MA
P Garage 7
Houston Methodist
R
LK
INS
UR
P McGovern Commons &
Research Institute
P Garage 1
MO
ST.
Trevisio
SU
ND
OO
CYCLOTRON AND RADIOPHARMACEUTICAL CORE
ST.
Texas Children’s Neurological Research Institute
M.D. Anderson Cancer Center
JOHNSON AVE.
BATES ST.
MAP LEGEND METRORAIL
M.D. ANDERSON BLVD.
D.
HWY 288
UNIVERSITY OF HOUSTON
BLV
Texas Children’s Texas Hospital Heart St. Luke’s Institute Hospital
D. BLV
OD
O SW
AE
BR
HOLCOMBE BLVD. SOUTH LOOP 610
ACCOMODATIONS
P
PARKING
IVE
RS
ITY
Rice Bioscience Research Collaberative
JO
HN
P
BLV
D.
Smith Tower
HM
Houston, TX 77030
houstonmethodist.org/research HMRI Communications & External Relations | RICORE-008 | MM | DH | 08.2014
AT E
RD .
ST.
EN
A
FA NN IN
HG
Jones Tower
Houston Methodist
Marriot
R P Garage 1
Research Institute
RO
EE
MA
WI
LK
INS
SS
EN
NB
LV D.
E.
C
UR
Trevisio
. ST
Baylor College of Medicine MO
P McGovern Commons &
AV E.
L UL
Mary Gibb Jones Building
ST.
ST ER LIN G
SU
ND
ST.
Texas Children’s Neurological Research Institute
BLV
D.
Texas Children’s Texas Hospital Heart St. Luke’s Institute Hospital
BATES ST. SON AVE.
6670 Bertner Avenue
UT
Hilton Houston Plaza/ Medical Center
P
DR YD
FR
P Garage 7
Scurlock Tower
UT
houstonmethodist.org/cyclotron
A
SO
Houston Methodist Research Institute
ST. NIN FA N
UN
RICE UNIVERSITY
SO
Director: Meixiang (Max) Yu, Ph.D. Email: myu@houstonmethodist.org 713.441.2921
Memorial Hermann Hospital
University of Texas Health & Science
P Outpatient Center
N
Cyclotron and Radiopharmaceutical Core
IDG
HM
A
UT
DRYDEN/TMC METRORAIL STATION
BR
SO
R
CA M
AIN
HOUSTON METHODIST RESEARCH INSTITUTE
AIN
The Houston Methodist Research Institute Cyclotron and Radiopharmaceutical Core facility can produce Positron Emission Tomography or PET tracers with half lives ranging from 2 to 110 minutes, including tracers that are not commercially available. In addition to the commercially available [18F]FDG compound, the Houston Methodist cyclotron facility can produce rare 15O,13N, 11C, 64Cu, and other compounds such as [11C]PIB, [18F]FLT, and [18F]FDOPA.
Ben Taub General Hospital
Baylor College of Medicine
BERTNER AVE.
NIN
ST.
RD .
WI
HOUSTON METHODIST RESEARCH INSTITUTE
C
M.D. Anderson Cancer Center
M.D. ANDERSON BLVD.
A
E.
Mary Gibb Jones Building
Scurlock Tower
Marriot
LV D.
. ST
L UL
ST.
Jones Tower
EN
NB
ST.
HG
AT E
EN
EE
AV E.
SO UT UT
P
FR
NG
Smith Tower
MI
D.
FA N
SO
A
Hilton Houston Plaza/ Medical Center
DR YD
HN
BLV
HM AIN
Rice Bioscience Research Collaberative
JO P
RF LE
ITY
AV E.
MA
RS
ST ER LIN G
LA
IVE
ST.
UN
RICE UNIVERSITY
SS
TA UB L
N
RO
University of Texas Health & Science
P Outpatient Center
P
Hermann Hospital
FA NN I
PARKING
BERTNER AVE.
P
Cyclotron and Radiopharmaceutical Core
The Houston Methodist Research Institute Cyclotron and Radiopharmaceutical Core produces radiopharmaceuticals for research and medical applications. The facility operates a GE PETrace cyclotron that produces tracers for Positron Imaging Tomography or PET. These clinical grade tracers are available to customers throughout the Texas Medical Center.
PET APPLICATIONS The on-site cyclotron facility enables Houston Methodist to engage in research studies that require rare custom tracers. The facility can produce multiple doses for a patient in a single day, and can offer cutting-edge PET imaging for patients that is not available elsewhere in the Texas Medical Center such as: • Oncology: PET imaging of types of cancer that are not possible with traditional [18F]FDG-based imaging, including imaging of prostate, renal, and certain types of brain cancers. • Neurology: PET is the most sensitive tool for specific diagnosis of Alzheimer’s disease and other dementias, and is used for locating epilepsy seizure foci prior to surgery. • Cardiology: The cyclotron facility produces tracers containing 15O and 13N that are the leading tools for PET detection of coronary artery disease and diseased tissue that will benefit from revascularization. • New drug development: PET can facilitate the speed of drug development with noninvasive measurement of in vivo biodistribution and pharmacokinetic profiles. With PET, only very low amounts of the experimental drug are administered, far below toxicity levels, enabling clinical human studies that expedite FDA approval pathways.
[18F]FHBG Gene therapy imaging
[11C]Choline Prostate cancer imaging
[11C]PIB
[11C]WAY-100,635
Beta-amyloid plaque imaging for Alzheimer’s disease
5-HT1A receptor imaging, for depression, anxiety, and schizophrenia
[11C]Raclopride
6-[18F]Fluoro-L-DOPA
Dopamine D2 receptor-imaging for age and mental disease-related motor and cognitive function
Brain tumor imaging, over 96% sensitivity
Our Specialized Services • cGMP production • Nuclear pharmacy
CYCLOTRON
PET RADIOPHARMACEUTICALS The facility produces [18F]FDG and other compounds:
• 18 F, 15O, 13N, 11C, 64Cu compounds • GE PETrace 16.5 MeV negative ion isochronous cyclotron • 9 hot cells • Rapid transport system to PET scanner and research floors
[13N]Ammonia Cardiac perfusion
[11C]Acetate Cardiac perfusion
[11C]Palmitate Fatty acid, beta-oxidation
• GE automated production and quality control procedures • GE radiopharmaceuticals preparation and distribution equipment