The 10 Most Influential Leaders in Healthcare in 2022 March2022

Editor’s Desk

Leading Humanity with Dedicated Efforts in Healthcare

Hlookslike?Leadershipcomesinvariousforms andshapes,whichdifferfrompersontoperson basedontheirapproach.Whenitcomestoleadershipinthe healthcaresector,therearehugeresponsibilitiesand challengesthatrequireseveralprominentsteps.

aveyoueverwonderedwhatauthenticleadership

Thetraitofhavingacrystal-clearvisionmustbethereason thatgetsyououtofbedeverymorningbecausethe authoritiesinthehealthcaresectormustdealwithhuman anatomyandawiderangeofemotions.Asaresult, demonstratinghumilityiscriticalinensuringthatthe patientistreatedcorrectly,bothphysicallyandemotionally Itisvitaltohaveemotionalintelligenceasaleaderin healthcarewhomustconnectwithnumerouspeopleevery day,exhibitingpatient-centricbehavior.

Aleadershouldbemorevocalabouttheworkethicas havingsoundcommunicationwithyourcolleaguesor subordinateshasthepotentialtomakeorbreakyourcareer. Asweknowthateducationcaterstotheutmostimportance inthiscompetitiveworld,generatingacompetitiveedgefor aleadertostandoutfromthecrowd.Intermsoftimeand education,theglobehascomealongway,andthesubjects ofscience,technology,engineering,andmathematics (STEM)arecurrentlythemostpopular TobeaSTEM leaderistooverseetheentirefunctioningoftheworldin thepresentandfuture.

Thehealthcaresectorishugeandchangingatabreakneck pace,resultinginmoreexpectations,particularlyin technology.Healthcaretechnologyandequipmentimprove everyyear,puttingthecompetitioneventighter.Healthcare practitionersmustkeepupwiththelatesttrendsand technologytogivethebestresults.

Beingaleaderinthehealthcarebusinessputsyouinavery responsibleposition.Everydecisionmustbecalculated, everyminutemustbecounted,andeverypatientmustbe content.Aleaderisinfluentialanddifferentfromothers becausetheyhaveovercomeeverydifficultybyproducing exceptionaloutcomeswhileremainingstrong.

Inthiseditionof "The 10 Most Influential Leaders in Healthcare," InsightsSuccesshasidentifiedsuch individualswhoaretransformingthehealthcarebusiness.

Learnabouttheaccomplishmentsofsuchchallenging personalitiesinoneofthemostsignificantareasby exploringmoresimilarandengagingstoriesaboutthem.

Readthearticlesauthoredbyourin-housewritersandthe CxOviewpointsofsomeoftheindustry'sleading professionalstogaininsightintothearea.

Havefunreading!

SonaliDhiwar

Sonali Dhiwar sonali.dhiwar@insightssuccess.com

Kaile Zagger

Global Leader Driving Disruption and

in

Stepping Up

Advancements in

Leader's Viewpoint

in

Living with Natalie Fée

Audrey Sommerfeld

Brandon

Collura

FeaturedPerson

BrandonSawalich

President&CEO

EliasChabtini

Founder&CEO

GregSavino

Founder&CEO

CompanyName

Starkey starkey.com

MedicaGroup medicagroup.com

BaybridgePharmacy baybridgepharmacy.com

KaileZagger CEO

MichaelCollura CEO

MarcRippen

CEO&Founder

ASPIRA aspirawh.com

INHOME IHPS.com

NatalieFee Founder

RoyFarfara

Founder&MD

Robert Lauritzen CEO

RichardS.Isaacs CEO&Executive Director

Alertgy alertgy.com

CitytoSea citytosea.org.uk

TrioxNano trioxnano.com

Cerebriu cerebriu.com

ThePermanente MedicalGroup permanente.org

Brief

StarkeyHearingTechnologiesisaprivatelyheld,global hearingtechnologycompany

AtMedicawedeliverBeautythroughtechnology

BaybridgePharmacysetitssightsonputtingthecustomerfirst, providingsuperiorqualitypatientcare,andworkingclosely withthepatient’sprescriberandinsurancecompany

AspiraWomen’sHealthInc.(formerlyknownasVermillion, Inc.Nasdaq:VRML)istransformingwomen’shealthwiththe discovery,development,andcommercializationofinnovative testingoptionsandbio-analyticalsolutionsthathelpphysicians assessrisk,optimizepatientmanagementandimprove gynecologichealthoutcomesforwomen.

InHomePersonalServiceshasstoodalonewhenitcomesto creatingindividualizedcareplansbasedontheclient’sspecific needs.

Alertgyhasrecentlybeenfoundedbyasmallteamof innovatorsthathavecollaboratedonchallengingtechnical programsovertheyears,specificallytoaddressthehighly desiredabilitytomeasurebloodsugarlevelswithanexternal wearablesensordevice.

CitytoSeaisanenvironmentalorganisation,campaigningto stopplasticpollutionatsource.

TrioxNanoLtdisaninnovativebio-technologycompany

Cerebriuimprovesworkflowefficiency,qualityandpatient outcomesindiagnosticimaging.

ThePermanenteMedicalGroupsareself-governed,physicianled,prepaid,multispecialtymedicalgroupscomposedofmore than23,000physicians.

Kaile Zagger

CEO of MAT Foundation, Private Equity Advisor, Board Member

Kaile Zagger

Global Leader Driving Disruption and Transformation in Healthcare

Innovation requires daring greatly but also having great insight. Developing products that are life changing and life saving require breaking sound barriers that have never broken before. Science is a process that takes us from unknown and unchartered to understanding and real - in a manner that is predictive, reproducible, reliable and true. An innovative transformation, particularly when it impacts patients well being and lives, is incredibly empowering and emotional.

hepandemicrevealedtheimportanceof

Tinteroperabilityinhealthcare.Healthcareasbeen undergoingamuchneededandnecessary transformationformanyyears,buthascometoacritical juncturewherestepsmustbetakeninordertosustainthe system.Livesareshortenedbymis-diagnosisorno diagnosisandmanyofthesecanbesavedthrougha strongerdigitalfoundationinwhichfacilitating communicationandhandlingcomplexanalyticstoensure betteroutcomes,efficacyandequity.Millionsoflivesare losttocancereveryyear;thelatediagnosisofcancer contributestohalfoftheselosses.Thedelayinthe treatmentincreasestherisksinvolved,minimizingthe chancesofsurvival.Globally,healthsystemshave problemswithcancertreatmentdelays,andseveralstudies canshedlightonthestatisticsofvariouscancer-associated withanincreaseintheriskofdeath.

KaileZaggerishighlightedtodayandjoinsustoshareher knowledgeandexperienceinherhighlysuccessful20+ healthcarecareer.Shehasspentyearsspanningthe healthcarespectrumcareareasanddeeplyadvocatesfor transformation,preventativemedicineandpersonalized care,particularlyforwomen,whotendtofallthroughthe cracksofthesystemduetotheirbenignpresentationof symptoms.Kailehasheldnumerousgloballeadership positionsamongstFortune50companies,hassuccessfully transformedmanyhealthcareverticalsandbuiltglobal businessdivisionsthatdeliveredlifesavingtechnologies andimprovedcare.Additionally,sheistheCo-Founderand

CEOofanon-profit,whosemissionistoprevent gynecologicaldiseasethroughtheeducationofthenongynecologicalandnon-oncologicalphysicians.Kaileisan activeBoardMemberandadvisestheprivateequity communitytoensurelifesavingtechnologiesfindtheirway topatients.Shehasbeenreveredbyherpeersasaworld classleaderandawarriorforwomen.

Servingformorethan20yearsinthehealthcaresector, Kalie,withhertransformationalleadership,hasfacilitated andwitnessednumeroustransformationaldiscoveriesto helpandboosttheindustry,achievingseveralfeatsonthe way

TheSteadyRise

Atthetenderageof13,Kailefoundoutabouthermother beingdiagnosedwithstageIVovariancancer.Despite sufferingfromcancer,Kaile'smotherpushedhertoexcelin herstudiesandhelpedtofinetunehertennisskills.Every effortandhardworkpaidoff,asKailelandedapositionat universityonaDivision1tennisteam. Unfortunately,her mothercouldneverseethefruitionoftheconfidenceshe entrustedKailewith,losingthebattleagainstovarian cancerat46.Kaileexpresses, "The world lost one of the greats the day she passed. She was well loved and a true gift to the world. She was far too young to die and her death never should have happened. The signs and symptoms were present for 2+ years before diagnosis," andconsidereditas anotherneedlessovariancancerdeathduetolate-stage diagnosis,whichis,tothisday,stilltoocommon.

If everyone is moving strongly forward in the same direction, success will inevitably follow.

you feel like you can no longer run with your legs, lean in to your team and begin to run with your heart.”

Kaile'sjourneyfromthatpointonwardsbecamemore challengingasshelumberedwithlessenedsupportfrom familyandfinancialsources.Fightingherwaythrough university,handlingmultiplepart-timejobs,Kailestudied hardandlandedherfirstpositioninGeneralElectric's GlobalLeadershipDevelopmentProgram,designedto buildandfosterthenextgenerationofbusinessleaders. UndertheinvaluabletutelageofJackWelch,shegainedan incredibleexperience,graduatingwithhonors,andaBlack BeltinSixSigma.Shehadafirmdesiretosignificantly impactthehealthcaresystem,whichsheknewtoowelland believedwashighlyfragmentedandbroken.

Initiatingherhealthcarecareerinelectrophysiology,Kaile workedasapacemakersalesrepresentative.Shehada fantasticfortunetoworkinseveralcareareasspanning fromneuromodulation,robotics,diagnosticimaging,and informaticstoearlydetectioncancerdiagnostics.Overthe lasttwodecades,KailehasworkedforseveralFortune500 companies,includingSt.JudeMedical,IntuitiveSurgical,

andGeneralElectricHealthcare.Kailefurtherco-founded andservedastheCEOofanonprofitfoundation,MAT Designation,fosteringearlydetectionofovariancancer

In2020,Kaile'sfiercecommitmenttoprevention,early detection,andmitigationoflate-stagediagnosisofthis malignancygotstronger.Kaileisregardedasa transformationalleaderandbuilder,whichharkensbackto theskillssheacquiredthroughthehardshipsthatbegan whenshewas13.Asapeople-centricleader,shebelievesin thepowerofateamandtheartisticapproachto constructingworld-classteams.Shementions, "Loving the transformation work is not an easy passion for embracing. You are cast as an agent of change, a disruptor, and sit forever in a highly challenging position. Yet the rewards are so high and I love the work." Kailebelievesthathealthcare doesn'thaveenoughleadersbraveenoughtostandapart andtakeinitiativesthatareoftendifficult,tedious, frequentlypoliticallychallenging,andrequireextreme levelsoffortitudebutarenecessary

Kailestatesthatthehealthcaresystemisriddledwith unnecessarilyhighcosts,packedwithproductsthatlack marketvalue,andstructuredvertically,negatively impactingpatientcare.Shesays, "We all have much work to do to get to where we need to be. It can only be achieved through courageous leadership that clearly carves an effective path forward and, ultimately, radically changes the way healthcare is delivered in the future. These are changes that will result in optimal healthcare for all of us."

TheTransformationalImpact

Kailenotesthathistoryisfullof greattransformationalstoriessuch asAmericanExpress,Apple,and Wipro,andalsoofthefailed transformationandprogression ofBlackberry,Yahoo,andJC Penney,tonameafew.Sheloves changemanagement, transformation,andbuilds,asshe grewupfacingchallengesand understandswhyandhow,at times,oneneedstoevolveanddig intobedeterminedtoprogress.

Toseetheresultsofovertakinga failingsituationandmakingit workisadreambroughttoreality

As life unfolds, it unveils that it moves, it breathes and is alive itself. To know that, demands that we understand the notion that we too must evolve along with it, or become obsolete. If you seek greatness, you must seek constant transformation of your heart, mind, insights and outlooks.

Kailehopestoachieveafluidhealthcaresystem-onethat isstructuredhorizontallyratherthanvertically,thereby establishingasysteminwhichthepatientistrulyatthe centerofcare.Thedecentralizedhealthcaresystemdesign hasmanymisdiagnosesandfartoomanylate-stagedisease diagnoses.Sheunderstandsthatsomeprogresshasbeen made,itismostcertainlynotenough.Inadequateand ineffectivetestingmustbeeliminated.Thecostmustbe takenout,investinginareasthatwillsignificantlyimpact people'slives.Adigitalhealthtransformationisrequired andessentialforhumankind'ssuccess.

oranaccelerationneverthoughtpossibleexcitesKaile.She expressesthatittakesmuchhardwork,andmostpeople don'tenjoythisprocessasitismuchmorecomplexthanthe jobsinwhichyouaretaskedwithgrowingat10%orjust marginallyimprovingprofitability.Kailewasfosteredinan environmentthatmadeherfacechallenges,beingthe primaryreasonshelovestakingonchallengingprojectsand aligningwithpowerfulteamstomakeachangeandreach newheights.Formorethan20years,Kaile'slovehas increasedfortransformationalworkthatcanofferto companies,society,andultimately,thepatients.

BetterthanFound Kaileisheavilyfocusedonhermission,committingto makingadifference,impactinghealthcare,particularly women.Shewantstoleavethisworldabetterplaceforher childrenandthenextgenerationstocome.Abolishing inequitiesacrossrace,gender,andsocioeconomicstatus drivesandfuelsherpassionformakingasignificant change.Kailerefusestoacceptthestatusquoprevalentin theseareasofinequity.Shebelievesthatthehealthcare sectormustmakedefinitiveprogress.Sheasserts, "On the positive side, the world is where it is because of incredible innovation and change agents. However, on the negative side, the world is where it is, unfortunately, because of the continued acceptance of mediocracy and an unwillingness to stand for change.”

AnothervitalareathatKaileishighlyfocusedoncenterson womenandgirls.Shesays, "Women and girls around the world continue to experience significant progress in terms of educational, employment, networking, and mentoring opportunities." AlthoughthePandemichasaccelerated digitalplatformsforlearning,earning,andconnecting,it alsohashighlightedgenderdisparities,similartothe inequitiesobservedineducationandhealthcare.Nearly1in 4girlsagedbetween15-19globallyarenotinvolvedin education,equitableemployment,ortrainingcomparedto1 in10boys.Adolescentgirlshavetherighttobesafe, educated,andhealthyinthesecriticalandformativeyears andastheymatureintowomen.Empoweringwomenand girlsandpromotinggenderequalityiscrucialto acceleratingsustainabledevelopment.

BequeathingNextGenerationofHealthcareLeaders Kaileadvisesup-and-comingleaderstolearneverything theypossiblycan.Beastudentandcontinuetogrowin everypossibleway.Behumbleanddon'tgetcaughtupin politics.Shesays, "Always do the right thing by building teams with people who are stronger and smarter than you are and empower them. Never be threatened by people better than you. Your role as a leader is to foster and enable the next generation of leaders and, by so doing, ignite dynamic growth. You cannot do that if you do not drive your team to unparalleled levels of brilliance and insight."

Leadershipisdefinedassettingastrong,uniquevision, hiringthebest,andremovingobstaclestosuccess.Inthis way,morecanbeachievedthaneverthoughtpossible. Kailementionsthatifyouarecaughtinanenvironmentthat doesnotprovidethis–getout.Yourlifeisshort.Youare valuable,andyourcontributionscanbesignificant."Ensure youcapitalizeoneveryday,thatyouarewell-positionedto addvalue,andthatyouarealignedwithleaderswhoare smartandbelieveinempowerment,"Kaileconcludes.

Audrey Sommerfeld Founder, and CEO Jump To Health, Inc.

The 10 Most Emerging Leaders in Healthcare, 2021

Audrey Sommerfeld

Helping People Radically Change their Health through Science of Sound Nutrition

Thesoundbodyistheproductofthesoundmindand soundnutrition.Havingahealthymindandhealthy nutritionplaysthemostimportantroleinthe overallhealthydevelopmentofpeople.Itisbelievedthat mentalhealthandphysicalhealthareinterrelated,and Healthydevelopmentofpeoplemeanshavingphysical fitnessandmentaltoughness.

“All health challenges can be improved by good nutrition,” believesAudreySommerfeld,ahealthcareleader.Having spent3decadesincompaniesandstartupsacrossnutrition, wellness,skincare,andOTCmedications,Audreyis committedtohelpingpeoplelivebetterlives.Currently,she istheFounderandCEOofJumpToHealth,Inc.,a companyaimingtoprovidemealplansandeducationon eatinghealthyfordifferentlifestylesandhealthconcerns.

ATakeonToday’sHealthcare

AccordingtoAudrey,healthcaretodayisabouthelping thosealreadysicktryingtogetbetterormanagetheir illnesses.Shehopestobegintoshiftasasocietyto prevention–tomoreeducationontheroleofnutrition.She expresses, “Today our physicians and health workers get very little education on nutrition – some sites say 8 hours or less in their career. We don’t teach this in school either. So consumers rely on the food industry to tell us what is healthy, and it is impacting our weight and our health. Sugar is cheap, it is addictive, and it is in all of our food, and it is making us sick.” Itwasthisrealizationthatledher toformJumptoHealthInc.

JumpToHealthisfocusedoneducationandahealth Journey–tohelpinspirepeoplewithinformation, recipes,toolsacommunityofsupport,recognition, andrewards.Ithasa12weekJourneyguarantee becauseonceyoustartonthepathtobetterhealth–yougetinnerfit.Yourhealthimprovesfromtheinside outandJumpToHealthdoesthiswithproductsbased onsoundnutritionscience,notonhype.

HelpingPeopleTakeChargeofTheirHealth

Audreyopinesthattoday,wearebombardedwithtv commercialsandinformationthatmakesitconfusing toknowwhatishealthy,andourdietsareloadedwith sugar.3outof4adultsareoverweight,andalmost1 in2areobese.Andourkids–aresufferingasaresult. Today1in3kidsareobesesettingthemupforshorter lives.Diabetesisnowbecomingachildhooddisease insteadofadult-onsetdiabetes.DiseaseslikeDiabetes, Cancer,Gallstones,FattyLiverDisease,Gout, Arthritis,HighBloodPressure,StrokeSleepApnea, Asthma,andotherhealthissuesareontherise,andall arerelatedtobeingoverweight.ADHDisnowa householdname.1in20kidsarealreadyon medicationformoodandattentionissues.ADHDhas grownover500%sincethe1980s.Heartdiseaseis becomingayoungerandyoungerissue–andexperts predictthattoday’skidswillhaveheartattacksas youngasage30.

Audreyfirmlybelievesthathealthynutritioncanplay abigpartinhelpingfightthesehealthissuesandJump

ToHealth™isheretohelp.ItoffersaHealthJourney–and itstartswithprovidingahealthybreakfast.Ithelpswitha betterbreakfast,bettertoolstohelppeopletakebackcharge oftheirhealth.

JumpToHealth’sbighairygoalistoendsugaraddiction, obesity,diabetes,inflammation,andallhealthchallenges thatcanbeimprovedbygoodnutrition.Itdoesthisby providingeducationonnutrition,simpleproductsolutions andkits,andmealplans,programs,andrecipesforfreeto itsmembers.

ProvidingHighestQualityProteinRichFood

Audreymentionsthatproteinqualityintheproteinshakes makethedifferenceandJumpToHealthhasaunique Tri-SorbProteinBlend™tobetterbuildleanmuscle,boost immunehealth,andhelponefeelsatisfied.Itcombinesthis withpatentedandclinicallystudiednutrientsshownto boostmoreproteinintoone’sleanmuscle+45%morewith aspecialaminoacid,and+25%morewithaspecial botanicalherb.Allthishelpstomakeiteasytodigestfor youngandoldalikeandgiveathletesbetterperformance too.Andwithapatented,clinicallystudiedprebiotic fiber–showntohelpboostguthealth,moodandfocus.

Moreover,Audreyalsosharesthattoday,1in2kids,and2 outof3adultsarenotgettingenoughcalciumforstrong

bones,teeth,muscles,andhormoneregulation.Thenews showmorekidsaregettingbrokenbonesasaresult.Thisis whyJumpToHealth’s‘ShakeThatTastesLikeCake™’ alsoincludesnutrientstoaidmorecalciumabsorption up–upto50%more.Anditsspecialproprietarysweetener systemisclinicallyshowntohelpbloodsugar,helpathletes havebetter-sustainedenergyandperformance,andhasfatburningpropertiestoo.

PracticalExamplesofImprovementinHealthofPeople

TravisBlackwasoverweight,nothappywithhimself,he wasprediabetic(A1Cwas6.4),histriglycerideswerehigh, andduetoaworkinjurywasnotabletoexercise.With JumpToHealthnotonlydidhelose50poundsandgofrom a55”waistto40”,butalsohisA1Cisnow5.1andhe loweredhistriglycerides100points.

JulieSnowbargerandherhusbandMarkhavemade significantstridesintheirhealth.Juliehaslost50pounds andgainednewenergy,andMarkhaslostweighttothe pointwherehisdoctorremovedhisbloodpressure medications.

ValuingVarietyofIdeasandInputs

Audreysaysthatteamwork,thoughtfulchallengingof beliefs,passionforchange,andtransparencyineverything isimportantasabusinessleader.Shebelievesthatmore brainsarebetterthanonebecauseagoodideacancome fromanywhereoranyone.

Every great dream begins with a dreamer. Always remember, you have within you the strength, the patience, and the passion to reach for the stars, to change the world.

PeopleatJumpToHealthtrytolisten,takeconstructive feedback,andcreateateamculturewheretheyvalueideas andinput.

TakingGuidancefromPeopleWhoTellstheTruth

Inheradvicetoemergingentrepreneurs,shesays “Your greatest competition is within yourself, and when you focus on the greater benefit for the consumer, you both win. During my career, I had many great mentors and I think it is important to find those people you can rely on to tell you the truth, to be a good sounding board, and who hold you accountable to be the best that you can be. Push yourself to learn, to listen, and never stop growing”

HelpingMillionsofPeopletoHaveaHealthyLiving

Inthenextfiveyears,JumpToHealthhopestotakeits missionglobal.Obesityandhealthissuesaregreataround theworld.Infiveyears,ithopestodramaticallygrowits companyanditsmissionandtohavemillionsofpeople sharetheirjourneybacktohealthylivingwithothers.It offersgreatword-of-mouthincentives,anditsgoalisto helpwholefamilies,communitiesradicallychangetheir futurehealthstartingtoday.

Brandon Sawalich President and CEO Starkey

Brandon Sawalich Leading an Industry to The Forefront of Medtech Innovation

Whenpowerfulenough,onepieceofguidance canshapesomeone’sfuture.Thisisexactly whathappenedforBrandonSawalichwhen BillAustin,founderofStarkey,said,"Itstartswithcaring, andpeoplearethebottomline."

ThesewordsshapedthecourseofSawalich'scareerand haveguidedhimforthepast28yearsatStarkey.Now,as thecompany'sPresidentandCEO,Sawalichleads Starkeyaroundthepurposeofcaring.

We,atInsightsSuccess,caughtupwithSawalichtolearn moreabouthisjourneyandhowheisleadingateamthatis

challengingthestatusquowhenitcomestothetechnology, designandproductionofhearingaids.

Below are the highlights of the interview:

Briefouraudienceaboutyourjourneyasabusiness leaderuntilyourcurrentpositionatStarkey.What challengeshaveyouhadtoovercometoreachwhereyou aretoday?

IstartedworkingatStarkeywhenIwas19yearsold;I cleanedhearingaidsthatneededtoberepaired.WhenI started,FounderBillAustintoldme,“Itstartswithcaring,

The 10 Most Influential Leaders in Healthcare in

andpeoplearethebottomline.”Mr.Austinestablished Starkeyin1967andremainsthecompany’sheartandsoul. Itookhiswordstoheart,andtheyhaveguidedmethepast 28years.IhaveworkedinnearlyeverycornerofStarkey, soakingupknowledgeandalwaysputtingpeoplefirst.I learnedeverythingIcouldaboutthisbusiness,fromthe needsofthehearingimpairedtocustomerservicetothe logisticsofmanufacturing.

WhenIstartedatStarkeyin1994,Ineverimaginedakid fromasmallcoalminingtowninSouthernIllinoiswould onedayleadaglobalcompanyof5,000talentedandcaring people.However,Mr Austintaughtmethatatitledoesnot definealeader Aservantleaderremembersthattheywork fortheirteam,nottheotherwayaround.Starkeyhas reinventedthehearingaidtohelptheworldhearbetterand livebetter.It’smyresponsibilitytoleadourteamwitha clearvisionandpurpose.

TellusaboutStarkey’smissionandvision.

Starkey’smissionistoserveourcustomersbetterthan anyoneelse.Thisstartswithacaringattitude,apeople-first cultureandexcellentproducts.Hearingprofessionalstrust ourtechnologytodeliverthebestoutcomesfortheir patients.Ourlatesthearingaid,EvolvAI,ispartofthemost advancedproductlineonthemarket.Patientsnolonger havetocompromiseonfeaturestogetthebesthearingaid fortheirhearingloss,andproviderscanfocusondelivering personalizedcare.

Starkey’svisionistoleadtheworldinhearinghealthand wellnessforpatient-drivencare.Thepatientcomesfirst, andthedigitalpatientdemandsmorethaneverbefore.Our teamworkswithpatientstolearnwhattheyneedandwant. Wethendelivercutting-edgetechnologywitheffortless usability

Howhaveyoumadeanimpactinthehearingindustry?

Whatisbestforthepatientisbestforourcustomersandis bestforStarkey.Puttingthepatientfirstalsomeans advocatingforthem.I’vespentadecadeworkingwith politiciansaroundthecountrytoeducatethemonhearing lossandourindustry.Policymakersmustunderstandthe roleofthehearingprofessionalandoftechnologysopatient needsarerepresented.Thiscontinuededucationiscritical togettingmorepeoplethehearinghelptheyneed.

As a global leader in manufacturing and cutting-edge hearing technology solutions, Starkey's high-performing teams move at the speed of innovation, driven by caring and a bigger purpose.

Undeniably,technologyisplayingasignificantrolein almosteverysector.Howareyouadvancinghearingaid technology?

Ourfirstpriorityissoundquality,butahearingaidcando morethanamplifysound.In2018,Starkeyrevolutionized thehearingaidwithLivioAI,theworld’sfirsthearingaid withartificialintelligenceandintegratedsensors.We transformedthehearingaidintoaHealthable devicewith™ unparalleledsoundqualityandgroundbreakingfeatureslike activitytracking,engagementtracking,falldetectionand alertsandreal-timelanguagetranslation.LivioAIwas namedoneofTIME’sBestInventions.

In2021,weraisedthebaragainwithEvolvAIwhichscans itsenvironment55milliontimeseveryhour,adjustingto theuser’slisteningenvironmentautomatically.In2023,we plantopushhearingaidtechnologytoplacesneverbefore thoughtpossible.

HowhasStarkeyimpactedtheglobalhearingindustry andwhatchangewouldyoustillliketobringtothe globalmarket?

AtStarkey,weprioritizepatientneedsandsatisfaction. Hearinghealthcareisessential,andthemorepeople understandtheimportanceofhearingandhowhearingis connectedtooverallhealthandqualityoflife,themore likelytheyaretoaddresstheirhearingloss.Starkey’s continuededucationonhearingloss,hearingtechnology andhearinghealthpolicyisunmatchedintheindustry We arealsoworkingtoreducethestigmaaroundhearingaids. Peopleusedtoseehearingaidsasasignofage.Now,more peopleseethistechnologyasawaytoimprovequalityof life.

What,accordingtoyou,couldbethenextbigchangein thehearingindustry?HowisStarkeypreparingtobea partofthatchange?

Thenextbigchangeintheindustrywillbedrivenbythe digitalpatient.Today’shearingaidwearersaretechsavvy andwillcontinuetoexpectmoreadvancedtechnology The digitalpatientwantsinnovationinhearingaidsandinthe

waytheyreceive care.Fromvirtualappointmentsto phoneappsallowingthemtomanagetheir ownsettings,today’suserdemandsflexibilityofcareand amorepersonalizedapproach.Theindustrywillhaveto continuetoadapttoaworld,andapatient,whoseneedsare advancingasquicklyasthetechnology

Wheredoyouenvisionyourselftobeinthelongrun, andwhatareyourfuturegoalsforStarkey?

MygoalforStarkeyhasneverbeentobethebiggest.My goalistobethebest.Westrivetoalwayshavethebest productperformanceandqualityandtogivethepatientthe bestuserexperience.Caringisthecornerstoneofour culture,anditstartswithourpeople–thebestandbrightest mindswhochoosetoworkherebecauseourworkis connectedtoagreaterpurposeofhelpingpeople.That foundationofcaringisfeltbyourcustomersandpassed alongtotheirpatients.Ifwecontinuedrivinginnovation beyondwhatwasthoughtpossibleandleadwithcaring,I don’tjustenvisionusbeingthebest,Iknowwewillbe.

Whatwouldbeyouradvicetobuddingentrepreneurs whoaspiretoventureintothehealthcaresector?

Focusonhelpingpeople.Ifyouhaveagreatproductand putpeopleoverprofit,therestwillfallintoplace.When youmakemistakesandfail(andyouwill),failfast,learn, adjustandkeepmovingforward.Itisn’taboutbeingthe smartestpersonintheroom.Surroundyourselfwithpeople smarterthanyouwhocanworktogether.Mostimportantly, thenextgenerationofsuccessfulentrepreneursneedsto leadwithheart.Itallstartswithcaring.

Technological Advancements in HEALTHCARE

Weliveinadigitalera,wheretechnologiesare emergingfasterthanwecanevenexperience. Humanityhascomealongwaytomakeliving betterineverymannerpossible.Asmuchastechnological advancementshavechangedtheindustrialandeconomic sectors,thegame-changingimprovementsinhealthcareare immense.

Theever-improvingtechnologyinthehealthsectorhas savedcountlesslives.TherightinventionofX-ray machinestoadvancedsurgicalpracticesandtheutilization ofArtificialIntelligencefurtherdevelopsexisting technologiesthatcanbegroundbreakingtomaketreatments moreaccessibleandincreaselifeexpectancies.

InnovationsinHealthcareTechnologies

Thepandemichasdisruptedlivesaroundtheglobe,creating chaosandfearofdemise.Thoughvaccinesarebeing developedatarapidpaceanddeliveredworldwide,itisof utmostimportancetostaysafeandtakenecessary precautions.Overthepastyear,itwaspossibletoidentify andtreatthesymptomsofthemostprimarycasestothe mostsevereduetoadvancedtechnology.Inthelastdecade, manydisruptingtechnologieshaveemergedwithnothing butthepatientinmind.

InformationTechnology:IThasavailedhealth practitionerstostoreandretrievedatarelatedtopatient's healthrecords,enhancingpatientinformationthrougha

legibleformatthatiseasytouse.Thesedatahelpin consultingthepatientanddiagnosingthedisease,reducing thechanceofmedicationerrors.Additionally,alertson medicationcanhelpinadheringtospecifictreatmentsand schedules.Therecordeddatacollectedcanleadto uniformityofpracticeacrossallhealthpractitionersand improvecommonconditionsbasedonpastdossiers.

3DPrinting:3Dprintinghasavastnumberofapplications, butitisusedtocreateimplantsorjointsforsurgeryinthe medicalfield.Itisfrequentlyusedindevelopingprosthetics asitcanmakeperfectmatchinglimbs.

Robotics:RoboticSurgeryhasbeenaroundforawhile. Roboticsprovidesprecision,flexibility,andcontroltoa surgeon'shandtooperateasnon-intrusiveaspossible.

VirtualReality:TheusageofVRdeviceshasincreasedat anacceleratedpace.Particularly,VirtualRealityhashelped medicalstudentshaveavirtualexperienceofreal-life proceduresandabettervisualunderstandingofhuman anatomy

Wearables:Whatbeganasafitnesstrackertotrackheart ratehasspreadwidelyinbecomingapotentialdeviceto preventoralertsevereconditionsbeforehand.

Patientsfocusonpreventionandmaintenance,demanding informationabouttheirhealthmorefrequentlyintoday's digitalage.Healthcarecompaniesinvestinwearable

devicesthatcanprovideupdatedmonitoringofpatients determiningtheplausibilityofhealthmishaps.

Atweakinwearabletechhasallowedeventodetect cardiovascularanomaliesearlier Wearablescanalsotrack calorielevels,hydration,andevenbodytemperature.A sweatmetersdetectorisusedforpeoplewithdiabetesto monitorbloodsugarlevels.Oximetersmonitortheamount ofoxygencarriedintheblood,oftenusedbypatientswith respiratoryillnesses.

ArtificialIntelligence:ArtificialIntelligence(AI) representstheepitomeofmedicalinnovation.Healthcare canbestimplementAIinareaslikeprecisionmedicine, drugsdiscovery,andgenomics.

AIcanpowerasophisticatedpatternrecognition,whichcan beavailedtohavepersonalizedtherapiestailoredaround thegeneticsandlifestyleofpatients.Biotechand pharmaceuticalcompaniesarealreadyusingmachine learningalgorithmstoshortenthedrugdevelopmentcycle.

Nanotechnology:Nanotechnologyisonthevergeofa transformationalchangethatcanoperateasaprecisedrug deliverysystemusingnanoparticlesandnanodevices.The so-callednanomedicineagecouldbecapableofbecoming cancertreatmenttoolsorminusculesurgeons.Though

Stepping Up

smartpillsarealreadyusedforcolonoscopy,itwon'ttake longtoseemorepracticalnanotechnologyapplications.

FeedingyourThoughts

Themerethoughtofvirtuallyvisitingadoctorfrom hundredsorthousandsofmilesawaywouldhavebeen difficulttobelieveafewdecadesago.Fromremote monitoringtoolsandwearablemedicaltechnologyto nanotechnology'sprecisedrugdeliverysystem,healthcare hasevolvedrapidly.Healthcareisasectorthatrequires highlyskilledindividualswithyearsofstudy;italso demandsinfrastructureandtools.Therobustinnovationin healthcareischangingthelandscapeoftheindustryevery year

Theadventofinnovativetechnologieshasmadedigital healthplausible,whichhavebeenprovenrevolutionaryin healthcare.Theprobabilityofinnovationinhealthcareis vast,andwecanexpecttechnologiesthatcangradually increaseimmunitytominimizeminorillnesses,infections. Thefutureofhealthcaremoveshandinhandwith technology;wehavetoprepareforthechangingworld, whichistheonlywayforward.

Michael Collura

Providing Quality Care to Seniors

anybusinessesarebornfromthenecessityto

Mmeettheneedsofthecustomers.ForMichael Collura,itwasaboutmakingpersonal connections,buildingrelationships,andgivingtheclients thechancetomaintaintheirindependence.Heisthe PresidentandCEOofInHomePersonalServices,oneof thelargesthomecarecompaniesinIllinois,andgrowing throughouttheUnitedStates.Heenjoyshisrolenot becauseofthesuccess,butbecauseofthefactthathis successisenjoyedbysomanyothers.Michaelhas surroundedhimselfwithtalentedindividualsthatmakeup inareaswherehefallsshort.Hebelieveshisteamisthe secrettohiscontinuedgrowthandsuccess.Withsucha talentedteambyhisside,hedecidedtoexpandthebusiness intoafranchisesystem.Todayheisofferingentrepreneurs theopportunitytobeapartofthisamazingbrandand history.

ALeaderwithStrongBusinessSkills

InHomePersonalServicessetouttobeaninnovativeand forward-thinkingcompanyfocusedonqualitycaretothe seniors.SincedayoneMichaelandhisteamhaveproudly servedthecommunitywiththosesamevalues.“We are here to provide care to seniors, veterans, and persons with disabilities. In Home Personal Services sees the industry, our opportunity, and our place within the industry in a very different way. I guess that is what makes us a leader”, says Michael.

AReliableHomeCareProvider

IHPSservicemodelsincludeawidearrayofcareoptions thatarealltailoredtomeettheindividualcareneedsof thosewhohavetrustedthecompanysince2004tobetheir provider Theteamprovidesthecarethatisneeded.No long-termcontractsorcommitments,nohourlyminimums, nosurprises.Whatmakesthecompanystandoutthemostis

thewayithasdeveloped,trained,anddeliverthecare.It hasseenchallenges,needsofthoseitcaresforaswellas theirfamiliesandthehealthcaresystemasawhole.The companyhasdevelopedmanyadvantageswithinthe franchisesystem,anditenjoysbeingabletobringthe differenceinthecareitprovidestothecommunityand clients.

RiseandShineintheTimesofPandemic Michaelstatesthatduringpandemiccrisis,thosewhowere onthefrontlinesofthecompanywerenotwillingto surrendertothetaskfacingthem.Ithasbeenatragic exampleofcourageandhope.Therewerecountless caregiversandcareproviderswhoknewaboutalltherisks theywerefacingwithCovidandtheyneveraskedtobe reassigned,taketimeoff,orabandontheseniorswho trustedIHPS.Thesecaregiversandfrontlinesdidn'tjust ensurethesafetyofthosewhoaremostvulnerable,they alsoensuredIHPSasabrandkeptitspromise.Whilean unspeakabletragedyforsomany,itwasalsothemost inspiringyearforInHomePersonalServicesbecausethe company'sfront-lineworkersneverbackeddownandthey neverstoppeddoingwhattheyneededtodo.Theyknewthe dangerandstill,theyperformedtheirdutiestoensurethe livesofothersweremadesafe.Thatwastruecourage.

Covidisaspermanenttothehealthcaresystemastheflu. Itishereforever.IHPShasalreadydevelopednew protocolsandtrainingtoensuretheongoingsafetyofthose itcaresfor.Ithasdevelopedawhollyuniqueand proprietaryAcuteHomeCaresystemforthedeliveryof carethatmeetspandemicstandardsforsafetyandinfection control.Theorganization’sabilitytocareforthesepatients today,tomorrow,andthose“longhaulers”isalreadyin placeandwhileithopestoneverhavetoproveitsabilityto doso,itisreadyforthenextpandemicineverywayitcan possiblybe.

Provide quality care that is affordable and worry-free

ATakeonLeadership

WhilesharinghisthoughtsonleadershipMichael emphasizesonIntegrity. IntegrityisasignificantpartofIn HomePersonalServicesanditsleadershiptraining.For Michael,itisthesinglemostimportanthumanattributethat isoftenthemostelusive. “Having true integrity today in our world would bring about the radical change that unfortunately most of our population is unable to recognize, acknowledge and achieve,” Michaelasserts.

RemovingObstaclesforOthers

Inhisadvicetoupcomingentrepreneurs,Michaelsays “First, do it because you care. This is not a business for those without a genuine desire to care for others. Second, do it your way. If you want to lead, then forge your own

Michael A Collura, Founder & President In Home Personal Services

path. I speak to prospective franchisees all the time and they ask me about the growth and success of other franchisees we have. My response is simple. Do you want to work up to their potential or your own? While some may see the value in benchmarking themselves against others or see this as a means to measure their own potential. I see it as a limitation you already entering into.”

Headds, “I say nothing about what I have achieved was done because I cared about what others were doing. I made my own path and today we are a brand being recognized in this article for just that. Nothing about us that is unique or innovative would exist if we just followed suit and worked to be like everyone else. Finally, embrace failure. If you find that word to be upsetting, you are not ready to be an entrepreneur. Because those of us that truly succeed first had to fail.”

‘‘

Robert Lauritzen

& Co-founder Cerebriu

Robert Lauritzen

An Ardent Leader on a Mission to Transform Radiology

AccordingtoWHO,nearlytwo-thirdsoftheworld’s populationhasnoaccesstodiagnosticimagingdue towhichpeoplearesufferingneedlesslyfrom preventablediseases.Accesstodiagnosticimagingservices hasagreatimpactonpublichealthwiththecreationof imagesofinternalstructuresusingX-raysorotherphysical waves,suchasultrasoundandelectromagneticwaves. Unfortunately,currentshortagesofhumanresourcesand obsoleteorbrokenequipmentaremakingitdifficultfor radiologistsandbiomedicalengineerstoprovideadequate accessinthecreationofsuchimages.

Withamissiontotransformradiologybyprovidingbetter toolsforradiologistsworldwide,RobertLauritzenteamed upwithAkshayPai,MadsNielsen,MartinLillholmand ErikDamtoformCerebriu,acompanythatimproves workflowefficiency,qualityandpatientoutcomesin diagnosticimaging.

RobertisaninternationalITlifesciencesexecutivewith 25+yearsofmanagementexperienceacrosshigh-tech MedTechstart-upsandlargecorporationsacrosspharma andITserviceproviders.Hehasheldvariousleadership rolesfordifferentpharmaceuticalcompanies.

DedicatedtotheDevelopmentofRadiology

CerebriuisanAIradiologycompanyautomatingMRI workflowsforfasterandpersonalizeddiagnosticimaging. Thecompanyimprovesworkflowefficiencyandqualityat thepointofcare.Itssoftwaresolution,CerebriuApollo, achievesthisbyautomatingMR-imageacquisition protocolsandtriageduringexaminationprovidingdecision supportatkeystagesofthediagnosticprocess.Ultimately, thisresultsinimprovedproductivity,prioritizingtheright patientsattherighttime,andlessstressforclinicians.It

aimstodemocratizeradiology,byenablingmorescanning andmorepatients,withoutburningouttheincredible radiologists.

“I believe we must rethink radiology to help a vastly growing global need for medical imaging-based diagnostics, and we can make a significant difference transforming the workflow using advanced technologies of our era,” saysRobert.

BringingaRealDifferenceinPeople’sLives

Apollobringstheinnovationofsmartprotocolinrealtime enablingadaptingscanningprotocolsbasedonthefindings ofinitialsequencesacquiredorcutshorttheexamination withnofindings.

Making breakthrough healthtech requires extreme adaptability, resilience, and patience. Create value for your users and customers every day.

The 10 Most Emerging Leaders in Healthcare, 2021

Talkingaboutsociety,thatincludesreducednonacute admissions,potentiallyimprovedhealthoutcomeswiththe prospectofthesmallerlengthofstay,reducedthechemical contrastgadoliniumconsumptionandcontrastwaste managementcosts,completescanningofstrokemimics, earlydetectionofstrokechameleons,ahigherdegreeof interventionandlateranyneurologicaldisease.

ImpactofPandemic

Sharinghisviewsontheimpactofpandemic,Robert mentionsthatitshowedhimandhisteamtwothings.One istheneedforprovidingthenecessarytoolsforclinicians todealwiththeincreaseddemandforhealthcare.Asof now,radiologycannotkeepupwiththeincreasedemand forneuroimaging.Robertandhisteamhaveseenthatthere isanincreaseinstrokepatientsduetothepandemic,yetnot enoughradiologiststocopewithit,that’sahugethreatto itshealthcaresystemandsociety.

Thesecondthinghementionsistheneedforunlockingthe powerofdatainordertoprovidebettercare.Themore hospitaldataisshared,themoreitcancapitalizeonAIto reducethebottleneckinthehealthcaresystemandprovide betterhealthcare.

SimplifyingRadiology

IntheopinionofRobert,thefutureofhealthcareismedical professionalsaugmentedbyAI.Hefurtherstatesthatevery hospitalgeneratesaround50petabytesofdata,yetlessthan 3%isactionable,analysedandused.Ifitmanagestobetter capitalizeonthatdata,undoubtedlyopportunitiesarise.AI willnotreplacetheroleofclinicians,butratherboostthem, relievingthemofmorestraightforwardcognitivetasks,to letthemfocusoncaseswheretheirexpertiseisneededthe most.

TheteamsatCerebriuthrivewithdiversityandequal opportunities.Halfofthecompanyhaveforeign backgrounds,andmorethanathirdarefemale,whichis prettygoodinatechstartup.

ATrueHigh-PerformanceTeam

Cerebriubringstogetherthesmartestbrainsinthefieldof AI/MLwithadistinctpurposetoimpacthealthcareinthe world.Eachoneofthemanagementteamhasaminimum ofadecadeofexperienceintheirfieldofexpertise. Moreover,Denmarkhasbeenrankedasoneofthehighest AIreadinesscountriesbyOxfordInsightsandthe InternationalResearchDevelopmentCentre(IDRC).

BestAdviceforanEarlyStartup

Inhisadvicetoemergingbusinessleadersaspiringto ventureintothehealthcarearena,Robertsays, “Learn fast. Fail fast. Embrace the challenge and pivot instead of clinging to an idea, that just does not work. Ensure to surround yourself with talent who could go on this journey with you when it’s great, and when it’s challenging. You will hear many times the word NO, but with courage, dedication, and patience, your chances of hearing YES are much higher.”

Adventures in Plastic-Free Living with Natalie Fée

Natalie Fée

n2014IwasworkinginTV,gettingabitfedupwith

Ithelackofcoverageofenvironmentalissues.Around thattime,IwasscrollingonFacebookandcameacross thetrailerforthefilmAlbatross.Isawthemostbeautiful, fluffiestAlbatrosschicks,dyingofstarvationintheirnests withtheirbelliesfullofplastic.Itwasheart-breaking;Iwas totallydevastatedandfeltagriefunlikeanythingI’dever experiencedwhenseeinghuman-causedenvironmental issues.Ithinkitwassomethingaboutseeingeveryday itemsthatIused-mybrandoftoothbrush,inkcartridges, bottlecaps-literallycausingthedeathofsomethingso magnificent.AndIknewinthatmomentIcouldn'tjustsit backandallowthistohappen.

FromthatdayonIsetaboutdoingsomethingaboutit.Ihad noideaCitytoSea,whichbeganwithamusicvideo,would goontobecomeoneoftheUK’sleadingvoicesonplastic pollutionorthatourcampaignswouldhaveasignificant impactonreducingpointlessplasticsonthehigh-street,in supermarketsandatgovernmentlevel.

Frompetitionsandmediacampaigns,tograssroots communityactionandeducationinschools,ourworkstops hundredsoftonnesofplasticfromgettingintoour ecosystemseachyear.Forexample,in2016weranourfirst consumercampaign.Itwasasimpleask,forallmajor retailersintheUKtostopsellingplasticcottonbudsand switchtopaperinstead.Whathappenednextwasatidal waveofpeoplepower

Over150,000signedapetitionandsoonmajorretailers wereresponding.Beforelongallnineofthemajor supermarketshadpledgedto#SwitchtheStick.Thismeans thatsince2017over420tonnesofsingle-use,nonrecyclableplastichasbeensavedannually.In2020theUK governmentcaughtupandcompletelybannedplasticcotton budstickswithsimilarlegislationexpectedacrossallofthe EUbythissummer

Leadershipis,ifanything,aboutcreatingimpactandCityto Seaarecertainlydoingthat.

CitytoSeastartedasanideainmyheadonariverbankbut hassinceevolvedintoaglobalcampaigningorganisation withdozensofmembersofstaff.Sincethoseearlydays we’vesavedhundredsofmillionsofpiecesofplastic throughawardwinningcampaigns.Attheheartofallof thesecampaignsisbehaviourchangeinsightandscienceto inspireanddrivechangefromthegrassrootsup.Making surewehaveimpactinallwedo.

Learningfromtheearly#SwitchTheStickcampaign,what weadvocateforarepositivesolutionsmadeeasy.For example,oneofourmostsuccessfulcampaignsRefill, showshowyoucanswaptheeasyconvenienceofbuyinga single-useplasticbottlewhenyouareoutandabout,toa freeRefillfoundthroughourgeo-locatedappthattellsyou whereyoucaneat,drinkandshopwithoutthepackaging. Makingswitcheseasyisandshowinghowtheycanbedone isabigpartofwhatwedo.Sohereare3simplestepsfor youtotaketowardsplastic-freeliving.Andremember,you aren’ttakingthesestepsalonebutaspartofaglobal movement.Andwhenyoutakethesestepsyouarenotjust stoppingplasticpollutionbutyou’reinspiringotherstodo thesame.

1.Doaplasticaudit

Knowledgeispower.Whenyouarecuttingbackonthe amountofplasticyouuse,doaplasticauditandcollect yourwasteforaweek.Thisnotonlyhelpsyougetafeelfor whatyou’reusing,butyoucanalsostarttocutouttheeasy toreplaceitems.

OurfriendsoveratEverydayhavecreatedasupersimple programmewitheverythingyouneedtoaudityourwaste forweekandunderstandwhatyou’reusing,andwhatthe impactofthatwouldbeoverayear Afterdoingthis,you canstarttothinkabouthowyoucancutouttheplasticthat youusethemost.

2.ChoosetoReuse Weareproudtoenableyoueat,drinkandshopwithoutthe plastic.It’stimetoavoidusingdisposable,single-use cultureandchoosetoreuse,asthereareplentyofreusable optionsoutthere.Ithasnowbecomeeasytoreduceplastic footprintwithoutbreakingthebank.

3.GoRoomtoRoom

Themoreyoulookaroundyourhousethemoreyousee single-useplastics.Frombathroomcleanerstothe vegetablesyougotthesupermarket.Plasticgets everywhere.Butwhetheryourworriedaboutnappiesor nectarineswe’vegotyoucoveredwithourplastic-free livingguide.

Thetidesareturningonplasticpollution.Moreandmore peoplearemovingawayfromharmfulsingle-useplastics.

Leader's Viewpoint

Astimehaspassedmyroleasaleaderincampaigningon plasticshaschangedfromoneofneedingtoinspireand energisepeopletooneofchannellingpeople’senergy(yes peoplelikeyou!).Peoplearedemandingchangeand businessesandgovernmentsalikearebeginningtositup andnotice.

It’snowallofourjobs,asleaders,tokeepthepressureup andtomakesurewemaketrulysustainablechoicesaway fromsingle-useplastics.

Andifyou’vegotplasticsnailed,youcantakeyourjourney furtherandhaveareadofmylatestbook,HowtoSavethe WorldforFree,whichhashundredsofwaysyoucan protectnotjustouroceans,butourentire,preciousplanet. Justinmylifetime,we’velosthalftheworld’swildlife. HALFofit.Gone.Andit’sourresponsibilitytomakesure wedon’tlosetheotherhalf.

NatalieFéeisanaward-winning environmentalist,authorofHowtoSavethe WorldforFree,keynotespeakerandfounder ofCitytoSea,aUK-basedorganisation runningcampaignstostopplasticpollutionat source.

AbouttheAuthor

time programming is the logical evolution of medicine”

TrioxNano

Creating Better Medical Solutions by Developing Programmable Nano Carriers

Healthcareindustryisoneofthemostimportant industriesamongallindustriesintheworld.

Ensuringthegoodhealthofpeoplebyapplying thelatestadvancesintheindustryisanimportantgoalall medicalinstitutionsandleaderspursueinthisfield. Technologicaladvancescanbeincrementalordisruptive. Ofthedifferenttechnologiesinthehealthcareindustry NanotechnologyandspecificallyDNAnanotechnologyis holdingthegreatestpromiseforhealthcareindustry's disruption.DNAisthemoleculethatstoresandtransmits geneticinformationinbiologicalsystems.ThefieldofDNA nanotechnologytakesthismoleculeoutofitsbiological contextandusesitsabilitiestoassemblestructuralmotifs andthentoconnectthemtogether Thisfieldhashada remarkableimpactonnanoscienceandnanotechnology,and hasbeenrevolutionaryinourabilitytocontrolmolecular self-assembly.

TakingDNAnanotechnologyastepfurther,anavid healthcareleader,RoyFarfaraMDisutilizingDNA machinerytocreatebettermedicalsolutions.6yearsago, Dr.FarfarafoundedTrioxNanoinIsraelandbeganhismost importantendeavourofcreatingprogrammablenano machinestobetterdeliverAPIstotheirtarget.

DevelopingtheBasisforProgrammingMedicineS.M.A.R.TNanoparticlesPlatform

TrioxNanostartedin2015todevelopprogrammable biologicnanocarriersthatareabletoaccuratelydeliver payloadstotheirtarget.Thecompanydevelopedthe S.M.A.R.T(StimuliMultiAdjustedResponsive Technology)nanoparticlesplatformforintelligentdelivery ofchemotherapytocancercells.S.M.A.R.Tplatform openedawindowtoavastfieldsofinventions,of intelligentnanoscalecomputerizedmachinesthatareable tosenseacombinationofmultiplevariables(atleast2)in theirenvironmentandexertactionofunloadingactive payloadsbasedonpreprogramedmechanisms.The

disadvantagewithSMARTwasitcouldonlybe programmedatthetimetheparticlewasmanufactured.

TranscendingMedicinebyProgrammingIt

Dr.FarfarafoundedTrioxNanowithavisiontotranscend medicinebyprogrammingit.Asasurgeonintheurology department,Dr.Farfarawastreatingpatientswithkidney, bladderandprostatecancers.Hebecamewellawareofthe limitedandrelativelyprimitiveoptionsofferedtometastatic patients(surgery/chemotherapy/radiation)anddecidedto tackletheproblemfromanotherangleandtrysolveit.The company’stechnologybasedonDNAmachinerywas developedandoptimizedthroughthelast6yearsby intensiveresearchdonebyTrioxNano’sultrasmartteam thatincludesexceptDr.FarfaraproficientPostDocsfrom Harvard,Oxford,RockefellerandtheNIH.

InducingRevolutionaryandDisruptiveProgrammable Solutions

TrioxNano’stechnologicalsolutionswillinducetwo disruptiverevolutionsinthenext5-10years.Thefirst revolutionistheabilitytoprogrammedicineinrealtime, thisimprovesthetherapeuticwindowofmostmedicine.It iscurrentlybeingtestedinTrioxNano’slabonhuman cancercells.Theprogramcodesarebasedonprevious literatureknowledgeforexampleinthecaseofTNBC cancer(averyaggressivebreastcancer),literaturestatesthe abundanceofproteinslikeNucleolin,Mucin1,PDL1onthe membraneofthesecancercells.

TrioxNanousesthisknowledgeandcreatesprogramsthat areuploadedontoitsmodularparticlesothatpatientwho presentsforexamplewithMucin1inhercancerwillreceive theMuc1relatedprogram.Butoncologicliterature (accumulatedhumanknowledge)isstillverylimitedand thatisthereasonTrioxNanodevelopedthesecond technologywhichcomplementsandfurtherenhancesthe potentialofPCPMprogrammedmedicine!

The 10 Most Emerging Leaders in Healthcare, 2021

Thesecondrevolutioncalled“tissuederivedprogramming” isadatarevolutionthatwillallowTrioxNanototranscend pastthecurrentknowledgegapandcomprehensively differentiatediseasedfromhealthytissues.Thisrevolution couldonlycommenceoncetheabilitytoprogrammedicine wasachieved.Tissuederivedprogrammingallowsitto uploadprogramsthatcandifferentiatetraitswhetherthey areknownorunknowntoliteratureexpressedonthetarget tissueANDnotexpressedonthehealthytissuesurrounding it.

suchasTNBCthatareknowntodatetopresent2-3 proteinscanbetargetedbythemanyyetundiscovered proteinstoday!

UtilizingDisruptive,NovelandDNAbasedTechnology TrioxNano’stechnologyisbasedonDNAmachinery,the pandemichasproventheadvantageofRNAvaccines comparedtooldertechnologiesofattenuatedvirus.RNA vaccinespresentasmallpercentageofthepotentialoffered tohumanitybyDNAbasednanotechnology.The

Rememberingthathumanknowledgetodateislacking, TrioxNanoisjustatthetipoftheicebergasto comprehensivelydescribingalltheproteinsexpressedona specifictissuesuchasatumour.Inthecaseofacancer patient,differentmetastasishavedifferenttraitsandthe cancercellskeepdynamicallyevolvingbasedonthe treatmentsbeinggiventothepatientthroughtime.Though proteomictechnologiesallowdifferentiatingthousandsof knownproteinsatatime,itdoesaddresstreatingtheseand requiredafurtherdegreeofcomplicationtoaddressthe correcttreatmenttothediagnosedtrait.TrioxNano’s technologyallowsittochooseanduploadthecorrect sequencesoutof10^35differentsequences.

Thisrevolutionmeansthedependencyonthecurrent humanknowledge(literature)canbebypassed,andcancers

technologyissodisruptiveandnovelthattodatethereisno competition,thoughDr.Farfarabelievesthesituationwill notstaythesameandin3-5(whichisthetimeittookto createtheknowhowandexpertisetostabilizeit) competitorswillfollow

ConciseAdvicetoAspiringEntrepreneurs

Dr.Farfaraadvisestoaspiringentrepreneursto

findingtherightteam.Heconsidersthatbeingpeopleorientedisthemostimportantvalueofabusinessleader. Hetellsthemthatfailureswillusuallyteachthemmore thensuccess,thereforepersistenceandperseveranceare required.Heasksthemtostaydedicatedtotheir

beliefsnomatterwhatandiftheyhavetheoptionchoose

over

Fabian

Cohen

Yoav

Toma

Sass

Liroy Lugasi PhD

Yakir Farfara