PHARMA PULSE

EXPLOTAB® is Sodium starch glycolate manufactured using Ethanol as a solvent available in grades as below

Brand name Compendial type pH value

Main application

EXPLOTAB® A 5.5-7.5 Superdisintegrant with rapid and high degree of swelling for tablet and capsule formulations. Especiallyfor poor water soluble actives and tablet matrices with higher pH values.

EXPLOTAB® CLV A 5.5-7.5 Special grade with increased number of crosslinkings.Especially suited for wet granulation applications.

EXPLOTAB® lowPH B 3.0-5.0 Special grade with low pH value.

VIVASTAR® is Sodium starch glycolate manufactured using Methanol as a solvent available in grades as below Brand name mulation ingredients and disrupting the tablet matrix. In capsules, the rapid and extreme swelling expels the contents to promote API release. 3

Importance of settling volume

A higher settling volume binds more disintegration energy. This leads to lower disintegration forces and longer disintegration times. EXPLOTAB® shows lower settling volume. Further, it shows better crosslinking leading to high disintegration force. 3

Formulation advice

1) EXPLOTAB® is normally used at a level of two-to-four per cent of the tableting mass. It is suitable for all tableting processes.

VIVASTAR® P A 5.5-7.5 Superdisintegrant with rapid and high degree of swelling for tablet and capsule formulations. Especiallyfor poor water-soluble actives. VIVASTAR® PSF A 5.5-7.5 Special grade with low methanol content. Especiallysuitable for alcohol and moisturesensitive actives.

Swelling of EXPLOTAB® EXPLOTAB® swells upon contact with media. It absorbs water and expands significantly, thereby rapidly pushing against the other for-

2) In wet granulation formulations, EXPLOTAB® can be used both intra-granular, extra-granular or both. When used in intragranular, it absorbs some of the granulation fluid. The potential formation of lumps by the active or other ingredients is minimised. 3

P 1000 SF A 5.5-7.5 Low/medium/ high-viscositygrade superdisintegrants forming translucent gels in water.

VIVASTAR® P 3500 A 5.5-7.5

VIVASTAR® P 5000 A 5.5-7.5

References

1) Daniel.M, Zeitler.A, A Review of disintegration mechanism and techniques. Pharmaceutical Research 32 (2017) 890–891

2) Comprehensive analysis into disintegration mechanisms: How reliable are textbook recommendations? Emily Sabath JRS Pharma.

3) https://www.jrs.eu/pharmawAssets/docs/brochures/br-explotab-prospekt.pdf

4) https://www.jrspharma.com/ pharma_en/media-library/data /explotab.php

Author Suyesh Kale Technical Manager, JRS Pharma India

Email: Suyesh.kale@jrsindia.com

EXPRESS PHARMA 55

4) https://www.jrspharma.com/ pharma-wAssets/docs/ brochures/vivapur-mcg.pdf February2023