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Director: Zheng Li, PhD Email: zli@houstonmethodist.org | 713.441.7962 houstonmethodist.org/preclinicalimaging
Houston, TX 77030
houstonmethodist.org/research HMRI Communications & External Relations | RICORE-001 | PA | DH | 09.2017
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Houston Methodist
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Director: Christof Karmonik, PhD Email: ckarmonik@houstonmethodist.org 713.441.7979 Medical Director: Steve H. Fung, MD Email: shfung@houstonmethodist.org houstonmethodist.org/mri-core
Director: Paolo Zanotti Fregonara, MD, PhD Email: pzanottifregonara@houstonmethodist.org 713.441.0803 houstonmethodist.org/pet_facilities
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Translational Imaging Core Facilities
CYCLOTRON & RADIOPHARMACEUTICAL CORE
The Houston Methodist Research Institute Translational Imaging Core Facilities provide Houston Methodist and the Texas Medical Center community with access to advanced high-performance imaging for research studies.
POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FACILITY
MRI IMAGING FACILITY The MRI Imaging Facility houses a state-of-the-art 70 cm wide-bore 3.0 Tesla whole-body human magnetic resonance imaging scanner. Its configuration makes this facility the ideal environment for performing preclinical and clinical translational imaging research studies.
The Cyclotron & Radiopharmaceutical Core has an on-site cyclotron, housed in the Research Institute building. This enables research studies that require rare custom tracers and short half-life materials, and/ or multiple doses in a single day. It includes a cGMP compliant production laboratory as required for the production of clinical grade radiopharmaceuticals.
The PET Imaging Facility is located on the first floor of the Research Institute building and operates a latest generation PET scanner for advanced imaging. The PET core studies neurodegenerative pathologies by using a variety of radiotracers to image biological targets such as proteins expressed during neuroinflammation and proteins that accumulate in the brain during the course of dementias, such as Alzheimer’s disease. The PET core provides quantitative analysis with full kinetic modeling and metabolite-corrected arterial samples.
PRECLINICAL IMAGING CORE The Preclinical Imaging Core provides the expertise necessary to perform multimodality imaging studies on preclinical study models. Imaging modalities include PET, SPECT, CT, MRI/MRS, ultrasound, and optical imaging. Available resources include the Iveon Dedicated PET System and the Iveon Multimodality SPECT/CT system (Siemens Medical Solutions), the Caliper IVIS-200 system, the Maestro in vivo fluorescence imaging system and 9.4 Tesla Bruker Avance MRI/MRS. Depending on the application, the core will provide users with full technical operation, comprehensive training, assistance with experimental design and data analysis, and ongoing research support.
Our Specialized Programs The Core Facilities are staffed by experienced research professionals and laboratory technicians who provide assistance with experimental design and specimen preparation, use of advanced imaging techniques, and use of complex image processing software for quantitative data analysis. We will help troubleshoot and optimize experiments to ensure the highest quality data is acquired. We offer comprehensive training, assistance in the design of experimental protocols, and ongoing consultation and support.