Top Myeloma Research at ASH 2023 from a Patient Perspective

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Thank you to our sponsors!

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We Want to Hear From You!

Feedback Survey At the close of the meeting a feedback survey will pop up. Click “continue” to complete the survey. This will also be emailed to you shortly after the workshop. Please take a moment to complete this survey.


Video Replay

A replay of the webinar will be made available on our website early next week. You can find it under the Publications and Broadcasts Tab, and then under IMF Broadcasts. A replay link will be directly emailed to all who registered for this webinar.


Top Myeloma Research Presented at ASH 2023

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Brian G.M. Durie, MD January 4, 2023


IMF Mission ASH 2023 ➢ Total Attendance: 32,000 (28,000 in-person; 4,000 virtual) ➢ Total Number of Abstracts: 7,000 ➢ Myeloma Abstracts: over 1,000 - Oral Presentations: 136 + LBA & Plenary - Posters: About 850

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Myeloma Support Group Leader Voices at ASH 2023 IMF Mission Read the Blogs: Myeloma Support Group Leader Voices at ASH 2023

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Myeloma Support Group Leader Voices at ASH 2023 IMF Mission

The ASH 2023 Experience with

Michael Tuohy, Patient (In-person)

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Jessie Daw, Patient (Virtual)


IMFMRD Mission What is the i2TEAMM?

The MRD i2TEAMM is an International Independent Team for the Endpoint Approval of MRD in Myeloma

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IMF Mission MRD i2TEAMM Update ➢ ACTIVE engagement with FDA for 2024 ➢ Optimistic MRD at 10-5 or better will be approved AS AN EARLY ENDPOINT FOR ACCELERATED DRUG APPROVALS ➢ Full approval still requires PFS benefit ➢ REAL WORLD USE OF MRD under review

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IMF Global Technology Platform Imaging

Iceland Early disease

Family Studies

Full sequencing

Germany

Retrospective studies

Mayo

Central Platform

France

Cure Trial

Spain

CLIA lab NGF & MASS SPEC

Immune monitoring

Pipeline trials Immune Therapy Database

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Asian Trials Network

Blood monitoring

Centralized NGF/risk assessment

Singapore Virtual Biobank

Single cell resistance analyses Trials Pending Latin America Network

Blood DNA mutational analyses Clinical trial assessment

Australia


IMFQ&A Mission

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IMF Mission Top ASH Abstracts

➢ 4-Drug Combos in Frontline ➢ - Daratumumab + Velcade-Revlimid-Dexamethasone (VRd)…PERSEUS Trial European Myeloma Network (EMN)… Late Breaking Abstract (LBA) - Isatuximab + Carfilzomib-Lenalidomide-Dexamethasone (KRd)…IsKia Trial (EMN 24)… Plenary

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IMF Mission Fibrinogen and Ferritin How are Fibrinogen and Ferritin involved in ICANS and and CRS? ▪ The study concluded that higher fibrinogen and ferritin values at baseline were associated with inferior overall survival after CAR T-cell therapy. ▪ Higher baseline absolute lymphocyte counts were linked to a higher risk of ICANS and higher grade of ICANS, an important toxicity to consider for patients receiving CAR T. ▪ Higher ferritin equated to shorter progression-free survival. CAR T-cell therapy is a highly effective treatment option, but outcomes and duration of response can vary widely, so if we can use widely available tests to help determine outcomes, this could possibly impact treatment decisions. ▪ Abstract 92: Inflammatory Biomarkers and Outcomes in Multiple Myeloma Patients after CAR T-Cell Therapy

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IMFNew Mission Two Key Projects

VIRTUAL TISSUE BANK

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IMMUNE THERAPIES REGISTRY

Confidential - Not for Distribution


IMF Mission Outpatient CAR T and Bispecifics Can we safely manage CAR T and bispecifics on an Outpatient Basis? Robin Tuohy

Care Partner and IMF Vice President – Support Groups

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Interview with Linda Huguelet on her CAR T treatment


IMF Mission PERSEUS Trial

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IMF Mission PERSEUS Trial

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IMF Mission PERSEUS Trial

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IMF Mission PERSEUS Trial

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IMF Mission IsKia Trial

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IMF Mission IsKia Trial

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IMF Mission IsKia Trial

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IMF Mission FRONTLINE 2024

❖ 4 Drugs can be approved ❖ HOWEVER …will they be reimbursed? … are added toxicity/side effects worth it?

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IMFQ&A Mission

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IMF Mission ASH 2023

STATUS OF MRD TESTING

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IMF Mission ASH 2023- STATUS OF MRD TESTING

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IMF Mission ASH 2023- STATUS OF MRD TESTING

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IMF Mission ASH 2023- STATUS OF MRD TESTING

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IMF Mission ASH 2023- STATUS OF MRD TESTING

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IMFQ&A Mission

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IMF Mission iStopMM Project

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IMF Mission iStopMM Project

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IMF Mission iStopMM Project

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iStopMM Project: The Flow Chart IMFRandomization Mission

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IMF Mission iStopMM Project

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IMF Mission iStopMM Project

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IMFQ&A Mission

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Other ASH 2023 Takeaways ➢ REAL WORLD DATASETS ➢ EMPHASIS on Equity & Access and outcomes ➢ New IMMUNE THERAPIES: Biology/outcomes ➢ HR SMM: Criteria, biology, therapies ➢ AND MANY CLINICAL PEARLS

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IMF Mission Clinical Pearls ➢ Taper DEX ➢ CAR T Access Improved/Safety Issues? ➢ Other CAR T: FasT CAR T/Dd BCMA/GPRC5D ➢ Teclistamab for HR SMM (IMMUNO Prism) vs R/KRd/Dara KRd/other ➢ Trispecifics: JNJ 5322 and HPN217 ➢ Immune therapy dose/duration questions ➢ SIDE EFFECTS: Infections/Skin, Nails, and Taste (dysgeusia) in addition to CRS/ICANS

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IMF Mission Final Comments

FINAL COMMENTS

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ASH 2024

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will be held in San Diego again!


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We Want to Hear From You!

Feedback Survey At the close of the meeting a feedback survey will pop up. Click “continue” to complete the survey. This will also be emailed to you shortly after the workshop. Please take a moment to complete this survey.


Video Replay

A replay of the webinar will be made available on our website early next week. You can find it under the Publications and Broadcasts Tab, and then under IMF Broadcasts. A replay link will be directly emailed to all who registered for this webinar.


Thank you to our sponsors!

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