Choi and B. Choi have been tapped to serve on national cardiac committees and been invited speakers at major national cardiovascular meetings.

CARDIAC IMAGING

Choi AD, et al. Prospective Evaluation of Cardiac Computed Tomography in Comparison to Intraoperative Findings in Reoperative Cardiac Surgery: Diagnostic Accuracy and Clinical Outcomes. Journal of the American College of Cardiology: Cardiovascular Imaging. 2016 Nov;9(11):1356-1357. Baron K, Choi AD, Chen MY. Low Radiation Dose Calcium Scoring: Evidence and Techniques. Current Cardiovascular Imaging Reports 2016; 9:12. Baron KB, Earls JP, Reiner J, Choi BG, Zeman RK, Choi AD. Cardiac CT in Multi-Vessel Coronary Vasospasm with Overlapping Takotsubo Cardiomyopathy. Society for Cardiovascular CT Case of the Month (Case of the Year Winner). Published online 2016 June 21.

Choi AD, Shanbhag SM, Bronson K, Rollison S, Katz R, Chen MY. Prevalence and Predictors of Atherosclerosis in 21st Century Younger Adults: A Cardiac CT Study. Society of Cardiovascular Computed Tomography Scientific Sessions, June 2016, Orlando, FL. Journal of Cardiovascular Computed Tomography Vol 10 (3). Choi AD, Shanbhag S, Bronson K, Rollison S, Katz R, Chen M. Prevalence and Predictors of Atherosclerosis in 21st Century Younger Adults: A Cardiac CT Study. Society of Cardiac CT. 2016. Knab A, Melo D, Yu J, Groves DW, Nelson EA, Bronson K, Stagliano M, Rollison S, Choi AD, Shanbhag SM, Chen MY. Dramatic Radiation Dose Reduction Over 7 Years of Experience for Coronary CT Angiography. Society of Cardiovascular Computed Tomography Scientific

Sessions, June 2016, Orlando, FL. Journal of Cardiovascular Computed Tomography Vol 10, Issue 3 (May-June 2016). Choi AD, Leifer ES, Shanbhag SM, Bronson K, Arai AE, Chen MY. Coronary Artery Calcium Scoring on 320 Detector Row CT Demonstrates Low Interscan Variability at Standard and 70% Reduced Radiation Dose. Winner, Toshiba Young Investigator Award at Society of Cardiovascular Computed Tomography Scientific Sessions, July 2015, Las Vegas, NV. Journal of Cardiovascular Computed Tomography Vol 10, Issue 3 (May-June 2016). Choi AD. Read with the Experts Session in Cardiac CT. Society of Cardiovascular Computed Tomography Annual Scientific Sessions. Orlando, FL, June 2016. Choi AD. Cardiac CT Image Acquisition. Nuclear Cardiology and Cardiac CT for Fellows in Training. American Society

of Nuclear Cardiology and Society for Cardiovascular CT. Precourse at the American College of Cardiology Scientific Sessions. Chicago, IL, April 2016. Ummat B, Mukherjee M, Parikh H, Craney L, Choi BG, Lewis JF. Clinical Implications of Right Ventricular Strain. J Am Soc Echo. 2016 Seattle, WA. Choi AD. Prospective Multicenter Registry on Radiation Dose Estimates of Cardiac CT Angiography in Daily Practice. (PROTECTION VI). National Institutes of Health. 2016. (Completed Research) Thomas DM, Abbara S, Choi AD, Cury R, Lee J, Maroules C, Nagpal P, Vazquez G, Villines TC, Zeb I, Blankstein R. Curriculum Guideline for Training Independent Readers (Level II) and Advanced Readers (Level III) in Cardiovascular Computed Tomography. Society of Cardiovascular Computed Tomography. 2016.

Choi AD. Cardiac CT in Coronary Artery Disease in the Young. CT-CADY Study. 2016. (Completed Research) Abbara S, Blanke P, Cheezum M, Choi AD, Han KB, Maroules CD, Marwan M, Naoum C, Norgard B, Rubinshtein R, Shoenhagen P, Villines T, Leipsic J. SCCT Guidelines for the Performance and Acquisition of Coronary Computed Tomography Angiography. A Report of the Society of Cardiovascular Computed Tomography Guidelines Committee. Journal of Cardiovascular Computed Tomography. 2016 Nov-Dec; 10(6): 435-449. Choi AD, Leifer ES, Yu J, Shanbhag SM, Bronson K, Arai AE, Chen MY. Prospective Evaluation of 74% Reduced Radiation Dose and Interscan Variability in Coronary Artery Calcium Scoring on 320-Detector Row CT. Journal of Cardiovascular Computed Tomography. 2016 SepOct;10(5):359-63.

DR. LISA W. MARTIN, PRINCIPLE INVESTIGATOR FOR NIH–WOMEN'S HEALTH INITIATIVE GW SITE.

For over 17 years GW has been a key member of the NIH-

Women’s Heart Health

sponsored Women’s Health Initiative (WHI), the largest cardiac epidemiologic study in US history. Lisa Martin, MD, principle investigator for the GW WHI site, has been a co-author on 15 papers in 2016-2017. This research has provided new understanding of women’s cardiac health and the interactions of genomics, diabetes, renal disease and stroke. Dr. Jannet Lewis, Director of GW Women’s Heart Center, along with Drs. Andrew and Brian Choi, are studying new imaging strategies to detect early atherosclerosis in women.

Ummat B, Mukherjee M, Parikh H, Craney L, Choi BG, Lewis JF. Clinical Implications of Right Ventricular Strain. Journal of the American Society of Echocardiography. 29(6): B94, 2016. Ummat B, Baron K, Mercader M, Reiner J, Zeman R, Choi AD. Bridging the Gap Multimodality Imaging in a 56 Year Old Patient with Sudden Death. Moderated Poster. American College of Cardiology Scientific Sessions, 2017. Washington DC. Choi AD, Bradley A, Shanbhag S, Kellman P, Levine O, Mancini C, Chen M, Arai A, Bandettini WP. Cardiovascular Magnetic Resonance in the Evaluation of Fibrofatty Infiltration for Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy (ARVD/C). Journal of the American College of Cardiology. Vol 69, Issue 11, Supplement 21, Page 1475, Mar. 2017.

Choi AD, Shanbhag SM, Yu J, Rollison S, Schuzer J, Stevenson C, Chen MY. Clinically Equivalent Coronary Artery Calcification Scoring at 75% Lower Dose Radiation with Forward Projected Model Based Iterative Reconstruction. 102nd Radiological Society of North America Scientific Sessions. Nov 2016. Bradley AJ, Baute SP, Robie SP, Zeman RK, Choi AD. Cardiac MRI to Assess for Autotransplantation Candidacy. Society for Cardiovascular MR Case of the Week. Published Online 2016 December. Sodhi G, Lewis JF. Does Improved Blood Pressure Correlate with Better Left Ventricular Global Strain? American College of Cardiology Scientific Sessions, 2017. Washington, DC.

Michelis KC, Narotsky DL, Choi BG. Cardiovascular Imaging in Global Health. In: DJ Mollura et al, editors. Radiology in Global Health: Strategies, Implementation, and Applications, 2nd edition. New York, NY: Springer Publishing.

WOMEN’S HEART HEALTH

Choi BG. Advancements in Diagnostics: Empowering the Patient. eHealth Initiative’s Creating a Continuum of Seamless Care Conference. Washington, DC, May 25, 2017.

Foraker RE, Martin LW, et al. Cardiovascular Health and Incident Cardiovascular Disease and Cancer: The Women’s Health Initiative. American Journal of Preventive Medicine. 2016 Feb;50(2):236-40.

Choi BG. Frontiers in Cardiac Ultrasound: Limits of Miniaturization. American Society of Echocardiography Scientific Sessions. Seattle, WA, June 11, 2016.

Azarbal F, Martin LW, et al. Lean Body Mass and Risk of Incident Atrial Fibrillation in Post-Menopausal Women. European Heart Journal. Aug 10, 2015 Eur Heart J. 2016 May 14;37(20):1606-13.

Arce CM, Martin LW, et al. Kidney Function and Cardiovascular Events in Postmenopausal Women: The Impact of Race and Ethnicity in the Women’s Health Initiative. Am J Kidney Dis. Feb; 67(2):198-208, 2016.

Johnson K, Martin LW, et al. Tissue Factor Pathway Inhibitor, Activated Protein C Resistance, and Risk of Coronary Heart Disease Due to Combined Estrogen Plus Progestin Therapy. Arterioscler Thromb Vasc Biol. 2016 Feb; 36(2):418-24. Simon M, Martin LW, et al. Prospective Analysis of the Association Between Statins and Pancreatic Cancer Risk in the Women’s Health Initiative. Cancer Causes and Control. Jan 8, 2016. Rodriguez F, Martin LW, et al. Racial and Ethnic Differences in Atrial Fibrillation Risk Factors and Predictors in Women: Findings from the Women’s Health Initiative. American Heart Journal. March 2016.

Heart disease continues to be the number one killer

Prevention

of men and women in the United States. According to the CDC, about 610,000 people in the US die of heart disease each year— that’s 1 in every 4 deaths. Focusing on prevention is essential in the reduction of cardiovascular disease-related morbidity and mortality. GW cardiologists Drs. Borden, Choi, Katz and Martin have been productive in leading research addressing lifestyle changes, genomic markers, new national guidelines, and innovative approaches to heart-healthy nutrition.

DR. BRIAN CHOI WITH GW 4TH YEAR MEDICAL STUDENT TANIA DHAWAN, PRESENTING RESEARCH AT 2016 AHA SCIENTIFIC SESSIONS ON HOW DIET AND NUTRITION SMARTPHONE APPS DEMONSTRATE POOR ADHERENCE TO THE 2015-2020 DIETARY GUIDELINES FOR AMERICANS.

Ermakov S, Martin LW, et al. The Associations of Leptin, Adiponectin and Resistin with Incident Atrial Fibrillation in Women. Heart. 102 (17)1354-62, 2016. Ma Y, Martin LW, et al. Impact of Incident Diabetes on Atherosclerotic Cardiovascular Disease According to Statin Use History Among Postmenopausal Women. Eur J Epidemiol. 2016 May 17. Gorczyca AM, Eaton CB, LaMonte MJ, Manson JE, Johnston JD, Bidulescu A, Waring ME, Manini T, Martin LW, et al. Change in Physical Activity and Sitting Time After Myocardial Infarction and Mortality Among Postmenopausal Women in the Women’s Health Initiative– Observational Study. JAHA. 2017;5.

Harrington LB, Blondon M, Cushman M, Kaunitz AM, Rossouw JE, Allison MA, Martin LW, et al. The Cross-Sectional Association Between Vasomotor Symptoms and Hemostatic Parameter Levels in Postmenopausal Women. Menopause. 2017, 4. LaMonte MJ, Martin LW, et al. History of Periodontitis Diagnosis and Edentulism as Predictors of Cardiovascular Disease, Stroke, and Mortality in Postmenopausal Women. Journal of the American Heart Association. 2017, 3. Schnatz PF, Martin LW, et al. Effects of Calcium, Vitamin D, and Hormone Therapy on Cardiovascular Disease Risk Factors in the Women’s Health Initiative: A Randomized Controlled Trial. Obstetrics and Gynecology. 2017, 1.

Liu C, Martin LW, et al. Meta-Analysis Identifies Common and Rare Variants Influencing Blood Pressure and Overlapping with Metabolic Trait Loci. Nature Genetics. 2016, 10. Ermakov S, Martin LW, et al. The Associations of Leptin, Adiponectin and Resistin with Incident Atrial Fibrillation in Women. Heart. 2016, 9. Bien SA, Martin LW, et al. Strategies for Enriching Variant Coverage in Candidate Disease Loci on a Multiethnic Genotyping Array. PLOS 1:2016. Ryan AJ, Choi AD, Choi BG, Lewis JL. Breast Arterial Calcification Association with Coronary Artery Calcium Scoring and Implications for Cardiovascular Risk Assessment in Women. Clinical Cardiology. 2017 Apr 26.

PREVENTION

Dhawan T, Choi BG, Katz R. Diet and Nutrition Smartphone Apps Demonstrate Poor Adherence to the 2015-2020 Dietary Guidelines for Americans. American Heart Association Scientific Sessions. Featured abstract. Circulation. 134:A20780, 2016. Pokharel Y, Tang F, Jones PG, Nambi V, Bittner VA, Hira RS, Nasir K, Chan PS, Maddox TM, Oetgen WJ, Heidenreich PA, Borden WB, Spertus JA, Petersen LA, Ballantyne CM, Virani SS. Adoption of the 2013 American College of Cardiology/ American Heart Association Cholesterol Management Guideline in Cardiology Practices Nationwide. JAMA Cardiol. 2017 Mar 1. Okunrintemi V, Spatz ES, Di Capua P, Salami JA, Valero-Elizondo J, Warraich H, Virani SS, Blaha MJ, Blankstein R, Butt AA, Borden WB, Dharmarajan K, Ting H, Krumholz HM,

Nasir K. Patient-Provider Communication and Health Outcomes Among Individuals With Atherosclerotic Cardiovascular Disease in the United States: Medical Expenditure Panel Survey 2010 to 2013. Circ Cardiovasc Qual Outcomes. 2017 Apr 10. Liang J, Martin LW, et al. Single-Trait and Multi-Trait Genome-Wide Association Analyses Identify Novel Loci for Blood Pressure in African-Ancestry Populations. PLOS Genetics. 2017, 5. Mahmoodi BK, Martin LW, et al. Association of Traditional Cardiovascular Risk Factors with Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies. Circulation. 2017:1. Zubair N, Martin LW, et al. Fine-Mapping of Lipid Regions in Global Populations Discovers Ethnic-Specific Signals and Refines Previously Identified Lipid Loci. Human Molecular Genetics. 2016, 12.

DR. GURUSHER PANJRATH, DIRECTOR OF GW HEART FAILURE AND CIRCULATORY SUPPORT CLINICAL AND RESEARCH PROGRAMS.

Heart Failure Heart failure is the most common cause of hospitalization in the elderly. Under the leadership of Dr. Gurusher Panjrath, our GW faculty are addressing the challenges of heart failure across all ages. Our research addresses new approaches to disease management, reducing hospitalizations, and heart failure complications related to diabetes and cancer treatments. On a national and international level, Dr. Panjrath has been selected by the American College of Cardiology to be a key organizer and spokesman at major medical conferences focused on the latest developments in heart failure research.

HEART FAILURE

Kim J, Panjrath G, Parikh H, Young H, Choi BG, Lewis JF. Use of Handheld Ultrasound in Ambulatory Heart Failure Patients: Relationship to Clinical Assessment and Outcomes. Journal of the American Society of Echocardiography. 29(6): B113, 2016. Panjrath G, Al-Saleh Q, Bostrom L, Robie S, Baute S, Rhein M, Katz R. Community Health Workers Reduce Readmissions in a High Risk Heart Failure Population. J Am Coll Cardiol. 2016;67: 1434-1434. Mazhari R, Toma IV. Immunogenic Aspects of Stem Cell Therapy in Cardiovascular Diseases. MJHS. 2016.

Bradley SM, Hess G, Stewart P, Armstrong E, Farmer SA, Wasfy J, Valle J, Sandhu A, Maddox TM. Implications of the PEGASUS-TIMI 54 Trial for U.S. Clinical Practice. Open Heart. 2017; 4(1). Farmer, SA, S Magasi, P Block, MJ Whelen, LO Hansen, RO Bonow, P Schmidt, A Shah, KL Grady. Patient, Caregiver, and Physician Work in Heart Failure Disease Management: A Qualitative Study of Issues that Undermine Wellness. Mayo Clinic Proceedings. 2016, 91(8): 1056-1065. Panjrath G, Ahmed A. Diagnosis and Management of Heart Failure in Older Adults. Heart Fail Clin. 2017 Jul;13(3): 427- 444.

Jain D, Russell RR, Schwartz RG, Panjrath G, Abraham NG, Aronow W. Cardiac Complications of Cancer Therapy: Pathophysiology, Identification, Prevention Treatment and Future Directions. Current Cardiology Reports. 2017 May;19(5):36. Sheriff S, Thogaripally MR, Panjrath G, et al. Digoxin and 30-Day All-Cause Readmission in Long-Term Care Residents Hospitalized for Heart Failure. J Am Med Dir Assoc. 2017 May 11. pii: S15258610(17)30187-1. Sheriff H, Lam PH, Arundel C, Dooley DJ, Panjrath G, et al. Discharge Hospice Referral is Associated with Lower 30-Day All-Cause Readmission in Hospitalized Patients with Heart Failure: A PropensityMatched Study of the Medicare-Linked OPTIMIZE-HF. American Heart Association Scientific Sessions. 2016.

Deedwania P, Lam PH, Panjrath G, et al. Discharge Heart Rate and Outcomes in Hospitalized Patients with Heart Failure and Preserved Ejection Fraction (HFpEF) and Stable Admission-to-Discharge Heart Failure. American Heart Association Scientific Sessions. 2016. Silva Enciso, J., Sodhi, G, Panjrath G. Cardiac Allograft Rejection. In: Mountis M, Bogar L. Contemporary Heart Transplantation. 2017. Tracy C. The Do’s and Don’ts: Impact on HF Outcomes. Heart Rhythm Society Scientific Sessions. Chicago, IL, May 11, 2017. Katz R. Diabetes and Heart Failure. Annual American Diabetes Association Postgraduate Symposium. Feb 2017.

Panjrath G. Navigating Slippery Slope of Advanced Heart Failure. Heart Failure Society of American Scientific Session. Orlando, Sept 2016. Panjrath G. Readmission in Heart Failure: Questions Unanswered. American College of Cardiology Scientific Sessions. Mar 2017. Panjrath G. Treatment Strategies for End Stage Heart Failure: Medications, Machines and Everything in Between. American College of Cardiology Scientific Sessions, Mar 2017. Panjrath G. Biomarkers in Acute and Chronic Heart Failure. Taiwanese Society of Cardiology Scientific Sessions. Taipei, Taiwan, Mar 2017.

Young Investigator’s Award The GW Heart & Vascular Institute provides annual research awards to young cardiology faculty and fellows-in-training as seed money to initiate their research. These grants allow researchers to produce initial data with which they can apply for other competitive grants for further investigation and project expansion. In 2016, GW Cardiology Fellows Drs. Gurpreet Sodhi and Ju Kim were the Institute’s Young Investigator Pilot Research Award recipients. Under the mentorship of Dr. Gurusher Panjrath, Dr. Sodhi investigated Effects of Juvenile Idiopathic Inflammatory Myopathies (JIIM) on the Heart. This work advanced the growing field of cardio-rheumatology. Dr. Kim, mentored by Dr. Jannet Lewis, conducted a study Use of Handheld Ultrasound to Guide Diuretic Management in an Outpatient Heart Failure Clinic, which he presented at the 2017 Annual Scientific Sessions of the American Society of Echocardiography. In 2017, GW Cardiology Fellows Drs. Andrew Bradley and Kaitlin Baron won the Institute’s Young Investigator Pilot Research Award. Dr. Bradley, mentored by Dr. Andrew D. Choi, studied Cardiac Magnetic Resonance in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy, in collaboration with investigators from the Arai Lab at the National Institutes of Health. Dr. Bradley’s research evaluated how novel techniques in cardiac MR imaging can help identify those at highest risk for this rare and potentially fatal disease. This work was featured at the 2017 American College of Cardiology Scientific Sessions held TOP: FACULTY LEAD AUTHOR DR. ANDREW CHOI AND PRESENTING FELLOW DR. ANDREW

in Washington, DC.

BRADLEY PRESENTING RESEARCH AT THE 2017

Dr. Baron, mentored by Dr. Andrew D. Choi, and with investigators from the Dr. Marcus Chen’s Lab at the

ACC ANNUAL SCIENTIFIC SESSIONS.

National Institutes of Health, studied early onset coronary artery disease in young adults. Their research,

ABOVE: DR. LEWIS AND PRESENTING FELLOW

Atherosclerotic Burden in 21st Century Adults by Cardiac CTA: Is age 50 the Magic Number? was

DR. SODHI AT THE 2017 ACC ANNUAL SCIENTIFIC

presented as a featured abstract at the 12th Annual Scientific Meeting of the Society of Cardiovascular CT.

SESSIONS.

This work highlighted the need for preventive strategies at an earlier stage before developing a heart attack. The Dr. Cyrus Katzen Foundation has been an annual supporter of this program.

NATIONAL MEMBERSHIP AND LEADERSHIP APPOINTMENTS

WILLIAM BORDEN, MD

ANDREW CHOI, MD

RICHARD KATZ, MD

National Cardiovascular Data Registry PINNACLE Research & Publications Committee

National Committee Member, Society for Cardiac Computed Tomography

Editorial Board–British Journal of Cardiology

American Heart Association Executive Database Steering Committee

Corporate Development Committee, Society for Cardiovascular Computed Tomography

Member, American Heart Association Council on Quality of Care & Outcomes Research Leadership Committee Member, American Heart Association Consumer Health and Quality Coordinating Committee

Best Abstract Committee, Society of Cardiovascular CT BRIAN CHOI, MD

Member, American College of Cardiology Informatics and Health IT Task Force, 2017–2020

Member, Advisory Committee, AcademyHealth Concordium Conference

Director, RAD-AID International, 2015 – present

Associate Editor, Circulation: Cardiovascular Quality and Outcomes

STEVEN FARMER, MD, PhD

Member, American College of Cardiology Population Health Management Task Force Vice-Chair elect, American Heart Association Council on Quality of Care & Outcomes Research

Member, ACC Task Force on Population Health Management 2015 –2017 Member, ACC Task Force on MACRA 2015 –2017 Member, ACC PINNACLE Registry Research and Publications Subcommittee 2009 –2016 Member, AHA QCOR Conference Program Committee 2014 –2017 Member, AHA Writing Group: Impact of Registries Legislation on Statewide Systems of Care

JANNET LEWIS, MD

American College of Cardiology Board of Governors, Governor for DC LISA W. MARTIN, MD

Society for Vascular Ultrasound, Academic Subcommittee Preceptor Guidelines 2015 Maturitas 2016, Circulation/AHA 2015, Official Reviewer MARCO MERCADER, MD

Association of University of Puerto Rico Alumni and Friends Abroad, Excellence and Achievement Award: Health 2016 GURUSHER PANJRATH, MD

Co-Chair and Moderator, Fellows and Early Career Physicians in Heart Failure and Transplant Symposium, Annual Scientific Session, American College of Cardiology 20162017 Program Planning Committee Member, Annual Scientific Session 2017 Abstract Captain, Heart Failure, Annual Scientific Session 2017

Heart Failure (clinical), American College of Cardiology Scientific Session 2017

ALAN SOLOMON, MD

Academic Cardiology Section Leadership Committee, American College of Cardiology 2016

Chairman, Writing Group, American College of Cardiology, EP Lab Accreditation Project

Chair, Resource Working Group, Academic Cardiology Section Leadership, American College of Cardiology Chair Elect, Heart Failure and Transplantation Section, American College of Cardiology, 2017 Work Group Member, Heart Failure Tool Kit, American College of Cardiology, 2017 Program Planning Committee Member, Annual Scientific Session 2018 Abstract Captain, Heart Failure (clinical), American College of Cardiology Scientific Session 2018 Editorial Board, VAD Journal Editorial Board, Progress in Transplantation Editor, ACC Heart Failure Self-Assessment Program Editorial Board, ACC.org

NCDR Writing Committee, American College of Cardiology

CYNTHIA TRACY, MD

Co-Chair EP Advanced Training Life Long Learning Statement. American College of Cardiology Heart Rhythm Society 20172018 Scientific Sessions Program Committee Member

SELECTED RESEARCH INITIATED IN 2016 –2017

HEART RHYTHM DISORDERS

CARDIAC IMAGING

Solomon AJ. The role of NOAC’s in

Choi AD. "QFR" for the evaluation

TAVR patients with atrial fibrillation.

of the physiologic significance of