THE NEW FACE OF POLYCAPROLACTONE:

from PRIME July/August 2023

The latest product news and technologies for the aesthetic and anti-ageing market dermamelan®

Gouri

Anti-ageing specialist Dr. Katarzyna Grudzień shares why deep skin rejuvenation treatment GOURI has become the treatment of choice in her practice

GOURI HAS BEEN clinically applied as an injectable for tissue augmentation, but it also functions as a skin tissue stimulator. It debuted in Europe as liquid polycaprolactone and found its use as a skin-firming, smoothening, and rejuvenating agent.

All the currently available injectables present an evolutionary continuum, starting with collagen, through non-cross-linked hyaluronic acid as well as cross-linked, to collagen stimulators. This advancement has resulted in increased product safety, cosmetic effect magnitude, and durability. The latest step in the development was made by utilising the CESABP (Collagenesis-Enabled Solubilised Active and Biodegradable Polymer) technology, which provided the means to create the first fully liquid collagen stimulator, making the treatment even more safe and easy.

Most collagen stimulators face limitations posed by PCL or PLLA-based compounds enclosed in 25-50 μm microspheres, the size of which allows these chemicals to avoid phagocytosis and short-term biodegradation in order to induce long-term collagen production. This solution comes with its own set of challenges: it is unavoidable that different-size particles move unevenly under the pressure exerted by the syringe plunger, sometimes clogging the lumen of the injection needle. Furthermore, such products need to be painstakingly massaged into the tissues to assure their even spread, otherwise an injection can result in long-term lumps. A rare, but serious adverse effect of occlusion, induced by damaging the endothelium of adjacent blood vessels, is also a potential risk to remember when using products like this.

What makes Gouri stand apart from its competitors are its:

■ Contents ready-to-use fully solubilised polycaprolactone

■ Effect mostly long-term dermal rejuvenation

■ Application liquid form allows the injector to cover large areas of skin with minimum effort

■ The time when the effect begins to be visible about 2 weeks post-treatment

■ Safety maximised, no serious adverse effects reported up to date.

Before conducting the Gouri treatment, two important points need to be communicated to the patient. Firstly, before the injection, the patient needs to take Cetirizine (an H1 receptor blocker) 0.5–1 hr beforehand. Secondly, the patient needs to avoid exposure to heat, sun, water, and alcohol ingestion for at least 24 hours following the procedure.

The protocol for injecting Gouri is quite intuitive and easily replicable. General guidelines state that our injection target is the deep dermis. Injections are retrograde linear using a cannula. Most patients get great results with just one treatment, but if necessary, 1–2 additional treatments 3–6 months apart can be applied.

Gouri is a truly innovative product, characterised by its increased safety of use and far better cosmetic outcomes in skin rejuvenation. It requires a sort of diligence on the operator’s part and the patient’s engagement in the treatment process, but it rewards these qualities by exerting a tremendous reversal effect to the senescence-process.

For more, visit: gorgeousgouri.com