The
Spring 2016
Laboratory Report A Publication of the Department of Pathology and Genomic Medicine
S
Department of Pathology and Genomic Medicine Develops First Hospital-Based Rapid Test for Zika Virus
tories of the Zika virus’ emergence and rapid spread throughout Central and South America have been featured on the front pages of all major media outlets for the past several weeks. Zika virus is similar to other mosquitoborne viruses such as West Nile, Dengue, and Chikungunya, and is also transmitted by Aedes mosquitos. However, the recent identification of Zika virus in semen and urine of infected patients suggests that human-to-human transmission may be possible. Although direct causation has not been proved, epidemiological studies have associated Zika virus infection during pregnancy with infant microcephaly
IN THIS ISSUE Rapid Zika Test Developed
1
Pathology Faculty Named to Top 100 List
2
Faculty to Receive Awards
3
New Microgrants Released
3
Books by Dept Faculty
4
Archives’ 90 Anniversary
4
th
Department Hosts Tuberculosis Symposium
(underdeveloped brains) and eye defects. An association between Zika virus infection and Guillain-Barré syndrome (GBS) also has been suggested. Taken together, these findings are cause for great medical concern. In response, the Department of Pathology and Genomic Medicine at Houston Methodist Hospital teamed up with Texas Children’s Hospital to develop, validate, and implement the first hospital-based rapid test for Zika virus. This direct Zika test was developed in a matter of weeks as part of the L.E. and Virginia Simmons Collaborative in Virus Detection and Surveillance. This collaborative program was made possible by the generosity of Mr.
and Mrs. Simmons, and is designed to facilitate rapid development of tests for virus detection in a large metropolitan area. The molecular diagnostic assay can be performed on serum, plasma, cerebrospinal fluid, amniotic fluid, and urine specimens. Typically, samples from patients suspected of being infected with the virus would be sent to a public health laboratory such as the Centers for Disease Control and Prevention. The turnaround time for results could be weeks to a month, but our test can render results within hours. “The rapidity of this test is especially important, and will give physicians the information they need to better manage their Continued on page 2
5
New Scholars Platform
5
Conference News
6
Chair’s Lecture
7
Grand Rounds
7
Publications
8
Keith Newton, MB(ASCP)CM, Medical Technologist (left) and Heather Hendrikson, MB(ASCP)CM, MBA, Manager of the Diagnostic Immunology Lab and Molecular Diagnostics Lab (right) worked closely with Randall Olsen, MD, PhD, Director of Molecular Diagnostics, to develop the rapid Zika virus test.
THE LABORATORY REPORT Spring 2016 Continued from page 1 patients,” said Randall Olsen, MD, PhD, Director of the Houston Methodist Molecular Diagnostics Laboratory, who with James M. Musser, MD, PhD, Chair of the Department of Pathology and Genomic Medicine, led the Houston Methodist team. This was done in collaboration with James Versalovic, MD, PhD, and James Dunn, PhD, from Texas Children’s Hospital. After details of the test were released on Wednesday, February 24th, over 500 major national and local news outlets published the story, including the Houston Chronicle, New York Times, Washington Post, and Time Magazine.
Additionally, the Department of Pathology and Genomic Medicine has implemented an active deferral policy for blood donation for the Houston Methodist Eileen
“The rapidity of this test is especially important, and will give physicians the information they need to better manage their patients”
- Randall Olsen, MD, PhD
Murphree McMillin Blood Donor Center. Potential donors are asked if they have recently traveled to a Zika-endemic area in the past month. If donors respond affirmatively, they are deferred from donating blood for 28 days based on recommendations by the American Association of Blood Banks (AABB), CDC, and FDA. “Our mandatory deferral policy safeguards our blood supply and protects our patients from the Zika virus,” said Tina Ipe, MD, Associate Medical Director of Transfusion Medicine.
Page 2 The Zika virus test can be ordered in MethOD. For more information on blood donation policies, please contact the Methodist Blood Donor Center at (713) 441-3415 or visit the Houston Methodist blood donation criteria site.
To date, all confirmed Zika virus infections in the US have been acquired during travel to a CDC-designated Zika endemic area. However, local transmission, particularly in Texas where Aedes mosquitos are common, may occur. Most infected people remain asymptomatic or have a mild self-limiting illness with fever, fatigue, arthritis, and malaise. To read more about the rapid Zika virus test, please go to: “Rapid detection test for Zika virus” on the HMH website. For questions regarding Zika virus testing, or any molecular diagnostics test, please contact Ms. Heather Hendrickson at: HLHendrickson@houstonmethodist.org or Dr. Randall Olsen at: RJOlsen@houstonmethodist.org.
Dr. Randall Olsen, Medical Director of Molecular Diagnostics, spearheaded the design and validation of the rapid Zika virus test.
Drs. Cagle, Powell, and Musser Named to The Pathologist Power List
T
he November 2015 issue of The Pathologist, a UK publication, features the inaugural Top 100 Power List. Three faculty members in the Department of Pathology and Genomic Medicine at Houston Methodist Hospital made it to this prestigious group. In alphabetical order they are Philip Cagle, MD, James Musser, MD, PhD, and Suzanne Powell, MD. A fourth physician in the top 100, Jerad Gardner, MD, completed his residency training in the Department. The Power List recognizes individuals with exceptional achievements who have had an impact on pathology. One of the goals of the list is to highlight the integral role of pathology and laboratory medicine in patient care and the molecular revolution. Nominations were solicited from the journal’s readers, and an independent broad-based judging panel of eminent lab professionals selected the top 100. Congratulations!
THE LABORATORY REPORT Spring 2016
Page 3
Department Faculty to Receive Prestigious Awards Dr. Mary Schwartz to Receive the 2016 John W. Overstreet Award Dr. Mary Schwartz, Medical Director of Surgical Pathology, has been chosen to receive the prestigious John W. Overstreet Award. This award is given annually to a Houston Methodist physician who “exemplifies the best of the medical profession.” Dr. Schwartz is a tireless advocate of excellence in patient care. She is an inspiration to hundreds of trainees and an invaluable resource to our clinicians. We are proud and extremely fortunate to have her as our colleague. Please join our Methodist physicians in congratulating Dr. Schwartz on this well-deserved award at the Doctor’s Day celebration at noon on March 30 in Crain Garden!
Mary Schwartz, MD
Dr. Philip Cagle to Receive the Chinese American Pathology Association (CAPA) Honorary Award Philip T. Cagle, MD, Medical Director of Pulmonary Pathology and Editor-in-Chief of the Archives of Pathology & Laboratory Medicine, will be the first recipient of the Chinese American Pathology Association (CAPA) Honorary Award. This is the highest accolade that CAPA presents to a world-renowned pathologist who also has been a strong supporter and advocate for CAPA. Dr. Cagle will receive the award at the 14th CAPA Annual Business Meeting on March 12, 2016, at the United States and Canadian Academy of Pathology (USCAP) annual meeting in Seattle. The ceremony will take place at the Sheraton Hotel, SH Metro Ballroom A, at 3:00 pm. Dr. Cagle will give a brief speech to the CAPA members and pathologists from China attending the meeting. If you are attending USCAP, please stop by and congratulate Dr. Cagle on this honor.
Philip Cagle, MD
Request for Applications: Department Microgrants
T
he Department of Pathology and Genomic Medicine has invited proposals for the Winter 2016 round of microgrants. This mechanism is designed to foster innovation and increase efficiency and expansion of our clinical services. Projects that are designed to help decrease diagnostic errors and increase patient safety (broadly defined) are especially encouraged. Each selected project will receive a budget and the work must start and be completed in a maximum of 4-6 months. The departmental review committee will consider several criteria in its assessment, including clinical need, likelihood of a significant return on investment, involvement of residents and/or fellows and multiple faculty, and likelihood of leading to external peer-reviewed publication and funding. Applicants are strongly encouraged to collaborate with colleagues from other Methodist departments, and if appropriate, colleagues in the Department of Pathology and Laboratory Medicine at Weill Medical College of Cornell University.
The results from two studies supported by department microgrants are currently in press. A study by Dr. Suzanne Crumley et al used next-generation sequencing of matched primary and metastatic rectal adenocarcinomas to determine genetic mutations associated with metastasis. The article is published in the Archives of Pathology and Laboratory Medicine and can be accessed here. A second study by Dr. Mathew Cykowski et al investigated the deposition of the TDB-43 protein in age-related neurodegenerative diseases and its functional significance. The results are currently in press in the Journal of Neuropathology and Experimental Neurology. The department anticipates funding up to six projects. The proposals will be reviewed and funding decisions will be made on a rolling basis until March 15, 2016. The proposals should be sent electronically to Ms. Liz Al-Ateeqi at LizA@houstonmethodist.org.
THE LABORATORY REPORT Spring 2016
Page 4
New Books Published by Department Faculty Lung and Pleural Pathology Dr. Philip Cagle, Medical Director of Pulmonary Pathology in the Department of Pathology and Genomic Medicine, has published the book “Lung and Pleural Pathology.” Doody’s medical reviews calls it “the first textbook to fully cover the revolution in pulmonary pathology.” Congratulations to Dr. Cagle and his faculty colleagues in the department who contributed chapters to this comprehensive textbook. These include Drs. Roberto Barrios, Yimin Ge, Blythe Gorman, Abida Haque and Hidehiro Takei. It also includes former trainees and visitors to our department, including Dr. Kirtee Raparia, currently at Northwestern University Medical Center, and Drs. Mizuki and Michiya Nishino of Harvard Medical School. Many recent graduates of our training program also contributed, including Drs. Eunice Choi, Sergio Pina-Oviedo, and Haijun (Steve) Zhou.
Advances in Surgical Pathology: Bladder Cancer Congratulations to Dr. Jae Ro, Director of Surgical Pathology for the Department of Pathology and Genomic Medicine, and former Department member Dr. Quihui (Jim) Zhai, on their book “Advances in Surgical Pathology: Bladder Cancer”. The book provides a comprehensive overview for diagnosing bladder neoplasms, with emphasis on new developments and recent advances. The book received excellent reviews from the independent professional review service at Doody’s Enterprises, Inc., which stated: “This is an excellent resource for pathologists who wish to quickly review the fundamentals of bladder biopsies. Overall, this is a valuable resource for pathologists...” Dr. Alberto Ayala, Vice Chair of the Department and Dr. Mukul Divatia contributed chapters, and Dr. Philip Cagle, Medical Director of Pulmonary Pathology, is one of the series editors. Excellent work!
T
Archives of Pathology and Laboratory Medicine: 90 Years
he Archives of Pathology and Laboratory Medicine celebrated 90 years in publication this past January. The journal’s Editor-in-Chief, Dr. Philip Cagle, is Director of Pulmonary Pathology for the Department of Pathology and Genomic Medicine. The 90th anniversary cover article was dedicated to smartphone microscopy, a relatively new and low-cost method of sharing patient data for longdistance surgical pathology consultation. This technologically-inspired cover illustrates how far the discipline of pathology has come in 90 years. Archives, the
longest continuously-published clinicallyoriented pathology journal in the U.S., has been on the forefront of documenting those changes. This is especially true under the leadership of Dr. Cagle, who in the past decade has made Archives the most widely read pathology journal in the U.S. There are several department faculty members involved with the journal as section editors and/or on the editorial board, and who contribute tremendously to the quality of the content. Dr. Cagle has written an editorial on the 90th anniversary of Smart phone microscopy, a low cost Archives, which can be accessed here. method for long-distance surgical pathology consultation, was featured on the cover of the 90th anniversary issue.
THE LABORATORY REPORT Spring 2016
Page 5
Houston Methodist Hosts the 4th Texas Tuberculosis Research Symposium
T
he Department of Pathology and Genomic Medicine and the Research Institute, in conjunction with UT Health Science Center, Houston, hosted the 4th Texas Tuberculosis Research Symposium (TTRS) on Friday, January 22nd in the John F. Bookout Auditorium. More than 100 tuberculosis researchers from the Texas Medical Center and beyond attended, including faculty, postdoctoral fellows, and graduate students. The day-long event featured 16 speakers reporting recent findings in tuberculosis epidemiology, animal models, drug resistance, biomarkers, vaccines, and several other key topics pertinent to this global crisis. Susan Dorman, MD, Associate Professor of Medicine in the Division of Infectious Diseases at Johns Hopkins School of Medicine, delivered the morning keynote talk describing her translational TB research and treatment clinical trial data. The afternoon keynote talk closed the symposium, with Deepak Kaushal, PhD, Director of the Tulane National Primate Research Center (TNPRC) and the Tulane University School of Medicine, providing data on his TB non-human
primate vaccine studies. Dr. Edward Graviss, Director of the Tuberculosis Laboratory and member of the Department of Pathology and Genomic Medicine, organized the symposium with co-organizers, Drs. Jeffrey Actor and Chinnaswamy Jagannath, both from the Department of Pathology and Laboratory Medicine at UT Health Science Center, Houston. Researchers continue to use new and cutting edge technologies to answer fundamentally basic, clinical, translational, and public health questions regarding tuberculosis. The tremendous success of this meeting can be seen in the research topics discussed, and the overall attendance, participation and interactions between researchers. The journal Tuberculosis has invited all speakers and poster presenters to submit a manuscript based on their presentations at the meeting to a special supplemental edition to be edited by Drs. Graviss and Actor and published in 2017. The World Health Organization estimates that one third of the total world population is infected with Mycobacterium tubercu-
losis, and that 1.6 million people died from tuberculosis in 2014. More research on containment, diagnosis, treatment, and prevention is desperately needed to stop the spread of this disease. Congratulations to all for an extremely successful symposium!
Drs. Edward Graviss (organizer) and Susan Dorman (keynote speaker) at the TTRS. The symposium was attended by over 100 investigators.
New Scholars Platform and the Department Academic Report
T
he Houston Methodist Hospital Institute for Academic Medicine (IAM) launched the Scholars platform on February 8th, 2016. This program tracks the research activity of all faculty members within the IAM, including publications, invited talks, meeting and working group participation, grants, clinical trials, and other academic activities. Starting with data from 2015 and moving forward, this program will be used to automatically update research activity and online faculty profiles. It will also help to identify complementary research interests with the aim of fostering collaboration across
departments and institutes. The Department of Pathology and Genomic Medicine is ranked first in research activities and second in publications throughout Houston Methodist and the Research Institute. Great work to all of our outstanding faculty, residents, and fellows who contributed to this fantastic accomplishment!
“That our department
For assistance in accessing Scholars or a tutorial on how to use the interface, please contact Kathryn Stockbauer, PhD, Manager of Academic Development, at: KStockbauer@houstonmethodist.org.
pursuits of our superb
ranked 1st in activities and 2nd in publications is further proof of the dedication to research and academic faculty.� - James M. Musser, MD, PhD
Chair, Department of Pathology and Genomic Medicine
THE LABORATORY REPORT Spring 2016
Page 6
Conference News
Houston Methodist Residents Win at Texas Society of Pathologists Annual Meeting The 95th Annual Meeting of the Texas Society of Pathologists was held at the Hilton Anatole Hotel in Dallas on January 15-17, 2016. Dr. Michael Deavers gave a talk titled “Common Problems in Gynecologic Pathology” and two of our trainees were winners in the abstract competition: Dr. Chunyan Liu won 2nd place and Dr. Brandon Driver won 3rd. Congratulations!
Chunyan Liu, MD, PhD Molecular Genetics Fellow
Poster Titles: Chunyan Liu, MD, PhD; Kristi Pepper, MB (ASCP); Heather Hendrickson, MB (ASCP); Philip T. Cagle, MD; Bryce P. Portier, MD, PhD. “Clinical Validation of a Novel Commercial RT-qPCR Screening Assay for Detection of ALK Translocations and Amplifications in NSCLC”. Brandon R. Driver, MD; Roberto Barrios, MD; Yimin Ge, MD; Abida Haque, MD; David Tacha, PhD; Philip T. Cagle, MD. “Folate Receptor Alpha Expression Level Correlates With Histologic Grade in Lung Adenocarcinoma”.
Brandon Driver, MD PGY3 Resident
PISA to be hosted by Department in 2016 The Department of Pathology and Genomic Medicine will host the 2nd annual meeting of Pathobiology for Investigators, Students, and Academicians (PISA). The meeting, “Breakthroughs in Biology: From Underlying Pathogenesis to Translational Medicine”, will take place on October 20-22, 2016, in the John F. Bookout auditorium at the Houston Methodist Research Institute. The deadline for abstract submission is June 30th, 2016. The website is still under construction, but please continue to check back at www.pisa2016.org for event details.
Department to Host Alumni Reception at USCAP Dr. James M. Musser, Chair of the Department of Pathology and Genomic Medicine, will host an alumni reception at the United States and Canadian Association of Pathologists (USCAP) Annual Meeting to be held this year from March 12th to 18th in Seattle, Washington. The reception will take place on March 14th from 5:00 – 7:00 pm in the SH Boren Room of the Sheraton Seattle Hotel. All current trainees, resident and fellow alumni, and faculty are encouraged to stop by and say hello to their colleagues!
Save the Dates: Upcoming Conferences Houston Society of Clinical Pathologists (HSCP): St. Regis Hotel, Houston, April 16, 2016 Cancer Biomarkers: Department of Pathology and Genomic Medicine, September 10, 2016 College of American Pathologists (CAP) : Las Vegas, Nevada, September 25-28, 2016
THE LABORATORY REPORT Spring 2016
Page 7
Chair’s Lecture: Karen Kaul, MD, PhD
T
he Department of Pathology and Genomic Medicine hosted the Chair’s Lecture on Wednesday, February 24th. The speaker, Karen Kaul, MD, PhD is the Duckworth Family Chair of Pathology and Laboratory Medicine at NorthShore University HealthSystem, in Evanston, Illinois. Dr. Kaul addressed some of the many challenges and opportunities facing the rapidly evolving field of clinical pathology. She noted that pathology diagnoses dictate 70% of downstream decision-making and spending, and that clinical laboratories are the primary source of medical information. Dr. Kaul also discussed compu-
tational pathology, noting that pathologists are in a unique position to analyze the wealth of data generated by healthcare information systems to streamline test ordering and facilitate physician communication. She also touched on the burgeoning field of personal pharmacogenomics and the challenges the clinical laboratory faces regarding implementing standard practice protocols for these cutting-edge tests. If you were unable to attend the seminar and would like a copy of Dr. Kaul’s presentation, please contact Ms. Liz Al-Ateeqi at LizA@houstonmethodist.org.
Remaining Grand Rounds for 2016 April 5 Jerad Gardner, MD University of Arkansas for Medical Sciences Soft Tissue Pathology
October 4 Lynette Sholl, MD Dana-Farber, Harvard Cancer Center Interpretation of NGS Gene Panel Reports
May 3 L. Jeffery Medieros, MD MD Anderson Cancer Center Hematopathology
November 1 Natasha Rekhtman, MD Memorial Sloan Kettering Cancer Center Management of Cytology Specimens for Biomarker Testing
June 7 Ming Zhou, MD New York University School of Medicine Update on the 2016 WHO Classification of Renal Tumors
December 6 Chung Che (Jeff) Chang, MD, PhD University of Central Florida Hematopathology
(No Grand Rounds July - September)
IN THE NEXT ISSUE: The L.E. and Virginia Simmons Community-Wide Virus Detection Program Fine-needle aspiration at Houston Methodist and outlying hospitals The Inaugural Houston Methodist Lung Cancer Symposium, October 8-9, 2016
THE LABORATORY REPORT Spring 2016
Page 8
PUBLICATIONS [Nov 2015 - Mar 2016] Ansari, M, Dela Garza, M, Deavers, MT, Balogh, J, Rosenberg, WR, Hai, S, Ruppe, M, Hamilton, DJ. Hypertensive emergency following embolization of a large adrenal myelolipoma adrenal medullary infarction, pheochromocytoma or acute sympathetic discharge? AACE Clinical Case Reports, 2015, 1, e216-e220. Cagle, PT, Bernicker, EH. Challenges to biomarker testing for PD-1/PD-L1 checkpoint inhibitors for lung cancer. Arch Pathol Lab Med., 2015, 139, 1477-1478. Cagle, PT. Pioneering spirit continues after 90 years. Arch Pathol Lab Med., 2016 140, 115. Cagle, PT. Ninety years of supporting the practice of pathology and laboratory medicine: Archives celebrates milestone anniversary. Arch Pathol Lab Med, 2016, 140, 11-12. Cagle, PT, Raparia, K, Portier, BP. Emerging biomarkers in personalized therapy of lung cancer. Adv Exp Med Biol., 2016, 890, 25-36. Chen, J, Xu-Monette, ZY, Deng, L, Shen, Q, Manyam, GC, Martinez-Lopez, A, Zhang, L, Montes-Moreno, S, Visco, C, Tzankov, A, Yin, L, Dybkaer, K, Chiu, A, Orazi, A, Zu, Y, et al. Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma. Oncotarget, 2015, 6, 55975614. Crumley, S, Okoye, E, Deavers, M, Coffey, D. The utility of core needle biopsy and fine-needle aspiration in the workup of tumors of suspected MĂźllerian origin. Acta Cytol, 2015, 59, 465-73. Danger, JL, Makthal, N, Kumaraswami, M, Sumby, P. The FasX small regulatory RNA negatively regulates the expression of two fibronectin-binding proteins in group A Streptococcus. J Bacter, 2015, 197, 3720-3730. DiNardo, AR, Hahn, A, Leyden, J, Stager, C, Baron, EJ, Graviss, EA, Mandalakas, AM, Guy, E. Use of string test and stool specimens to diagnose pulmonary tuberculosis. Int J Infect Disease, 2015, 41, 50-52. Driver, BR, Barrios, R, Ge, Y, Haque, A, Tacha, D, Cagle, PT. Folate receptor-alpha expression level correlates with histologic grade in lung adenocarcinoma. Arch Pathol Lab Med, 2015 Nov. 24 [Epub ahead of print] PMID: 26599808. Flores, AR, Jewell, BE, Versalovic, EM, Olsen, RJ, Bachert, BA, Lukomski, S, Musser, JM. Natural variant of collagen-like protein a in serotype M3 group A Streptococcus increases adherence and decreases invasive potential. Infect Immun., 2015, 83, 1122-1129. Hahn, NM, Knudsen, BS, Daneshmand, S, Koch, MO, Bihrle, R, Foster, RS, Gardner, TA, Cheng, L, Liu, Z, Breen, T, Fleming, MT, Lance, R, Corless, CL, Alva, AS, Shen, SS, et al, Neoadjuvant dasatinib for muscle-invasive bladder cancer with tissue analysis of biologic activity. Urol Oncol., 2016, 34, 4.e11-4.e17. Howley, MM, Painter, JA, Katz, DJ, Graviss, EA, Reves, R, Beavers, SF, Garrett, DO. Evaluation of QuantiFERON-TB gold intube and tuberculin skin tests among immigrant children being screened for latent tuberculosis infection. Ped Infect Disease J., 2015, 34, 35-39. Kim, K, Cho, YM, Park, BH, Lee, JL, Ro, JY, Go, H, Shim, JW. Histological and immunohistochemical markers for progression prediction in transurethrally resected high-grade non-muscle invasive bladder cancer. Inter J Clin Exper Pathol., 2015, 8, 743750. Kim, M.J, Divatia, MK, Lee, JH, Shen, S, Miles, BJ, Hwang, JH, Ayala, AG, Ro, JY. Collagenous micronodules in prostate cancer revisited: Are they solely associated with Gleason pattern 3 adenocarcinomas? Inter J Clin Exper Pathol., 2015, 8, 34693476. Lee, H, Ro, JY. Differential expression of GSK3-beta and pS9GSK3-beta in normal human tissues: Can pS9GSK3-beta be an epithelial marker? Int J Clin Exper Pathol., 2015, 8, 4064-4073. Li, L, Xu-Monette, ZY. Ok, CY, Tzankov, A, Manyam, GC, Sun, R, Visco, C, Zhang, M, Montes-Moreno, S, Dybkaer, K, Chiu, A, Orazi, A, Zu, Y, et al. Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma. Oncotarget, 2015, 6, 23157-23180.
THE LABORATORY REPORT Spring 2016
Page 9
PUBLICATIONS [continued] Li, Y, Xuan, J, Song, Y, Qi, W, He, B, Wang P, Qin, L. Nanoporous glass integrated in volumetric bar-chart chip for point-ofcare diagnostics of non-small cell lung cancer. ACS Nano, 2016, 10, 1640-7. Liu, C, Pepper, K, Hendrickson, H, Cagle PT, Portier BP. Clinical validation of a novel commercial reverse transcription-quantitative polymerase chain reaction screening assay for detection of ALK translocations and amplifications in non-small cell lung carcinomas. Arch Pathol Lab Med., 2015 Nov 24, [Epub ahead of print] PMID: 26599807. Lockwood, AM, Perez, KK, Musick, WL, Ikwuagwu, JO, Attia, E, Fasoranti, OO, Cernoch, PL, Olsen, RJ, Musser, JM. Integrating rapid diagnostics and antimicrobial stewardship in two community hospitals improved process measures and antibiotic adjustment time. Infect Control Hosp Epidemiol., 2016 Jan 7:1-8. [Epub ahead of print] PMID: 26738993. Makthal, N, Gavagan, M, Do, H, Olsen, RJ, Musser, JM, Kumaraswami, M. Structural and Functional Analysis of RopB – a major virulence regulator in human pathogen Streptococcus pyogenes. Mol Microbiol. 2015 Dec 29. [Epub ahead of print] PMID: 26714274. Manchandani, P, Zhou, J, Ledesma, KR, Truong, LD, Chow, DS, Eriksen, JL, Tam, VH. Characterization of polymyxin B biodistribution and disposition in an animal model. Antimicrob Agents Chemother, 2015, 60, 1029-34. Musser, JM, Zhu, L, Olsen, RJ, Nasser, W. Reply to “Emergence of the same successful clade among distinct populations of emm89 Streptococcus pyogenes in multiple geographic regions”. MBio, 2015, 6, e01838-15. Nguyen, DTM, Bang, ND, Hung, NQ, Beasley, RP, Hwang, LY, Graviss, EA. Yield of chest radiograph in tuberculosis screening for HIV-infected persons at a district-level HIV clinic. Inter J Tuberc Lung Dis, 2016, 20, 211-217. Ok, CY, Ye, Q, Li, L, Manyam, G C, Deng, L, Goswami, RR, Wang, X, Montes-Moreno, S, Visco, C, Tzankov, A, Dybkaer, K, Zhang, L, Abramson, J, Sohani, AR, Chiu, A, Orazi, A, Zu, Y et al. Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma - is it necessary? Oncotarget, 2015, 6, 13935-13946. Park, IH, Kong, SY, Ro, JY, Kwon, Y, Kang, JH, Mo, HJ, Jung, SY, Lee, S, Lee KS, Kang, HS, Lee, E, Joo, J, Ro, J. Prognostic implications of tumor-infiltrating lymphocytes in association with programmed death ligand 1 expression in early-stage breast cancer. Clin Breast Cancer, 2016 Feb;16(1):51-8. Epub 2015 Aug 6. PMID: 26364145. Pagaoa, MA, Royce, RA, Chen, MP, Golub, JE, Davidow, AL, Hirsch-Moverman, Y, Marks, SM, Teeter, LD, Thickstun, PM, Katz, DJ. Risk factors for transmission of tuberculosis among United States-born African Americans and Whites. Tuberculosis Epidemiologic Studies Consortium (Graviss, EA). Int J Tuberc Lung Dis, 2015, 19, 1485-92. Olsen, RJ, Raghuram, A, Cantu, C, Hartman, MH, Jimenez, FE, Lee, S, Ngo, A, Rice, KA, Saddington, D, Spillman, H, Valson, C, Flores, AR, Beres, SB, Long, SW, Nasser, W, Musser, JM. The majority of 9,729 group A Streptococcus strains causing disease secrete SpeB cysteine protease: Pathogenesis implications. Infect Immun., 2015, 83, 4750-4758. Rhim, JH, Luo, X, Xu, X, Gao, D, Zhou, T, Li, F, Qin, L, Wang, P, Xia, X, Wong, SA. High-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells. Scientific Reports, 2015, 5, 16237. Salazar, KL, Zhou, HS, Xu, J, Peterson, LE, Schwartz, MR, Mody, DR, Ge, Y. Multiple Human Papilloma Virus infections and their impact on the development of high-risk cervical lesions. Acta Cytologica, 2015, 59, 391-398. Shah, RB, Li, J, Cheng, L, Egevad, L, Deng, FM, Fine, SW, Kunju, LP, Melamed, J, Mehra, R, Osunkoya, AO, Paner, GP, Shen, SS, et al. Diagnosis of Gleason pattern 5 prostate adenocarcinoma on core needle biopsy: An interobserver reproducibility study among urologic pathologists. Am J Surg Pathol, 2015, 39, 1242-1249. Sholl, LM, Aisner, DL, Allen, TC, Beasley, MB, Borczuk, AC, Cagle, PT, et al. Programmed death ligand 1 immunohistochemistry- A new challenge for pathologists: A perspective from members of the Pulmonary Pathology Society. Arch Pathol Lab Med, 2016 Jan 18. [Epub ahead of print] PMID: 26780537. Strickland, BA, Cachia, D, Jalali, A, Cykowski, MD, Penas-Prado, M, Langford, LA, Li, J, Shah, K. Weinberg, JS. Spinal anaplastic oligodendroglioma with oligodendrogliomatosis: Molecular markers and management: case report. Neurosurgery, 2016, 78, E466-73.
THE LABORATORY REPORT Spring 2016
Page 10
PUBLICATIONS [continued] Stucker, KM, Schobel, SA, Olsen, RJ, Hodges, HL, Lin, X., Halpin, RA, Fedorova, N, Stockwell, TB, Tovchigrechko, A, Das, SR, Wentworth, DE, Musser, JM. Haemagglutinin mutations and glycosylation changes shaped the 2012/13 influenza A(H3N2) epidemic, Houston, Texas. Eurosurveillance, 2015, 20, 18. Sun, H, Tan, W, Zu, Y. Aptamers: Versatile molecular recognition probes for cancer detection. Analyst, 2016, 141, 403-415. Takei, H, Rouah, E, Ishida, Y. Brain metastasis: clinical characteristics, pathological findings and molecular subtyping for therapeutic implications. Brain Tumor Pathol, 2016, 33, 1-12. Tran, TAN, Deavers, MT, Carlson, JA, Malpica, A. Collision of ductal carcinoma in situ of anogenital mammary-like glands and vulvar sarcomatoid squamous cell carcinoma. Int J Gyn Pathol, 2015, 34, 487-494. Truong, L, Mai, K. Obstructive nephropathy: What the surgical pathologist should know. Pathology Case Reviews, 2015, 20, 250-255. Truong, LD, Seshan, SV. Enigma (partially) resolved: phospholipase A2 receptor is the cause of “idiopathic� membranous glomerulonephritis. Am J Physiol Renal Physiol, 2015, 309, F1000-2. Wang, L, Lingappan, K, Jiang, W, Couroucli, XI, Welty, SE, Shivanna, B, Barrios, R, et al. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med, 2015, 82, 147-159. Xu-Monette, ZY, Tu, M, Jabbar, KJ, Cao, X, Tzankov, A, Visco, C, Cai, Q, Montes-Moreno, S, An, Y, Dybkaer, K, Chiu, A, Orazi, A, Zu, Y, et al. Clinical and biological significance of de novo CD5+ diffuse large B-cell lymphoma in Western countries. Oncotarget, 2015, 6, 5615-5633. Xu-Monette, ZY, Dabaja, BS, Wang, X, Tu, M, Manyam, GC, Tzankov, A, Xia, Y, Zhang, L, Sun, R, Visco, C., Dybkaer, K, Yin, L, Chiu, A, Orazi, A, Zu, Y, et al. Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP. Modern Pathol., 2015, 28, 1555-1573. Xu-Monette, ZY, Deng, Q, Manyam, GC, Tzankov, A, Xia, Y, Wang, XX, Zou, D, Visco, C, Dybkaer, K, Li, J, Zhang, L, Liang, H, Montes-Moreno S, Chiu, A, Orazi, A, Zu, Y, et al. MYC mutation profiling and prognostic significance in de novo diffuse large B-cell lymphoma. Clin Cancer Res, 2016 Feb 29 [Epub ahead of print] PMID: 26927665. Xu-Monette, ZY, Zhang, S, Li, X, Manyam, GC, Wang, XX, Xia, Y, Visco, C, Tzankov, A, Zhang, L, Montes-Moreno, S, Dybkaer, K, Chiu, A, Orazi, A, Zu, Y, et al. p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function. Aging, 2016 Feb 14. [Epub ahead of print] PMID: 26878872. Ye, Q, Xu-Monette, ZY, Tzankov, A, Deng, L, Wang, X, Manyam, GC, Visco, C, Montes-Moreno, S, Zhang, L, Dybkaer, K, Chiu, A, Orazi, A, Zu, Y, et al. Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma. Oncotarget, 2016, 7, 2401-2416. Yu, G, Li, H, Yang, S, Wen, J, Niu, J, Zu, Y. ssDNA aptamer specifically targets and selectively delivers cytotoxic drug doxorubicin to HepG2 cells. PLoS One, 2016, 11, e0147674. Zhou, H, Mody, RR, Luna, E, Armylagos, D, Xu, J, Schwartz, MR, Mody, DR, Ge Y. Clinical performance of the Food and Drug Administration-approved high-risk HPV test for the detection of high-grade cervicovaginal lesions. Cancer Cytopathol, 2016 Jan 15. [Epub ahead of print] PMID: 26774025.
THE LABORATORY REPORT is a publication of the Houston Methodist Department of Pathology and Genomic Medicine Editor-in-Chief April Ewton, MD
Editorial Committee Hazel Awalt, MD Christopher Leveque, MD Claudia Molina, MD Seema Mullick, MD Thu Ngo, MD
Steven Shen, MD, PhD Ping Wang, PhD
Department Chair James M. Musser, MD, PhD
Editorial Coordinator Kathryn Stockbauer, PhD
Houston Methodist Hospital Roland Cruikshank, MBA Manuel Hinojosa, MHA