Nutramedic &Cosmetics

bility, bioavailability, safety, stability, and as a carrier of the involved molecules.

By including vitamin C in liposomes or inclusion complexes with beta- cyclodextrins, the pharmacokinetic properties of encapsulated vitamin C are significantly changed during oral administration. The rate of absorption of encapsulated vitamin C is increased compared to the absorption pattern of ordinary vitamin C. The advantages of encapsulation are5:

• accelerated absorption in the gastrointestinal tract

• longer shelf life of the product

• protection of the intestines from irritating effects higher bioavailability.

Biostile microencapsulated vitamin C is based on a natural source of organic vitamin C from rosehip (Rosa canina) fruit extract, which is surrounded by a beta-cyclodextrin microcapsule.

The binding of vitamin C in the inclusion complex enables protection from external influences and controlled release in the digestive system. In this way, a more even and controlled release of vitamin C is achieved than, for example, in the case of taking pure synthetic ascorbic acid3. This ensures greater biological absorption and more stable amounts of vitamin C in the blood plasma. The amount of vitamin C in tissues and organs and the rate of excretion of excess vitamin C through the kidneys also depend on this.

The advantages of including dietary supplements in beta-cyclodextrins7 are:

• increased hydrophilicity and improved solubility of the included molecule in water, chemical stabilization of reactive or unstable molecules,

• protection against dehydration, hydrolysis, oxidation and photodegradation,

• increased bioavailability (increased permeability through biological barriers), facilitated passage of water-soluble substances through the mucous membrane,

• reduced irritation and prolonged contact time at the point of absorption.

References:

1 Alehagen et.al., 2015. Smanjena kardiovaskularna smrtnost 10 godina nakon suplementacije selenom i koenzimom Q10 tijekom četiri godine: rezultati praćenja prospektivnog randomiziranog dvostruko slijepog placebom kontroliranog ispitivanja u starijih građana. PLoS jedan.

2 Alehagen et.al., 2018. I dalje smanjena kardiovaskularna smrtnost 12 godina nakon suplementacije selenom i koenzimom Q10 tijekom četiri godine: Validacija prethodnih 10-godišnjih rezultata praćenja prospektivnog randomiziranog dvostruko slijepog placebom kontroliranog ispitivanja u starijih osoba . PLoS jedan.

3 Carr et.al., 2013. Sintetski vitamin C ili vitamin C dobiven iz hrane –jesu li jednako bioraspoloživi? Hranjive tvari.

4 Davis et.al., 2016. Liposomalno inkapsulirana askorbinska kiselina: utjecaj na bioraspoloživost vitamina C i sposobnost zaštite od ishemijsko-reperfuzijske ozljede. Nutr Metab Insights.

5 López-Lluch et.al., 2019. Bioraspoloživost dodataka koenzima Q10 ovisi o lipidima nosačima i solubilizaciji. Prehrana.

6 Lykkesfeldt et.al, 2019. Farmakokinetika vitamina C, hranjive tvari

7 Roos et.al., 2017. Engineering Foods for Bioactives Stability and Delivery, Springer-Verlag New York.

8 Shukla et.al., 2018. CoQ10 super-vitamin: Pregled primjene i biosinteze. 3 Biotehnologija.

9 Svend et.al., 2014. Učinak koenzima Q10 na morbiditet i mortalitet kod kroničnog zatajenja srca: rezultati Q-SYMBIO: randomiziranog dvostruko slijepog ispitivanja, JACC.

10 Šumiga et.al, 2019. Antimikrobni premazi papira koji sadrže mikroinkapsulirano ulje Cymbopogon citratus. Premazi

11 Terao et.al., 2006. Povećanje oralne bioraspoloživosti koenzima Q10 kompleksiranjem s γ-ciklodekstrinom u zdravih odraslih osoba. Istraživanje prehrane

12 Viscovich et.al., 2004. Farmakokinetika vitamina C običnih i sporo otpuštajućih formulacija u pušača. Klinička prehrana.

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