Modern Pharmaceuticals - 16-31 July 2012 by Infomedia18

16-31 July 2012 I Vol 1 I No 2 I `100

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In Conversation With 14

Special Focus 15

Interface 17

Policies & Regulations 20

Bhavesh Patel MD, Marck Biosciences Ltd

Strategies of pharma HR Recruiting and retaining the right talent

E Balaji MD & CEO, Randstad India

Central Drugs Standard Control Organization Needs an overhaul

Agila enters Canadian market AGILA Specialties Pharma Corporation, Canada, a part of Strides Arcolab, has formed a Joint Venture (JV) with Jamp Pharma to introduce a variety of quality injectable generic drugs in Canada. This sales and marketing joint venture will operate under the name ‘Agila-Jamp Canada Inc’ in which Agila will hold 70 per cent stake and the remaining 30 per cent by Jamp Pharma. Agila-Jamp will be launching around 40 products in the next 2 years.

Mylan sues Warner Chilcott, Mayne Pharma over Doryx MYLAN Pharmaceuticals Inc sued Warner Chilcott Plc and Australiabased Mayne Pharma Group Ltd alleging that they tried to restrict generic competition to their acne drug Doryx. Warner Chilcott and Mayne made minor changes with no therapeutic benefit to Doryx to delay approval of competing generic versions of the drug, Mylan said in the lawsuit.

DRL launches ibandronate sodium tablets in US DR Reddy’s Laboratories launched ibandronate sodium tablets (150 mg), a bioequivalent generic version of Boniva tablets, in the US market. The company has launched ibandronate sodium tablets following an approval by the US FDAof Dr Reddy’s ANDA for Ibandronate sodium tablets.

Chelsea to implement corporate reorganisation CHELSEA Therapeutics International, Ltd’s Board of Directors plans to implement a corporate reorganisation that includes a reduction in force, executive changes and changes to the company’s Board of Directors, and has authorised a plan to explore and evaluate strategic options for the company; with the goal of optimising long-term stockholder value.

Ranbaxy to boost biosimilars business RANBAXY Laboratories Ltd will soon launch at least three copies of biotech medicines in India by 2015, mostly to treat cancer, and needs to develop such high-tech drugs to remain a serious player in the global generics business, stated Arun Sawhney, CEO, Ranbaxy. The company’s goal is to seek initial approval for all the drugs in India and then seek approval within four to five years in Europe and the United States.

AIOCD to support market-based pricing formula THE All India Organisation of Chemists and Druggists (AIOCD) has welcomed the Government’s draft proposal to move away from cost-based pricing to market-based drug pricing policy saying that it will best address patient needs and balance industry growth. It however said the proposal can be further strengthened if the Weighted Average Price (WAP) of all the brands formula is taken rather than taking WAP of top three selling brands as mentioned in the proposal. Commenting on this, J S Shinde, President, AIOCD, said, “At a time when the Indian pharma industry is facing challenges on multiple fronts, the WAP of all brands formula will result in greater impact on the industry in comparison to the WAP of top three brands formula proposed in the draft NPPP 2011 to best meet access, affordability, innovation and quality needs of patients.” Elaborating he added, “WAP of all brands formula takes in to account almost 90 per cent of the cumulative market share under price control by value in comparison to around 60 per cent taken into account by WAP of top three brands. WAP of all brands formula will result in more patient savings on National List of Essential Medicines (NLEM)

Shinde

formulations than the WAP of top three brands formula.” He further added that while WAP is being calculated on top three brands the price reduction is 8 per cent and if all the brands are considered then the reduction is 13 per cent. He suggested that the prices of the drugs must be arranged in descending order and median of the prices should be calculated. Shinde believes that pharma companies are also following market-based strategy. Over the last 2 decades, patients in India have suffered on account of the non-transparent and complicated cost-based pricing regime (DPCO,

Government keen to double exports in 5 years RECENTLY Anand Sharma, Union Minister of Commerce, Industry and Textile, chaired the first meeting of Consultative Group on pharmaceutical exports. Sharma highlighted that it was the entry of Indian generic medicines in the global supply chain that started an ethical debate worldwide between generics versus patented drugs, and ultimately the right of every citizen to access affordable quality medicines were Dr Jain upheld. The minister also apprised that substantial opportunities exist for Indian pharma industry in emerging economies like Russia, Africa and South America. He assured that the industry captains that the Government will take up the non-tariff barriers being mounted by US as also EU against Indian

pharma industry in bilateral forums at appropriate levels. Dr Rajesh Jain, Joint MD, Panacea Biotec Ltd, who was also present at the forum, said, “The Government of India is serious and shows its commitment to develop exports in the next 5 years. The companies wanted the support of Government in order to realise this.” He added that the companies demanded faster regulatory system, adequate infrastructural support, and removal of unnecessary steps in the application process. He further highlighted that the outhouse clinical trial should be part of R&D tax deduction and the benefit of tax deduction should be after Minimum Alternate Tax (MAT). - Chandreyee Bhaumik

1995), which has hampered patient access to essential medicines. Shinde stated that out of 74 drugs in DPCO 95, 26 are out of market and share of 48 have shrunk in sales. And thus, the patients are genuinely suffering. Discussing the Government of India’s reaction to this, Ameesh Masurekar, Director, AIOCD AWACS, said that the Government of India is deliberately delaying the whole process. Therefore, the association is of the opinion that market-based pricing would balance patient as well as industry interests, and prevent formulations going off the market on account of an unviable manufacturing environment as happened during costbased pricing regime. It would also facilitate an environment that would attract more players to the market, further intensifying competition and provide more options to patients. Further, the association suggested that non-essential strengths, dosages and combinations not specifically listed in the NLEM 2011 be not included in the scope of the policy as such a move would burden the industry and stifle growth and adversely impact availability of essential medicines. - Chandreyee Bhaumik

InnoPack India 2012, to be held in Mumbai CPHI Conferences is launching InnoPack India 2012, which will take place during 11-13 September at the Holiday Inn Hotel, Mumbai. It is a strategic initiative focusing on the critical issues pertaining to pharma packaging. This event will cover an array of issues like innovative packaging materials to effectively comply with international standards, anti-counterfeiting measures, 2D bar-coding implementation, quality and cost control measures under primary, secondary and tertiary packaging and will provide solutions to comply with the regulatory protocols, safeguard your drug and enhance patient care. With eminent speakers such as Edward Dunn, Senior Director, Packaging Technology; William Bosley, Senior Labelling Specialist, Watson Pharmaceuticals; Prabir Das, Vice President Packaging Development, Mylan, etc already on board, InnoPack India 2012 will bring together 80+ heads of packaging development and packaging R&D from pharma manufacturers, and will provide practical take-aways to develop innovative, intelligent, integrated and cost-effective packaging solutions.

Modern Pharma•16-31 July 2012

CONTENTS In Conversation With

Bhavesh Patel MD, Marck Biosciences Ltd

Special Focus

HR in Pharma Strategies of pharma HR Recruiting and retaining the right talent

15 16

IT in transactional HR functions Providing a structured framework

Interface E Balaji MD & CEO, Randstad India

Pradeep Vaishnav Senior Director- Human Resources, India and South Asia, Sanofi

Facility Visit

Karnavati Engineering Pvt Ltd Pharma manufacturing with a panache

FOUNDER & EDITOR, NETWORK 18 Raghav Bahl PRESIDENT & EDITORIAL DIRECTOR, TV 18 Senthil Chengalvarayan SENIOR EDITOR Manas R Bastia

Insight & Outlook

FEATURES EDITOR Arshia Khan

Policies & Regulations Central Drugs Standard Control Organization Needs an overhaul

EDITORIAL TEAM Chandreyee Bhaumik, Parita Dholakia, Shibani Shah, Hemantraj Ratnakumar, Jasleen Kaur Batra (Bengaluru) ASSISTANT ART DIRECTOR Varuna Naik DESIGN Sachin Bhogate

Strategy Medical practioners Does your clinical meeting make a ‘point’?

REGULAR SECTIONS 05 Editorial / Guest Editorial 24 Event List 06 News, Views & Analysis

25 Book Review

22 Technology Transfer

26 Products

23 Tenders

28 Marketplace

23 Projects

30 List of Products & Advertisers

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Modern Pharma•16-31 July 2012

Editorial

PPP: Perfect path to progress? f late, price control of pharmaceuticals in India has publicly been one of the most contentious issues. So much so, it affects all the stakeholders of this crucial sector – right from producers to consumers and policy makers to distributors/retailers. While it is essential to have an ‘inclusive’ growth of this sector by ensuring affordability, availability and accessibility of medicines for the millions of citizens, the right formula to have ‘satisfactory’ price control over pharma products in the domestic market still remains elusive. Perhaps the time is now ripe to solve this riddle by factoring in all possible variables required for this ‘formulation’ rather than having the conventional cost-based and/or market-based models. Some of the additional parameters can be investment in pharma R&D, logistics and distribution, among others. Since pharmaceuticals and healthcare are part of the same value chain, it will be apt to closely analyse some of the recent figures in the latter and more importantly, contribution of its two key spending segments. The public sector in India accounts for a meagre 20 per cent of the total healthcare expenditure, ie, only 1 per cent of the GDP, which is among the lowest in the world. The share of private sector, at the same time, in healthcare expenditure of the country is as high as 80 per cent, which is among the highest in the world. To achieve the much needed

Editorial Advisory Board Ajit Singh Chairman, ACG Worldwide & Head, ISPE

Dr Abraham Patani Past President, IDMA & CMD, Inga Laboratories

Dr Gopakumar G Nair IPR Consultant & Advisor

Dilip G Shah Chairman, IGPA & Secretary General, IPA

Daara Patel Secretary General, IDMA

scale-up in Indian healthcare, a pragmatic approach calls for joining of hands by both the public and private sectors through Public Private Partnership (PPP) rather than trying individually to tackle this imminent challenge of enormous proportion. With fast changing socio-economic mix in India as well as the predominant disease patterns, the role of the government is also seeing a radical shift from being a provider to a payer of healthcare services. Amid this, to have a sustainable, standardised and well-integrated PPP model in pharma & healthcare, the country needs to have a single, unified and futuristic accreditation/regulatory framework in place, with a clear mandate of 3 Ps (People, Processes and Performance). Easier said than done, the key to success in such PPP projects will lie in effectively managing the interests of all stakeholders across different welldefined roles. Before signing off, our heartfelt thanks to all our readers who have promptly shared their valued feedback. During these early days of brand new Modern Pharma, such responses will further aid our endeavour to better serve the sector. Looking forward to more such interactions!

Manas R Bastia manas@infomedia18.in

Guest Editorial

Consumer backed authentication: Protecting brands globally n the 21st century, technology and computer systems play an integral part of everyday human life. Technology is being harnessed not only to improve the wellbeing of people, but to protect and save lives. IT systems make information more accessible to patients and provide consumers ways to take greater control of their health and livelihood. In an effort to curb the multi-billion dollar global counterfeit trade market, there are solutions that empower consumers to ensure the genuineness of their products through a simple text message. Although such solutions work for any tangible good, including pharmaceutical products (medicine), automotive parts, agrochemicals, food and beverage, and even handbags, efforts are focussed on combating counterfeit medicines. The pharmaceutical industry is particularly vulnerable to counterfeiting, and it can be quite dangerous and even fatal to consumers. In developing countries, the problem of counterfeiting important goods is exacerbated by weak regulatory oversight and high levels of illiteracy. In addition, counterfeit drugs cause further devastation in areas where diseases such as malaria, diabetes, AIDS and

tuberculosis are rampant, since people do not receive proper medications. Globally, over 700,000 people per year are estimated to die from fake tuberculosis and malaria drugs alone. We will not trick you into thinking that there’s one ‘silver bullet’ technology to stop counterfeit trade. It is a complicated problem that requires multiple layers of interventions; both socioeconomic remedies and technology-based solutions. Consumer backed authentication caters for track and trace across the entire supply chain, there is still a need for chemical tests at ports and borders, frequent factory quality control inspections and post-market surveillance to detect sub-standard drugs due to mishandling. These chemical tests are typically costly and it is hard to get such testing centers to all corners of large developing nations. However, consumers are everywhere, and they are a vigilant force that could be leveraged effectively (with the right tools) in the fight against counterfeits. With the explosive growth in mobile phone access in the developing world, it makes a lot of sense to use a participatory, ‘grass roots’ technology that is prevalent in such resourcechallenged environments.

The easy-to use, easy-tounderstand consumer backed authentication works right at the consumer level, and takes only a few seconds to use. Immediately after purchasing a product, consumers will find a label on the package that they can scratchoff to reveal a one-time use, item specific code. Then, they text the code to secure phone number and receive a message confirming that the product is authentic or warning that it may be counterfeit. Along with protecting their consumers from harmful replicas of their products and increasing profits once lost to counterfeiters, brand owners can gain valuable market intelligence through the proprietary online client portal. In various countries, initial efforts to tackle counterfeiting have already begun. In India, the Directorate General Foreign Trade (DGFT) has initiated an action of mass serialisation to protect ‘Brand India.’ However, there is much confusion and apprehension in the industry on whether mass serialisation alone can provide a foolproof solution against counterfeiting. Dr Ashifi Gogo Chief Executive Officer, Sproxil Inc

Modern Pharma•16-31 July 2012

News, Views & Analysis

Poonawalla Group to invest over 70 - 80 million over the next 3 years Group is committed to SERUM Institute of India, investing over the flagship company of the 70 - 80 over $ 1 billion Poonawalla million over the next Group has announced the 3 years to augment the acquisition of Bilthoven infrastructure and enhance Biologicals, Netherlands. the manufacturing capacity Through the acquisition, of the Bilthoven’s facilities. Serum will get access to Serum Institute has one of the technology and expertise for world’s largest vaccine making the injectable polio manufacturing facilities L-R: Adar Poonawalla and Dr Cyrus Poonawalla vaccine (Salk). A unique with the Health Minister of The Netherlands, at Pune, India and with capability and expertise Her Excellency Edith Schippers this second manufacturing that is currently possessed facility based in Europe, by a mere three other vaccine 35 years. Bilthoven Biologicals the company aims to access the manufacturing plants globally. was owned by the Government developed markets of Europe and This first overseas acquisition by of Netherlands. Serum the US for its existing and future the Poonawalla Group will also Institute of India (Cyrus products in the pipeline.” He provide the Group and Serum Poonawalla Group) has acquired added, “It was for the technology an important manufacturing base 100 per cent shares of the and base in Europe for us to make in Europe, along with access to company from the Government our products there and use at as a the important European and the of Netherlands. base for Europe. Serum produces US markets. Serum Institute, Elaborating on this, Adar almost a billion doses every year the Group’s flagship company, Poonawalla, Executive Director, of vaccines and we will expand has had business dealings with Poonawalla Group and Serum both here and there by around Bilthoven Biologicals for the last Institute, said, “The Poonawalla 30 per cent.”

Merck India to educate and provide platform to ‘influencers’ through Project EffexX MERCK India classifies individuals who recommend products to the end consumer as ‘influencers’. They believe that is important for them to know about the ingredients of the product and bearing this in mind it has launched a Project EffexX, an online portal that enables experts to interact with influencers, about the products and technologies being used in the industry. They eventually plan to bring the end consumers and experts exchange and share ideas that will prove mutually beneficial to both. Siddhartha Sengupta, Head Pigments, Merck India, said, “Through project EffexX we want to empower people and educate people about what goes into the making of

the products they use. The stake holders are primary consumers but the key part is played by ‘influencers’ like architects, designers, hair

Sengupta

stylists, spas, dermatologists, packaging designers who recommend people about

EMD Millipore wins prestigious R&D Magazine 100 Award

Sweeney

EMD Millipore, the Life Science division of Merck, Darmstadt, Germany, has received the R&D Magazine 100 Award for its product, the Samplicity®Filtration system. The 50th annual R&D 100 Award recognises the 100 most technologically significant products introduced into the marketplace over the past

year. The Samplicity®Filtration system provides a higher throughput, ergonomic alternative to syringe-tip filters for the preparation of liquid chromatography samples. The system is utilised in R&D laboratories testing drug dissolution, food safety, cosmetics, biofuels and pharmacokinetic and pharmacodynamic properties of drugs. “This award is a testament to our commitment to offer our customers breakthrough technologies they can use to keep up with rapid advances in life science. With this system, we have met the demands of today’s ultra-fast, ultra-sensitive chromatographic analyses,” said John Sweeney, Head Bioscience Business Unit, EMD Millipore.

the kind of product that one should use. We want to get them on this website, discuss talk and educate them about the products that they recommend since this will give them a better understanding of key ingredients of the product.” Merck India also provides technical knowhow, guidance and facilities to its customers who are aiming to expand. Although they do not provide financial assistance, they provide them with a platform and expertise from the inception to launching if the product. Sengupta added, “We believe in co-creation and that’s what we call the process of finding a partner and creating something together and making someones dream into a reality.” - Shibani Shah

Patent expiry of blockbuster drugs to benefit generics manufacturers: Frost & Sullivan THE global generic pharma market is likely to witness strong growth in the next few years owing to the patent expiration of key blockbuster drugs and the judicious cost containment efforts of governments and healthcare service providers worldwide. “The patent expiry of several major blockbuster drugs between 2010 and 2017 will fuel the growth of the global generic pharma market,” according to Frost & Sullivan. “The trend is shifting towards less competitive, yet commercially attractive segments such as difficult-to-produce generics, speciality generics and biosimilars.” Leading global generic pharma manufacturers have been proactive in forging strategic alliances with branded pharma companies for marketing rights and exclusivity in producing generic versions of blockbuster drugs such as Lipitor, Cozaar and Crestor, among others. market leaders such as Teva, Sandoz and Mylan are increasingly focussed on biosimilars, as this segment provides a competitive edge and presents huge profit margins. While these are positive signs for market participants, a potential dampener is the progressively stringent regulations and price control measures being imposed by governments. As competition intensifies, generic drug manufacturers will have to make careful choices about the product segments that they wish to compete in and the appropriate time of entry into the market. “Large MNC generic firms need to adopt a differentiated approach by opting for products with technologically challenging formulations, products that require significant regulatory support, and products with limited availability of APIs,” said the research analyst. “Small and medium-sized firms should focus on products with relatively higher profit margins.”

GSK pleaded guilty GLAXOSMITHKLINE (GSK) has been pleaded guilty for promoting two drugs for unapproved use and also failing to report safety data about a diabetes drug to the US FDA. GSK will pay the sum of $ 3 billion, which includes a $ 1 billion criminal fine and forfeiture and $ 2 billion to resolve civil settlements and will be monitored by government officials for next 5 years. The charges against GSK included illegal promotion of Paxil, an antidepressant, for treating depression

in children from 1998 to 2003, even though it was not approved for anyone under age 18. The company also promoted Wellbutrin, typical antidepressant and smoking cessation aid, from 1999 through 2003 for weight loss, sexual dysfunction, substance addictions and attention deficit hyperactivity disorder. The company also conceded charges that it held back data and made unsupported safety claims over its diabetes drug Avandia.

Astrazeneca and Cellworks collaborate ASTRAZENECA and Cellworks announced a collaboration supported by the Wellcome Trust to speed the design of novel combination therapies for the treatment of drugsensitive and resistant tuberculosis. Cellworks and AstraZeneca will pull from a pool of existing antiinfective drugs and attempt to find an effective combination with better efficacy and lower toxicity than the treatment regimens provided. Under this collaboration, Cellworks will use its proprietary predictive platform to model drug for Multi Drug Resistant Tuberculosis (MDR-TB) and rationally identify ‘synergistic combinations’ with highest efficacy and lowest possible toxic burden and validate the best combination using invivo models.

Dr Anand Anandkumar, MD, Cellworks Group India, said, “Cellworks is honoured to take the lead on this unique drug development project which has the potential to save thousands of lives globally. We are proud to be working with scientists from AstraZeneca on such a socially valuable project, funded by one of the world’s leading science foundations.” Dr Manos Perros, Head Infection Innovative

Medicines Unit, AstraZeneca, said, “AstraZeneca is pleased to join this effort to speed the delivery of improved treatment combinations for TB patients worldwide. Our continued investment in infectious disease research has positioned us to collaborate with organisations such as Cellworks and we would like to acknowledge and thank the Wellcome Trust for funding this important work.” Dr Richard Seabrook, Head - Business Development, Wellcome Trust, said, “We are delighted to be supporting this collaboration, which has a strong mix of both innovation and drug development expertise.”

Modern Pharma•16-31 July 2012

News, Views & Analysis

AMRI to upgrade, invest and increase its reach in regulated markets ALBANY Molecular Research, Inc (AMRI) has recently relocated its compound-library capabilities to Hyderabad. Talking on the development Bruce J Sargent, Senior VP - Drug Discovery, AMRI, explained, “Compound libraries are a key starting-point in drug discovery; AMRI provides this service to pharma and biotechnology companies in many locations. Consolidation of the capability in India allows AMRI to Frost leverage its existing cost-structure Sargent and to integrate the technology with our other drug discovery offerings. these programmes, which are directed Pharma markets – including the India at a whole range of targets from well market – ultimately benefit through the established to novel. At its Hyderabad effective discovery of novel drugs for centre, AMRI also plans to establish new laboratories that are equipped to conduct commercialisation.” AMRI Hyderabad will provide parallel synthesis chemistry enabling various chemistry services for its the ability to design and synthesise pharmaceutical, biotechnology and custom libraries of molecules for agrochemical customers. The medicinal pharmaceutical screening. Mark Frost, Senior VP chemistry team will support customer projects in therapeutic areas such as Administration and CFO, AMRI, metabolic diseases, oncology and CNS. commented, “Hyderabad Research The centre will focus on the chemistry of Center was a significant investment

PharmaSecure launches psConnectTM: A mobile health platform PHARMASECURE has launched psConnectTM - a mobile health (mhealth) platform that enables a variety of providers to offer mhealth services to patients. The task force for the Union Health Ministry has recommended SMS authentication as the ideal means of combating the counterfeit drug problem. Initially, three services will be provided: free health tips, refill reminders and health advice. The psConnectTM establishes a twoway channel of communication between the manufacturer and the consumer that can be used to disseminate important drug safety information, educate consumers about their particular ailments Kar and inform patients about key public health initiatives. The platform provides manufacturers numerous possibilities to increase their market advantage, distinguish their brand and create loyal consumers. Speaking about the launch Kishore Kar, VP - Sales and Marketing, PharmaSecure PAS India, said, “PharmaSecure has established itself as a trusted name in the mobile authentication solution space and it’s the right time for us to take the next step. The consumer is empowered with information about his medicine, knowledge on a particular ailment, refill reminders to purchase medicine, health tips and ready accessibility to a doctor – everything with just one tap on his mobile phone. We are proud to be associated with HealthFore for these services.” Commenting on the launch Nitin Goyal, Senior VP, HealthFore, added, “We are delighted to extend our Medi-Life service on the psConnectTM platform. The coming together of mobile telephony and the medical expertise is the only way to make affordable healthcare available pan India.”

Maddala

in 2006 when we first created the operation. It was a modest investment to add the library capability.” With the Indian pharma market graduating to become a global leader Subramanyam Maddala, President India Operations, AMRI, said, “The pharma market in India is expected to touch $ 74 billion in sales by 2020 from the current $ 11 billion, according to a PricewaterhouseCooper (PwC) report. The growth rate for the domestic Indian pharma market is set to rise over

medium-term.” He highlighted, “The revenue CAGR over the past 3 years had been 12.4 per cent, but it is expected to be up at 15.3 per cent from FY12 to FY14, Barclays Capital Equity Research said here in its report – India Healthcare & Pharmaceuticals.” Maddala added, “AMRI is planning to improve its positioning by investing in new capabilities in the coming years. The further investment in medicinal chemistry, computational chemistry and custom library synthesis resources at HRC is a step in that direction. Apart from this we intend to further invest in niche generic APIs with global generic companies. We plan to invest in upgrades of our facilities to increase our reach to regulated markets like the US, Europe, etc, as well as invest in potential facility expansions for branded APIs to become a more important partner to major pharmaceutical companies.” - Shibani Shah

Modern Pharma•16-31 July 2012

News, Views & Analysis

Pfizer appoints Aijaz Tobaccowalla as India Managing Director PFIZER Ltd, the Indian arm of Pfizer Inc, has appointed Aijaz Tobaccowalla as the Managing Director to replace Kewal Handa, who had earlier this year announced his intention to retire in August 2012. “With more than 20 years of experience in the pharmaceutical industry, Aijaz, is a seasoned leader who will continue to lead Pfizer India through this exciting period,” said Ahmet Goksun, Regional President, Emerging Markets Europe, Russia, India and Turkey (EURIT), Pfizer.

Aijaz Tobaccowalla

Tobaccowalla would be taking over as MD from August 16, it added.

Ferring, Albireo sign licensing agreement FERRING Pharmaceuticals has entered into a licensing agreement with Albireo for elobixibat, a first-inclass compound for Chronic Idiopathic Constipation (CIC) and Irritable Bowel Syndrome With Constipation (IBS-C). Under the agreement, Ferring gained elobixibat global marketing rights, excluding Japan and a small number of Asian markets. Michel Pettigrew, Executive Board President and COO, Ferring,

said, “Elobixibat complements the company’s gastroenterology portfolio, which includes Pentasa for IBD and Picoprep for bowel cleansing. What is more, it fits well with our company philosophy of ‘People Come First’ - in particular the patient, as it addresses a problem that affects from 15 per cent up to almost a third of the population but that has seen little progress in treatment options over the years.”

He joined Wyeth in 1991 and since then has held a number of positions in business technology as a member of the leadership teams of Pfizer WBB, R&D, and PCBU, the company said. In 2009 Tobaccowalla was appointed to his most recent role, leading business technology for Pfizer’s all biopharmaceutical business units. Handa, who will retire from the company in August after two decades of association with the firm, is credited with Pfizer’s entry into branded generics segment in India.

Mylan aims to create $1 billion injectables franchise MYLAN Inc (Mylan Institutional business) has received final approval from the USFDA for its ANDA for preservative-free Thiamine Hydrochloride Injection, 100 mg/mL, packaged in 200 mg/2 mL multiple-dose vials. This product is indicated for the treatment of thiamine deficiency. Thiamine hydrochloride injection, 100 mg/mL, had US sales of approximately $ 18.6 million for the 12 months ending March 31, 2012, according to IMS Health. Mylan is shipping this product, presented in 25-vial packs, immediately. Currently, Mylan has 169 ANDAs pending FDA approval representing $ 83.9 billion in annual sales, according to IMS Health. Thirtyseven of these pending ANDAs are potential first-to-file opportunities, representing $ 25.6 billion in annual brand sales, for the 12 months ending December 31, 2011, according to IMS Health. According to the Mylan spokesperson, “We identified injectables as one our key growth drivers through 2018 and are aiming to create a $ 1 billion franchise in injectables. - Chandreyee Bhaumik

Cipla appoints a new head for global respiratory business CIPLA announced Frank Pieters as the Head of European Region and the Global Respiratory Business. He comes on board with over 30 years of experience in the pharmaceutical industry in different senior management positions, with the unique background in respiratory medicine. Dr Yusuf K Hamied, CMD, Cipla Ltd, said, “Frank brings a wealth of expertise in the respiratory domain. With him at the helm, Cipla

Pieters

would like to capture the huge commercial upside of 30 years experience in Cipla’s

respiratory medicine; both in emerging and regulated markets. Apart from global respiratory business, Frank will also spearhead the generics and value-added product portfolio across the European region through strategic alliances.” Pieters said, “After spending many interesting years both at GSK and Teva, I am thrilled to join the Cipla, helping to expand both the respiratory business worldwide and the European business.”

India to give free generic drugs: Waters launches its A Frost & Sullivan perspective new online centre WITH a budget deficit hovering around 6 percent and the economy poised to achieve a growth of only 6 percent this year, it will be interesting to see how the Government manages to accrue funds for making this policy a success. Even with the policy in place in Rajasthan and Tamil Nadu the stark reality is that medicines are out of stock in almost all clinics. “The real challenge for the government will be to check leakages in the system. This policy might not be successful like the Mahatma Gandhi National Rural Employment

Guarantee Act (MGNREGA) scheme if proper checks are

Dr Sharma

not kept. Second challenge will be the procurement process. If the medicines are

Government likely to invest ` 2,000 crore for pharma R&D

Vaidya

THE Government is likely to form a venture capital fund of ` 2,000 crore to promote R&D in the pharmaceutical sector and is talking terms with Exim Bank for the same. “It

is important the Government of India focusses on R&D in India. Today, there are several tropical diseases that people in India suffer from, like malaria, typhoid and many more. The R&D in such areas is very poor and MNCs are not taking them up and the companies in India do not have the required capital. Hence, this investment would definitely help the pharma sector in India,” said Raj Vaidya, VP, Chairman - Communication Pharmacy Division, Indian Pharmaceutical Association. - Jasleen Kaur Batra

not procured directly but via 3rd parties then there is a huge possibility of supply of inferior drugs,” said Dr Ajay Kumar Sharma, Practice Head - Pharma, Healthcare Practice, Frost & Sullivan, South Asia & Middle East. “Another challenge is that medicines hardly constitute 25-30 percent of all healthcare expenditures. The real cost is the delivery of the services; the government has not been successful in building the necessary infrastructure and human resources in the last 3 decades,” he added.

WATERS Corporation marked it’s the 25th anniversary of the start of business operations in India, with the initiation of online ordering through a new order centre. Scientists and customers can now search and order Waters quality parts, sample preparation products, chemistries and consumables online at www. waters.com/order. With the new order center now open, Waters is introducing several new features designed to facilitate ordering and lower

transaction costs by including the posting of real-time product availability, local currency pricing, available discounts, order tracking and special offers. Scientists are now able to select products of interest and easily share their cart with procurement professionals.

Dr Batra’s appoints new MD and a new CEO DR Akshay Batra has been appointed the Managing Director and Hari Nair the Chief Executive Officer of Dr Batra’s Positive Health Clinic Pvt Ltd to help the organisation scale new heights of professional and patient-care glory. Dr Akshay Batra played an instrumental role in setting up Dr Batra’s B Perfect Pvt Ltd – a daycare aesthetic centre. Hari Nair, an MBA from XLRI Jamshedpur, who had earlier worked with Tata

Dr Batra

Steel, H & R Johnson, and Marico, joined Dr Batra’s as the Chief Operating Officer (COO) of the Products Division. In his new role as a

Nair

CEO, it will be his endeavour to scale up the business to new heights, through organic and inorganic growth measures.

Modern Pharma•16-31 July 2012

News, Views & Analysis

Russia should open up its ACEP commends congress for passing market to India: Sharma legislation that addresses drug shortages RUSSIA should open its booming $ 19 billion pharmaceutical market and expedite the list of 500 drugs that it currently imports from India, said Anand Sharma, Commerce Minister, Industry and Textiles, during a recent visit to St Petersburg, urging Russian authorities to let Indian pharmaceutical companies form joint partnerships with Russian companies. Sharma India has asked Russia to establish a nodal agency to create a joint committee for implementation of Memorandum of Understanding (MoU) between Indian and Russian pharma companies, especially in the field of quality control

and standard requirements on conformity assessment of pharmaceuticals and biopharmaceuticals. India has already nominated its own nodal agency - The National Institute of Pharmaceutical Education and Research (NIPER) under the Department of Pharmaceuticals. Russia’s pharma market grew to $ 19 billion in 2011 from $ 6.6 billion in 2005, expanding at a compound annual growth rate of 23 per cent. However, there are a number of non-tariff barriers Russia imposes, which makes it difficult for foreign companies to enter this market, in terms of drugs registration and R&D of new drugs.

NPS signs amended agreement with Amgen

NPS Pharmaceuticals, Inc, a speciality pharmaceutical company developing orphan therapeutics for rare gastrointestinal and endocrine disorders, has amended its license agreement with Amgen for royalties from sales of cinacalcet HCl. Under the revised agreement, NPS will receive a onetime $ 25 million payment in July 2012 in exchange for its rights to receive royalties under the license agreement that are earned after December 31, 2018. The amendment also limits the royalty offset of the royalty advance that NPS received from Amgen in August 2011 to $ 8 million per quarter with royalties in excess of $ 8 million paid to NPS for the respective quarter, thereby extending the royalty advance repayment period. After the repayment of the royalty advance and a 9 per cent per annum discount factor on the outstanding balance, Amgen will resume paying NPS all royalties earned through December 31, 2018. As of June 30, 2012, NPS owed Amgen a balance of $ 92 million on the royalty advance. “This agreement significantly accelerates our cash flow with at least $ 75 million of incremental cash expected through 2013. These funds are expected to fully support the cash requirements to launch both Gattex and Natpara, and represent a critical step in our transition to a selfsustaining commercial-stage organisation. This innovative transaction underscores our commitment to accessing capital at the lowest possible cost and in a manner that is in the best interests of our shareholders,” said Luke M Beshar, EVP and CFO, NPS Pharmaceuticals.

THE American College of Emergency Physicians (ACEP) commends the United States Senate on passing legislation that will create a federal ban on certain synthetic drugs. The bill will be passed as a law once it receives the President’s signature. Under this new law, the FDA will also require drug shortages to be reported to the FDA with at least six months notification. Specifically, the reporting requirement applies to drugs ‘intended for use in the prevention or treatment of a debilitating disease or condition, including any such drug used in emergency medical care during surgery.’ Dr David Seaberg, President, ACEP, said, “This law will give FDA the much-needed authority to require drug manufacturers to report any discontinuance, interruption or other adjustment that would likely result in a shortage,

especially those drugs needed to provide emergency care. Obtaining this information in a timely manner will allow the FDA to work with other manufacturers to produce the drug or reallocate resources to ensure the right drug is in the right community at the right time. Emergency physicians do not have the luxury of advanced planning to secure alternative drugs when severely injured patients arrive in the emergency department and the most effective medication is unavailable. The best course of action is to ensure that we do not find ourselves in that situation in the first place.” The law will also ban two of the 17 ‘bath salts’ chemicals that are currently legally sold in the US. Seaberg adds that emergency physicians witness firsthand how these dangerous synthetic drugs are harming users. These products contain chemicals

that imitate the hallucinogenic or stimulant properties of marijuana, cocaine, ecstasy and methamphetamine, which can cause severe paranoia that may cause harm to the patient and others. The GAO will also conduct a study to examine the cause of drug shortages and provide recommendations to alleviate such shortages. Specifically the GAO must also consider what extent healthcare providers, including hospitals and physicians, are able to adjust care effectively to compensate for the drug shortages and what impediments exist that hinder these efforts.

Modern Pharma•16-31 July 2012

News, Views & Analysis

In Brief Strides redeems FCCBs due 2012 net debt/equity at 0.75 STRIDES Arcolab has redeemed the outstanding $ 80 million FCCBs on due date. The company had originally raised $ 100 million FCCBs in 2007 and had bought back $ 20 million during 2009. The total payout for redeeming the outstanding bonds was $ 116 million including the redemption premium of 45.06 per cent. Post this redemption, there are no outstanding FCCBs. Dr T S Rangan, Group CFO, said, “The company diligently planned the redemption thereby achieving substantial de-leveraging of its balance sheet. We take this opportunity to thank the bond holders for their participation in our growth story.”

Mylan confirms first-to-file patent challenge relating to Pristique® MYLAN Inc has been sued by Pfizer Inc, Wyeth LLC, Wyeth Pharmaceuticals Inc, and PF Prism C V in connection with the filing of an Abbreviated New Drug Application (ANDA) with the US FDA for desvenlafaxine succinate extended-release tablets, 50 mg and 100 mg. This product is the generic version of Pfizer’s Pristiq® tablets, which are indicated for the treatment of Major Depressive Disorder (MDD) in adults.

Bristol-Myers to acquire diabetes drug maker Amylin BRISTOL-MYERS Squibb and Amylin Pharmaceuticals, Inc recently announced that Bristol-Myers Squibb will acquire Amylin for $ 31 per share in cash, pursuant to a cash tender offer and second step merger, or an aggregate purchase price of approximately $ 5.3 billion. The total value of the transaction, including Amylin’s net debt and a contractual payment obligation to Eli Lilly & Company, together totaling about $ 1.7 billion, is approximately $ 7 billion. The acquisition has been approved by the boards of directors of Bristol-Myers Squibb and Amylin.

BMS and Pfizer receive CRL from US FDA for Eliquis (apixaban) BRISTOL-MYERS Squibb and Pfizer recently said that the US FDA has issued a Complete Response Letter (CRL) regarding the New Drug Application (NDA) for ELIQUIS® (apixaban) for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation. “There is a significant unmet need to reduce the risk of stroke in patients with atrial fibrillation,” said Elliott Sigal, MD, PhD, Executive VP and Chief Scientific Officer, Bristol-Myers Squibb. “We believe that the two large trials called ARISTOTLE and AVERROES have established the therapeutic profile for ELIQUIS and demonstrated a meaningful advance over the standard of care.”

Teva announces progress of biologic investigational drugs TEVA Pharmaceutical Industries Ltd recently announced the presentation of clinical results for its biologic oncology candidates, lipegfilgrastim and balugrastim, at the Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO) 2012 International Symposium on Supportive Care in Cancer held in New York June 28-30. Lipegfilgrastim and balugrastim are long-acting Granulocyte ColonyStimulating Factors (G-CSF) being evaluated for their ability to reduce the duration of severe neutropenia in breast cancer patients undergoing chemotherapy.

Ipsen’s Somatuline receives marketing approval in Japan IPSEN and its partner Teijin have received manufacturing and marketing approval from the Japan’s Ministry of Health, Labour and Welfare (MHLW) for Somatuline® 60/90/120 mg for sc injection (lanreotide acetate). In Japan, Somatuline® is indicated for the treatment of growth hormone and IGF-I (somatomedin-C) hypersecretion and related symptoms in acromegaly and pituitary gigantism (when response to surgical therapies is not satisfactory or surgical therapies are difficult to perform). Somatuline® will be available in a new enhanced presentation with a pre-filled syringe that does not need reconstitution and with a retractable needle that enhances safety for caregivers.

1QFY13E is expected to be a strong and steady quarter: Kotak Institutional Equities R EPORT by Kotak Institutional Equities states that 1QFY13E is expected to be a strong and steady quarter though not a spectacular one marred by hikes in tax rates and forex losses for certain companies. Priti Arora, Analyst, Kotak Institutional Equities, said, “While yearon-year (y-o-y) sales growth is expected to remain strong for all, we expect PAT growth to be mixed with a few companies reporting flat/PAT decline y-o-y due to hikes in tax rates and lower EBITDA margin y-o-y, forex losses and absence of licensing income. SUN and Divis remain our top picks; we advise using any weakness to add ahead of results.” She added, “Overall, we expect 1QFY13E to be one of the stronger quarters in FY2013E driven by low base of revenues in 1QFY12, ongoing exclusivities in US, pick-up in base business sales from the slew of launches in the US since FY2012 and benefits from rupee depreciation. We expect most of the frontline generic

companies to report strong sales growth of above 25 per cent boosted by higher realisation in rupee terms, exclusivity sales in US for DRL, Lupin, Ranbaxy, Glenmark and SUN on account of Ziprasidone, Lipitor, Cutivate and Stalevo and Lipodox respectively and pickup in domestic sales growth due to pick-up in underlying growth, low base in 1QFY12; Ranbaxy, DRL, Cipla and Cadila reported single-digit growth rates in 1QFY12, additions of sales from Eli Lilly deal for Lupin.

Despite strong sales growth, we expect mixed EBITDA margin trends across companies and expect EBITDA margin to decline y-o-y for Glenmark, Cadila and Glaxo on account of high base last year and higher import content leading to higher import cost for Glaxo. Arora highlighted, “We expect DRL, SUN, Lupin and Ranbaxy to report highest EBITDA margin improvement y-o-y of over 100 bps due to ongoing sales from exclusivities in the US and operating leverage benefits due to pick-up in base business sales growth for SUN and Ranbaxy. However, we expect PAT to remain flat/decline y-o-y for Cadila, Glenmark, Dishman, Jubilant and Ranbaxy due to lower EBITDA margin y-o-y, forex losses in 1QFY13E versus forex gains in 1QFY12, absence of research/licensing income (Glenmark, Cadila) and hikes in tax rates (Cadila, Dishman).”

IACC honours Baxter THE Indo-American Chamber of Commerce (IACC) has awarded Baxter ‘The Best US Company Operating in India’ under the ‘Other Services’ category. The award was presented at the 8th IndoAmerican Corporate Excellence Awards (I-ACE 2012) ceremony in Mumbai. The award was given to the organisation based on human capital management, corporate social responsibility and overall contribution to Indo-US business. Anish Bafna, MD, Baxter India Pvt Ltd said, “This award is recognition of Baxter’s commitment to creating lasting social, environmental and economic value for our stakeholders in India’s healthcare

community. Baxter employees in India are motivated by a sense of responsibility and desire to make a difference. On behalf of the 1100 employees, we thank the IACC for this honour and recognition of our contributions to India’s needs for the past 15 years.” A distinguished independent jury comprising of business leaders from Indian and US based companies and the consular corps from the US Consulate evaluated the various participating companies. The ceremony was attended by over 300 guests including representatives from the Indo-US business community, government and business leaders, industrialists and members of the US-India Business Community.

China amends patent law in fight for cheaper drugs CHINA has overhauled parts of its Western countries are flagging. The intellectual property laws to allow amended Chinese patent law allows its drug makers to make cheap Chinese move comes Beijing to issue compulsory licences copies of medicines still under to eligible companies to produce within months of patent protection in a move likely generic versions of patented drugs a similar move to unnerve foreign pharmaceutical during state emergencies, or unusual by India to end companies. The Chinese move circumstances, or in the interests of monopoly of comes within months of a similar the public. For reasons of public expensive cancer move by India to effectively end health, eligible drug makers can also drug the monopoly on an expensive ask to export these medicines to cancer drug made by Bayer AG by other countries, including members issuing its first so-called compulsory of the World Trade Organisation licence. Similar action by China will ring alarm (WTO). Compulsory licences are available to bells in Big Pharma, since the country is a nations to issue under WTO rules in certain cases vital growth market at a time when sales in where life-saving treatments are unaffordable.

Modern Pharma•16-31 July 2012

News, Views & Analysis

The 5th Pharma Leadership Summit & Business Leadership Awards to be held in Mumbai Annual THE 5 th Pharmaceutical Leadership Summit & Business Leadership Awards 2012 will be held in Mumbai on Friday, 21st September at Hotel Hilton, Mumbai. It is being organised by Pharmaleaders in association

with various associations of the Pharmaceutical & Biotechnology Industry & supported by the Ministry of Commerce, Government of India & Maharashtra as the State Partner. Leaders will debate on ‘Brand India Pharma in line with the Indian

Government’s objective & vision to project Indian Pharma Industry in the global map.’ It will felicitate Business Leadership Awards to top performers in 30 categories. It is expected to see more than 200 CEOs participation from overseas.

Ampio contracts with Syngene AMPIO Pharmaceuticals, Inc (AMPE), a biopharma company conducting clinical trials on its three lead drugs (Ampion™, Optina™ & Zertane™), licensing distribution of these drugs and developing additional new drugs, is proceeding with the development plan for a combination product to treat both Premature Ejaculation (PE) and Erectile Dysfunction (ED). Vaughan Clift, MD, Chief Regulatory Officer, Ampio,

noted, “Contrary to rumours that the FDA did not recognise PE as a treatable ailment, the FDA has expressly adopted the definition of PE as a disease condition, using the definition of PE provided by the International Society for Sexual Medicine (ISSM) Ad Hoc Committee

Marken launches global regulatory consultation services MARKEN has launched ‘Marken Consultation Services’. This service provides global customs and agency regulation expertise for the pharma industry. Import and export requirements are increasingly more complicated with ever-changing industry guidance and governmental regulations. Marken has been able to overcome these regulatory challenges for its customers. Marken keeps up to date with these changing regulations and provides solutions when necessary in order to keep shipments on time. Marken experts include licensed customs brokers, import specialists, and life science experts, aggregating more than 100 years of combined trade and regulatory compliance experience. “Navigating US customs and government agencies for shipping drugs, biologics, specimens and APIs is a daunting and timeconsuming task for the pharma industry, but this is what we do. We are offering this service to clients seeking advice before they start their planning. We engage clients early in their process so we can lead them through the maze of regulations, thus allowing them to focus their energies on R&D,” said Dan Bell, Director- Commercial Operations & Regulatory Compliance, Marken.

Bayer declares data from the Phase III ALSYMPCA BAYER HealthCare recently announced updated data from the pivotal Phase III ALpharadin in SYMptomatic Prostate Cancer (ALSYMPCA) trial for its investigational drug radium-223 dichloride in men with Castration-Resistant Prostate Cancer (CRPC) and symptomatic bone metastases. “Bone metastases are one of the main causes of morbidity and death in patients with castration-resistant prostate cancer, yet until now there has been little progress made towards developing therapies that treat the cancer when it has spread to the bone,” said Dr Chris Parker, Principal Investigator, ALSYMPCA.

(ie, PE is characterised by ejaculation Ampio was recently awarded multiple patents worldwide for combinations of Zertane™ with any PDE5 inhibitors and for reduction of side effects of Tramadol. These patents will benefit from a full patent life and are important for negotiations with potential partners whose PDE5 inhibitors patent protection has expired or are about to expire which could be greatly extended by Ampio’s patents.”

In Brief Biogen and Isis collaborate BIOGEN Idec and Isis Pharmaceuticals, Inc have entered into an exclusive, worldwide option and collaboration agreement under which the companies will develop and commercialise a novel antisense drug for the treatment of myotonic dystrophy type 1 (DM1), which is also known as Steinert disease.

Roche to cut 1000 jobs ROCHE site in Nutley (New Jersey, USA) is to be closed and around 1000 jobs will be cut. The respective R&D activities are to be consolidated in Switzerland and Germany. The planned site consolidation and the streamlining of research activities within Roche’s pharma research and early development unit will support efficient allocation of resources for the group’s expanding product development pipeline. Roche Pharma will continue to have presence with Pharmaceuticals Translational Clinical Research Center of about 240 positions.

Sony DADC collaborates with Sony Medical SONY DADC BioSciences has joined forces with its Sony Medical Business Unit (MBU) to develop and manufacture smart consumables for its new SH800 cell sorting instrumentation system. Christoph Mauracher, Head - BioSciencess, Sony DADC said, “The company was chosen based on its technical and commercial merits. The project presented significant technical challenges regarding redesign and precision including manufacturing to ISO 13485 standards.”

Modern Pharma•16-31 July 2012

News, Views & Analysis

In Brief Weight loss drug approved by US regulators US regulators recently approved Arena Pharmaceuticals’ (ARNA) weight-loss drug Belviq - the first new prescription diet pill cleared for sale in the US in 13 years. In approving Belviq (formerly known as lorcaserin), the US FDA followed the recommendation of an outside panel of experts who voted 18-4 with one abstention last month to support the weight-loss drug, while still voicing concerns about lackluster efficacy and lingering safety questions.

Natco Pharma loses Copaxone patent litigation against Teva THE US District Court for the Southern District of New York has upheld the contention of Teva Pharmaceuticals (Teva) that NATCO Pharma`s (the company) Abbreviated New Drug Application (ANDA) for the generic version of Copaxone Â® infringes all the asserted claims of Teva Pharmaceuticals. NATCO has filed, with its partner Mylan Inc, in June 2008, an ANDA seeking approval for marketing of the generic version of the relapsing, remitting multiple sclerosis drug Copaxone Â® and obtained a Para IV certification which essentially challenges the existing patents held by Teva Pharmaceuticals.

Astellas launches hyperphosphatemia medication in Japan ASTELLAS Pharma launched Kiklin capsules 250mg (generic name: Bixalomar) in Japan for the treatment of hyperphosphatemia in patients on dialysis with chronic kidney disease. The amine-functional polymers, Kiklin capsules, demonstrated the clinical efficacy in decreasing serum phosphorus concentration, in addition to a preferable long-term safety profile, in Phase III studies in patients on dialysis with chronic kidney disease in Japan.

Eisai to enter the Russia with the launch of epilepsy drug Zonegran ENTRY into the Russian marketplace is part of Eisai’s expansion plans, which include having a presence in the top 20 pharmaceutical markets and help treat more than 500 million patients by 2015. Zonegran (zonisamide) is expected to be available across Russia as adjunctive therapy in the treatment of adult epilepsy patients with partial seizures, with or without secondary generalisation by the end of Eisai’s financial year 2012 (30 March 30, 2013).

HAL Allergy extends GMP contract manufacturing activities HAL Allergy BV has succeeded in extending its GMP contract manufacturing activities for clinical batch supply of both recombinant and viral products. The Dutch inspectorate had granted the permit extension after inspection of the operational activities in the BSL2 clean rooms and development laboratory in June 2012. Commenting in this regard, Harry Flore, CEO, HAL Allergy, explained, “This is a big step forward in our goal of becoming a key biotech service company. Modern production- and laboratory facilities and over 50 years experience in vaccine production will be key asset in partnerships with our customers.”

Optimer’s Dificid® (fidaxomicin) tablets approved by Health Canada OPTIMER Pharmaceuticals, Inc recently declared that Dificid® (fidaxomicin) tablets were approved by Health Canada for the treatment of Clostridium Difficile infection (CDI), in adults 18 years of age and older and that Dificid is now available to treat patients in Canada. This approval was based on Health Canada’s evaluation of two large MNC Phase III clinical trials demonstrating that Dificid was as effective as oral vancomycin in providing an initial clinical response and was superior in providing a sustained clinical response for 28 days post treatment. Dificid is the first new treatment for CDI to be approved in Canada in over 20 years.

Himalaya launches its first prescription nutri-health product THE Himalaya Drug Company launched HiOwna-Jr for kids, a prescription-based nutritional supplement that promotes physical and mental growth and enhances immunity in children from age two to pre teens. It has been launched in two flavours strawberry and chocolate. “HiOwna-Jr is a unique health formulation that contains herbs widely known in Ayurveda for promoting child health,” said Philipe Haydon, CEO – Pharmaceuticals, The Himalaya Drug Company. “We developed HiOwnaJr keeping in mind the overall physical and mental growth in children and stronger immunity. That is why, in addition we have also included herbs known for their superior health benefits. HiOwna-Jr is fortified with 13 essential vitamins A, B1, B2, B6, B12, C, D,E, K, Niacin, Biotin, Folic acid, and Pantothenic acid and 9 minerals Iron, Iodine, Calcium,Phosphorus, Magnesium, Zinc, Chromium, Selenium and Molybdenum. It also has ragi (finger millet) that improves nutritive status; maricha (black pepper), a bio-availability enhancer;

Mandukaparni (centella), a cerebral activator, also known as ‘brain food’ in Ayurveda; and amalaki (Indian gooseberry), an immunity enhancer and the richest source of Vitamin C in nature,” added Haydon. “HiOwna-Jr is the only health supplement in India to have pea protein along with the traditional whey protein,”

explained Dr Ajay Tumaney, Group Leader—Functional Food Development. He also highlighted, “Colostrum or ‘first milk’ is an excellent source of immunoglobulins, proteins that fortify the immune system and fight infections. It also contains proline-rich polypeptides that have a unique ability to modulate the immune system.” HiOwna-Jr. contains 30 times more colostrum per gram,

compared to other brands available in the category. A recent Frost and Sullivan report pegged the nutraceuticals market in India at $ 1480 million in 2011, expected to reach $ 2,731 million in 2016 at a CAGR of 13.0 percent. Of this, the nutritional and health supplements are the largest subcategory accounting for 64 per cent of the market. “Over the next two to three years, we intend to build the HiOwna into a 100 crore business. Eventually, we will have a separate business vertical exclusively focused on nutritional and health products for children and people of different age groups addressing different conditions,” said Philipe. “We have high expectations from HiOwna and the 100 crore target seems well within reach. Firstly, we have a unique product. Additionally, we are clearly recognised as the face of contemporary Ayurveda. Finally, doctors trust Himalaya’s products. We enjoy their confidence of being an R&D driven company. As always, Himalaya will highlight the science behind HiOwna Jr,” he added.

Intensifying treatment with NovoMix® 30 improves blood glucose control NEW data from a subgroup analysis of the A1chieve® study show that intensifying treatment with NovoMix® 30 (Biphasic insulin aspart) can significantly improve blood glucose control in people with type 2 diabetes with a reduced incidence of hypoglycemia. The results are from a subgroup analysis of 1033 patients, who were first treated with NovoMix® 30 twice-daily then intensified to three-times daily over the 24-week study period. The results show that patients had significant improvements in their blood glucose control without compromising safety. Before initiation with NovoMix® 30, the average blood glucose control (HbA1c) among this subgroup of patients was (as high as) 9.8 per cent, despite the fact that 80.6 per cent

were receiving oral glucose-lowering drugs. This figure is well above the American Diabetes Association (ADA) recommended target of 7 per cent and such poor blood glucose control puts people at high risk of developing diabetesrelated complications. The overall incidences of hypoglycaemia were reduced from 4.26 to 3.76 events / person-year. Commenting on the data, Professor Philip Home said, “The study shows that premix insulin aspart when increased to three injections daily is an effective option for people with type 2 diabetes whether starting insulin or moving from other insulins. Improvements in blood glucose control of this magnitude would be of clinical importance to the people achieving it.”

Movianto and LEO Pharma extend their business partnership throughout Europe MOVIANTO, the logistics and transportation provider specialised in the pharma industry, has extended its existing agreement with LEO Pharma in order to encompass further European countries. Already providing logistics services to LEO Pharma in the UK, Denmark and the Czech Republic, the company has now awarded exclusive contracts to Movianto in Germany, Switzerland, Austria, the Netherlands and Belgium, now covering the majority

of Europe. Movianto around Europe will be undertaking full order to cash solutions on a country level for the client’s full portfolio of dermatology and thrombosis products. The range of services provided includes order entry, pick &pack and transportation, invoicing as well as cash collection and the handling of returns. The products will be delivered to wholesalers, pharmacies, hospitals and doctors. Steen Winther, Director - Group Logistics, LEO

Pharma, commented,”We have been highly satisfied with the services provided by Movianto in the UK, Denmark and the Czech Republic and so it was a clear decision for us to extend the contract to include further countries. Movianto has shown great flexibility and excellence of service. The consolidation of service providers has also been of benefit to us and we are looking forward to continuing our successful relationship with the company.”

Modern Pharma•16-31 July 2012

News, Views & Analysis

PharmaSuite to offer improved VICAM’s immunoaffinity column time to obtain results to enhance laboratory analysis

ROCKWELL Automation has released Rockwell Software PharmaSuite, version 4.0, the next generation of manufacturing execution system software specifically targeting regulated industries. Leveraging more than 20 years of experience in pharmaceutical manufacturing, PharmaSuite enhancements set a new standard for lower risk, lower cost and time to results while meeting the regulatory requirements found in the life sciences industry.

“The enhancements to Rockwell Software PharmaSuite reinforce our commitment to the life sciences industry,” said John Genovesi, VP Information Software and Process Business, Rockwell Automation. “The new version offers significant performance, usability and deployment advantages enabling our customers to reduce cost of compliance and improve their manufacturing capabilities.” PharmaSuite allows regulated manufacturers to meet their operational goals and productivity requirements in a consistent and predictable way. It tracks material, equipment and personnel involved in the manufacturing process and maintain a complete electronic batch record. PharmaSuite is based on S88 and S95 standards, which allows for better integration with other enterprise systems involved in manufacturing operations.

Bio-Rad’s QX100™ PCR awarded BIO-RAD Laboratories, Inc’s QX100 Droplet Digital PCR system won R&D Magazine’s R&D 100 award. These awards recognise the 100 most technologically significant products introduced into the marketplace over the past year. “The QX100 Droplet Digital PCR system provides single copy PCR resolution to accelerate discoveries and new strategies for the research of inherited disorders, cancer, and infectious disease,” said Richard

Kurtz, Bio-Rad Division Marketing Manager, Gene Expression Division. Digital PCR, and more specifically droplet digital PCR (ddPCR™), is a refinement of real-time PCR that enables researchers to directly quantify and amplify nucleic acids, including DNA and RNA. With ddPCR the sample is separated into a large number of partitions and the amplification is carried out in each partition individually.

VICAM®, a Waters® Business, introduced the DON-NIV™ WB Immunoaffinity (IA) column, the only IA column in the market to simultaneously screen for Deoxynivalenol (DON) and Nivalenol (NIV). Coupled with liquid chromatography analysis, the DON-NIV WB column provides over 90 per cent recovery of both DON and NIV and doubles the productivity of commercial, government and food safety research laboratories. “The new DON-NIV WB column provides rapid and simple sample

preparation using the superior strength of monoclonal antibody technology. DON and NIV are analysed simultaneously in the same sample, facilitating efficient research and more effective risk management for industry,” said Dr Stephen Powers, Head - Research & Development, VICAM. “DON was the first trichothecene mycotoxin to be regulated by many countries. Increased interest in related toxins such as NIV drives the need for improved technologies,”

commented Marjorie Radlo, General Manager - Director of Operations, VICAM. DON and NIV are trichothecene mycotoxins produced by fusarium molds. Animal feeds which are contaminated with fusarium toxins cause feed refusal, weight loss, vomiting and diarrhoea – resulting in significant health, production, and economic risks. NIV has also been linked to lung and brain haemorrhage and bone marrow injury through disruption of DNA and protein synthesis.

Cole-Parmer unveils fluid handling and lab equipment at ACHEMA 2012 COLE-PARMER, a global leader in fluid handling, life science, general laboratory products, instrumentation, and equipment, presented a wide range of Fluid Handling and Lab Equipment at Achema 2012. Attendees of ACHEMA had the opportunity to see a variety of Masterflex® pump systems live at the event. Lab equipment featured included

the Cole-Parmer® Rotational Viscometer, the StableTemp® Modular Block Heaters, the

Stir-Pak® high-speed, lowtorque overhead stirrer system is a heavy-duty modular system that allows users to customise components to suit their mixing application. Several high-quality Oakton® thermometers were also available, including the Oakton® TempTestr® Infrared Thermometer with laser vision to pinpoint the center of the measurement area.

Modern Pharma•16-31 July 2012

In Conversation With

Staying true to one’s dreams What started as a dream in 1997, for Marck to become the leaders in manufacturing IV fluids, has today become a reality. Under the leadership of Bhavesh Patel, MD, Marck Biosciences, the company has grown more than 10 times over the last decade. Excerpts from the interview with the versatile leader.

Parita Dholakia parita.dholakia@infomedia18.in

While driving his blackcoloured Mercedez Benz (S-Series), the down-to-earth MD of Marck Biosciences, Bhavesh Patel explained how he tries to instill the values of simple living to his son. He does not consider his house or his car to be his priced possessions, and laughs off by saying, “All that belongs to the company.” He holds a Bachelor’s degree in Mechanical Engineering and a Master’s degree in Business Administration (Finance). After quitting a finance career, he held on to his dreams of doing something of his own. From mutely observing the operations of various companies in different verticals, he decided to be a part of the pharma industry. He says he wanted the industry to be capital intensive, should have scope for expansion and growth and be a generic product and not one which needed aggressive branding. Thus, Marck started its operations in 1997 near Kheda, Gujarat, with IV fluids and parenterals. In this free-spirited conversation, Patel takes us through the crescendo of his personal and professional life.

Start of the empire Armed with a Masters in Finance, Patel dabbled his hand as a merchant banker for a short while. But soon, he realised he had to fuel his dreams to open a company further, and quit. “At that time my parents were in the US and I wanted to migrate there. But somehow things took a different route,” he says. After quitting his job, he went back to Ahmedabad. He surveyed the options, travelled abroad extensively and studied different companies minutely, “I listed down a few segments that I was interested in, and that included auto ancillaries and medical instruments.” After thoroughly studying different sectors he came up with a specific criteria

for the industry he would enter. After arranging the necessary funds, he set up Marck at Kheda district in Ahmedabad, Gujarat. It is spread over 25 acre with a built-up area of around 19,000 square metre. It is capable of manufacturing Large Volume Parenterals (LVP) and Small Volume Parenterals (SVP). The facilities are ISO-certified and cGMP compliant. They meet the requirements of the regulatory authorities of countries such as the UK, Australia and groups like the EU. So why the name ‘Marck’ and he says, it was decided after some family member suggested it as per some astrological beliefs. Prod him further on whether things have come easily, he shurgs it off saying, not at all. The growth figures of the company tell a tale of steady perservernce and constant efforts. “If there was one thing that I could do differently since the start of the company, I believe it would be to be methodical since day one. I was not very methodical and systematic at the start, and learnt it the harder way,” he says, matter of factly.

Tough times Patel had to face tremendous challenges in various forms to reach where he is today. At the time of establishing the company, getting the required finance was a task. He needed an investment at the tune of Rs 22 crore to set up the unit and the stock market was in bad shape. “I relied on personal finances at the start. I gathered money from friends and family, and even bank loans. It was tough to gather money through different sources and put things in perspective,” he recollects. The company had a turnover of over ` 6.5 crore in its very first year, and today Patel has plans to soon reach the ` 100 crore mark. After that hurdle was surmounted, a calamity at the plant became another. During the trial run of the plant in 1998, heavy rains affected the city. The manufacturing facility was partly submerged and there was considerable damage. He says, “Being in its infancy, the floods caused

a major blow. It took around three to four months to get the facilities back in action.” Thus, Patel proved that he is stronger than the problems, and moved on. The setback caused to the rains, pushed the company a bit further and created problems in obtaining the licence and the delayed production cost. But that too was conquered eventually.

How successful has ‘Marck’ been in leaving a mark in the industry since inception? Marck Biosciences was started in 1997 with one small line for making intravenous solutions; today we have more than seven Blow-Fill-Seal (BSF) lines. Over a period of time, Marck Biosciences has successfully moved from the image of a manufacturer to a preferred partner for many Indian as well as international pharma companies We also are the top three companies in the

country to make SVP. Marck Biosciences is among the few Indian pharma companies who have geared their production facility to become a versatile manufacturer of 0.5 ml injectibles to 1,000 ml irrigation solutions. We are also the first company in the world to launch Paracetamol IV in a plastic pack. I believe Marck Biosciences has successfully proved its versatility in the BFS space and is truly an emerging leader in the market.

How have you ensured that Marck has maintained the quality over a period of time? I believe that a good manufacturing facility is the one that has good hardware, evolved systems & trained manpower. We have extensive 48 hours induction programme, 45 days on-job training and evaluation of performance at various

Quick bytes Message to youngsters: Work hard; there is no substitute for hard work! One word that sums up all tips for success: ‘Execute’ Tech savvy? Not much. E-mails are seen on a paper; writes down the next point of action

stages. This programme has worked for us and we intend to continue the same, but lot more can be done. With the increasing developments in the Indian pharma industry, competition is only going to get tougher and quality standards stricter. I think that most pharma companies are adhering to quality standards, and will need to continue doing the same. It is a matter of losing the market and brand value for a company, once they lose out on quality.

If not Marck… I probably would have been involved with something that had to with ‘technology,’ and mostly something of my own. I definitely would not have continued in banking.

What next? Personally, I am happy the way things have panned out. I would have not continued my financial job streak for sure; I definitely would have gotten into doing something technical. At Marck, we are working across six therapeutic segments. Overall, the emerging market trends would continue to vary from segments to segments.

Modern Pharma•16-31 July 2012

Special Focus

Strategies of pharma HR

as there is a lot comparison between co-workers and the pharmaceutical industry in general is being competitive by the day,” expresses Rajarshi. He adds, “As for compensation, there needs to be some kind of clarity between companies of similar stature. For instance, companies below ` 100 crore should be in one stature and so on; once the stature is marked the compensation for the same stature should be more or less the same. There should not be a great amount of disparity in terms of compensation as it further increases the sense of incompetence and lack of confidence in the employee.”

Recruiting and retaining the right talent Due to increasing competition many employees succumb to the pressure job change at regular intervals. It is important for a company to spot the problem and find solutions to ensure that they can retain their employees. We discuss the various challenges faced by employees and also the retention strategies adopted by various pharma companies.

Jasleen Kaur Batra jasleen.batra@infomedia18.in

eing happy and satisfied at work is a rare combination. For the employee, it not only gives the feeling of being worthy but also helps him/her give their best to the company. However, there are a few problems being faced by employees today in terms of compensation, a healthy work environment, a support team and many more that ultimately lead to attrition. Being a highly organised and knowledgeoriented industry, pharma sector requires employees who are highly skilled and talented; the loss of an employee may affect the company negatively.

Core of the problem As globalisation has kicked in and a number of MNCs have entered the Indian pharmaceutical industry space, resulting in increased exposure for the employee. This in turn has increased the

Comparison (between present and previous companies) forces people to get into a shell and not produce the desired results, or sometimes even think of a job change. D G Rajarshi Managing Consultant, Pharma Resource

expectation an employee has from an organisation. Due to these expectations, a number of issues have come to the surface. “Though there is ample skill available in the market, the sole problem of finding the right candidate for the right job still remains. Pharmaceutical companies today are not able to find the best candidate for their positions due to the same reason,” informs D G Rajarshi, Managing Consultant, Pharma Resource. The production or R&D experience required for one company may not be the same everywhere, and hence, it is important that the candidate is extremely specialised in his/ her field. Due to which it is also important that recruitment is done after a close look at the candidate’s profile. Inspite of being aware of this a number of companies rush through the process of recruiting a fresher. “At the entry level, companies are in a hurry to recruit people as they believe they can train the employee as per their requirements, so whichever is the quickest recruitment they go ahead with that. But in my opinion the entry level recruitment is the most crucial of the lot. As the employee is a beginner it is important to ensure that the candidate is hired for a department he/she has an inclination towards; only then will they be in a position to produce the desired results. Today, manpower is available and India is churning up a lot of qualified graduates, but the required importance to technical skill is not given; the focus should be technical skills and not soft skills. It is only when the outlook towards this changes, will the entry level problems wash away,” explains Rajarshi. One of the topmost problems being faced besides entry level recruitment is the increasing attrition rate. Several factors aid to this; right from the work environment, promotional avenues, compensation, etc. Another factor is redundancy; with

Various retention strategies

fast developing technology even the most experienced people in the industry are overpowered by the feeling of being redundant as they do not have access to the latest upgradation programs and lack training. “The work environment also plays a major role. The work environment of a company depends on the culture of the particular company, which varies from one company to the other. It is found that most of the new recruits tend to compare the work culture of the current company with that of their previous one. As no two companies can be the same; there is always a difference and this comparison forces people to get into a shell and not produce the desired results, or sometimes even think of a job change,” says Rajarshi. Also, companies in the pharmaceutical sector do not involve the family as much as the other industries do. Motivation from within the home is very poor. “A few challenges are also being faced in terms of sourcing profiles for unique positions, ie, bio analytical, FDA auditing skills, lack of good communication skills, lack of domain knowledge, frequent job changes by candidates – low on employer stickiness and absorbent salary expectations at senior levels and more offer drops,” informs Suresh Anubolu, Chief Human Resources Officer, GVK BIO. Though these factors play a vital role in making an employee leave an organisation, there are various ways in which these can be worked upon and exits can be restricted.

Overcoming the challenges Recruitment on the whole is a tedious and a challenging job. However, besides this every industry witnesses certain industry-specific challenges, which they need to overcome to ensure that the employees are working in a stress free and relaxed environment, which makes them want to continue working in the same company. For beginners, the work environment of a company is completely in the hands of the management. “A company must perform a kind of benchmarking exercise to observe what the employee desire. The kind of promotional avenues the employees would like to have should also be looked into

If one is given the option of internal transfer, the employee not just enjoys his/ her work as they work in the department of their liking but their loyalty towards the company also increases. Suresh Anubolu Chief Human Resources Ofﬁcer, GVK BIO

To retain the employee, the company first needs to identify the problem within the organisation. “They need to find out where the company is lacking. For instance, for one company the problem can be compensation, in the other it could be environment, etc. Depending on the stature of the company, the right compensation and environment can be provided,” says Rajarshi. Creating an encouraging atmosphere with regards to awards, regular appraisals, public announcement of one’s achievements are a few steps being taken by various pharma companies today to ensure that the employee is happy at his/her workplace and wishes to continue. “In addition to these, a few more strategies that are recently being adopted are faster career growth. This involves internal transfer. This is an extremely effective strategy, as employee might not be satisfied with his/her department. If one is given the option of internal transfer, the employee not just enjoys his/her work as they work in the department of their liking but their loyalty towards the company also increases,” explains Anubolu. Further explaining the other strategies, he adds, “Fairness in pay – as per market data, higher education policy, job rotation and rewards and recognition are crucial factors and must be followed by all companies to retain their employees. It is not just important to pay the employee well, but to ensure that he/she is working in a perfect environment with a blend of all these factors is equally important.” With so much of talent available, getting the right person for the right job remains a challenge. “Every company has an HR department and they have their Key Performance Indicators (KPIs) at all levels and sometimes the focus is to catch someone from a bigger company. In the race to get someone bigger and better people, one tends to miss the calibre and skills of the person they hire,” concludes Rajarshi.

Modern Pharma•16-31 July 2012

Special Focus

IT in transactional HR functions

Providing a structured framework From maintaining time record to ensuring accurate payroll transactions, HR of a pharma company takes care of all. But manually the work becomes cumbersome. Hence, IT ensures error free and smooth work structure. Read on to find more about the difference that it brings.

Chandreyee Bhaumik chandreyee.bhaumik@infomedia18.in

t is definitely more than often that we have faced attendance problems in the company and with a click of the mouse the Human Resource (HR) department of the company has come forward with solutions. Indeed it is no rocket science or magic but definitely it takes a lot to be organised and ‘well managed’ as they call it. And extending a helping hand in this matter had been the inclusion of IT in the HR department of the company. For any organisation, the HR department is one of the most vital departments. And HR cannot function without adequate IT solutions. IT makes the task easier and more efficient. The role that started with managing payroll system has broadened its horizon now.

Current scenario Today, HR is an efficient tool for managing the talent pool of a company along with increasing their productivity and skills. Talking in this regard, Dr G P Naik, Director, International Institute of Human Resource Management (IIHRM), avers, “HR managers are traditionally known for carrying out routine functions like time office, security, canteen, payroll, statutory compliance and so on. But over the past 20 years the revolution of globalisation and

The decision to automate transactional HR activities or carry out manually is basically a question more of mindset rather than financial constraints. Dr G P Naik Director, International Institute of Human Resource Management (IIHRM)

than financial constraints. Today, there are hundreds of technology service providers in the market than ever before who are willing to come to one’s office, customise the software to one’s requirement and maintain it without interruption. Costs have come down substantially and even for as low as ` 10,000 a year so that smaller organisations can have their transactional HR activities automated.” Commenting on the cost factor, Shah says that this involves simple software and in most of the cases cost is not a hindrance. He adds, “The cost varies from ` 10,0001,00,000 depending on the variety. The ones that perform simple calculations cost ` 10,000 and with increase in the performance capacity the cost also increases.”

Future ready

privatisation has brought world class organisations to open their offices in India. These organisations also brought with them the best practices in HR that can add value to business beyond the traditional routine activities.” Dr Naik adds that the HR professionals in India then realised that if they have to engage meaningfully to contribute for the success of business, they have to divest themselves of the mundane HR activities. Dr Naik highlights, “Two approaches that emerged to provide solace to HR managers at this juncture are outsourcing and automation. Functions such as employee services that cannot be handled by technology like employee relations was outsourced and the transactional activities like payroll, attendance, leave records, induction training were automated.” Seconding his thought, Suketu Shah, Director, Soham Computers, elaborates, “In a pharma company, never less than 100 employees are working at one time. Thus, IT helps in giving an order to the attendance system. With the help of IT direct data is obtained and through automated systems calculation of PF, loans, etc, becomes easier.”

Transactional HR In a pharma company transactional HR functions are the routine activities carried out in the HR department like payroll, statutory returns, time management, attendance and so on. Dr Naik elaborates, “These activities are well defined, voluminous and repetitive in nature. Manually handling these traditional HR

activities is expensive, time consuming and capable of causing frequent errors. Hence, right answer to these problems was found through automation or computerisation. Initially, there was skepticism about automation in HR because of

The situation of automating transactional HR functions is well on time in pharma organisations and evolving in the traditional manufacturing sector.

the high investment and the resistance to technology due to lack of knowledge.” Dr Naik adds that HR managers were also worried about losing their jobs since it will be taken over by the computers. He emphasises, “But as we moved along with the changing times, cost of automation not only came down but quality of services improved; more and more HR managers became techno savvy and they reinvested their roles from being record keepers to business partners.” Transactional HR functions are structured, time bound and repetitive in nature; for example, calculation of provident fund or income tax deduction. Dr Naik says, “In case of smaller organisations having five or 10 employees it is possible even today to do them manually. But in larger organisations automating these functions will save the cost of manpower, improve the speed and accuracy, and

relieve the HR managers from unimportant activities to enable them focus on business.” Elaborating further in this note, Shah adds, “Nowadays, with IT in place, in a pharma company it is possible to know the detailed information about the employees, like his areas of work, his educational qualification, professional skills, experiences, etc.”

Cost factor In most of the cases where technology is involved cost becomes a deterrent, bringing a hindrance to the progress path. Discussing the cost factor, Dr Naik elaborates, “The decision to automate transactional HR activities or carry out manually is basically a question more of mindset rather

In a pharma company, never less than 100 employees are working at one time. Thus, IT helps in giving an order to the attendance system. Suketu Shah Director, Soham Computers

Performing HR functions in a pharma company does not require any advanced knowledge in IT. Dr Naik says, “The challenges in automation of transactional HR are how one changes the mindset of service providing HR functionaries and service using employees. Service providers in manual system had lot of power and control on the service users. Similarly some service users like workers union leaders also had a ground to raise an issue about routine activities like attendance marking, salary payment, etc. When one automates, the people who were in control feel losing grip over the matter and brand automation as bad for the business. Hence, changing the mindset of people is the bigger challenge.” He continues, “The situation of automating transactional HR functions is well on time in pharma organisations and evolving in the traditional manufacturing sector but the situation is under control. Organisations are realising that the benefit of automation is much more than the cost involved for implementation.” He explains that organisations learn from each other’s experience as aptly described in the social learning theory of Albert Bandura. He reiterates, “HR associations such as National Institute of Personnel Management and National HRD Network shall organise more collaborative seminars and meetings with HR technology service providers to promote meaningful understanding. At the same time, HR technology companies should devise far more user friendly technology and pricing strategies, which are affordable to even the smallest HR department.” Therefore, IT has definitely brought decorum to the management of the employee strength of a company and thereby brought more productivity to the talent pool.

Modern Pharmaâ&#x20AC;˘16-31 July 2012

Special Focus: Interface

Indian pharma companies are taking big leap from survival to competitive strategy, â&#x20AC;Śinforms E Balaji, MD & CEO, Randstad India. He discusses the current trends as well as the challenges being faced by the pharmaceutical companies with respect to HR and also sheds some light on the trends that would soon dawn upon us.

Jasleen Kaur Batra jasleen.batra@infomedia18.in

From an HR perspective, what are the trends in pharmaceutical marketing and sales functions today? Pharmaceutical sales professionals stay on top of the trends in the latest sales software applications; the newest prospective customers and their own networking base work for referrals. A pharmaceutical marketing consultant needs to know where to fit in the scheme of things relating to the clientsâ&#x20AC;&#x2122; best interest to make sales. While a pharmaceutical marketing consultancy remains a top choice for many clients, others prefer to use their own websites and in-house marketing plans to move their products. Others shop online for their inventory through the many global trading portals open now. Attrition at sales representative level remains a challenge for HR professionals. The attrition stands at around 30 per cent, which is a huge number if one considers that an average pharmaceutical

company would have at least 1,000 sales professionals. A huge chunk of the recruitment budget is spent every year on replacement of frontline sales professionals. Few steps that HR professionals have taken to curb this trend is to overview the compensation of sales professionals; however, this has had little impact on attrition itself. How can a pharmaceutical company respond to cost control? The Indian pharma industry is witnessing attrition of 30 per cent at the field level and around 10 per cent at managerial levels. A few key HR-related measures that pharma companies can adopt in controlling cost are: HR should become a strategic partner to the organisation: It is important that the HR teams in pharma organisations plan their management development, competency benchmarking, performance management and compensation strategies meticulously to ensure they retain and enhance productivity of employees and focus on conducive work culture

Flexible workforce to suit business requirements: Outsourcing and contract staffing are evolving trends that pharma companies have adopted for functions such as sales and IT. This provides them with tremendous flexibility to meet business demand at lower costs Leverage technology and social media collaboration and marketing: There are various cloud-based applications that can be used to monitor the productivity and collaboration of employees. The overall investment in technology can be reduced through these tools. Also, social media has created a way to establish a direct link with employees and customers. These technology levers can serve effectively in employee engagement. What are the challenges faced by the pharmaceutical companies today in terms of recruitment? How can the HR department help overcome that? A few measures can be taken, which are: Creating a strong employer branding for the company:

The HR in collaboration with the marketing team should create employer brand awareness among the institutions where the employable community is being groomed. This could be play a major role in creating visibility and inviting talent to the organisation Employability of the technically qualified community: The pharma selling happens through quick, smart and timely interaction with a member of the medical practicing community. The chunk of students or already employed members of the organisations somewhere seem to miss out on communication and the right attitude required to not just sell pharma but to win the space with the doctors. The HR department should play a vital role in assessment of employees and ensure training to members not just on the technical aspects of the products, but also extensively invest in improving personality, presentation and communication skills. Compensation and added benefits are the biggest driving force for an employee. How can a pharma company maintain a balance between the benefits to the employees and maintain profits within the company? While 80 per cent of metrics used by large pharmaceutical companies to determine incentives are financial, only 12 per cent are related to drug development and commercialisation. R&D is the backbone of any leading MNC pharma company and that is what gives them an edge over their nearest competitors. Pharmaceutical industry sales and R&D functions have operated on the premise that activity yields results, but that formula does not work. The pharmaceutical industry now has to turn itself inside out and focus on investments that produce results for customers. What have been the strategic changes in the pharma recruitment market over the years?

Every organisation has the option of choosing candidates from two sources: external and internal. Sources within the organisation (transfer of employees, promotions, referrals) are internal. These minimise cost and also enable a ready talent pool for the company at any point in time. The external sources are largely different portals and outsourcing agencies. Companies have now opened upto RPO and VMS models, which are complete outsourcing of the recruitment process to manpower agencies. This is turn helps them to concentrate on core activities. What kinds of retention strategies would you suggest for a pharma company to follow? The Indian pharma industry is growing exponentially, and companies are taking the big leap from survival to competitive strategy. Hence, there is a constant demand for the best talent, and the subsequent result is heavy attrition. Compensation also plays a vital role in the retention of quality talent and attrition is a serious issue in the pharma industry as it is knowledgebased and employees are its assets. An encouraging work atmosphere, good culture, need- and skillbased training and career growth with adequate salary are some provisions that control attrition. What trends do you foresee for pharma in the future? Many MNCs have been eyeing to buy leading Indian pharmaceutical companies and grow inorganically as the latter have a greater understanding of the industry and have appreciative penetration into the Indian markets. Indian companies have responded to this challenge by expanding their field force and trying to spread their wings to reach out to maximum number of customers. The Indian government wary that prices of the drugs would increase if the trend continues, and this has delayed the process of takeover of Indian pharmaceutical companies.

Modern Pharma•16-31 July 2012

Special Focus: Interface

We realised 3-4 years ago that in order to manage the younger generation we should have different ways ...says Pradeep Vaishnav, Senior DirectorHuman Resources, India and South Asia, Sanofi. He talks about the nitty-gritty of HR in pharma and how the work culture can be made more interesting.

Chandreyee Bhaumik chandreyee.bhaumik@infomedia18.in

What are the current oft-noticed trends in pharma HR? The often noticed trend in pharma is that we grow our own leadership team. If we look at Sanofi, we are in the business for the last 50 years in India. And here most of the people have started from the ground level and today most of them have reached the top leadership positions. The typical trend in pharma, unlike the BPOs or the telecom industry, is that leadership is developed from within the company. Thus, today’s most of the decision makers in the company, directors or marketing heads, or others have all grown from within. They had joined probably 20 years ago and today they have reached these leading positions. This is unique to most of the pharma companies. Primarily, I would like to highlight the present young generation joining the organisation at the ground level and they have different expectations in terms of their career, compensation and other matters. And one of the challenges of the HR is how to integrate them. And 3-4 years ago we realised that in order to manage the younger generation we should have different ways. For this purpose, we have a programme called ‘Pratimbh’, where we intervene at the managerial level, helping them to comprehend their relationship with the young generation. What is the primary qualification that you look for while recruiting? The presence of Sanofi is everywhere. Therefore, the primary qualification differs. In manufacturing, we consider people with chemistry background more relevant. Electrical, mechanical and other engineers are also relevant for this. For, formulation development, which is more research driven activity, we look for scientists and regulatory people. Largely, they are required to be MPharm or PhDs for the

formulation development plant. For R&D, we consider medical doctors, those who are MDs in pharmacology, etc. Thus, largely, we prefer employees from science and pharmacy background since they are expected to constantly interact with the doctors and logic out the science behind the drugs. Next, the employees should be well acquainted with physiology also. What kind of soft skills does Sanofi prefer? It is difficult to give a general opinion but overall the person should be patient centric. It should be remembered that the person, who is joining the pharma sector, is not joining the industry to sell/push the pills in the market. They need to know the efficacy of the drugs and how are the drugs helping the ultimate consumer. Even during the interviews conducted, we try to gauge the sensitivity of the applicant. Here, I must emphasise on the fact that we are moving from a typical pharma company to healthcare industry. When one is looking at pharma company one is selling drugs, but when one is looking at healthcare company then one is looking at the larger picture. Moreover, the person should be extremely transversal in nature. He should always be aiming at results, by not only selling but also bringing awareness

The most important element in engaging employees is being able to share with them in the company’s vision of where we want to reach in the next 5 years. to the doctors. Thus, it is important to know how he will be communicating with the doctors since we must remember that here the consumers are all high profile well educated doctors unlike the FMCG products where one sells it to the distributors. Which are the retaining practices followed in your company? More than retaining practices I would like to refer them as

engagement practices since retention includes lot of external factors like the job outside, money, location. At Sanofi, a recent survey revealed that our engagement score to be around 85 per cent. The most important element in engaging employees is being able to share with them in the company’s vision of where we want to reach in the next 5 years. Sanofi has developed various programmes for this purpose. Each of our programmes such as Disha, Pragati, Lakshya and many others are designed for employees to develop them so they can build their careers at Sanofi, and grow with the organisation. What has also helped us is our strength-based philosophy that lays emphasis on developing strengths of employees rather than focussing on their weaknesses. Through our programmes, we help our employees to identify their key strengths and optimising these accordingly. Further, at Sanofi we are continuously evolving and are changing our business models and thus people

should be adaptable various changes.

What are the ‘other than work’ HR initiated activities in your company? Here, we conduct various programmes for employees

What has also helped us is our strengthbased philosophy that lays emphasis on developing strengths of employees rather than focussing on their weaknesses.

and try to involve their families involved as well. We have one function called, ‘Kids at work.’ This year we had invited the children (below 12 years) of our employees and conducted several fun programmes. The response was huge as there were around two hundred people. Five years back the programme that started with 20-30 children, and today it has achieved so much.

Again, we have programmes on Dassera, Christmas Eves, etc. We also have picnic sort of programmes where the employees meet outside with their spouses. These are the programmes of the corporate office. We also have similar programmes for the manufacturing sites. As far as the field personnel are concerned, those who are super achievers, they are offered free trips with their spouse to either Paris or a place in Asia Pacific. Then, there are also small Sunday outings for these people. Additionally, there are also Corporate Social Responsibility (CSR) initiatives by the company. Our intention is that whatever CSR activity we do, we want our employees to be actively involved in them. We are happy to share that we have an Employee Vounteer Group for CSR. We also have Health, Safety, Environment (HSE) programmes under which we organise activities and awareness programmes focussing on employee health and safety.

Modern Pharma•16-31 July 2012

Facility Visit

Karnavati Engineering Ltd

Pharma manufacturing with a panache Parita Dholakia parita.dholakia@infomedia18.in

arnavati Engineering Ltd (KEL) was started in 1981, with a focus on transforming machines to pharmaceutical excellence. A sister concern of Cadila Pharmaceuticals Ltd, the initiative to establish KEL was taken by Indravadan Modi, Chairman, Cadila Pharmaceuticals. Today, the organisation has come off age in carving out a huge name for itself in the market for its outstanding quality and customer service. It is an ISO 9001:2008 company with state-ofthe-art infrastructure and manufacturing capabilities for pharmaceutical machineries, toolings, line and allied accessories confirming to the highest standards of quality and reliability. It is accredited by the Government of India as ‘Export House’.

Striving for a happier and healthier tomorrow, Gujarat-based Karnavati Engineering Ltd is on its way to become a leading pharmaceutical machinery manufacturer in India and a significant global player. A technology-driven pharma manufacturing machinery- providing company, we trace the growth story since its inception.

Tablet press machine

excellence in technology, based on world-class research and development,” avers Modi. Explaining about the customer-centric services that KEL provides, he says that engineers are available for support all through the day. Mostly people send their technical problems via e-mail, and in rare cases they receive odd-hours phone queries. The company’s Kalweka brand has carved its niche as an all purpose equipment for research and development in pharmaceuticals, chemicals, cosmetics and food industries. KEL has several products divided as per the kind of manufacturing required (R&D/ Lab/Pilot/Production scale) and which industrial segments the machine caters to.

Providing manufacturing excellence

Infrastructural benefits Being end-to-end solution providers in the tablet presses category and capsulation, it has a vast range of products for pharmaceutical machinery sector. It has a presence across the board in tablet compression, tablet press accessories, capsule filling equipment, capsule filling equipment accessories, laboratory equipment and granulation equipment. Several turn key projects in pharma plant design and erection, clean room panel, liquid line, tablet line, soft and hard gelatin capsule line and packaging line, are executed by the company. The Gujarat-based plant is located at Kadi, which is some 40-odd kms away from the Ahmedabad Airport. Set in an industrial area, the entire plant is spread across more than

100 acre of land. The entire manufacturing operation is divided among the four major buildings across the vast area. Two of the major buildings deal with manufacturing of the various parts and pieces that are required for the instruments (Manufacturing lab and Manufacturing room). A separate section is dedicated to the Quality Control (QC) section and packing the goods before exporting them. One of the building deals with the entire assembling of the machines and the trial run is also undertaken here. This is where we witnessed live trials for its brand new ‘Mini II’ tablet manufacturing machine (which is a labscale production machine) that generates a record large number of tablets per hour.

Also, manufacturing machines for veterinary products (tablets and capsules) were running for trials. Most of these machines are completely automated and have as high as 5-level password protection. Explaining the workforce and the working pattern, Mukund Modi, Sr VP, KEL, informs, “Major workforce in the manufacturing section comprises males; females are largely seen in the QC and R&D department. Since the manufacturing operation is on most days of the week, we have people working in different shifts of days/timings of the day.” This ensures that KEL can output maximum of the products in a continuous manner.

Brimming with action With an aim to be a significant global player in the chosen field of pharmaceutical machinery and allied equipment manufacturing, leveraging on human resource, technology, continual improvement of quality management system, experience and expertise, the company has come a long way since its inception. Talking about the investment in R&D and manufacturing ratio, Modi says, “A considerable part of our revenues are invested into R&D. We have in-house

experts in the field who dedicatedly work on the projects and are constantly available for technical support. Most of pharma manufacturing companies

KEL boasts of bringing many firsts into the market. It was the first company to introduce small batch (R&D) tablet presses domestically. It led the industry for designing front controls for better ease of use in production machines. Table top fully automated capsule machine in early days when capsulation was considered to be a bulky affair, was introduced by KEL. Been the believers of collective growth, the company has brought forward systems that facilitate and reinforce the same. Its management systems cover quality, health, safety and environment. These systems focus on managing operations effectively and are largely certified in accordance with international quality and environmental management standards. A large share

Strong presence of Karnavati Engineering Ltd More than 25 years of rich experience Over 1,700 successful installations across the globe Export to more than 50 countries across the globe Strong domestic presence with 5 branches across India Strong global presence with network of 30 business associates More than 200 loyal customer base across the globe hire freelancers for designing their equipement, and this keeps on changing from project to project. But here at Karnavati, we do not have freelancers. All the experts are on our payroll and work for us on all projects.” The team work of the employees has to be commendable since the assembling and entire nitty-gritty of fixing all the small pieces and parts of a machine together requires too much of concentration and dedication. A motivated work force and commitment from management has helped KEL maintain a steady pace at all times. “At the end of the day, we are happy to achieve total customer satisfaction and achieve leadership in chosen markets, products and services across the globe through

of its revenue is provided by exports. “Products are manufactured with the latest technology, and we always provide quality work. It is no wonder that several developed countries order our products,” avers Modi. With an aim to provide products and services which contribute positively to society and improve the quality of life for our employees and the communities, most operations carried out KEL are a testimony to this aim. KEL has been at the helm of technology revolution in the field of pharma machinery for a decade and has become synonymous with tablet press series worldwide. Time shall tell how the growth of this technology and solutions-driven company goes further.

Modern Pharma•16-31 July 2012

20 Insight & Outlook: Policies & Regulations

Central Drugs Standard Control Organization

Needs an overhaul The reputation of pharma industry in any country is based on its capability to develop, manufacture and market drugs, which are effective, safe and meet the laid down quality standards. Country’s drug regulatory authority therefore plays a key role in guarding the public health by ensuring that these criteria are fully met.

in enforcing various regulations of the Drugs Act, is making the approval process ad hoc and nontransparent, resulting in proliferation of irrational combinations, counterfeit drugs , non-compliance with GMP, rampant abuse of potent drugs like antibiotics, steroids, medicines for pregnancy termination, etc due to dispensing without prescription as well as misbranding (changing the active ingredient / swithout changing the brand name ). The parliamentary committee has also challenged the qualifications of the person required for the position of DCGI. In most developed countries (including China, Brazil, etc) FDA is headed by people with strong science background (eg, MD, PhD in medicine, pharmaceutical sciences, pharmacology, chemistry, molecular biology, etc). The pharmaceutical industry is slowly moving from Chemistry to Biology. It is expected that over 40 per cent drugs approved by US FDA in 2015 are likely to be biologics. Also, biosimilars offer a huge opportunity to Indian pharma.

Reforms required To handle such complex products based on future technologies such as biotechnology including genomics, proteomics, stem cells as well as nanotechnology we need domain experts in the regulatory agencies. However, even a progressive state

hile the Indian pharma industry has grown to become the `Medicine Shop` to the world with over $ 21 billion in sales (domestic + export ) in 2011, the Indian regulatory authority, however, has failed to keep pace with this phenomenal growth and is mired in controversies. Whether it is the appointment to the post of highest office, ie Drug Controller General of India (DCGI), or the recent indictment of the Parliamentary Committee on the new drug approval process where 30 odd new drugs were approved by the DCGI’s office without clinical trials. According to this committee many drugs were approved based on `personal perception` rather than `scientific evidence` and were based on `managed` endorsement of the medical experts. This will not only result in public losing faith in the ability of Central Drugs Standard Control Organization (CDSCO) in guarding the public health but also country’s image in the eyes of global customer in the quality of drugs manufactured in India affecting our exports. India is increasingly becoming a `Destination of Choice` for outsourcing clinical trials because of abundance of patients of diverse gene pool, availability of well qualified scientists, proficiency in informatics and cost competitiveness. However, India

is slowly losing its edge due to its slow moving new drug approval process resulting in many international and even Indian majors moving to countries such as China, Singapore, Thailand, Brazil, etc, leading to loss of millions of dollars in revenue.

The inconsistency between the state and central drug control agencies in enforcing various regulations of the Drugs Act, is making the approval process ad hoc and non-transparent Intellectual Property Rights Another important issue is the one related to protecting Intellectual Property Rights (IPR). For instance, USFDA follows the system of patent linkage. This is a practice of linking drug marketing approval to the patent status of the original product and not allowing the grant of marketing approval to any third party prior to the expiration of the patent term. Patent linkage system requires that the generic manufacturer gives proof to the FDA that the new drug for which an approval is sought is not covered by a valid patent in that

Major players and some of their biosimilar products Companies

Biosimilar products launched

Teva

TevTrophin (hGH), Interferon alpha 2b, Tevagrastim (G-CSF), Epo

Sandoz

Omnitrope (Somatropin), Binocrit (epo), Zanzio (G-CSF)

Biocon

Insulin, Epo, G-CSF, Streptokinase, and BioMAb EGFR

Dr. Reddy’s

Reditux (Rituximab), Grafeel (Filgrastim)

country. Indian FDA should follow the patent linkage system to protect the IPR of the originator. India also does not have Data Exclusivity (DE) in place. Most developed countries (including China, Korea, etc) honours DE. This means that generic company can launch their drug only after a lapse of certain period (eg, 5 years in USA) after the approval of the original drug, which means that the generic company cannot use the original data generated by the patent holder to get the marketing approval. Since clinical trials are quite expensive and take several years to complete, the data generated in such trials is an important intellectual property of the patent holder and must be protected. The DCGI claims that all the data submitted for approval is always held confidential. However, confidentiality is difficult to enforce in practice and therefore India needs to grant DE. Such changes will significantly attract more clinical trial outsourcing to India. India’s imports from China, particularly of APIs are on the increase. For instance, for penicillin-derived products, India is completely dependent on China. To ensure that the Chinese manufacturer conforms to the international GMP, Indian regulator should periodically inspect the manufacturing facilities of such exporters for GMP compliance by sending a team of well-trained FDA inspectors to overseas facilities. Although this process has begun, it needs to be strengthened.

The formation of CDA was proposed and approved by the cabinet way back in 2007, but like most government policies, it is still hibernating due to bureaucratic apathy and vested interests.

like Maharashtra is content with an IAS officer heading the FDA for last several years. At one point of time, it even had a police commissioner as Commissioner of the FDA. Several representations in this regards to Maharashtra Government have fallen on deaf ears. Solution to above problems lies in having a Central Drug Authority, an autonomous body on the lines of US FDA headed by an outstanding technocrat (of the calibre of someone like Dr R A Mashelkar , former Director General of CSIR). The formation of CDA was proposed and approved by the cabinet way back in 2007, but like most government policies, it is still hibernating due to bureaucratic apathy and vested interests. CDSCO therefore needs comprehensive reforms recommended by various committees quite a while ago including formation of CDA. This will not only restore the confidence of general public in the quality of drugs it consumes but will go a long way in realising the aspirations of the Indian pharmaceutical industry in becoming a global leader.

Bringing a change To bring about the above changes, the most important reform we need is the organisation structure of the regulatory agency, ie, FDA. The inconsistency between the state and central drug control agencies

Dr Ajit Dangi President & CEO, Danssen Consulting avdangi@gmail.com

Modern Pharma•16-31 July 2012

Insight & Outlook: Strategy

Medical practitioners

Does your clinical meeting make a ‘point’? In the need to keep pace with latest research and technology, older surgeons need to be aware of the improved operative methods so as to keep up with their junior colleagues. Consequently, hospitals, which employ a large number of medical specialists, will only enlist the services of those physicians who are experts in the most recent and financially rewarding techniques. And for keeping themselves abreast, pharmaceutical companies provide certain incentives to medical practitioners. A look. cience is constantly evolving and newer things are being discovered every day. Practitioners of medical science need constant up gradation of their knowledge and skills so as to deliver better results to their patients. Besides, physicians need to keep reading and attending seminars and conferences to know that certain drugs once considered useful are now being withdrawn due to recently understood adverse effects. Clinical procedures or surgical techniques undergo rapid transformation in their methods either because of newer addition of equipment or due to discovery of fresh data about pitfalls in the traditional technique. Gadgets such as the endoscope, the CCTV, the 3-D digital camera and now robotic surgical assistants have transformed the way operations are done. Patients who have access to ‘Dr Google’ on their mobile phone are armed with questions about small surgical cuts, limited blood loss and shorter hospital stay and the physician he/she visits better be prepared to give convincing answers to his queries. Therefore, even physicians or surgeons who may not be directly involved in performing the newer procedures need to be aware of what is being done by his colleagues using the recent machinery.

see their western counterparts bringing in the credit system to compel their members to be on par with the best across the globe. Consequently, the Medical Council of India (MCI) swung into action and now they have made it compulsory for doctors to upgrade their theory knowledge and clinical skills. According to their guidelines, for the renewal of their qualification-registration, doctors must earn 30 credit points every 5 years. These points are obtained either by carrying out research and publishing it in journals, delivering talks at specified specialty conferences/ workshops, writing chapters in textbooks or authoring a textbook. Those who are unable to carry out any of these activities can earn points by attending conferences/ seminars/workshops, which are approved by the local branches of the MCI.

Drug manufacturers spend huge sums to get original research workers and clinicians from overseas in order to address local physicians about their work. All this time, money and effort is wasted if there is poor attendance.

Credit point compulsory Hitherto, not all practising physicians used to update their knowledge by reading journals or attending clinical meetings. Once he acquires the medical licence to practice his science, nobody questioned whether he was keeping abreast of newer developments in his field. Without having up-to-date knowledge, the medical advice provided or drugs prescribed may not be in the best interest of the patient. This issue was clearly realised by the fraternity and they could

Like in the west, the MCI has clearly outlined the way such meetings need to be conducted, the specific content of the programme, the venue at which it is to be held, etc, so as to standardise the Continuing Medical Education (CME) programme format, which was gradually being reduced to a farce. According to their guidelines, if the guest speaker is invited from abroad, for a one-hour talk, the delegates earn one credit point. For local

experts, the regional branches of the council need to conduct a 3-hour session in order to earn the same point. Under such a scenario, most of the routine ‘drug-promotion clinical meetings’ hosted by pharmaceutical companies either to launch newer drugs or the ‘thanksgiving’ party for an already established brand is out of the purview of the recommendation. Although such gatherings will continue, the impact of the same is gradually getting diluted.

Pharma losing ground About two decades ago there were just a handful of pharmaceutical players, dominated by MNCs. These companies had a limited range of drugs, which had a huge market, even as small pharmaceutical companies, which had a good hold on the local market, thrived alongside. At that time, physicians looked forward to pharmaceuticalsponsored events as it was an opportunity to bond with their colleagues over meals while picking up a few clinical tips from invited speakers. Today, with the mushrooming of local and multinational pharmaceutical companies in the country, there is a ‘clinical meeting’ being conducted in some part of the country, every weekend! That is not all. In the middle of the week there would be a live webcast of a talk by an eminent international expert to which you can log in and participate. The easy availability of medical updates through e-mail alerts from online journals and regular supply of books and journals from pharmaceutical companies keep physicians

who are interested in newer developments very well informed. There is no need for the doctor to attend all clinical meetings to learn about recent advances. Consequently, drug manufacturers find it difficult to attract doctors to attend their meetings.

Pharma companies will have to work out an annual calendar of events keeping all their product range in mind and invite specific doctor-groups, in line with the MCI recommendations.

Skip if no ‘point’ When an Medical Representative (MR) comes with such an invitation, a junior physician who is yet to get busy in his practice may be able to make the most of such meetings, the senior practitioner who tries to get some free time, scurries for cover. Physicians have to per force attend CMEs authorised by the MCI in order to earn credit points. Some of the Sundays get utilised in the process and they hardly get any time to spend with the family or go on personal outings. Therefore, when an MR invites the doctor for ‘a talk by an eminent guest speaker,’ the first thing the latter enquires is whether it will earn him points! ‘No point, no meeting,’ is the mantra for the present day physician. Drug manufacturers spend huge sums to get

original research workers and clinicians from overseas in order to address local physicians about their work. All this time, money and effort is wasted if there is poor attendance. Pharmaceutical companies would do well to avoid such a fiasco by ensuring that speakers are invited for talks in such a way that they meet the criteria for the audience to earn credit points. This will ensure double incentive to the attending doctors who will not only get to carry some additional take home messages as well as achieve the CME target set by the medical council.

Put more thought Pharmaceutical drug companies will have to work out an annual calendar of events keeping all their product range in mind and invite specific doctorgroups, in line with the MCI recommendations. The speaker will now have to be chosen more carefully to ensure that the audience is rewarded with genuine new data on disease or drugs rather than listen to the same ‘standardised powerpoint presentation.’ One hopes that drug manufacturers, will divert their energies to organising genuine, academically enriching CMEs, which will be beneficial to physicians in more ways than one. Mr Marketing Manager, have you got the point?

Dr Rajan T D Pharma Consultant & Practising Dermatologist rajantd@gmail.com

Modern Pharma•16-31 July 2012

Technology Transfer As part of our endeavour to spread the technology culture, this section provides a means to promote and facilitate exchange of select technologies. We strive to bring together suppliers of such technologies with suitable users for negotiations and industrial collaboration.

Technology Offered A novel process Foramides Synthesisamides synthesis The present technology provides with an amidation reaction of unprotected a-amino acids in water under neutral conditions with various aliphatic, aromatic and heteroaromatic amines in the presence of coupling reagent l,l’-carbonyldiimidazole (CDI) at ambient temperature to obtain the corresponding a-amino acid amides. Areas of application Medical and pharmaceutical industry Forms of transfer Technology licensing Anti-ulceritic APIs An Indian company offers anti-ulcer drugs like omeprazole, pantaprazole, omeprazole sodium, omeprazole magnesium and esomeprazole magnesium for operations in manufacturing processes. Areas of application Formulation industries Forms of transfer Consultancy Clorsulon and its intermediates An Indian company offers clorsulon, a highly potent anthelmintic drug, which is administered to de-worm the intestines of sheep and cattle. Areas of application Pharmaceutical industry Forms of transfer Consultancy Detection and analysis of heavy metals in the industrial effluents The present technology relates to a device and method for detecting and also measuring the concentration of copper in an industrial effluent. This device comprises of an ion selective electrode (ISE) coupled to immobilise Bacillus sphaericus strain characterized in producing Urease on its one end and to a voltage measuring device which is calibrated to indicate the concentration of the heavy metal in the solvent at its other end. Areas of application Industrial effluents, accumulates Forms of transfer Technology licensing Filter cleaning system An Indian company offers an automatic filter media cleaning equipment with drying system. It consists of air wash, water wash and drying facilities. Areas of application Filter media cleaning Forms of transfer Joint venture, equipment supply Formulation for leucoderma It is well known that these diseases have property of recurrence and most of the medicines used for cure have various side effects and also the disease

is not fully cured. The company offers the formulation that is quite effective in curing all the above three diseases in short period of time. In case of leucoderma after application of the formulation there starts formation of patches (natural colour of skin) within a week. Areas of application Pharma and medical industry Transfer terms Joint Venture, technology licensing, research partnerships Herbal formulation for psoriasis and eczema An Indian company offers an innovative herbal formulation that has the ability to control & cure psoriasis and eczema within one month of application of the formulation. Areas of application Herbal medicine Forms of transfer Joint venture, technical services, technology licensing Natural preparation for anxiety relief A company offers food supplement in the form of tablets that effectively relieves mild to moderate anxiety problems. The ingredient is an herbal extract, which has been scientifically proved for its efficacy. Efficient decrease of anxiety symptoms, quick onset of action and no side-effects are reported to be the advantages of this product. Areas of application Pharmaceutical industry Forms of transfer Equipment supply Process of preparation of nanoparticles for drug delivery system The present invention is related to a process for the preparation of the novel nanoparticles of apotransferrin or transferrin which are useful for the preparation of a pharmaceutical composition facilitating easy delivery of the drug. Areas of application Medical and pharma industry Forms of transfer Technology licensing Pharmaceutical composition for the treatment of ophthalmic disease A company can offer technology for manufacturing a drug useful in the treatment of opthalmic disorders. A composition comprising Lithium chloride is the product which causes retinal cell regeneration. Areas of application Pharma and medical industry Transfer terms Consultancy, technical services, technology licensing

Technology Requested Biotechnology for wastewater treatment system A Thailand-based company, a wastewater service provider, is involved in the R&D of new technology for water, wastewater and waste treatment. It requires new ideas related to technology for developing its strength in the field of wastewater. Areas of application Biotechnology, engineering Forms of transfer Consultancy

Manufacturing technology of hepatits B, tetanus, diphtheria and pertussis vaccines An Indian company is interested in a complete technology for start up of manufacturing of combination vaccines from bulk to formulations including supply of protocols for manufacturing and production strains. Areas of application Human vaccines Transfer terms Others

Calcium Gluconate A company needs technology for manufacturing of Calcium Gluconate Areas of application Pharmaceutical industry Forms of transfer Technical services, project report, others

Manufacturing of liquid bio fertilisers An agro biotech company is looking for a proven technology for manufacturing of liquid bio fertilisers. They would like to know the kind of technology that could be offered and a procedure of buying the technology along with the cost incurred. Areas of application Biotechnology Transfer terms Others

Extract of medicinal and aromatic plants A company is interested in putting up a multi-purpose herbal extraction plant for the extraction of medicinal and aromatic plants and herbs like artemisinin/quinine sulphate and other alkaloids. Areas of application Pharmaceutical industry Forms of transfer Others IV fluid manufacturing as SME An Indian company needs new and good technology to start which is a subservient of genetic manufacturing of IV fluids. Areas of application Medical technology Forms of transfer Technical services, others Kite grading engineering A company is looking for kite grading, which is a subservient of genetic therapy research particularly for the cardiovascular novice. Areas of application Medical research Transfer terms Others Manufacture of intravenous fluids A company requires know how and technological requirements for the manufacture of intravenous fluids. Know how should include where to obtain appropriate grade raw materials. Areas of application Pharma/medical Forms of transfer Others

Manufacturing technologies for montelucast, rosuvastatin, ursodeoxy cholic acid, D-biotin A company needs API/bulk drug manufacturing technologies for montelucast, rosuvastatin, ursodeoxy cholic acid and D-biotin Areas of application API/bulk drug Forms of transfer Others Pharma grade mannitol knowhow A company is on the look out for a commercially proven latest technology & know how (turnkey) mannitol in India. The estimated production capacity is 600 tonnes per annum. Areas of application Pharmaceuticals Forms of transfer Others Pharmaceutical Lyophilisation plant A Peru based company is looking for a Lyophilisation plant for pharmaceutical use. Capacity shall be around 175 to 200 square feet, for the lyophilisation of 20,000 vials of 10 mL per day. Areas of application Pharma and food processing industry Forms of transfer Others

Information courtesy: Dr Krishnan S Raghavan, In-Charge, Technology Transfer Services Group, Asian and Paciﬁc Centre for Transfer of Technology (APCTT) of United Nations Economic and Social Commission for Asia and the Paciﬁc (UNESCAP), APCTT Building, C-2, Qutab Institutional Area, New Delhi – 110 016, India.Tel: +91-11-3097 3758 (Direct), +91-11-3097 3710 (Board), Fax: +91-11-2685 6274 E-mail: srinivasaraghavan@un.org, Web: www.apctt.org. For more information on technology offers and requests, please log on to www.technology4sme.net and register with your contact details. This is a free of cost platform provided by APCTT for facilitating interaction between buyers and seekers of technologies across the globe. After submitting technology offer or request to this website, you are requested to wait for at least two weeks for receiving a response from a prospective buyer / seeker through this website, before contacting APCTT for further assistance. Share and Solicit Technology The mission of Modern Pharma is to spread the technology culture. Here is an opportunity to be a part of this endeavour by sending your technology on offer or technology requirements. If you belong to any of these two categories, you are invited to furnish the techno-commercial details for publication. The write-up needs to be as per the format of this section with information about the particular technology offered or requested, its areas of application and forms of transfer. Contact us: Modern Pharma, Network18 Media & Investments Ltd, ‘A’ Wing, Ruby House, J K Sawant Marg, Dadar (W), Mumbai 400 028. Tel: 022-3024 5000, 3003 4695 Fax: 022-3003 4499 Email: spedit@infomedia18.in

Modern Pharma•16-31 July 2012

Projects

Projects New projects and expansion activities are the barometers of industrial growth. These also present business opportunities to service providers like consultants, contractors, plant & equipment suppliers and others down the value chain. This feature will keep you updated with vital information regarding new projects and capacity expansions being planned by companies in the pharma/lifesceinces industry. Dishman Pharmaceuticals and Chemicals Ltd Project type: New facility Project news: Dishman is undertaking an investment program for construction of new facilities at its existing manufacturing site in India. Project location: India Project cost: NA Implementation stage: Ongoing Contact details: Dishman Pharmaceuticals and Chemicals Ltd Deepak Pandya, Company Secretary and Head (Legal) Bhadr-Raj Chambers Swastik Cross Roads Ahmedabad - 380009 Tel: 079 2644 3053/079 2644 5807 Fax: 079 2642 098 4384

Flamingo Nanded pharmaceutical plant project Project type: New facility Project news: Flamingo Pharmaceuticals Ltd with presence in acute therapies such as antibiotics and antipyretic is planning to set up a state-of-the-art plant at the SEZ in Nanded, Maharashtra, based on USFDA/UKMHRA specifications. Project location: Nanded, Maharashtra Project cost: ` 144.84 crore Implementation stage: Ongoing Contact details: Flamingo Pharmaceuticals Ltd 7/1, Corporate Park, Sion Trombay Road P O Box No. 27257 Chembur, Mumbai – 400071 Maharashtra

Drugs/Medicine Org

: State Pharmaceuticals Corporation of Sri Lanka TRN : 11653493 Desc : Supply of montelukast tablets 10 mg DSLD : NA BOD : July 25, 2012 Loc : Colombo, Sri Lanka BT : Global (ICB)

Centrifugal lube oil cleaner Diesel Locomotive Works 11657234 Supply of centrifugal lube oil cleaner NA July 27, 2012 Varanasi, Uttar Pradesh Domestic (NCB)

Laminar flow system Org : United Nations Office of Project Service (UNOPS) TRN : 11664601 Desc : Supply of anaesthesia, spectrophotometer, laminar flow system and other items DSLD : NA BOD : July 27, 2012 Loc : New Delhi, India BT : Domestic (NCB)

Centrifuging machine Org

Granules India Ltd second project Project type: Expansion Project news: Granules India Ltd is planning for an expansion of its existing facility. It will also be undertaking an investment programme at its Gagillapur facility comprising of expanding the capacity of its multi-product tableting and PFI plants and its warehousing capacity with automated storage systems. Project location: Gagillapur, Andhra Pradesh Project cost: NA Implementation stage: Ongoing Contact details: Granules India Ltd B V R K Srinivas – AVP Formulations Plot No. 160/A & 161/E Gagillapur Village Qutubullapur Mandal RR District - 500 043 Andhra Pradesh Tel : +91 8418 255233, 257222 Email: srinivas.bvrk@ granulesindia.com

Shasun Pharmaceuticals Ltd’s setting up pharmaceuticals manufacturing facility at Vizag Project type: Manufacturing facility Project news: Shasun Pharmaceuticals plans set up a manufacturing facility at Vishakhapatnam and increasing the capacity of existing plants by 2013. Project location: Vishakhapatnam, Andhra Pradesh Project cost: ` 250 crore Implementation stage: Ongoing Contact details: Shasun Pharmaceuticals Ltd 3rd & 4th floor, Batra Centre 28, Sardar Patel Road Guindy, Chennai 600032 Tamil Nadu Website: http://www.shasun.com/ Tel: 91-44-43446700 Fax : 91-44-22350278 Vivimed Labs Ltd expansion project Project type: Expansion Project news : Vivimed Labs Ltd, plans to expand capacity for existing products, and develop and create capacity for new products. Project location: Hyderabad, Andhra Pradesh

Project cost: $42 million Implementation stage: Ongoing Contact details: Vivimed Labs Ltd, K S Sastry Veernag Towers Habsiguda Hyderabad - 500 006 Andhra Pradesh Tel: 040 2717 6005/6 Fax: 040 2715 0599 Email: info@vivimedlabs.com Zydus Pharmez expansion project Project type: SEZ Project news: Zydus Infrastructure Ltd, a part of Zydus Cadila Healthcare Ltd, plans to invest an additional `100 crore on the expansion of Pharmez, its SEZ for the pharma industry. Project location: Ahemdabad, Gujarat Project cost: ` 100 crore Implementation stage: Ongoing Contact details: Zydus Infrastructure Ltd Zydus Tower, Satellite Road Ahmedabad - 380015 Gujarat Tel: 91-79-26868100

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Drugs/Medicine Org : State Pharmaceuticals Corporation of Sri Lanka TRN : 11628128 Desc : Supply of salmeterol xinafoate 50 mcg + fluticasone propionate 250 mcg, dry powder capsules for breath induced device -1,500,000 capsules for 2013 DSLD : NA BOD : July 30, 2012 Loc : Colombo, Sri Lanka BT : Global (ICB)

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Modern Pharma•16-31 July 2012

Event List

N AT I O N A L E V E N T S US Georgia-India Life Sciences Opportunities Summit The summit will feature a one-day “how-to-with India life sciences” series of speakers, a Business to Business matching (B2B) focus tailored for Atlanta companies in the vaccines and CROs, CMO areas, etc. The event aims to bring decision makers under one roof; August 23, 2012, ITC Maratha, Mumbai For details contact: FDASmart Tel: +91 96196 61452 Email: Rbalani@fdasmart.com Website: www.fdasmart.com/events/ macoclife

Annual Pharmacovigilance 2012 The event aims to discuss the latest technologies, methodologies and introducing pharmacy automations on work practices of pharmacovigilance, recent successful strategies and business models to bring out new medicines, keeping abreast of the changes impacting the drug safety industry, etc. Further, there will be discussion on global marketing strategies; August 31, 2012, Hyatt Regency Mumbai For details contact: Virtue Insight Tel: +91 44 64536444 Fax: +91 44 64536443 Email: info@virtueinsight.com Website: www.virtueinsight.com

Automation 2012 All leading companies in industry will

showcase their latest products and help one find the solutions at the show. The show brings latest technologies from an interesting array of fields such as: factory automation, process automation and control systems, robotics & drives, field instrumentation & smart sensors bus technologies, software solutions, wireless technology, building automation, and hydraulic & pneumatic automation in renewable energy. From technocrats to solution providers, vendors and tech-buffs, the fair is all set to draw every one alike; September 7-10, 2012, NSE Complex, Mumbai

AHMEDABAD

PUNE

CHENNAI

LUDHIANA

Gujarat, Oct 5-8, 2012

Maharashtra, Nov 2-5, 2012

Tamil Nadu, Nov 22-25, 2012

Punjab, Dec 21-24, 2012

INDORE

AURANGABAD

RUDRAPUR

HYDERABAD

Madhya Pradesh, Jan 11-14, 2013

Maharashtra, Feb 1-4, 2013

Uttarakhand, Feb 23-26, 2013

Andhra Pradesh, June 7-10, 2013

India’s premier industrial trade fair on products and technologies related to Machine Tools, Hydraulics & Pneumatics, Process Machinery & Equipment, Automation Instrumentation, Packaging & Auxiliaries, IT Products, Electrical & Electronics, Material Handling and Safety Equipment.

For details Network18 Media & Investments Ltd

Ruby House, 1st Floor, J K Sawant Marg, Dadar (W), Mumbai 400 028. • Tel: 022 3003 4651 • Fax: 022 3003 4499 • Email: engexpo@infomedia18.in

sourcing companies, production & purchase professionals, and international business representatives; September 8-10, 2012, Gujarat University Exhibition Hall, Ahmedabad.

For details contact: IED Communications Pvt Ltd Tel: +91 22 22079567 Fax: +91 22 22074516 Email: arokiaswamy@ iedcommunications.com Website: www.iedcommunications.com

For details contact: Orbitz Exhibitions Pvt Ltd Tel: +91-22-24102801 Fax: +91-22- 24102805 Email: ramesh.v@orbitexhibitions.com Website: www.orbitzexhibitions.com

Pharmac India

Indian Pharma Expo 2012

It is a-three-day event that aims towards highlighting several issues of the industry. This will be large hub of reputed professionals from pharma formulation, herbal products, veterinary drug, medical & disposal, pharma machinery and many other sectors. There will be visitors from pharma company marketing/ purchase/export executive, marketing company & consultant, merchant exporters, contract manufacturers, pharma distributors, generic & OTC manufacturer & wholesalers, Government supplier, liaison agents,

Indian Pharma Expo 2012 is the perfect solution to meet the needs of the rapidly growing Indian pharma industry; to be able to network under one roof. There will be discussions on regulatory issues affecting the pharma market, commercial strategies and business models of key players, maximising revenue, overcoming challenges and achieving growth and revaluating possible development scenarios. Further, there will also be discussions on effective marketing strategies; September 22-23, 2012, Pragati Maidan, New Delhi

For details contact: UBM India Pvt Ltd Tel: +91 22 6612 2600 Fax: +91 22 6612 2626-27 Email: info.india@ubm.com Website: www.ubmindia.in

Indian Lab Automation conference and exhibition ILA 2012 will feature three technical conference tracks; Drug Discovery and Development, Advances in Bioanalysis and Advances in Genomics and Informatics. Each track will provide attendees with the opportunity to listen to presentations on cutting edge research in specific application areas, with an underlying theme of automating the technique, equipment or associated informatics; October 30-31, 2012, Renaissance Hotel & Convention Centre, Mumbai For details contact: Select Biosciences Ltd Tel: +44 1787 315110 Fax: +44 1787 315111 Email: enquiries@selectbiosciences.com Website: www.selectbiosciences.com

I N T E R N AT I O N A L E V E N T S JCBBB 2012 The 3rd Journal Conference on Bioscience, Biochemistry and Bioinformatics (JCBBB 2012) aims to provide a forum for researchers, practitioners, and professionals from the industry, academia and government to discourse on research and development, professional practice in bioscience, biochemistry and bioinformatics. This is one of the leading international conferences for presenting novel and fundamental advances in the fields of bioscience, biochemistry and bioinformatics. It also serves to foster communication among researchers and practitioners working in a wide variety of scientific areas with a common interest in improving bioscience, biochemistry and bioinformatics related techniques; September 1-2, 2012, Phuket, Thailand For details contact: International Journal of Bioscience, Biochemistry and Bioinformatics Tel: +91 422 2611146 Fax: +91 422 2611043 Email: ijbbb@vip.163.com Website: www.ijbbb.org

International Symposium on Pharmaceutical Reference Standards The event aims to discuss current topics and future approaches related to pharma reference standards. Pharmaceutical reference standards are essential for the quality control of

medicines. The symposium will bring together stakeholders involved in the production, characterisation and use of reference standards to exchange their views and opinions on the different issues related to the subject; September 3-4, 2012, EDQM Premises, Strasbourg, France For details contact: EDQM Public Relations Division & Documentation Tel: +33 0 3 88 41 31 50 Fax: +33 0 3 88 41 27 71 Email: beatrice.barth@edqm.eu Website: www.edqm.eu

NCCR 2012 The 6th National Conference for Clinical Research 2012 (NCCR 2012) aims to serve as a platform that aims to bring together clinical investigators, industry professionals, regulatory agencies and policy makers in order to address the issues and challenges of the industry. By gathering people from various research disciplines, the event aims to foster constructive and forward looking discussions, sharing of experiences, and mutual commitment towards the betterment of humanity; September 23-25, 2012, Sunway Pyramid Convention Centre, Malaysia For details contact: Association of Clinical Registries, Malaysia (ACRM) Tel: +603 4044 3060 Fax: +603 4044 3080 Email: contact@acrm.org.my Website: www.nccrconference.com

CSBio 2012 CSBio 2012 will also cover the engineering sciences related to the pharmaceutical industry, in both material and manufacturing sciences. This conference would like to gather like minded researchers and industrial counterparts who are involved in designing, developing and improving industrial processes and equipment for large-scale chemical and pharma manufacturing; planning and testing methods of manufacturing; developing methods for the treatment of bi-products; devising production processes that are safe, efficient, profitable and environmentally sound; October 3-5, 2012, Bangkok, Thailand For details contact School of Information Technology Tel: +66 2470 9834 Fax: +66 2872 7145 Email: csbio2012@sit.kmutt.ac.th Website: www.csbio.org

CPhI Worldwide The event hosts over 1900 exhibitors and is the market leader for the global pharmaceutical ingredients industry. CPhI Worldwide has three co-located events: ICSE, P-MEC Europe and InnoPack. These events focus on specific sub-sectors of the pharma ingredients industry and provide visitors and exhibitors with additional capability to network and do business in dedicated areas; October 9-11, 2012, Feria de Madrid, Spain

For details contact: UBM India Pvt Ltd Tel: +91 22 6612 2600 Fax: +91 22 6612 2626-27 Email: info.india@ubm.com Website: www.ubmindia.in

2012 Nanotechnology Conference The event aims to bring together a panel of highly-accomplished nanotechnologists and well recognised authorities in various aspects of nanomedicine. This unique international conference offers an opportunity for pharma scientists, clinical researchers, physicians, therapists and industrial leaders to discuss the important international breakthrough developments in drug discovery, drug development, drug delivery, drug therapy and commerce to share their thoughts. The four-day conference will focus on the basic studies through translational efforts and clinical trials and address topics of novel issues concentrating more on recent advances, difficulties, and breakthroughs. This is how the event aims to reach out to the experts and decision makers of industry; October 31- November 3, 2012, Riviera Maya, Mexico For details contact Zing Conferences Tel: +44 1223 750020 Fax: +44 1223 280270 Email: info@zingconferences.com Website: www.zingconferences.com

The information published in this section is as per the details furnished by the respective organiser. In any case, it does not represent the views of Modern Pharma.

Modern Pharma•16-31 July 2012

Book Review

Editor: Willow J H Liu Price:

Bioactive Compounds from Natural Resources

Editor: Corrado Tringali

This is a fairly technical and voluminous book that deals with natural resources as sources of biologically active compounds in detail. The author has elucidated in the first chapter the potential biodiversity and chemodiversity available in the ecosystem as potential targets. Glances into the marine, fungal and plant ecosystems do give important leads into potential newer molecules. The follow-up chapters on metabolic engineering, computational approaches and application of electronic circular dichroism dwell in significant details into the application of newer technology for discovery and production of these compounds. The majority of the second half of the book deals with specific therapy areas. The application of newer biotechnology methods to natural resources has been clearly defined for specific areas like antivirals, malaria, wound healing, anti-tumour agents, etc. Each section describes in brief the potential targets and newer methods of processing these active compounds. The chapter dedicated to Chinese traditional medicine and Australian marine organisms gives a regional perspective to the topic. A good book for researchers, practitioners and pharma manufacturers actively involved in bioactive compounds derived from natural products.

Price:

` 11,100/-

Publisher: CRC Press Distributor: Wisdom Book Distributors, Hornby Building, 1st Floor, 174, D N Road, Mumbai 400 001, Tel: 022 2207 4484/6631 8958, Telefax: 022-2203 4058 Email: thadam@vsnl.com

Traditional Herbal Medicine Research Methods

` 8,400/-

Publisher: Wiley Publications Distributor: Wisdom Book Distributors, Hornby Building, 1st Floor, 174, D N Road, Mumbai 400 001, Tel: 022 2207 4484/6631 8958, Telefax: 022-2203 4058 Email: thadam@vsnl.com

Over the last few years, there has been an increasing interest and acceptance of traditional herbal medicine among Westerners. But often these therapies lack robust scientific data, which makes their widespread acceptance and commercial production difficult. This brilliant book attempts to shed light on every aspect of R&D of traditional medical products. The author in her opening chapter lays a good foundation of the types and diversity of traditional medical systems practiced across the world and the loop holes in studies planned regarding the same. The chapter on collection and identification of raw herbs impresses the need for quality raw material in the initial start up process of herbal medicine. The next few chapters on extraction, isolation, identification, and bioassays of bioactive compounds from herbs give a conventional chemist’s perspective of traditional products. The section of chapters dealing with animal studies, safety studies and planning of clinical trials helps an investigator in the process of generating mainstream data regarding the herbal products efficacy and toxicity. The book also gives a glimpse into the various regulations, GMP rules and quality control methods with respect to herbal preparations. The book ends with a brief overview of traditional Chinese medicine, its principles and various herbal formulations. A simple read even for the uninitiated in herbal medicine, for chemists and practitioners of herbal medicine.

Reviewer: Dr Mandar Kubal, Consultant - Infectious Diseases and HIV AIDS, Infectious Diseases and Pulmonary Care (IDPC)

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CEO Roundtab

le 15

Future trends in the Indian pharma industr and the role of media to y bridge the need gap

Venus gets for antibioticUS patent drug

Alembic settle s patent case with Novar tis

You can send us Technical Articles, Case Studies and Product Write-ups. The length of the article should not exceed 1,200 words, while that of a product write-up should not exceed 100 words.

tion With

ALEMBIC Pharmaceutic with Brecke als along nridge (US), has settled Pharmaceutical a patent case Novartis for with rivastigmine capsules used tartrate for treating The compa dementia. nies have settled Paragraph IV patent litigati their Novartis for on with rivastigmine capsules, tartrate a generic version of Exelon capsul es of Novar tis.

s 18

Recent advance s in the pharma cold chain The need to get tech-sav vy

Insight & Outlo

ok 22

Sales force automa Say ‘no’ to manual tion errors

Waters to ex

pand in Indi

Ireland attr

the near future. The expansion phase II woould be of at Ahmed and Chand abad igarh. Besides expans ion Waters partne ring is also with pharm aceutic companies, al CROs and agencies with government research capabil the goal of expand ing ities, increas efficiency, ing laboratory and naviga regulatory ting comple compliance x worldwide. requirements Waters with Dr Reddy’ has recent partner ed s Laboratories, Therapeutic Lambda Research Ltd, Agricultural Product Export the Marine/ Agency and Development the India Protection Environmenta Agency. l

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pharma

FOR pharm aceuticals, EU marke the the t is going throug EU region has typical an inflection h charac teristics of small manuf such as MSD,point. MNCs Germa operating. acturing base, ny is a could help Johnson Irish Govern Johnson, tender ment is highly Pfizer, Abbot& driven, where radical benefiin achieving proact as France Lilly, Roche t, is an ive, busine of expediting ts in terms and ss friendly Teva, Taked , Novar tis, driven innovators drugan a, Genzy strategy by go-to-market Ireland astute visionary. Allergan, me, a backgrmarket. With such 40 per cent, has Gilead, Astella reducing costs best highly some of the Bristol s, absolu ound, it becomes of inventory.” -Myers Positive skilled talent. tely essent The Irish prospects It has Glaxo Smith Squibb and ial for Japanese pharm Kline sector is about life sciences appro a standard, EU for have establi a ved industry shed their THE prospe 45 billion foothold cts tax rate of corpo ration in Ireland market over for Japan’s pharma . Besides, 12.5 per Indian cent on the compa all mediu nies such are very tradin g as Relian positive, said m term profits . Additionally Life Scienc by Resear a report , Ireland es and Ranba ce ch an excelle has have a country has and Markets. The nt strong presen xy double taxatio network of too. K V ce pensi onabl one of the largest n avoidance Subramaniam e treaty with Presid ent , popul ations healthcare 55 countries , is readily CEO, the world in Reliance Life and the accessible, including Sciences, said, govern India. Recognising “Reliance appreciates investment ment Life Scienc this, the Irish in biomedical es Pvt Government Ltd, India, and the research had acquir place a nationhas put in GeneMedix ed balances the regulatory regime plc, al Strateg requirements for Scienc biotechnology a UK-based Subram y major stakeh e, of the aniam olders. and Innova Technology 2007. This company in tion (SSTI) Batra provided the 1990s. with an GSK to buy In line with in opportunity us Indian pharm this, a companies signifi cant enter to to have Toctino for eczema drug the fundin (mainl Europ ean g and an on-gro £ support are biopharma und While y export oriented). EU presen GLAXOSMI 146 million available to market.” ce in order THKLINE innovation fuel the EU Minakshi to expand hasannounce Plc (GSK) across indust pharma Batra, India market into the d that it research Director, territories. eczema drug EU billion is worth $ 48 is and educat ry, India Irelan An on-gro Toctino from buying , $ 16 billion ion. Additionally said, “Each d, presen und the Pharmaceutic Basilea , there is is for 25 ce either in country generics, a a in sales per terms of £ 146 million Ltd, for an initial and marke huge oppor presenting provid cent tax credit ($ 227 million ting or a ed to organi Toctino is India. Batra tunitie s for for ). the only R&D & innova sations prescription said, “The medic ine tion.” appro ved treatm ent - Chandreyee for the Bhaumik of severe QUINTILES hand eczem chron ic recently a agreements announced potent topica unresponsive to to of the l regional headquestablish a Quinti It is comm steroids in adults. les Gilling New Health,” said ercially availab Dennis s, CBE, Execut Shanghai and arters for China 14 countr in le in in Quint China to ive ies, approv signific Chairman, , Quintiles iles, “By lab testing antly expand ed in 15 countries, $ 14 million is investi broade capabilities investment and is in ng “With its to establi in China. a phase III and infrast ning our 4000-s trial in the burgeo sh a new quare-metre ructure here, Quintiles US. growing healthc ning economy and is ready to (43,00 feet) headqu partner with our biopha arters in Shangh 0 square billion citizen are needs for its rma custom China and 1.3 look s, China ers as nearby Asian ai to serve to realise the oppor China’s potent they “This demon tunities and exemplifies To countries. strates our provid e ial.” to challenges the infrast commitment this district essential and to for its growth ructur e Ling Zhen, Gener China,” said strategy al Manag Quintiles’ er, operations in China.

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The articles should preferably reach us in soft copy (either E-mail or a CD). The text should be in MS Word format and images in 300 DPI resolution & JPG format.

Special Focu

Indravadan Modi Chairman, Cadila Pharma ceuticals Ltd

VENUS Remed ies has receive patent from d the its new antibio US Patent Office for WATERS targets drug tic product, which India, one of the leadin analytical The produc resistant infections. companies g t, CSE 1034, under the is curren found to has been tly process of be its facility wide range effective against a in Bengaluru. expanding facility is “The new drug resista of likely to have nt set of labora an infections, tories, upgrad improved facilities and ed trainin includ ing g more office the completed, space. When ‘superbugs’. the new facility will approximatel Mufti be y Suhai l floor space,” 16,000 square feet Sayee d, in informed Vice President, Art Caput President, Water o, Inc. To expand s Division, Water Sayeed Venus Medic s the existin al at Peenya g facility Research , Bengaluru, Centre has investe the compa patent of CSE , said, “The US d an ny of ` 2 million approximate amoun development 1034 is a landmark t . Besides this, for initiat in Mumb the labs process of ing the ai, Delhi commerciali and Hyder will also this novel sation abad underg of o an expans drug.” ion in Caputo

Dear Reader, ‘Modern Pharma’ solicits original, well-written, application-oriented, unpublished articles that reflect your valuable experience and expertise in the pharmaceutical industry.

In Conversa

tment in Ch

ina

The final decision regarding the selection and publication of the articles shall rest solely with ‘Modern Pharma’. Authors whose articles are published will be sent a complimentary copy of that particular edition. Published by Network18 Media & Investments Ltd, ‘Modern Pharma’ is one of the leading fortnightly magazines exclusively meant for producers and user fraternities of the pharmaceutical industry. Well supported by a national readership of over 80,000 and our strong network of 26 branch offices across India, this magazine reaches out to key decision makers among the Indian manufacturers of pharma products, machinery and allied sectors. Brought out in association with Hong Kong-based Ringier Trade Media Ltd (one of the world’s largest trade publishing houses with more than 200 special interest titles and offices in every major country), it ensures that advertisers are able to promote their products and services across the globe at no extra cost. So get going and rush your articles, write-ups, etc… Thanking you, Yours sincerely, Manas Bastia Senior Editor Network18 Media & Investments Ltd ‘A’ Wing, Ruby House, J K Sawant Marg, Dadar (W) Mumbai 400 028 India

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Modern Pharma•16-31 July 2012

Products

Aerosol photometer

Pharma refrigerator

The latest version, Model 2i, is used for leak testing of HEPA filters. The upstream aerosol mass concentrations are displayed in actual mass concentration values of micrograms per litre (µg/l). Other features include user settable Aerosol Noise Suppression (ANS) which allows for more stable aerosol measurements when poor mixing is present, three unique data report functions – continuous, monitoring & summary modes, large 4.3 “ LCD display, thermal printer option to meet documentation requirements & USB output.

The pharma refrigerator has double walled chamber, with two different inner chambers. The two chambers are connected with common wall between the two chambers. Interior and exterior is made of stainless steel. Upper chamber temperature is – 20° C, lower chamber temperature is 2 to 8°C and temperature uniformity is ± 1°C.

MeasureTest Corporation Mumbai - Maharashtra Tel: 022-2202 7982 Email: sheesh@mtnl.net.in Website: www.measuretest.com

Newtronic Equipment Company Pvt Ltd Mumbai - Maharashtra Tel: +91-022-28679326 Mob: 9821089932 Email: nmehta@newtronic.in Website: www.newtronic.in

Pharma print cartridge

These orbital shaking incubators are designed for precise temperature control and simultaneous shaking applications required in fermentation studies, enzyme reactions, life science, tissue culture and biotechnology research labs. The brushless induction motor with variable frequency drive is suitable for continuous operation. The powerful fan motor is available for forced air circulation to maintain uniform conditions inside the chamber and has hermetically sealed compressor with CFC free refrigerant.

The pharma print cartridge and felt pad/roller are made for blister packaging machine, FFS machine and coding machine. Absorbing material used is poly porous in various microns varying from 1 micron to 25 micron, depending upon the requirement of customer. The absorbing capacity of these cartridges is quite high and the cartridges are hard so the impression is good as there is cotton cloth knitted sleeves (covering) which is used to avoid direct contact of stereo with roller. The cartridges are made in various ID, OD and length depending on customer’s requirement. The maximum OD can be 85 mm, length up to 300 mm.

Remi Elektrotechnik Ltd Mumbai - Maharashtra Tel: +91-022-40589888 Mob: 09820627422 Email: sales@remilabworld.com Website: www.remilabworld.com

Process Instrumentation & Controls Vadodara - Gujarat Tel: 91-0265-235 7228, 232 0756 Mob: 09228753005 Email: batchprinting@yahoo.com Website: www.piccode.com

Deep freezers

Microfluidiser processor

Orbital shaking incubators

These deep freezers are designed for storage of biological samples in biotech, life science, clinical research as well as medical & pharmaceutical specimens, serums, vaccines, blood components. These freezers are available with temperatures up to -20°C and – 40°C. It has features such as microprocessor controller with LED display, adjustable trays, electrical circuit breaker, overload cut off relay for compressor and sensor failure alarm. Remi Elektrotechnik Ltd Mumbai - Maharashtra Tel: +91-022-40589888 Mob: 09820627422 Email: sales@remilabworld.com Website: www.remilabworld.com

well as liposomal encapsulation and cell disruption with the fewest number of passes. TTL Technologies Pvt Ltd Bengaluru - Karnataka Tel: 080-2525 1859 Email: tmidirect@ttlindia.com Website: www.ttlindia.com

Rotary bottle washing machines

Cole-Parmer India Mumbai - Maharashtra Tel: 022-6716 2222 Email: vinita.singh@coleparmer.in Website: www.coleparmer.in

Electrolyte analyser The rotary bottle washing machines NRWM – 96 are multifunctional machines that meet the GMP requirements of washing glass and plastic bottles. These operate on the rotary principle ‘GENEVA’ mechanism and require manual loading and unloading of bottles. The output consists of 4300 to 9000 numbers & direction of the machine is clock wise. National Pharma Machinery Ahmedabad - Gujarat Tel: +91-079-3090 3433, 3093 3433 Email: sales@nationalinda.co.in Website: www.nationalpharmamachinery.com

Linear bottle washing machines

The linear bottle washing machines facilitates inline washing operation and are built on rigid structure & are enclosed with elegant matt finished SS body cover. The cleaning is supported by tow inbuilt water tanks and pumping system. The output ranges from 3000 to 4200 bottles, & direction of movement is left to right. National Pharma Machinery Ahmedabad - Gujarat Tel: +91-079-3090 3433, 3093 3433 Email: sales@nationalinda.co.in Website: www.nationalpharmamachinery.com

Syringe pumps

The portable M-110P microfluidiser processor is a bench-top lab machine that requires no compressed air or cooling water. Designed to operate at up to 30,000 psi process pressure, this portable microfluidiser processor requires a standard 20 A, single-phase household electrical outlet and is easily incorporated into any laboratory setting. Utilising Microfluidics’ fixed geometry diamond interaction chamber technology and ceramic plunger, the processor easily enables the production of nanosuspensions and nano-emulsions, as

time are easily displayed. When used with check valves, the pump draws fluid from a reservoir while opposite side dispenses fluid. After dispensing the user-settable volume, the pump automatically switches direction and dispenses from the other side while the just-consumed side is being refilled. Full-metal chassis provides noise isolation and anti-vibration features for increased reliability.

The world’s first single syringe pump has a touch screen interface and a new clamping mechanism which holds a single syringe (glass, plastic, or stainless steel) from 0.5 µL to 60 mL. The large color display allows the user to see all the operating parameters. Syringe sizes, flow rate, volume delivered & the elapsed

The ST-100 electrolyte analyser is used for measurement of sodium, potassium and chloride in whole blood, serum, plasma and diluted urine. This also has a built-in lithium ion battery with power back-up of 10 hours. The ST-100 is completely automated, microprocessor-controlled electrolyte system that use current ISE technology to make electrolyte measurements. It is compact, economical and easy-to-use. The instrument has long life, provides high-performance and has maintenance-free electrodes. Sensa Core Medical Instrumentation Pvt Ltd Hyderabad - Andhra Pradesh Tel: +91-8455-223400 Mob: 09866861878 Email: sales@sensacore.com Website: www.sensacore.com

Formaldehyde analyser

Formaldehyde analyser provides absolute concentrations for formaldehyde (HCHO) in aqueous media. It has RS232 serial port for computer interface The measurement ranges from 0 to 5 µ g/ml.The analyzer is widely demanded in the market for numerous applications.It can be available in varied specifications as per their requirements and needs.The equipment is available at pocket friendly price. Formaldehyde analyzer is suitable for the measurement of formaldehyde in aqueous solution. Uniphos Envirotronic Pvt Ltd Mumbai - Maharashtra Tel: +91-22-61233500 Mob: 9909994063 Email: gasdetection@uniphos.com Website: www.uniphos-she.com

Looking For A Specific Product? Searching and sourcing products were never so easy. Just type MPH (space) Product Name and send it to 51818 eg, MPH Laboratory software and send it to 51818

Modern Pharma•16-31 July 2012

Products Dual wavelength diffractometer Its Mova source is up to 2.5x more intense than a standard Mo sealed tube X-ray source. Its Nova source (Cu) up to 3x more intense then a 5kW rotating anode with optic. It has simple and automatic switching between wavelengths. This is ideal for small molecule and protein crystallography and is fast, high resolution, automated data collection and processing. It has optional aircooler radiator for a self-contained system independent of any external water supply. Agilent Technologies India Pvt Ltd New Delhi - Delhi Tel: 91-011-46237100 Email: agilent@agilent.com Website: www.agilent.co.in

Pumps E-Series AirOperated DoubleDiaphragm (AODD) pumps are self-priming and provide gentle displacement of fluids. They are equipped with the patented PERSWING P® air control system, which ensures accurate reversal of the main piston and is characterized by low noise levels. They are created from a solid plastic block, offering advantages like increased pump security due to an innovative ring-tightening structure, increased capacity, decreased air consumption, reduced noise level, optimized flow pattern and a pulsation damper suitable for flange connection. Dover India Pvt Ltd Chennai - Tamil Nadu Tel: +91-44-26271020 Email: akmurthy@destaco.com Website: www.doversolutions.co.in

Spectrophotometer

The Optizen 3220UV is used for analyzing components that require multiple wavelengths, time course operations and getting stable data sheets. It has USB ports for user-friendly programming updates and other accessory connections. It has universal sample cell holder that holds 8 cells. It has superb optics for maximized accuracy, exceptional precision and reliability. It has user-friendly software with scanning and time course capacities with versatile data processing. Jay Instruments & Systems Pvt. Ltd. Navi Mumbai-Maharashtra Tel: +91-22-2767 2955/0092 Email: ledsales@jayinst.com Website: www.jayinst.com

TrayCell The TrayCell is a fibre-optic ultra-micro cell designed for the UV/Vis micro volume analysis of DNA/RNA and proteins. It is designed for measurements of DNA/ RNA or protein samples and enables highly accurate analysis of extremely small samples with remarkable reproducibility. Its dimensions are equivalent to a standard cuvette in order to work in most spectrophotometers. It is used for nucleic acid analysis, determination of the incorporation frequency of fluorescent dye labels (FOI), protein analysis (A280, BCA, Lowry etc.) & all UV/Vis analysis utilizing the wavelength range of 190 to 1100 nm. Hellma GmbH & Co. KG Müllheim-Germany Tel: +49(0) 7631/182-0 Fax: +49(0) 7631/135 46 Email: info.analytics@hellma.com

De-humidifier The AD 420 dehumidifier is incorporated with fully hermetically sealed rotary c o m p r e s s o r, protected a g a i n s t overloading and vibrationinsulated bearings. It has an axial fan with plastic fan wheel (with winding protection). Condenser and evaporator are made from copper piping covered with aluminium fins. Cooling circuit is made from copper piping with capillary tube and filter dryer. There is a service connector on the suction side. Automatic defrosting is controlled by Dry-Logic. The casing is aluminium, powder-coated & offers protection class IP X4. Origin Dehumidifiers Mumbai-Maharashtra Tel.: 022 – 22044156, Fax: 022 – 22875114 Email: sales@origincorp.com Website: www.origincorp.com

Moisture analyzer balance

Tablet hardness tester

The portable Tablet hardness tester model iHT 100 is designed for simple, inexpensive & “in-situ” measurement tablet hardness testing. This enables the user to react quickly to adjust the compression force of a tablet press and reduce the costs created by tablets produced out of specified hardness limits. The safety cover is to be opened; the sample placed in the measuring station and is pressed against a metal plate (connected to an electronic load-cell) moved by a hand wheel, until the sample brakes. The result of the measurement is shown on the built-in-LCD in N, Kg or lb. Every time the unit is switched ON, it fulfils an automatic half-calibration (zero calibrated). Erweka India Ahmedabad-Gujarat Tel: +91 92280 22065 Email: sales@erwakaindia.com Website: www.erwakaindia.com

Capsule filling machine The automatic capsule filling machine is an encapsulation equipment. Its features include compact, sturdy, covered with stainless steel panels, hood covered with acrylic guard. The fill weight adjustment takes place within seconds. It is provided with tamping mechanism for powder filling, which enables capsules to be filled with a weight variation with ±2 per cent. The variable AC frequency drive for main motor ensures speed adjustment. Faulty capsule and filled capsule ejection stations come with individual air controls. It is simple to operate and easy to maintain and has special purpose gauges for quick and easy change over. Anchor Mark Pvt Ltd Mumbai - Maharashtra Tel: 022-28682001, Mob: 09320036904 Email: sales@anchormark.com Website: www.anchormark.com

FRP storage tank

The new MB series moisture analyser comes with halogen heating which removes moisture from entire area of the sample. It has user friendly visualization display for process of drying & selection from four profiles for drying. It gives detailed print out of the analysis in compliance with GLP/GMP standards. It has a built-in RS 232C interface for PC or printer & large LCD display with AEP (Advanced Eye Protection).

The FRP storage tank is manufactured by hand lay-up and/or by filament winding process for the storage of highly corrosive chemicals, acids and wastes. It is available in capacity up to 250 kl in various shapes, like square, round, rectangular vertical and horizontal with flat bottom or conical bottom. The key feature of this tank is that it offers resistance to chemical and weather. It is lightweight, easy-tomaintain featuring good physical and mechanical strength. The reaction vessel is available with suitable lined agitator, gear box and electric motor.

Citizen Scale (I) Pvt. Ltd. Mumbai-Maharashtra Tel: 022-4243 770; Fax: 022-4243 7800 Email: channel@citizenscales.com Website: www.citizenscales.com

EPP Composites Pvt Ltd Rajkot - Gujarat Tel: 02827-287059 Email: marketing@epp.co.in Website: www.atikagroup.com

Bottom discharge centrifuge This centrifuge is fitted with a cake scrapping arrangement, which can be motorised or hydraulically operated to enable to scrape the stickiest of cakes. The cake is discharged through the bottom chute provided. This results in reducing manual labour, less cake handling loss and uniform cake washing. The centrifuge is offered in vapour-tight construction with nitrogen blanketing for hazardous chemicals. CIP design with built-in cleaning nozzles ensures no product cross-contamination. The centrifuge is offered in three-point pendulum suspension and four-point inertia plate mounted designs to suit application considerations. United Engineering Enterprises Mumbai - Maharashtra Tel: 022-23083990, Mob: 09820761808 Email: uenggent@gmail.com Website: www.united-centrifuges.com

Ball valve This ball valve comes with pneumatic rotary actuator. The valve is of on/off type with screwed, flanged, socket weld, triclover end in threepiece design. It is available in SS-304 and SS-316 investment castings and is fitted with doubleacting pneumatic rotary actuator that operators through 90-degrees angular movements of ball valve or butterfly valves. Pneumatic actuator is mounted directly on the shaft of the valve. The actuator is supplied with solenoid valve mounted on it. It is available in different sizes up to 4” to control fluids such as steam, chemicals, oil, air, and water. Madho Controls Pvt Ltd Thane - Maharashtra Tel: 022-25883252, Mob: 09820066046 Email: madho@vsnl.com Website: www.madhocontrols.com

Air-cooled single-stage pump The oil-lubricated air-cooled singlestage pump comes with multi-vane built-in anti-suck back system. It is provided with oil recirculation system having exhaust filters to produce mist-free exhaust. The pump is available with capacities ranging from 15 m³/hr to 150 m³/hr. The pump is used in various applications like packaging, bottle filling, pick and place, leak detection, heat treatment, distillation, suction in hospitals, oil purification, degassing and drying, etc. Advantages of the pump are less oil, less power, noise less and pollution free compared to normal oil seal vacuum pumps. Toshniwal Instruments (Madras) Pvt Ltd Chennai - Tamil Nadu Tel: 044-26252716 Email: sales@toshniwal.net Website: www.toshniwal.net

The information published in this section is as per the details furnished by the respective manufacturer/distributor. In any case, it does not represent the views of

Modern Pharma

Modern Pharmaâ&#x20AC;˘16-31 July 2012

Marketplace

Modern Pharmaâ&#x20AC;˘16-31 July 2012

Marketplace

Modern Pharma•16-31 July 2012

30 List of Products & Advertisers Looking For A Specific Product? Searching and sourcing products were never so easy. Just type MPH (space) Product Name and send it to 51818 eg, MPH Laboratory software and send it to 51818 Product

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Aerosol Photometer ....................................... 26 Activated carbon filter.....................................BC Air-cooled single-stage pump .........................27 Atlantic green nitrile gloves ...............................3 Autoclave gaskets ..............................................28 Automatic carton over printing with embossing machine........................................28 Automatic label gumming machine...............28 Bacteriological chamber..............................FIC Ball valve ............................................................27 Barcode patient ID bands................................29 BOD incubator ...............................................FIC Bottom discharge centrifuge ...........................27 Braided house....................................................28 Cable................................................................. 28 Capsule filling machine ...................................27 Carton dispensing machine.............................28 Chain pulley block............................................28 Cold chamber..................................................FIC Colour masterbatches ......................................29 Cords ..................................................................28 Corona treater sleeves ......................................28 Counter & power supplies.................................7 Crabs ..................................................................28 Crane ..................................................................28 Deep freezer .................................................... 26 Deep freezer.....................................................FIC De-humidifier ...................................................27 Demineralisation plant ...................................BC Diaphragm vacuum pump & compressor ....28 Double sided rotary..........................................11 Dual wavelength diffractometer .....................27 Dual zone chamber ........................................FIC Electro-de-ionization ....................................BC Electrolyte analyser ...........................................26 Encoder ................................................................7 EOT/hot cranes .................................................28

Product

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Product

FBD gasket ...................................................... 28 Flame proof hoist .............................................28 Formaldehyde analyser.....................................26 FRP storage tank...............................................27 Gaskets ............................................................. 28 Gear boxes .........................................................28 Gloves ...................................................................3 Goliath crane .....................................................28 Goods lift ...........................................................28 Hand / power operated label gumming machine ......................................................... 28 High speed automatic big size label over printing machine ............................................28 High speed automatic carton over printing machine..............................................................28 High speed automatic label counting machine ...........................................................28 High speed automatic label over printing machine..............................................................28 High speed automatic lid dispensing machine ...........................................................28 High speed automatic wallet dispensing machine ...........................................................28 High speed tablet presses.................................11 Hot air oven ....................................................FIC Humidity chamber .........................................FIC Incubator .......................................................FIC Industrial control & sensing device..................7 Inflatable gaskets ...............................................28 Inverter/variable frequency drive......................7 Jib crane ........................................................... 28 Labels ............................................................... 29 Laboratory & medical equipments.............. BIC Laboratory oven..............................................FIC Large diameter welded pipes...........................28 Level controller ...................................................7 Linear bottle washing machine.......................26

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Measuring & monitoring relay for 1ph/3ph............................................................ 7 Medium speed tablet presses...........................11 Microfluidiser processor ..................................26 Moisture analyser balance ...............................27 Monorail trolley ................................................28 Motion control....................................................7 Motorized chain pulley block .........................28 O rings ............................................................. 28 Oil seal................................................................28 Orbital shaking incubator ...............................26 Other process equipment ................................11 Pharma print cartridge ................................. 26 Pharma refrigerator ..........................................26 Photo electric sensor ..........................................7 Photostability chamber ..................................FIC Pilot / lab scale tablet presses ..........................11 Plastic masterbatches........................................29 Pressure sand filters .........................................BC Printer ................................................................29 Profiles................................................................28 Programmable logic controller .........................7 Programmable terminal.....................................7 Proximity sensor .................................................7 Pump & valve ....................................................28 Pumps ................................................................27 Reverse osmosis unit.....................................BC RFID .....................................................................7 Roller compaction systems ..............................11 Rotary bottle washing machine ......................26 Rotary tablet press ............................................11 Safety light curtain ........................................... 7 Seamless pipes ...................................................28 Sections ..............................................................28 Sheet ...................................................................28 Side channel vacuum pump & compressor ..28 Silicone FBD gaskets.........................................28

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Silicone rubber braided hose ..........................28 Silicone rubber compound..............................28 Silicone rubber cords/square/strips ................28 Silicone rubber corona treater sleeve .............28 Silicone rubber extruded gasket & profile.....28 Silicone rubber moulding ................................28 Silicone rubber sheets.......................................28 Silicone rubber sleeves (ITI approved) ..........28 Silicone rubber sponge.....................................28 Silicone rubber tubing .....................................28 Silicone transparent platinum cured tubings .............................................................28 Softening unit...................................................BC Spectrophotometer ...........................................27 Sponges ..............................................................28 Squares ...............................................................28 Stainless steel pipes ...........................................28 Strips...................................................................28 Switching relay ....................................................7 Syringe pumps ..................................................26 Tablet hardness tester .................................... 27 Tablet press machine ........................................11 TC gaskets ..........................................................28 Temperature controller ......................................7 Timer ....................................................................7 Tooling & spares ...............................................11 TPU masterbatches...........................................29 Transfer trolley ..................................................28 Transparent tubings..........................................28 Traycell ...............................................................27 Tubes ..................................................................28 ‘U’ tubes ........................................................... 28 Ultra filtration systems....................................BC Vision sensor..................................................... 7 Welded pipes ................................................... 28 Wire rope hoist .................................................28

BC-Back cover, BIC-Back inside cover, FIC-Front inside cover

Advertiser’s Name & Contact Details

Alok Masterbatches Ltd

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Advertiser’s Name & Contact Details

Heattrans Equipments Pvt Ltd

T: +91-79-25830742

T: +91-011-41612244

Hi-mek Analytica 28

Prayag Polytech Pvt Ltd

W: www.prayagmb.com Shree Siddhivinayak Industries

T: +91-022-25336370 E: himek@vsnl.com

E: bhavyapolymers@yahoo.co.in

Mack Pharma Tech

W: www.bhavyapolymers.com

T: +91-02551-230877

W: www.minivacpumps.com

E: sales@mackpharmatech.com

Suraj Limited

Jacsons Engineers

E: info@cadmach.com

T: +91-22-28458372 FIC

W: www.mackpharmatech.com

T: +91-79-25841491

BIC

T: +91-2762-224114

Cadmach Machinery Co Pvt Ltd

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E: delhi@prayagmb.com

W: www.technoind.com

W: www.alokmasterbatches.com

Advertiser’s Name & Contact Details

T: +91-011-47262000

E: info@technoind.com

E: sales@alokindustries.com

Bhavya Polymers

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E: minivac9@hotmail.com

T: +91-79-27540720 28

E: suraj@surajgroup.com

T: +91-79-25841814 W: www.cadmach.com

W: www.surajgroup.com

E: info@jacsonsengrs.com

Food & Pharma Specialities

Techno Industries

W: www.jacsonsengrs.com

T: +91-120-4236204

Kimberly Clark Hygiene Products Pvt Ltd

E: info@foodpharma.in

T: +91-020 - 30547175

E: info@sevitsil.com

W: www.foodpharma.in

E: marketing.india@kcc.com

W: www.sevitsil.com

T: +91-2762-224814

W: www.in.kcprofessional.com Great Eastern Impex Pvt Ltd

TSA Process Equipments Omron Automation Pvt Ltd

T: +91-011-2347431/32 E: sales@geipl.com W: www.geipl.com BC-Back cover, BIC-Back inside cover, FIC-Front inside cover

T: +91-22-42288400 E: in_enquiry@ap.omron.com W: www.omron-ap.com

7 T: +91-0250-3293221 E: base@tsapepl.com W: www.tsawatersystems.com Our consistent advertisers

RNI No: MAHENG / 2008 / 27125, Postal Regd No: G / NMD / 122 / 2011 - 13, Posted at P.C Stg. OfďŹ ce, GPO, Mumbai 400 001 On 19th & 20th Of Every Month, Date Of Publication: 16th Of Every Month