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– an American Red Cross app for dog owners with illustrations and videos about dog emergencies such as falls, burns and seizures. nimal Poison Control Center –a searchable database to determine whether something that has been consumed is cause

– the app is connected to a fitness monitor which tracks your dog’s fitness and

– it can access an entire medical history for your dog and give a reminder when your dog is due to have any

Help your pet get around better by enhancing their comfort and vision by placing a couple of drops into their eyes daily

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Note: US$ prices are subject to shipping and handling (and additional taxes where appropriate).

Disclaimer: All educational information is provided under the IAS terms and conditions (which may change without notice) and does not replace the advice of your physician. Restrictions may apply in some countries.

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Yes, it’s possible to take too much niacinamide! I really like working with engineers with their health concerns, as engineers are very meticulous. Over three decades ago, I told an engineer suffering from osteoarthritis about Dr. Kaufman’s work, advised him to follow Dr. Kaufman’s recommendation about taking one gram of niacinamide thrice daily. He asked if Dr. Kaufman ever reported adverse or overdose effects; I told him that Dr. Kaufman told us that ‘low-grade nausea’ was and is an indicator of too much niacinamide for that person. Didn’t see him again for several months when he came in about another health concern, but first reported that his joint pain had been completely gone for several months. However, after three weeks he started having a little ‘low-grade’ nausea, so he decided to continue since his pain was much less. However, he also reported that the low-grade nausea got a bit worse and cause him to “barf into the toilet” twice before he cut the dose back to a total of 2500 milligrams a day, which was not associated with any nausea, so he decided to stay at that quantity, particularly as he reported his overall energy levels were much improved from what they were before he first started the niacinamide. He has continued the lower quantity with no other problems; the osteoarthritis pain remains gone.

Other functions

In 1979, an article titled; Nicotinamide is a brain constituent with benzodiazepine like actions was published (15) by the pharmaceutical research department of F. HoffmanLa Roche & Company, Ltd.

‘Benzodiazepines’ is the fancy pharmaceutical company word for the patented medicines Librium®, Valium®, and other tranquilizers. Of course, being pharmaceutical company employees, they “got it exactly backward.”

Since niacinamide has been present in humans and animals for as long as humans and animals have been on planet Earth, a more accurate title would have bee; Benzodiazepines are patented artificial molecules with niacinamide-mimetic activity. Mimetic (meaning mimicking, but not exactly duplicating) is the most accurate description for the activity of these un-natural molecules.

As soon as this 1979 article was published, any physician who really is striving for the best health effects, (with of course minimal if any adverse effects) should have switched all their Librium®, Valium® or other un-natural patent medicine medication treatments to Nature’s original molecular substancenicotinamide!

Even in 2022, these un-natural patent medications are still recommended by some physicians instead of Nature’s molecule, niacinamide.

Remember, too much niacinamide for any one person results in low-grade nausea which always means having to cut back the dose to the 24-hour total that does not cause any nausea.

Conclusion; niacinamide and aging

As you’ve likely assumed already, the older we are, the more we need to take the maximum daily 24-hour quantity of niacinamide so we can energize our bodies as much we can every day, without causing lowgrade nausea. Of course, some (but not all) of us can make enough niacinamide in our own bodies when we’re younger, but as we grow older, we’re likely to internally synthesize less

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References:

1. Springer International Publishing Switzerland. 2015.

2. Van Zant F, et al. Normal Range of Acidity from Youth to Old Age. Archives of Internal Medicine 1932;49(3):345.

3. Xiang A, et al. Association of Maternal Diabetes with Autism in Offspring. JAMA 2015;313(14):14251434.

4. https://www.webmd.com/diabetes/gestational diabetes-guide/ what-causes-gestational diabetes #1

5. https://www.diabetes.org/diabetes/gestationaldiabetes/ how-to-treat-gestational-diabetes and less niacinamide with time; I have seen reports of zero, and near zero in ‘older’ individuals. But no, I am not going to write that niacinamide is a ‘longevity’ molecule, (there’s so-far no research reporting that) but it is an energizing molecule at all ages, particularly as we all get older.

6. Kotake Y, Ueda T, et al. The Physiological Significance of the Xanthurenic Acid-Insulin Complex. J Biochem. 1975;77:685-687.

7. Bennink HJ, Schreurs WH. Improvement of oral glucose tolerance in gestational diabetes by pyridoxine. Br Med J. 1975 Jul 5;3(5974):13-5.

8. Spellacy WN, Buhi WC, Birk SA. Vitamin B6 treatment of gestational diabetes mellitus: Studies of blood glucose and plasma insulin. Am J Ob Gyn 1977;127(6):599-602.

9. Sprince H, Lowy RS, et al. Studies on the urinary excretion of “xanthurenic acid” during normal and abnormal pregnancy: A survey of the excretion of “xanthurenic acid” in normal nonpregnant, normal pregnant, pre-eclamptic, and eclamptic women. Am J Obstet Gyn. 1951;62:84.

10. Vandelli, I. The use of vitamin B. (pyridoxine) for suppressing the elimination of xanthurenic acid in pregnant and non-pregnant women following the oral intake of a measured quantity of tryptophan. Acta vitamin. (Milano) 1951;5:55.

11. Wachstein M, Gudaitis A. Disturbance of vitamin B6 metabolism in pregnancy. II. The influence of various amounts of pyridoxine hydrochloride upon the abnormal tryptophane load test in pregnant women. J Lab Clin Med. 1953;42:98.

12. Wachstein M, Lobel S. Abnormal tryptophan metabolites in human pregnancy and their relation to deranged vitamin B, metabolism. Proc Soc Exp Biol (N.Y.) 1954;86:624.

13. Brown RR, Thornton MJ, Price JM. The Effect of Vitamin Supplementation on the Urinary Excretion of Tryptophan Metabolites by Pregnant Women. J Clin Invest. 1961.

14. Ren S-G, Melmed S. Pyridoxal Phosphate Inhibits Pituitary Cell Proliferation and Hormone Secretion. Endocrinology. 2006;147(8):39363942.

15. Mohler H, Polc, Cumin, et al. Nicotinamide is a brain constituent with benzodiazepine like actions. Nature. Vol 278. 5 April 1979.

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