Narcolepsy - Pipeline Review, H2 2015 Is Released Narcolepsy - Pipeline Review, H2 2015 Summary Global Markets Direct s, Narcolepsy - Pipeline Review, H2 2015, provides an overview of the Narcolepsys therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Narcolepsy, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases. It also reviews key players involved in the therapeutic development for Narcolepsy and special features on late-stage and discontinued projects. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Direct s team. Drug profiles/records featured in the report undergoes periodic updation following a stringent set of processes that ensures that all the profiles are updated with the latest set of information. Additionally, processes including live news & deals tracking, browser based alert-box and clinical trials registries tracking ensure that the most recent developments are captured on a real time basis. The report enhances decision making capabilities and help to create effective counter strategies to gain competitive advantage. It strengthens R&D pipelines by identifying new targets and MOAs to produce first-in-class and best-in-class products. Note*: Certain sections in the report may be removed or altered based on the availability and relevance of data for the indicated disease. Scope - The report provides a snapshot of the global therapeutic landscape of Narcolepsy - The report reviews key pipeline products under drug profile section which includes, product description, MoA and R&D brief, licensing and collaboration details & other developmental activities - The report reviews key players involved in the therapeutics development for Narcolepsy and enlists all their major and minor projects - The report summarizes all the dormant and discontinued pipeline projects - A review of the Narcolepsy products under development by companies and universities/research institutes based on information derived from company and industry-specific sources - Pipeline products coverage based on various stages of development ranging from pre-registration till discovery and undisclosed stages - A detailed assessment of monotherapy and combination therapy pipeline projects - Coverage of the Narcolepsy pipeline on the basis of target, MoA, route of administration and molecule type - Latest news and deals relating related to pipeline products Reasons to buy - Provides strategically significant competitor information, analysis, and insights to formulate effective R&D development strategies - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage - Develop strategic initiatives by understanding the focus areas of leading companies Identify and understand important and diverse types of therapeutics under development for Narcolepsy - Plan mergers and acquisitions effectively by identifying key players of the most promising pipeline Devise corrective measures for pipeline projects by understanding Narcolepsy pipeline depth and focus of Indication therapeutics - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope - Modify the therapeutic portfolio by identifying discontinued projects and understanding the factors that drove them from pipeline.
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Introduction 6 Global Markets Direct Report Coverage 6 Narcolepsy Overview 7 Therapeutics Development 8 Pipeline Products for Narcolepsy - Overview 8 Pipeline Products for Narcolepsy - Comparative Analysis 9 Narcolepsy - Therapeutics under Development by Companies 10 Narcolepsy - Therapeutics under Investigation by Universities/Institutes 11 Narcolepsy - Pipeline Products Glance 12 Late Stage Products 12 Clinical Stage Products 13 Early Stage Products 14 Narcolepsy - Products under Development by Companies 15 Narcolepsy - Products under Investigation by Universities/Institutes 16 Narcolepsy - Companies Involved in Therapeutics Development 17 Bioprojet SCR 17 Evotec AG 18 Flamel Technologies S.A. 19 Grupo Ferrer Internacional, S.A. 20 Jazz Pharmaceuticals Plc 21 Sanofi 22 SK Biopharmaceuticals Co., Ltd. 23 2
Taisho Pharmaceutical Holdings Co., Ltd. 24 Theranexus SAS 25 Narcolepsy - Therapeutics Assessment 26 Assessment by Monotherapy Products 26 Assessment by Combination Products 27 Assessment by Target 28 Assessment by Mechanism of Action 30 Assessment by Route of Administration 32 Assessment by Molecule Type 33 Drug Profiles 34 (modafinil + THN-02) - Drug Profile 34 Product Description 34 Mechanism of Action 34 R&D Progress 34 arbaclofen - Drug Profile 36 Product Description 36 Mechanism of Action 36 R&D Progress 36 BTD-001 - Drug Profile 37 Product Description 37 Mechanism of Action 37 R&D Progress 37 Drugs to Agonize Orexin Receptor for Narcolepsy - Drug Profile 39 Product Description 39 Mechanism of Action 39 R&D Progress 39
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EVT-501 - Drug Profile 40 Product Description 40 Mechanism of Action 40 R&D Progress 40 JZP-386 - Drug Profile 41 Product Description 41 Mechanism of Action 41 R&D Progress 41 pitolisant - Drug Profile 42 Product Description 42 Mechanism of Action 42 R&D Progress 42 SAR-110068 - Drug Profile 44 Product Description 44 Mechanism of Action 44 R&D Progress 44 SKL-N05 - Drug Profile 45 Product Description 45 Mechanism of Action 45 R&D Progress 45 Small Molecules to Agonize Orexin Receptor 2 for Insomnia - Drug Profile 47 Product Description 47 Mechanism of Action 47 R&D Progress 47 Small Molecules to Agonize Orexin Receptor for Narcolepsy and EDS - Drug Profile 48 Product Description 48 Mechanism of Action 48 4
R&D Progress 48 Small Molecules to Inhibit Dopamine Transporter for CNS and Metabolic Disorders - Drug Profile 49 Product Description 49 Mechanism of Action 49 R&D Progress 49 sodium oxybate - Drug Profile 50 Product Description 50 Mechanism of Action 50 R&D Progress 50 sodium oxybate - Drug Profile 52 Product Description 52 Mechanism of Action 52 R&D Progress 52 TS-091 - Drug Profile 53 Product Description 53 Mechanism of Action 53 R&D Progress 53 Narcolepsy - Recent Pipeline Updates 54 Narcolepsy - Dormant Projects 58 Narcolepsy - Discontinued Products 59 Narcolepsy - Product Development Milestones 60 Featured News & Press Releases 60 Nov 20, 2015: Narcolepsy treatment recommended for approval 60 Jul 15, 2015: Theranexus Success of phase 1 trial on the safety of a new treatment of narcolepsy and launch of efficacy studies 60 Jun 04, 2015: Jazz Pharmaceuticals to Present Abstracts from Ongoing Evaluations of Xyrem(sodium oxybate) at SLEEP 2015 61
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May 07, 2015: Jazz Pharmaceuticals and Concert Pharmaceuticals Provide JZP-386 Program Update 62 Dec 19, 2014: Flamel Technologies Announces Positive Results of a Second Clinical Trial with Micropump Sodium Oxybate 62 Dec 09, 2014: Jazz Pharmaceuticals and Concert Pharmaceuticals Provide JZP-386 Program Update 63 Dec 02, 2014: Jazz Pharmaceuticals Announces First Patients Enrolled in Phase 3 Trial of Xyrem (Sodium Oxybate) In Children and Adolescents Who Have Narcolepsy with Cataplexy 64 Jul 21, 2014: Jazz Pharmaceuticals and Concert Pharmaceuticals Provide a Phase 1 Clinical Trial Update on JZP-386 64 Jun 02, 2014: Jazz Pharmaceuticals Presents JZP-110 Phase 2b Data for the Treatment of EDS Symptoms In Adults With Narcolepsy 65 May 27, 2014: Jazz Pharmaceuticals to Present Data On Compound In Sleep Pipeline During APSS Annual SLEEP Meeting 66 Appendix 67 Methodology 67 Coverage 67 Secondary Research 67 Primary Research 67 Expert Panel Validation 67 Contact Us 67 Disclaimer 68
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