3 minute read
Sinetrol®
by InPharma
Sinetrol® adipose beiging benefits
The metabolic health challenge
Weight management is and will remain a major concern worldwide. More than one billion people globally, including 1 in 5 women and 1 in 7 men will be living with obesity by 2030 (world obesity atlas 2022). Consumers are aware of the issues linked to obesity and 31% of global consumers say that they are currently on a diet to lose weight. (2021, FMCG Guru). The common belief that weight management is simply a matter of deprivation is obsolete. Today we know that the goal of improving and stabilizing body composition is primarily to improve the metabolic health and the quality of life of an individual. Dietary supplements are therefore a strategy to achieve these objectives healthily by contributing to weight management through multiple mechanisms. Fytexia a life science company expert in scientifically-supported micronutrients, delivers Sinetrol® a proprietary nutraceutical ingredient targeting the improvement of body composition. Fytexia delivers active ingredients supported with scientific proof to formulate finished products. The company’s mission is to reduce risk factors for non-communicable diseases and improve quality of life.
Sinetrol® – adipose beiging benefits
Sinetrol® is a natural combination of polyphenols extracted from citrus and guarana targeting body weight management. Sinetrol® reduces the excess of fat mass and improves long-term body composition.
The ingredient is formulated from highly characterized bioactive polyphenols: naringin and hesperidin, expressed as flavanones > 40%, acting with a low dose of caffeine. Non-allergen, non-GMO, Halal, gluten-free and suitable for vegetarians, Sinetrol® is available in powder form at a daily dosage of 630 mg.
Sold in more than 25 countries, Sinetrol® has been investigated in several clinical studies. The citrus polyphenol extract has a granted approval by international authorities. The South Korean Ministry of Food & Drug Safety (MFDS)’s health claim approval recognizes the ability of Sinetrol to “help reduce body fat” in the overweight population. It is also registered to Health Canada (NPN 80059820), with approved claims on its weight loss efficacy, and has several certifications.
Safe, characterized & effective
More than 10 years of research have been conducted to support the mechanism of action and clin-
ical benefits of Sinetrol® on body composition, using gold-standard methodology during interventional studies with follow-up. Sinetrol® has been clinically investigated on more than 300 subjects including both Caucasian and Asian populations.
The action of Sinetrol® relies on its patented mechanism of action on the physiological energetic pathway of lipolysis. It destores fats accumulated as triglycerides within white adipose cells and turns them into energy production within adipose tissue, which dissipates the released fats as heat. This effect of Sinetrol® avoids further restorage of fat within adipose tissue. Both in vitro and ex vivo studies demonstrated that the benefits of Sinetrol® are explained by two complementary mechanisms of action, driven by the ability of Sinetrol® to mimic adipose cell phenotype change from white to beige, i.e. from a storing category of adipose cells to an energy metabolism-driven adipose cell category.
Subjects taking Sinetrol®’s supplementation increased their resting energy expenditure by 180kcal/ day. This consequently led to a significant drop of 5% of their excess body fat mass. Body composition is rebalanced with a significant improvement in the lean-to-fat-mass ratio. 65% of the total fat loss was from the trunk area: Index of Central Obesity decreased significantly. A follow-up after the end of the supplementation confirms that Sinetrol® supports long-lasting benefits. One month after the end of the supplementation: subjects continue to reduce body fat mass.
Sinetrol® Key outcomes
• Proven mechanism of action: adipose beiging benefits • Increase in resting energy expenditure • Rebalanced body composition: significant reduction of body fat mass without lean mass loss
• Significant results on body weight, waist and hip lines • Long-lasting benefits: subjects continue to experience adipose beiging benefits
Fytexia Group
Fytexia Group is an expert life science company in developing scientifically-supported active nutrients for healthcare products. Fytexia’s mission is to reduce risk factors for non-communicable diseases and mild infections by offering innovative nutritional supplements from our scientific research and inspired by recognized public health food practices.
www.fytexia.com FYTEXIA SAS ZAE VIA EUROPA 3 rue d’Athènes 34350 Vendres – FRANCE
