ABSTRACT & COMMENTARY
Endocrine and Nutritional Relationships in Centenarians Results from a retrospective cohort study REFERENCE
Fu S, Ping P, Li Y, et al. Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females. J Transl Med. 2021;19(1):436. STUDY OBJECTIVE
This study was implemented to explore the links among sex hormones, bone turnover, abdominal obesity, nutritional status, and centenarian longevity in the oldest females, comparing those aged more than 100 years to those younger. DESIGN
Retrospective cohort study using data collected from the China Hainan Centenarian Cohort Study. PARTICIPANTS
Five hundred centenarian females and 237 females aged 80 to 99 years Inclusion criteria: (1) Participants were aged at least 80 years old; (2) Participants volunteered to join the study with written informed consent; (3) Participants were conscious and were able to complete home interviews, physical examinations, and blood analyses. Exclusion criteria: If personal identity information was incomplete; identification cards showed an age of less than 80 years; or participants refused to comply with study requirements, including the collection of blood samples. No participants received vitamin D, exogenous steroids, or other treatments that could affect their sex hormones and bone turnover. No centenarians with oophorectomies participated in the current study. STUDY PARAMETERS ASSESSED
• Geriatric nutritional risk index
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Lorinda Sorensen, ND, LAc Tessaundra Sidden, ND Candidate
PRIMARY OUTCOME MEASURES
• Nutritional status
• Abdominal obesity • Sex hormones • Bone turnover KEY FINDINGS
There were lower levels of height, weight, waist circumference, serum albumin, and geriatric nutritional risk index (P<0.05 for all) in oldest female participants compared to females aged 80 to 99 years. Abdominal obesity was lower in the oldest of old compared to those aged 80 to 99 years (P<0.05). Centenarian females had lower levels of FSH and higher levels of PRL, progesterone, and estradiol compared to females aged 80 to 99 years (P<0.05 for all). The oldest of old females had higher levels of osteocalcin, Beta-CrossLaps, and PTH and greatly decreased levels of 25(OH)D3 than females aged 80 to 99 years (P<0.05 for all). Geriatric nutritional risk index had an inverse relationship with LH, FSH, progesterone, estradiol, osteocalcin, Beta-CrossLaps, and PTH (P<0.05 for all). Abdominal obesity had an inverse relationship with LH, FSH, osteocalcin, Beta-CrossLaps, and 25(OH)D3 (P<0.05 for all). LH levels had a positive relationship with osteocalcin, Beta-CrossLaps, and PTH. It had a significant inverse relationship with 25(OH)D3 (P<0.05 for all).
• Abdominal obesity
FSH levels had a positive relationship with osteocalcin, Beta-CrossLaps, and PTH (P<0.05 for all).
• Prolactin (PRL), progesterone, estradiol, follicle-stimulating hormone (FSH), luteinizing hormone (LH)
Progesterone levels had a positive association with osteocalcin and Beta-CrossLaps (P<0.05 for all).
• Osteocalcin, Beta-CrossLaps, parathyroid 25-hydroxycholecalciferol D3 (25(OH)D3)
Estradiol levels had a positive relationship with Beta-CrossLaps but a negative relationship with 25(OH)D3 (P<0.05 for all).
hormone,
©2022 NATURAL MEDICINE JOURNAL. ALL RIGHTS RESERVED. NMJ, MAY 2022 SUPPLEMENT—VOL. 14, NO. 51 (SUPPL)
