John W. Deming Department of Medicine 2021-2022 Annual Report

ANNUAL REPORT 2021-22

JOHN W. DEMING DEPARTMENT OF MEDICINE

Mission

Vision

To be a distinctive, preeminent research-intensive medical school, transforming health through discovery, lifelong learning, and patient-centered health care.

We improve human health and foster healthy communities through discovery and translation of the best science into clinical practice and education; to deliver the highest quality patient care and prepare the next generation of distinguished clinical and scientific leaders.

Table of Contents

John W. Deming Department of Medicine Values 2

By the Numbers 3

Chair’s Message 5

Office of the Chairman 7

Student Programs 8

Medicine Residency ............................................................................................................................................................................................... 9

Section of Cardiology 15

Section of Clinical Immunology Allergy & Rheumatology 21

Section of Endocrinology 27

John W. Deming Department of Medicine Charitable Giving

.......................................................................................... 38

Section of Gastroenterology 39

Section of General Internal Medicine and Geriatrics 45

Hurricane Ida 54

Section of Hematology and Medical Oncology 55

John W. Deming Department of Medicine Awards of Excellence 67

Section of Infectious Diseases 71

Section of Nephrology and Hypertension ....................................................................................................................................... 77

Section of Pulmonary Diseases, Critical Care and Environmental Medicine 87

2022 Owl Award Winners 98

Division of Biomedical Informatics & Genomics 99

Center for Aging .................................................................................................................................................................................................. 107

Center for Tranlational Research in Infection and Inflamation 110

Tulane Research Innovation for Arrhythmia Discoveries 111

The LA Center for Bleeding and Clotting Disorders 115

Clinical Translational Cooperative Laboratory 121

Neuroscience Laboratory 121

Publications 122

Our Values

OUR VALUES

The Deming Department of Medicine espouses the following values: RESPECT – Treat everyone, regardless of position or authority, with kindness and courtesy

ETHICAL INTEGRITY – Do the right thing, even when its hard or inconvenient COMMUNICATION – Have clear and timely communication that is focused on achieving solutions

ACCOUNTABILITY – Know and do what is expected of you in your role

DRIVE FOR EXCELLENCE – Continuously deliver and improve your best work Tulane University School of Medicine (TUSOM) values diversity. Tulane defines diversity broadly to include: persons of color, members of the LGBTQIA community, members of diverse ethnic groups including those typically underrepresented in medicine, members of economically disadvantaged groups, and any others who bring a different perspective to the learning environment. The school of medicine believes in a rich educational experience for all students through the infusion of cultural competency, sensitivity, and attentiveness. Additionally, the school of medicine values the sum total of ideals and perspectives of all individuals engaged in and connected to the educational process.

We are committed to implementing policies in collaboration with the School of Medicine, hospital systems, and community to eliminate biases among racial groups.

Victor J. Thannickal, MD Professor

The Harry B. Greenberg Chair of Medicine John W. Deming Department of Medicine

Welcome to the Tulane University School of Medicine John W. Deming Department of Medicine in New Orleans. Our department is committed to excellence in medical education, research and clinical service. In addition, we are committed to engaging our community to improve the health of both our individual patients and the population at large. The faculty are led by outstanding physician scientists, clinicians, and educators.

Our doctors deliver clinical services at Tulane Medical Center, the Southeast Louisiana Veterans Health Care System, and the University Medical Center of New Orleans. These institutions offer a wide range of educational, clinical and research opportunities. Our faculty are among the most respected clinicians in the region and country.

The John W. Deming Department of Medicine is also one of the largest and most successful research departments in the School of Medicine. Our research extends from the basic sciences of physiology and disease to the application of knowledge in the clinical and community setting. The faculty are also prominent members of a number of university-wide Centers such as the Cancer Center, the Bioinformatics and Genomics Center, the Center for Translational Research in Infection and Inflammation, the Gene Therapy Center, the Renal and Hypertension Center, the Abdominal Transplant Center, and the Center for Aging.

In addition to our clinical services and research programs, we have innovative education programs at all levels: student, resident, fellow and continuing medical education. Please visit the appropriate areas of the web site to learn more.

The John W. Deming Department of Medicine is most proud of the people who make up the complete department team, from staff to residents, post-doctoral fellows, and faculty. Our guiding principles and values are respect, ethical integrity, communication, accountability, and drive for excellence. We invite you to experience the collaborative, inclusive, energetic, and innovative spirit here at Tulane.

Victor J. Thannickal, MD

The Harry B. Greenberg Chair, John W. Deming Department of Medicine

Victor J. Thannickal, MD Chairman

Vecihi Batuman, MD

Dana Keren

Executive Vice Chair

Executive Director and Associate Chair

Clint Schibner Operations Manager

Erica G. Moore

Administrator

Crystal Guillemet-Williams Marketing & Communications Manager

Kelly Martin Senior Executive Secretary

Monique Lecompte Senior Credentialing Specialist

Deborah England Director of Budgets & Financial Reporting

Chloe Ball Senior Accountant Grants & Contracts

Tulane University School of Medicine, John W. Deming Department of Medicine, comprises one Residency Program, nine sections, one division, and nine centers. Sections offer clinical service, research, and educational learning. Sections rotate between three inner city hospitals in downtown New Orleans.

Tulane Medical Center: The Tulane Medical Center is a hospital located in New Orleans, Louisiana. The Tulane Medical Center has centers covering nearly all major specialties of medicine and is the primary teaching hospital for the Tulane University School of Medicine.

University Medical Center LCMC Health: University Medical Center LCMC Health is a 446-bed non-profit, public, research, and academic hospital located in the Tulane - Gravier neighborhood of New Orleans, Louisiana, providing tertiary care for the southern Louisiana region and beyond.

Southeast Louisiana Veterans Affairs: Southeast Louisiana Veterans Health Care System (SLVHCS) provides quality, compassionate, safe health care to Veterans throughout 23 parishes in southeast Louisiana.

Office of Student Programs

Abigail Byren, MD Instructor of Medicine Director

Student Programs & Internal Medicine Core

Clerkship

Tulane School of Medicine clerkship, students will have an opportunity to train through working at our partnered hospitals. Tulane Medical Center, University Medical Center LCMC Health, and the Southeast Louisiana Veterans Affairs Health. Students do clinics and inpatient wards, with primary courses being Internal Medicine Core clerkship and the Internal Medicine Acting Internship.

There are numerous elective courses, and the numbers are constantly changing. With over 40 different educational offerings, students can choose their direction of study.

The Deming Department of Medicine Student Programs has been very successful in residency advising for students interested in Internal Medicine. For the class of 2021, 22% (41/191) matched into categorical Internal Medicine or an Internal Medicine-combo residency program; 100% of students applying into an Internal Medicine or an Internal Medicine combined residency program were successful. For the current 2022-2023 application season, we anticipate similar numbers of students applying to categorical Internal Medicine or an Internal Medicine combined residency program.

We are consistently recognized by the students for excellence. At the 2022 Owl Club Awards we won Best Clerkship and Best Overall Department.

FACULTY

Abigail Byrne, MD Instructor Core Clerkship Director Director of Student

Programs

Celeste Newby, MD Assistant Professor Acting Internship Director

Internal Medicine Residency Program (IMRP)

Deepa Bhatnagar, MD Associate Professor of Medicine & Pediatrics Program Director Internal Medicine Residency Program

Tulane School of Medicine Internal Residency is one of the oldest institutions in the country and has been providing care for the citizens of New Orleans since 1834. When LSU School of Medicine opened in the 1940s, the two medical schools partnered to provide care to the underserved at Charity Hospital.

In the aftermath of Hurricane Katrina in 2005, the Tulane Internal Medicine residents kept clinical operations running for New Orleans in temporary hospitals and clinics for months. Charity Hospital was closed, but the “Spirit of Charity” never faltered. Like our wonderful city, the residency program pushed forward, highlighting its strength and resiliency in the wake of one of the United States’ most devastating natural disasters.

Today, Tulane residents are working to impact the future of healthcare in the city of New Orleans with our presence at University Medical Center LCMC Health, and Southeast Louisiana Veterans Affairs Health, and Tulane Medical Center.

CLINICAL ACTIVITIES

All rotations and clinics are at Tulane Medical Center, University Medical Center LCMC Health, and the Southeast Louisiana Veterans Affairs Health. Our Department also has some residents that are part of the RIGHT Program who do rotations out of the country.

The Department is always looking to expand, and we are looking into placing residents in rural rotations within the state and the Tulane University Student Health Clinic.

Internal Medicine Residency Program (IMRP)

SERVICES PROVIDED

In-patient

Wards Inpatient Hospitalist ICU CCU

Emergency Medicine Geriatrics

Subspecialty rotations (ex. Primary Care, IM Subspecialties)

Alternate Specialty Experience (ex. Ortho, palliative Medicine, Sleep Medicine, Rehab Medicine)

RESEARCH ACTIVITIES

Resident Scholarly Activities come from participation in specialty and subspecialty conferences as presenters, such as Deming Department of Medicine Scholarship Day, journal clubs, QI projects, and resident participation with faculty on various research projects, journal publication submissions, and elective research rotations.

StAAR Program (Research Track): Tulane’s Stimulating Access to Research in Residency (StARR) Pro- gram’s long-term goal is to increase the number and diversity of highly trained, independent, interdisciplinary board-certified physician-scientists engaged in heart, lung, and blood diseases research. The program focuses on heart, lung, and blood diseases because of the impacts on human health, the existing knowledge gaps for these diseases across the research spectrum, and the strength of this focus at Tulane. Internal medicine resident candidates may apply for the research track. Dedicated research time is provided over 18 months with salary support during the fall of their PGY-2, PGY-3, and PGY-4 years through the Stimulating Access to Research in Residency (StAAR) program.

EDUCATIONAL ACTIVITIES

Our Mission: A residency program with a purpose to teach social justice and medical science. We strive to deliver the highest quality care to diverse patient populations where we are preparing the next generation of clinicians, educators, investigators, and leaders.

RESIDENT MAKEUP

Internal Medicine Residency Program (IMRP) Residents have four categorical makeups: Categorical Categorical STARR (Stimulating Access to Research in Residency)

PARTNERING RESIDENCY PROGRAMS

Categorical Primary Care Preliminary

Internal Medicine-Pediatrics (4-year program, 6 residents per year)

Internal Medicine – Psychiatry (5-year program, 2 residents per year)

Prelim Advanced Residency Programs

Anesthesiology

Radiology

Ophthalmology Neurology

Psychiatry (PGY1s in this Program spend four months this PGY rotating with IMRP)

Internal Medicine Residency Program (IMRP)

TULANE MED-PEDS

The Tulane Med-Peds residency includes twenty-four residents (six per class) who spend four years training in Internal Medicine and pediatrics and graduate eligible for certification by the American Board of Internal Medicine and The American Board of Pediatrics.

In their training, Tulane Med-Peds residents have the opportunity to work within five separate health care systems in New Orleans: Tulane Medical Center, University Medical Center LCMC Health, Southeast Louisiana Veterans Affairs Health, Children’s Hospital of New Orleans, and Ochsner Hospital, as well as multiple community sites. In addition, they provide longitudinal primary care to patients of all ages at a dedicated Med-Peds Resident continuity clinic.

Tulane Med-Peds residents hold numerous leadership roles within the program and institution and have multiple ongoing projects focused on education, community service, and community engagement.

There are Masters/PhD and other special educational programs in the residency program including: Pathways to Distinction Hospital Administration

Subspecialty – Hematology and Oncology, Gastroenterology, Pulmonary, Palliative Care, Cardiology, Allergy/Immunology, Rheumatology, Nephrology, Infectious Diseases

Leadership in Medical Education Primary Care Hospital Medicine

RIGHT (Resident Initiative in Global Health at Tulane) Program

STARR (Stimulating Access to Research in Residency) Program

Graduates of the program have gone on to teaching and administrative roles within Tulane (including leaders of the combined and both categorical residency programs and directors of medical student clerkships and courses), the city (including medical advisor to the Orleans Parish School Board), the state (CIO for the Louisiana Department of Health), and the country (CMO for the Department of Homeland Security).

AWARDS & ACCOMPLISHMENTS

The Internal Medicine Residency had two trainees recognized for Resident of the Year and Intern of the year for the 2020-2021 fiscal year.

Wren Fondren, MD

UMC Resident of the Year

Elaine Huang, MD

UMC Intern of the Year

Internal Medicine Residency Program (IMRP)

2020-2021

GRADUATION AWARDS

Resident & Intern Awards

Chad Caplan, MD

Outstanding Interpersonal and Communication Skills by an Intern Bo Nebolisa,MD & King Emmanuel, MD

Outstanding Interpersonal and Communication Skills by a Resident

Abigal Spaedy, MD

Outstanding Systems Based Practice by an Intern

Rachel Shepard, MD

Outstanding Systems Based Practice by a Resident

Rajiv Heda, MD

Outstanding Medical Knowledge by an Intern

Stella Radosta, MD

Outstanding Medical Knowledge by a Resident

Sheela Sheth, MD

Outstanding Professionalism by an Intern

Ashley Russell, MD

Outstanding Professionalism by a Resident

Elaine Huang, MD

Outstanding Practice-Based Learning and Improvement by an Intern Tameka Smith, MD

Outstanding Practice-Based Learning and Improvement by a Resident

Alexis Katz, MD & Kate Peacock, MD

Outstanding Patient Care by an Intern

Janet Kim, MD

Outstanding Patient Care by a Resident

Amy Meyer, MD Intern of the Year

Wren Fondren, MD Resident of the Year

Attending & Fellow Awards

Kristin Bateman, MD

Inpatient Attending of the Year

Schuyler Williams, MD

Outpatient Attending of the Year

Ugo Ezema, MD

Fellow of the Year

Internal Medicine Residency Program (IMRP)

PHILANTHROPY

The section is honored to have the Jack E. Shangold Endowed Fund to help in financial contributions.

ADVOCACY

Internal Medicine Residency does a variety of outreach services in the community such as, having a Diversity and Community Engagement Committee, Wellness Committee, and various resident-run community activities including dog walking and volunteer clinics.

FACULTY

Deepa Bhatnagar, MD Program Director

Kristen Bateman, MD Associate Program Director

Adrian Baudy, MD Associate Program Director

Anthony Marsh, MD Associate Program Director

21-22 Chief Residents (PGY4s/Faculty):

Deep Sangani, MD

Amiee Sutherland, MD Wren Fondren, MD

Temeka Smith, MD

STAFF

Kathryn Conyers, JD

Senior Administrative Program Coordinator

Donna Darensbourg

Robert Miller, MD Associate Program Director

Erica Tate, MD Associate Program Director

Jerald Taggart, MD Associate Program Director

William Dickinson, MD Rachel Shephard, MD Leigh Deshotels, MD Michael Conner, MD

Graduate Medical Education Program Administrator II

Lauren Nassar

Graduate Medical Education Program Administrator I

Siera Swan

Senior Administrative Program Coordinator

Ka’Lynde Smith, MBA

Senior Graduate Medical Education Program Administrator II

A Resident’s Life

Internal Medicine Residency Program (IMRP)

Cardiology

Jose Wiley, MD, MPH Professor Chief Section of Cardiology

CLINICAL ACTIVITIES

The Section of Cardiology in the John W. Deming Department of Medicine at Tulane University School of Medicine encompasses leading clinical, educational and research programs focused on the prevention and treatment of cardiovascular diseases. It offers comprehensive heart and vascular clinical care at locations in Metairie at the Tulane Doctors Multi-specialty clinic on Veterans Memorial Boulevard, the Tulane Doctors Napoleon clinic Uptown, and at the multi-specialty clinic at Tulane-Lakeside Hospital, in New Orleans at Tulane Medical Center, University Medical Center LCMC Health, the Southeast Louisiana Veterans Affairs Health and in Covington, Louisiana at the Dermatology Clinic.

Our physicians specialize in: interventional cardiovascular procedures, structural heart interventions, advanced heart failure treatment, electrophysiology treatment, advanced arrhythmia management, preventative cardiology services, lipid management, hypertension management, women’s heart disease treatment, peripheral vascular (or arterial disease) management, cardiac and vascular imaging, endovascular interventions, and endovascular treatment for venous disease.

The Section of Cardiology’s nationally recognized clinical faculty are dedicated to the education and training of physicians in Cardiovascular Diseases. Because our physicians are also academic cardiologists, patients can be assured that each case is thoroughly reviewed and all available treatment options are considered. Our faculty members are leaders of research and development in their sub-specialties, often sharing their knowledge by lecturing around the country regarding the latest methods of treating cardiac and peripheral artery disease. The Section of Cardiology also has basic and translational scientists in addition to clinical investigators, participating in numerous research trials.

SERVICES

General Cardiology

Interventional Cardiology

Electrophysiology

Heart Failure

Consult Coverage (Including Electrocardiogram Reads)

EP Consult Coverage

Catheterization Lab Procedures

EKG

Structural heart interventions

Echo Stress Test

Nuclear Stress Test

TEE CTA Vascular TCD TAVRs

ECMO Procedures

Cardiology

EDUCATIONAL ACTIVITIES

Cardiovascular Diseases Fellowship

The Tulane University Cardiovascular Disease Fellowship is a three-year program that trains fellows in clinical cardiology practice and teaches the knowledge, skills, clinical judgment, attitudes, and values essential to the practice of cardiology. We strive to foster humanistic and ethical attributes in our trainees, and we encourage an appropriate balance between academic endeavors and clinical service.

Tulane cardiology fellows rotate at Tulane Medical Center, Southeast Louisiana Veteran’s Health, and University Medical Center LCMC Health. Services include cardiac catheterization, non-invasive imaging, electrophysiology, cardiology consults, CCU, and congestive heart failure. We strongly encourage fellows to participate in basic or clinical cardiovascular research. Fellows receive training and supervised experience in evaluating and managing various acute and chronic cardiovascular conditions. They will become proficient in all aspects of cardiovascular disease, including chronic coronary heart disease, congestive heart failure, arrhythmias, acute myocardial infarction, and other acute ischemic syndromes, lipid disorders, hypertension, cardiomyopathy, valvar heart disease, pulmonary heart disease, peripheral vascular disease, infections and inflammatory heart disease, and adult congenital heart disease.

The Office of Graduate Medical Education (GME) ensures that all residents and fellows at Tulane University School of Medicine are provided an accredited, educational experience of the highest quality. This three-year Cardiovascular Disease Fellowship program complies with all Accreditation Council for Graduate Medical Education (ACGME) requirements, in addition to following the guidelines and recommendations of the American College of Cardiology (COCATS).

At the end of the training period, fellows will be equipped with the knowledge, skills, and abilities to meet the requirements for certification in cardiovascular diseases, as determined by the Accreditation Council for Graduate Medical Education. These include experience and training in ambulatory medicine, in-patient experience, and unique clinical experiences and research. The Fellowship program offers considerable flexibility and can be tailored to fit individual needs.

Cardiology

INTERVENTIONAL CARDIOLOGY FELLOWSHIP

The Tulane University Interventional Cardiology Fellowship is a one-year program that teaches fellows in the knowledge, skills, clinical judgment, attitudes and values that are essential to the practice of interventional cardiology. We strive to foster humanistic and ethical attributes in our trainees and encourage an appropriate balance between academic endeavors and clinical service.

The training includes didactic conferences, weekly case conferences, and individual fellow and faculty clinical patient reviews (pre-and post-procedure) to discuss risks, benefits, results, treatment strategies, and complications. Trainees also assist in teaching cardiology fellows, medicine residents, and other student groups. Interventional cardiology fellows also will lead case discussions at cardiac catheterization conferences.

The program’s emphasis gives fellows ample opportunities to learn appropriate technical skills for safe coronary and peripheral intervention using multiple devices, including rotational cather ectomy, balloons, stents, filter devices, and advanced refine diagnostic catheterization skills. Ample coronary procedures are available to meet required procedure volumes.

Interventional Cardiology fellows rotate at Tulane Medical Center, Southeast Louisiana Veterans Affairs Health, and University Medical Center of New Orleans LCMC Health. An equal amount of time is spent at each institution. Trainees are strongly encouraged to participate in basic or clinical cardiovascular research. The trainee will move from participation in procedures under very close supervision to independent activity during the program.

PGY Levels: 2 - PGY - 7

Program Director: Anand M. Irimpen, MD

CARDIAC ELECTROPHYSIOLOGY FELLOWSHIP

Tulane University Cardiac Electrophysiology Fellowship Program is designed to train physicians in the highest level of practice in managing cardiac arrhythmias. Our program provides a comprehensive education in the diagnosis and management of arrhythmias beginning with the scientific foundations of cardiac electrophysiology. Building upon this foundation, our trainees will develop the knowledge and skills necessary to diagnose and manage cardiac arrhythmias, including a broad spectrum of invasive and noninvasive procedures.

The EP fellows receive training in all aspects of cardiac electrophysiology and have increased exposure and responsibility in invasive procedures, including diagnostic electrophysiology studies, mapping and catheter ablation of supraventricular and ventricular tachycardias, transvenous and subcutaneous cardiac device implantation/extraction, and left a trial appendage closure devices in the EP laboratory. The fellows also become competent in non-invasive procedures such as cardioversions and tilt table testing. In addition to electrophysiology and cardiac device outpatient clinics, the trainee will consult on in-patients with arrhythmias and implanted devices at our three participating sites: Tulane Medical Center, University Medical Center of New Orleans LCMC Health, and Southeast Louisiana Veterans Affairs Health providing exposure to

Cardiology

diverse patient populations and hospital organizations. The fellows spend time in electrophysiology and cardiac device outpatient clinics, allowing the trainee to observe and manage patients longitudinally and gain experience with device follow-up and management

At the end of the training period, fellows will be equipped with the knowledge, skills, and abilities to meet the requirements for certification in Clinical Cardiac Electrophysiology, as determined by the Accreditation Council for Graduate Medical Education.

Program Director: Nassir Marrouche, MD

AWARDS & ACCOMPLISHMENTS

Gholam Ali, MD

PGY Levels: 2 - PGY - 7

Associate Program Director: Bassam Wanna, MD

Fellow National Lipid Association (FNLA) 2021

Keith Ferdinand, MD

Honorary Fellow, Preventive Cardiac Nurses Association, April 2021

Robert Hendel, MD

Master of the American College of Cardiology (MACC) & ACC’s 2021 Distinguished Awardees

Nassir Marrouche, MD James H. Youngblood Excellence in Leadership Award from the Heart Rhythm Society

Frederick Helmcke, MD C. Ray Thorpe Faculty of the Year 2020-2021

Robert Hendel, MD

Best Doctors in New Orleans: Cardiovascular Diseases 2021 New Orleans Magazine Anand Irimpen, MD

Best Doctors in New Orleans: Cardiovascular Diseases 2021 New Orleans Magazine

Colleen Johnson, MD

Best Doctors in New Orleans: Cardiac Electrophysiology 2021 New Orleans Magazine

Keith C. Ferdinand, MD

2022 SOM Faculty Recognition Award for Professionalism

Jose M. Wiley, MD, MPH

Member, Interventional Section Leadership Council of the American College of Cardiology

Cardiology

FACULTY

Gholam Ali, MD Associate Professor

Hamid Alai, MD Assistant Professor

Asif Anwar, MD Associate Professor

Mark Cassidy, MD Professor

Eoin Donnellan, MD Assistant Professor

Keith Ferdinand, MD Professor

Frederick Helmcke, MD Associate Professor

Robert Hendel, MD Professor Anand Irimpen, MD Professor Director Interventional Cardiology Fellowship Program

Colleen Johnson, MD Associate Professor Thierry Le Jemtel, MD Professor Director Cardiology Fellowship Program

RESEARCH FACULTY

Eckhard Alt, MD, PhD Professor

Omar Kreidieh, MD Assistant Professor

Nassir Marrouche, MD Professor

Director, Heart & Vascular Institute & Director, Cardiac Electrophysiology Fellowship Program

Zach Rozenbaum, MD Assistant Professor

Madhur Roberts, MD Assistant Professor

Nitin Sabharwal, MD Assistant Professor

Gary Sander, MD Professor

Aaron Sweeney, MD Assistant Professor

Juan Terré, MD Associate Professor

Chloe Villavaso, MN, APRN Instructor

Bassam Wanna, MD Assistant Professor

Monique Young, ACNP-BC Instructor

Ali Alsaad, MD Assistant Professor

Siddharth Bhansali, MD Professor of the Practice

Patrice Delafontaine, MD Executive Dean

Jack R. Aron Chair of Administrative Medicine Professor Physiology, and Pharmacology

Amitabh Pandey, MD Assistant Professor

William “Zach” Rowalt, FNP-C Instructor

Jose M. Wiley, MD, MPH, FACC, FACP, FSCAI Professor Chief, Section of Cardiology

Reza Izadpanah, PhD Assistant Professor

DELAFONTAINE RESEARCH GROUP

Mitzi Alfortish Medical Research Specialist

Svitlana Danchuk Lab Supervisor 1

Yusuke Higashi, PhD Associate Professor

Charles “Seth” Lott Medical Research Specialist

Sydney Stewart Medical Research Specialist

Sergiy Sukhanov, PhD Associate Professor

Yasmine Rashad Medical Research Specialist

Tadashi Yoshida, PhD Assistant Professor

Cardiology

STAFF

Patricia Barrows Executive Secretary

Suzanne Bowers, RN Nurse Specialist, Mobile Cardiology

Cassandra Albert Graduate Medical Education Program Administrator II

Susanna Torres Section Administrator

Cathy Willard Operations Manager II Deborah Williams Administrative Program

Coordinator

Deborah Brent Patient Registration Coordinator

Kellie Thomas, RN Clinic Manager III

Akara Francois Medical Assistant, Certified

Raquel Daniels Medical Assistant, Certified

Kunal Sameer, MD MHA Clinic Manager II

Carey Gaddis, LPN LPN Coordinator

Carla Mauberret, RN

Registered Nurse

Deborah Breaux Medical Assistant

Cynthia Thornton Medical Assistant

Toni Lukes Cardiac Sonographer

Clinical Immunology, Allergy and Rheumatology and Histocompatibility and Immunogenetics Laboratory (HLA

G. Wild, MD, FAAAAI, FACAAI Professor Chief Section of Clinical Immunology, Allergy & Rheumatology

Lab)

The Section of Clinical Immunology, Allergy and Rheumatology’s mission is to serve patients through our clinical endeavors while training the most excellent Allergists and Immunologists who will practice our specialty, conduct research, and themselves go on to teach subsequent generations of outstanding physicians in the field. We strive to provide excellent care for patients in our Allergy and Immunology and Rheumatology clinics, educate and train outstanding physicians in Allergy and Immunology to evaluate, diagnose, and manage patients with the highest degree of scientific and clinical excellence, provide histocompatibility testing support for the Tulane Multi-Organ Transplant Programs, including kidney, liver, heart, and pancreas, as well as allogeneic and autologous bone marrow transplantation, through our Histocompatibility and Immunogenetics Laboratory.

CLINICAL ACTIVITIES

The Clinical Immunology and Allergy Unit included the Immunology and Allergy Research Laboratory and the Histocompatibility and Immunogenetics Laboratory. Facilities contain over 12,550 sq. ft. of laboratories.

The Clinics are located at Tulane Medical Center, which includes campuses in downtown New Orleans and Metairie. The Education program allows Fellows to rotate through the clinics and consultation services of affiliated hospitals, including the Southeast Louisiana Veterans Affairs Health and Ochsner Medical Center. Second-year fellows also provide care at the NOELA Community Health Center, a federally funded clinic established for underserved patients in New Orleans East. This variety in training settings allows fellows to care for a diverse patient population and ultimately provides a broad and fulfilling educational experience.

Southeast Louisiana Veterans Affairs Health

Laurianne G. Wild, MD

Evan Atkinson, MD, MS

SERVICES

Tulane Medical Center

Laurianne G. Wild, MD

Margaret Prat-Huntwork, MD, MPH

John Huntwork, MD

New Orleans East Hospital

LCMC (FQHC site)

Margaret Prat-Huntwork, MD, MPH

Allergy, Immunology and Rheumatology quality care

Human Histocompatibility Laboratory Services for the Tulane Transplant team

Laurianne

Clinical Immunology, Allergy and Rheumatology and

Histocompatibility and Immunogenetics Laboratory (HLA Lab)

PROCEDURES

Joint injections

Joint aspirations

Allergen Immunotherapy (Rush and conventional build-up) Drug, Food and Aeroallergen skin testing Food and drug challenges

HLA Typing, Antibody Identification, and Cross-matching

RESEARCH ACTIVITIES

Fellows are provided opportunities to complete their research requirements through participation in newly designed research protocols or ongoing projects. To provide fellows with the skills needed to complete various types of research projects, early in their fellowship, they are required to attend the Methods in Clinical Research course given by John Carlson, MD, PhD. The primary goal of conducting research during the fellowship is to further one’s appreciation for a general understanding of research principles and foster habits for the critical interpretation of scientific literature. The fields of allergy and immunology are rapidly evolving.

EDUCATIONAL ACTIVITIES

The Accreditation Council for Graduate Medical Education (ACGME) fully accredits the Tulane Allergy and Clinical Immunology Fellowship training program. Our program is a combined Internal Medicine and Pediatrics Program permitting entry of residents trained in Internal Medicine, Pediatrics, or both. All trainees receive comprehensive clinical training in adult and pediatric allergic and immunologic diseases. Our educational activities curriculum includes:

Allergy and Immunology Fellowship Program

Description of Program: High-quality training in Clinical Allergy and Immunology

Weekly Case conferences jointly with LSU Allergy and Immunology

Weekly Conferences Online Allergy

Weekly Journal Club

Weekly Abbas Immunology Series

Weekly Practice Parameters review

Board review twice weekly starting in October

Attendance and presentation at the Louisiana Society of Allergy, Asthma, and Immunology annual meeting

Attendance and poster presentations at the American Academy of Allergy, Asthma and Immunology

Attendance and poster presentations at the American College of Allergy, Asthma and Immunology

The goal for the program is to train highly qualified clinical immunologists and allergists who practice patient-centered care.

Clinical Immunology, Allergy and Rheumatology and Histocompatibility and Immunogenetics Laboratory (HLA Lab)

AWARDS & ACCOMPLISHMENTS

Laurianne G. Wild, MD

Best Doctors in New Orleans, New Orleans Magazine 2021, 2022

Messenger, Tulane Professionalism Committee Faculty Advisory Committee Member Senator, Tulane University Member, Professionalism Advisory Board Member, Professionalism Program Trio Director, Deming Department of Medicine Awards of Excellence Committee

Margaret Prat-Huntwork, MD, MPH

Tulane Owl Club Award for Best Attending Physician in Pediatrics

Tulane Pediatrics Department Katherine Knight, MD Award for Outstanding Advocacy for Children’s Healthcare

Castle Connolly Top Doctors 2021, 2022

Messenger, Tulane Professionalism Committee Pediatric Clerkship Director Co-Director of the Tulane Asthma Center of Excellence

Evan Atkinson, MD, MS, FAAAAI, FACAAI, F(ACHI)

Messenger, Tulane Professionalism Committee Member, VHA Field Advisory Board for Allergy Chair, AAAAI VHA Allergists Committee Director, Histocompatibility & Immunogenetics Laboratory

Clinical Immunology, Allergy and Rheumatology and Histocompatibility and Immunogenetics Laboratory (HLA Lab)

The Tulane Histocompatibility and Immunogenetics (HLA) Laboratory provides critical, timely services for transplant programs at Tulane Medical Center, Children’s Hospital of New Orleans, and the Louisiana Organ Procurement Agency. Our HLA lab has been in operation for over 40 years and is one of 150 labs in the US. The field of laboratory transplant immunology is relatively small, and our team members’ expertise is in high demand. Our director Dr. Crowe has over 40 years of experience, is a prior president of the American Society for Histocompatibility and Immunogenetics (AHSI) and is heavily involved in educating colleagues and mentoring newcomers to the field.

Lab supervisors Kellie Jordan and Kathleen Pendergrass collectively have 47 years of experience in the field. Their technologists Gabriel Sanchez, Kensie Smith, Leilani Gammada, Peizhu Li, Peyton Culclager, and Steven Kim work tirelessly to provide routine and on-call testing services including HLA typing for LOPA and flow cytometric cross-matches to facilitate final decisions about patient-donor pairings for renal transplantation. David Waters support day-to-day operations, which include obtaining patient samples needed for pre-transplant monitoring. Rosalind Walters helps manage operations, not a small feat considering the complexity and unique demands of what the lab does. The lab has been growing and currently training two future directors, Drs. Evan Atkinson and Loren Gragert, PhD. This year, despite the COVID-19 pandemic, the lab has conducted 30% more testing than the prior year. The section is proud of the work supporting transplantation, saving lives from the bench one test at a time! They are also proud to support themselves financially through testing performed in accordance with Center for Medicare & Medicaid Services (CMS) regulations. On top of that, they contribute both monetarily and via their expertise to the Department of Medicine.

FACULTY

Allergy and Clinical Immunology

Evan Atkinson, MD, MS Assistant Professor

Margaret Prat-Huntwork, MD, MPH Assistant Professor

STAFF

HLA Laboratory Staff

Kellie Jordan, MS, CHS Laboratory Supervisor

Kathleen Pendergrass, BS Laboratory Supervisor

Rosalind Walters, BS Section Administrator

Laurianne G. Wild, MD Professor

Rheumatology

John Huntwork, MD Assistant Professor

Peizhu Li, MS HLA Laboratory Technologist III

Kensie Smith, BS HLA Laboratory Technologist I

Gabriel Sanchez, BS HLA Laboratory Technologist I

Peyton Culclager, BS HLA Laboratory Technologist I

HLA Laboratory Faculty

Evan Atkinson, MD, MS HLA Lab Director

Loren Gragert, PhD HLA Lab Director-in-training

Quynh Pham, BS HLA Laboratory Technologist I Courtney Hargove, BS HLA Laboratory Technologist I Miya Carter, BS HLA Laboratory Assistant

Publications

Clinical Immunology, Allergy and Rheumatology

Subcutaneous Immunotherapy for Pollen Food Allergy Syndrome: Systematic Review

Finley, A (Finley, Abigail); Atkinson, E (Atkinson, Evan)

Journal Of Allergy And Clinical Immunology Meeting

Abstract: 340 Volume: 147 Issue: 2 Pages: AB107-AB107

Supplement: S Published: FEB 2021

Don’t Rush to Judgement: Systemic Reactions During Rapid Desensitization to Multiple Aeroallergens

Grieb, A (Grieb, Alegra); Chastant, A (Chastant, Alexandra); Atkinson, E (Atkinson, Evan)

Journal Of Allergy And Clinical Immunology

Meeting Abstract: 412 Volume: 147 Issue: 2 Pages: AB129AB129 Supplement: S Published: FEB 2021

Dosing Aeroallergen Immunotherapy from Freshly Prepared Maintenance Vials: To Adjust or Not?

Oberhelman, K (Oberhelman, Katherine); Sutherland, A (Sutherland, Aimee); Atkinson, E (Atkinson, Evan)

Journal Of Allergy And Clinical Immunology Meeting

Abstract: 414 Volume: 147 Issue: 2 Pages: AB129-AB129

Supplement: S Published: FEB 2021

Can allergists provide adequate asthma care in the setting of a school-based health center? Article in Press: Margaret P. Huntwork MD, Alyssa T. Go, Nadia A. Sherif, Theodore K. Lee and Katherine M. Rilett

Annals of Allergy, Asthma & Immunology, Copyright © 2021 American College of Allergy, Asthma & Immunology

Chabot A, Huntwork M. Turmeric as a Possible Treatment for COVID-19-Induced Anosmia and Ageusia. Cureus. 13(9): e17829. doi:10.7759/cureus.17829. September 08, 2021.

Le T, Huntwork M, Carlson J. “Co-existing Exercise-Induced Anaphylaxis and Venom-Induced Anaphylaxis Without Evidence of Systemic Mastocytosis.” Poster Presentation at AAAAI Annual Meeting, held virtually, February 2021.

Copley H, Gragert L, Leach A, Kosmoliaptsis, V. (2021) Influence of HLA class II polymorphism on predicted cellular immunity against SARS-CoV-2 at the population and individual level. Frontiers in Immunology 12:6-8.

Israeli S, Gragert L, Maiers M, Louzoun Y. (2021) HLA Haplotype Frequency Estimation for Heterogeneous Populations Using a Graph-Based Imputation Algorithm. Human Immunology 82(10) 746-757.

Sajulga R, Madbouly A, Fingerson S, Gragert L, Bashyal P, Bolon YT, Maiers M. (2021) Predicting HLA-DPB1 Permissive Probabilities through a DPB1 Prediction Service towards the Optimization of HCT Donor Selection. Human Immunology 82(21) 903-911.

Mayor N, Wang T, Lee SJ, Kuxhausen M, Vierra-Green C, Barker DJ, Auletta J, Bhatt VR, Gadalla SM, Gragert L, Inamoto Y, Morris GP, Paczesny S, Reshef R, Ringden O, Shaw BE, Shaw P, Spellman S, Marsh SGE. (2021) Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation. Journal of Clinical Oncology 39:21 2397-2409.

Story, MS, Wang T, Bhatt VR, Battiwalla M, Badawy SM, Kamoun M, Gragert L, Brown V, Baxter-Lowe LA, Marsh SGE, Gadalla SM, Schetelig J, Mytilineos J, Miklos D, Waller E, Kuxhausen M, Spellman S, Lee S, Armistead PM (2021) Genetics of HLA peptide presentation, and impact on outcomes in HLA-matched allo-HCT. Transplantation and Cellular Therapy 27:7 591-599.

Kransdorf E, Pando M, Stewart D, Lindblad K, Patel J, Kim I, Zhang X, Maiers M, Kobashigawa J, Gragert L. (2021) Stem Cell Donor HLA Typing Improves CPRA in Kidney Allocation. American Journal of Transplantation 21(1) 138-147.

Lalli P, Lunz J, Murphey C, Gargert L. (2022) Change Calculated Panel Reactive Antibody (CPRA) Calculation. U.S. Department of Health & Human Services, HRSA https:// optn.transplant.hrsa.gov/policies-bylaws/public-comment/ change-calculated-panel-reactive-antibody-cpra-calculation/

John W. Deming Department of Medicine

Vivian A. Fonseca, MD, FRCP Assistant Dean for Clinical Research Chief

Section of Endocrinology Professor, Tullis-Tulane Alumni Chair in Diabetes

Endocrinology

CLINICAL ACTIVITIES

The Section of Endocrinology’s mission is to provide high-quality patient care and consult services for patients with a wide range of endocrine-related problems. We achieve this mission through quality patient care, innovative clinical and basic research, and nationally recognized medical education.

Faculty are dedicated endocrinologists providing clinical services at Tulane Medical Center and Tulane Lakeside Hospital, University Medical Center of Louisiana LCMC Health, and Southeast Louisiana Veterans Affairs Health. The services provided at each location are medical nutrition therapy (MNT), diabetes self-management education, and patient support. Clinics in all three institutions have been recognized by organizations such as the American Diabetes Association, which has given recognition for the quality of our physician providers and our patient education programs. We have demonstrated dedication to our primary mission of providing quality care for diverse populations at all three hospitals and clinics.

EDUCATIONAL ACTIVITIES

Our educational mission is highlighted by our fellowship training program, which has graduated numerous fellows who have gone on to join leading physicians at other universities and in private practice. A highlight of the program is our annual Diabetes/Endocrinology Update, a popular and successful program for several years. In addition, our faculty members have served as visiting professors and speakers at several national universities and conferences, including those of the American Diabetes Association, the Endocrine Society, the American Association of Clinical Endocrinologists, and the American College of Physicians.

The Tulane University School of Medicine, Department of Medicine, Section of Endocrinology offers an Accreditation Council for Graduate Medical Education (ACGME) accredited two-year fellowship program exposing training physicians to a full complement of patient care, teaching, and research opportunities at the completion of which trainees are subspecialty board eligible. The program is available to 4 qualified applicants who wish to pursue an academic or clinical career in endocrinology, diabetes, and metabolism.

Clinical and in-patient training takes place at three affiliated teaching facilities: Tulane Medical Center, University Medical Center LCMC Health, and the Southeast Louisiana Veterans Affairs Health.

Endocrinology

RESEARCH ACTIVITIES

The Section of Endocrinology has strong translational and clinical research programs. Its cutting-edge basic and translation- al diabetes research program focuses on improving islet functional mass in diabetes and finding novel ways to prevent diabetes and obesity in a gender-specific manner. Funding comes from the American Diabetes Association, the National Institutes of Health (NIH), and the pharmaceutical industry. Faculty are con- ducting several major national and international trials, which the NIH funds. Through our clinical trials, we have resulted in several publications in leading medical journals. Our research programs endeavor to find innovative ways to treat and cure common endocrine conditions that would improve the quality of life for people with endocrine disorders.

THE CENTER FOR DIABETES AT TULANE MEDICAL CENTER

The Center is an American Diabetes Association (ADA) recognized program. It is primarily a multidisciplinary education teaching resource for adult patients with diabetes and their families, primarily in the outpatient setting. The Center for Diabetes Education provides education on diabetes-related self-care skills, self-management, and counseling on medical nutrition therapy for adult and pediatric patients and their families. Patients are assessed and educated per the American Diabetes Association’s Standards for Recognized Quality Self-Management Education programs. Comprehensive outpatient group classes are also offered in addition to individual counseling. Outpatients are seen with a physician referral, by appointment, and during MD Endocrine clinic visits. Patients are also followed through telephonic and electronic communication when seen by the Tulane Endocrine service.

ADA NATIONAL STANDARDS FOR DIABETES SELF-MANAGEMENT EDUCATION (DSME)

Diabetes Self-Management Education (DSME) is a critical element of care for all people with diabetes and is necessary to improve patient outcomes. The National Standards for DSME are designed to define quality diabetes self-management education and assist diabetes educators in various settings to provide evidence-based education. Because of the dynamic nature of health care and diabetes-related research, these standards are reviewed and revised approximately every five years by key organizations and federal agencies within the diabetes education community.

AWARDS & ACCOMPLISHMENTS

Vivian Fonseca, MD, FRCP

New Orleans Best Doctors – New Orleans Magazine 2022

Expertscape – Named Best specialists in diabetes worldwide 2021

Gerald Reaven Distinguished Leader in Insulin Resistance Award 2022

Dragana Lovre, MD

Castle Connolly Top Doctors 2021

Exceptional Women in Medicine in New Orleans 2021

Global Leadership Academy attendee 2022 (nominated by the Endocrinology Society President) with commitment to advancing endocrine research and practice worldwide

Franck Mauvais-Jarvis, MD, PhD

VA Senior Clinical Scientist Investigator Award 2022

Yilin Yoshida, PhD

American Diabetes Association, Young Investigator Award 2021

Podium speaker of the 2022 Annual BIRCWH Meeting (one of the three among all BIRCWH scholars in 2022)

FACULTY

Vivian Fonseca, MD, FRCP Professor

Franck Mauvais-Jarvis, MD, PhD Professor

Hongju Wu, PhD Professor

STAFF

Gayle Evans Operations Manager

Michelle Frederick Graduate Medical Education Program Administrator II

Robert Galagan, MD Assistant Professor

Dragana Lovre, MD Associate Professor

Charidie Menesses, RN,BSN, MSA CDCE

Diabetes Registered Dietician

Susie Villalobos Manager Diabetes Program

Anna Kiefer

Diabetes Sr. Registered Dietician

Endocrinology

Aanu Sihota, MD Clinical Assistant Professor

Saritha Tirumalasetty, MD Clinical Instructor

Yilin Yoshida, PhD, MPH Assistant Professor

Paula Mota de Sa Postdoctoral

MM Fahd Qadir Postdoctoral

Publications Endocrinology

Yoshida, Y., Shi, L., Fonseca, V.A., et al. Factors associated with Diabetes SelfManagement Education and Support programs in Louisiana. BMJ Open Diabetes Research & Care (in press).

Furman RE, Harlan TS, LeBlanc L, Furman EC, Liptak G, Fonseca VA. Diabetes INSIDE: Improving Population HbA(1c) Testing and Targets in Primary Care With a Quality Initiative. Diabetes Care 2020;43:329336

Desouza CV, Holcomb RG, Rosenstock J, Frias JP, Hsia SH, Klein EJ, Zhou R, Kohzuma T, Fonseca VA. Results of a Study Comparing Glycated Albumin to Other Glycemic Indices. J Clin Endocrinol Metab 2020;105:677-687

Davidson JA, Desouza C, Fonseca V, Frias JP, Van Gaal L, Giorgino F, Chao J, Dex TA, Roberts M, Saremi A, Leiter LA. Glycaemic target attainment in people with Type 2 diabetes treated with insulin glargine/lixisenatide fixed-ratio combination: a post hoc analysis of the LixiLan-O and LixiLan-L trials. Diabet Med 2020;37:256-266

DeSouza C, Cariou B, Garg S, Lausvig N, Navarria A, Fonseca V. Efficacy and Safety of Semaglutide for Type 2 Diabetes by Race and Ethnicity: A Post Hoc Analysis of the SUSTAIN Trials. J Clin Endocrinol Metab 2020;105

Mann JFE, Fonseca VA, Poulter NR, Raz I, Idorn T, Rasmussen S, von Scholten BJ, Mosenzon O. Safety of Liraglutide in Type 2 Diabetes and Chronic Kidney Disease. Clin J Am Soc Nephrol 2020;15:465-473

Peng XV, Ayyagari R, Lubwama R, Shi L, Price-Haywood EG, Hollander P, Fonseca V. Impact of Simultaneous Versus Sequential Initiation of Basal Insulin and Glucagon-like Peptide-1

Receptor Agonists on HbA1c in Type 2 Diabetes: A Retrospective Observational Study. Diabetes Ther 2020;11:995-1005

Satou R, Cypress MW, Woods TC, Katsurada A, Dugas CM, Fonseca VA, Navar LG. Blockade of sodium-glucose cotransporter 2 suppresses high glucoseinduced angiotensinogen augmentation in renal proximal tubular cells. Am J Physiol Renal Physiol 2020;318:F67-f75

Shao H, Shi L, Fonseca V. Comment on Segar et al. Machine Learning to Predict the Risk of Incident Heart Failure Hospitalization Among Patients With Diabetes: The WATCH-DM Risk Score. Diabetes Care 2019;42:22982306. In Diabetes Care United States, 2020, p. e25

Yoshida Y, Cheng X, Shao H, Fonseca VA, Shi L. A Systematic Review of Cost-Effectiveness of Sodium-Glucose Cotransporter Inhibitors for Type 2 Diabetes. Curr Diab Rep 2020;20:12

Shao H, Shi L, Fonseca VA. Using the BRAVO Risk Engine to Predict Cardiovascular Outcomes in Clinical Trials With Sodium-Glucose Transporter 2 Inhibitors. Diabetes Care 2020;43:1530-1536

Alkhatib AL, Kreniske J, Zifodya JS, Fonseca V, Tahboub M, Khatib J, Denson JL, Lasky JA, Lefante JJ, Bojanowski CM. BMI is Associated with Coronavirus Disease 2019 Intensive Care Unit Admission in African Americans. Obesity (Silver Spring) 2020;28:1798-1801

Bachmann KN, Roumie CL, Wiese AD, Grijalva CG, Buse JB, Bradford R, Zalimeni EO, Knoepp P, Dard S, Morris HL, Donahoo WT, Fanous N, Fonseca V, Katalenich B, Choi S, Louzao D, O’Brien E, Cook MM, Rothman RL, Chakkalakal RJ. Diabetes

medication regimens and patient clinical characteristics in the national patientcentered clinical research network, PCORnet. Pharmacol Res Perspect 2020;8:e00637

Davidson JA, Desouza C, Fonseca V, Frias JP, Van Gaal L, Giorgino F, Chao J, Dex TA, Roberts M, Saremi A, Leiter LA. Glycaemic target attainment in people with Type 2 diabetes treated with insulin glargine/lixisenatide fixed-ratio combination: a post hoc analysis of the LixiLan-O and LixiLan-L trials. Diabet Med 2020;37:256-266

Katzmarzyk PT, Martin CK, Newton RL, Jr., Apolzan JW, Arnold CL, Davis TC, Price-Haywood EG, Denstel KD, Mire EF, Thethi TK, Brantley PJ, Johnson WD, Fonseca V, Gugel J, Kennedy KB, Lavie CJ, Sarpong DF, Springgate B. Weight Loss in Underserved Patients - A ClusterRandomized Trial. N Engl J Med 2020;383:909-918

Rosenstock J, Ampudia-Blasco FJ, Lubwama R, Peng XV, Boss A, Shi L, Fonseca V. Real-world evidence of the effectiveness on glycaemic control of early simultaneous versus later sequential initiation of basal insulin and glucagonlike peptide-1 receptor agonists. Diabetes Obes Metab 2020;22:22952304

Parajuli KR, Zhang Y, Cao AM, Wang H, Fonseca VA, Wu H. Pax4 Gene Delivery Improves Islet Transplantation Efficacy by Promoting β Cell Survival and α-to-β Cell Transdifferentiation. Cell Transplant 2020;29:963689720958655

Thethi TK, Sigel A, Japa S, Katalenich B, Liu S, Nguyen T, Larrazolo J, Syu S, Carefoot E, McDuffie R, Fonseca V. Racial and sex differences in the polymorphisms of the endocannabinoid

Department of Medicine

John W. Deming

Publications Endocrinology

receptor genes in obesity. J Diabetes Complications 2020;34:107682

Wang M, Zhou T, Li X, Ma H, Liang Z, Fonseca VA, Heianza Y, Qi L. Baseline

Vitamin D Status, Sleep Patterns, and the Risk of Incident Type 2 Diabetes in Data From the UK Biobank Study. Diabetes Care 2020;43:2776-2784

Yoshida Y, Fonseca VA. Diabetes control in Asian Americans - Disparities and the role of acculturation. Prim Care Diabetes 2021;15:187-190

Xu W, Schiffer L, Qadir MMF, Zhang Y, De sa PM, Keevil BG, Wu H, Arlt W, Mauvais-Jarvis (2020) Intracrine testosterone activation in human pancreatic islets stimulates β cell function. Diabetes,69(11): 2392-2399. (PMID: 32855171)

Parajuli, KR, Zhang Y, Cao, AM, Wang H., Fonseca VA, and Wu H (2020) Pax4 gene delivery improves islet transplantation efficacy by promoting β cell survival and α-to-β cell transdifferentiation. Cell Transplantation, in press. (PMID: 33086892)

Kim DS, Song L, Gou W, Kim J, Wu H, Liu B, Muise-Helmericks RC, Li Z, and Wang H (2021)

GRP94 is an IGF-1R chaperone and regulates β cell death in diabetes.

Nature Communications,under review

Marlatt K*, Lovre D*, Beyl R, Tate C, Hayes E, Burant C, Ravussin E, Mauvais-Jarvis F. Effect of conjugated estrogens and bazedoxifene on glucose, energy and lipid metabolism in obese postmenopausal women. European Journal of Endocrinology. Accepted. *First co-authors

Sex and gender: modifiers of health, disease, and medicine.

Kevorkian JP, Lopes A, Sène D, Riveline JP, Vandiedonck C, Féron F, Nassarmadji K, Mouly S, Mauvais-Jarvis F, Gautier JF, Megarbane B. Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide improve the outcome of hospitalized COVID-19 patients - the Coca-Cola cohort study. J infect. 2021. Feb 9:S01634453(21)00058-X. PMID: 33577902

Mauvais-Jarvis F*, Campesi I, Carrero JJ, Franconi F, Gouni-Berthold I, Berthold H, Heiman ML, Kautzky-Willer A, Murphy A, Regitz-Zagrosek V, Reue K. Sex- and gender-based pharmacological response to drugs. Pharmacol Rev. 2021 Apr;73(2):730-762. PMID: 33653873

Tramut B…, Gautier, JF, Hadjaj S, Cariou B, Mauvais-Jarvis F*, Gourdy P. Sex disparities in COVID-19 presentation and outcomes in hospitalized adults with diabetes: insights from the CORONADO study. Eur J Endoc Submitted

Quadir MMF, Morford JJ, Allard C, Mauvais-Jarvis F*. Loss of nuclear estrogen receptor-α impairs hypothalamic glucose transport and mitochondrial function. A transcriptomic analysis in mice.

Research Endocrinology

Franck

Mauvais-Jarvis, MD, PhD Professor Price-Goldsmith Professor of Nutrition

Dr. Mauvais-Jarvis is the Director of the Diabetes Discovery Research and Sex-Based Medicine Laboratory. Dr. Mauvais-Jarvis’ research program focuses on basic research, translational approaches and clinical studies to understand the role of biological sex and sex hormones 1) in diabetes and obesity, with the goal of developing sex-based therapies. He also studies the role of biological sex, diabetes and obesity in COVID-19 severe outcomes. He has authored over 150 publications on sex differences and the role of sex hormones in diabetes and obesity in journals including Diabetes, Proceedings of the National Academy of Science of the USA, Nature Medicine, Journal of Clinical Investigation, Cell Metabolism, Cell Reports and the Lancet. He is the Editor of the book “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity”. He also serves as Editorial Board member of Diabetes, Molecular Metabolism, JCI Insights, Biology of Sex Differences, and as Associate Editor of the Journal of Diabetes and its Complications. He is the principal investigator of research grants from the National Institutes of Health and the Veterans Health Administration and has received awards from organizations including the Juvenile Diabetes Research Foundation, the American Diabetes Association, the American Heart Association, the March of Dimes Research Foundation and the French Diabetes Association. He is an elected member of the American Society for Clinical Investigation.

Research

NIH COBRE Sex-Based Biology & Medicine (SBM) submitted and reviewed (Score 56) NIH MPI R01 COVID-19 submitted and not funded (with Jay Kolls and Xuebin Qin)

ADA COVID-19 and diabetes grant submitted and funded Tulane COE in SBM internal grant submitted and funded VA Merit Award competitive renewal submitted

Suppl 1. 992-P.

J Lemos, D Baidal, R Poggioli, V Fuenmayor, A Alvarez, E Linetsky, F Mauvais-Jarvis, C Ricordi, R Alejandro. Prolonged Islet Allograft Function in Patients With Type 1 Diabetes After Islet Transplantation Is Associated With Female Sex of Donors and Recipients. Transplantation. 2021. 105. S38-39.

J Xie, Y Zu, A Alkhatib, T Pham, F Gill, A Jang,

S Radosta, G Chaaya, L Myers, J Zifodya, C Bojanowski, N Marrouche, F Mauvais-Jarvis, J Denson. Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans. Critical Care Medicine. 2021.49.51

M Elgazzaz, ED Lazartigues, F Mauvais-Jarvis. Perinatal Exposure to a Western Diet Alters Hypothalamic Gene Expression and Predisposes to Diabetes in Adult Male Mice. Diabetes, 2021. 70. Suppl 1. 172-OR.

M

Research Endocrinology

Difference in the Progression of Metabolic Syndrome Severity from Normoglycemia, Prediabetes, to Diabetes. Diabetes. 2022. 71.Suppl1. 1196-P

K Simon,

Foidart,

Dixon,

Gabbay, W Utian. A Randomized, Doubleblind, Placebo-controlled Trial to Determine the Safety and Efficacy of Estetrol (E4) for the Treatment of Patients with Confirmed SARSCoV-2 Infection (COVID-19). Menopause. 2022. 28 (12), 1447

Mauvais-Jarvis F, Fonseca VA, Prieto MC. Sex differences in soluble prorenin receptor in patients with type 2 diabetes. Biol Sex Differ 2021;12:33

Tang Y, Shah H, Bueno Junior CR, Sun X, Mitri J, Sambataro M, Sambado L, Gerstein HC, Fonseca V, Doria A, Pop-Busui R. Intensive Risk Factor Management and Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: The ACCORD Trial. Diabetes Care 2021;44:164-173

Shi L, Fonseca V, Childs B. Economic burden of diabetes-related hypoglycemia on patients, payors, and employers. J Diabetes Complications 2021;35:107916

Dr Fonseca is an active clinician and has a large referral practice of complex patients from across the state and gulf coast. He has an active research program through PCORI, LACaTs and 2 clinical trials and assists Dr Wu with translational planning in the type 1 diabetes gene therapy program. He applied for a very large PCORI grant to be the coordinating center of a large trial and will reapply shortly. He is also involved in the COVID Recovery study. In his role in LACaTs he is the director of the Professional Development Core and runs the MSCR course. He also supervises clinical research in the CTU and the Endocrine Fellowship Program.

Research Publications Yoshida Y, Fonseca VA. Diabetes control in Asian Americans - Disparities and the role of acculturation. Prim Care Diabetes 2021;15:187190

Visniauskas B, Arita DY, Rosales CB, Feroz MA, Luffman C, Accavitti MJ, Dawkins G, Hong J, Curnow AC, Thethi TK, Lefante JJ, Jaimes EA,

Fonseca VA, Sood M, Galindo RJ. Rationale for the Use of Combination Injectable Therapy in Patients With Type 2 Diabetes Who Have High A1C (≥9%) and/or Long Duration (>8 Years). Clin Diabetes 2021;39:141-145

Davis J, Israni R, Mu F, Cook EE, Szerlip H, Uwaifo G, Fonseca V, Betts KA. Inpatient management and post-discharge outcomes of hyperkalemia. Hosp Pract 2021:1-7

Geng T, Wang M, Li X, Zhou T, Ma H, Fonseca VA, Koh WP, Huang T, Heianza Y, Qi L. Birth weight modifies the relation between adulthood levels of insulin-like growth factor-1 and type 2 diabetes: a prospective cohort study. BMJ Open Diabetes Res Care 2021;9

Khatib JE, Shao Y, Shi L, Fonseca VA. The Association Between Baseline Insulin Treatment and Cardiovascular Events: A Meta-Analysis. J Endocr Soc 2021;5:193

Li X, Zhou T, Ma H, Liang Z, Fonseca VA, Qi L. Replacement of Sedentary Behavior by Various Daily-Life Physical Activities and Structured Exercises: Genetic Risk and Incident Type 2 Diabetes. Diabetes Care 2021; Alhinai A, Patel K, Fonseca VA, Sebastiani G. Non-invasive diagnosis of nonalcoholic fatty

John W. Deming Department of Medicine

JM

F Mauvais-Jarvis, K Kaminska, D Bystritsky, A Vishnevsky, G

F

Vivian Fonseca, MD, FRCP Professor Assistant Dean Clinical Research

liver disease in patients with type 2 diabetes. J Diabetes Complications 2021;35:107

Shi Q, Lin Y, Fonseca VA, Shi L. Optimizing treatment goals for long-term health outcomes among patients with type 2 diabetes mellitus. BMJ Open Diabetes Res Care 2021;9

Lovre D, Bateman K, Sherman M, Fonseca VA, Lefante J, Mauvais-Jarvis F. Acute estradiol and progesterone therapy in hospitalised adults to reduce COVID-19 severity: a randomised control trial. BMJ Open 2021;11

Yoshida Y, Chen Z, Baudier RL, Krousel-Wood M, Anderson AH, Fonseca VA, MauvaisJarvis F. Early Menopause and Cardiovascular Disease Risk in Women With or Without Type 2 Diabetes: A Pooled Analysis of 9,374 Postmenopausal Women. Diabetes Care 2021;44:2564-2572

Yoshida Y, Hong D, Nauman E, Price-Haywood EG, Bazzano AN, Stoecker C, Hu G, Shen Y, Katzmarzyk PT, Fonseca VA, Shi L. Patientspecific factors associated with use of diabetes self-management education and support programs in Louisiana. BMJ Open Diabetes Res Care 2021;9

Hongju Wu, PhD. Associate Professor

CURRENT: Jaguar Gene Therapy, Inc. Title: AAV-Pax4 gene therapy for diabetes (continuation). Total: $1,802,505. Duration: 07/01/2022-06/30/2024. Role:

PI. (Final signature pending)

Jaguar Gene Therapy, Inc. Title: AAV-Pax4 gene therapy for diabetes. Total: $728,000. Duration: 01/01/2021-06/30/2022. Role: PI.

Tulane SOM-TNPRC pilot grant. Title:

Research Endocrinology

Exploiting the therapeutic benefits of Pax4 for islet transplantation using nonhuman primate models. Total: $60,000. Duration: 01/01/2020 –12/31/2021. Role: PI.

PEER-REVIEWED PUBLICATIONS:

Wu, H. and Batuman, V (2021) Novel treatments and the future of diabetic nephropathy: what is on the horizon? Diabetes and Kidney Disease, 2nd edition, edited by E.V. Lerma and V. Batuman), Springer.

Kim DS, Song L, Gou W, Kim J, Wu H, Liu B, Muise-Helmericks RC, Li Z, and Wang H (2022) GRP94 is an IGF-1R chaperone and regulates β cell death in diabetes. PNAS, under review.

Wu, H and V. Batuman. Novel Treatments and the future of DKD: what is on the horizon? Diabetes and Kidney Disease 2nd edition (2022), Chapter 28: p601-635. Publisher: Springer. Edited by Lerma and Batuman. Dragana Lovre, M.D. Associate Professor

Effects of Novel Estrogens on Glucose and Lipids in Postmenopausal Prediabetic Women Veterans

COMPLETED Tulane Physician Scientist Pipeline Program (PSPP)

Highlighted Poster Presentation. Gupta S, Lovre D, Galagan

Yoshida Y, Gillet SA, Brown MI, Zu Y, Wilson SM, Ahmed SJ, Tirumalasetty S, Lovre D, Krousel-Wood M, Denson JL, Mauvais-Jarvis F. Clinical characteristics and outcomes in women and men hospitalized for coronavirus disease 2019 in New Orleans. Biol Sex Differ. 2021 Feb 5;12(1):20. PMID: 33546750. Lovre D, Bateman K, Sherman M, et al. Acute oestradiol and progesterone therapy in hospitalised adults to reduce COVID-19 severity: a randomised control trial. BMJ Open. 2021;0:e053684. PMID: 34848523

Presentations

Kontoghiorghes P, Lovre D, Galagan R. Occurrence of Hepatocellular Carcinoma in a 40-Year-Old Male With MEN2A Syndrome. (P-56) The Endocrine Society Annual Meeting, March 2021. *accepted for virtual poster presentation due to COVID-19.

Lee TH, Lovre D, Galagan R. Metastatic Adrenocortical Carcinoma Co-Secreting Multiple Steroid Hormones. Metastatic Adrenocortical Carcinoma Co-Secreting Multiple Steroid Hormones. The Endocrine Society Annual Meeting, March 2021. *accepted for virtual poster presentation due to COVID-19.

Gupta S, Lovre D, Galagan R. New Onset of Graves’ Disease After COVID-19: Case Series (#481). American Thyroid Association 90th Annual Meeting. October 2021. *Virtual

Diabetes and its Complications (in press).

Yoshida, Y., Chen, Z., Baudier, R.L., Anderson, A.H., Fonseca, V.A., Mauvais-Jarvis, F. Sex difference in progression of metabolic syndrome severity in diabetes development. JAMA Network Open (in press).

Lee, C.C., Tan, J., Yoshida, Y., Ma, K.S.K., Mauvais-Jarvis, F. Gender differences in healthprotective behaviours and its implications for COVID-19 pandemic in Taiwan: A populationbased study. BMC Public Health (in press).

Yoshida, Y., Chen, Z., Baudier, R.L., Anderson, A.H., Fonseca, V.A., Mauvais-Jarvis, F. Menopausal hormone therapy and risk of cardiovascular events in women with prediabetes or type 2 diabetes: A pooled analysis of 2917 postmenopausal women. Atherosclerosis. 2022 Jan 22;344:13-19. doi: 10.1016/j. atherosclerosis.2022.01.016. Epub ahead of print. PMID: 35114556.

Denson, J.L., Gillet, A.S., Zu, Y., Brown, M., Pham, T., Yoshida, Y., Mauvais-Jarvis, F. et al, Metabolic Syndrome and Acute Respiratory Distress Syndrome in Coronavirus Disease 2019. JAMA Network open vol. 4,12 e2140568. 1 Dec. 2021, doi:10.1001/jamanetworkopen.2021.4056

Sathi, B.K., Yoshida, Y., Weaver, M. L., Nolan, L., Leiva- Salinas, C. Unusually High Prevalence of Stroke and Cerebral Vasculopathy in Hemoglobin SC Disease: A Retrospective Single Institution Study. Acta Haematol. 2021 Nov 8:1-9.

Yoshida, Y., Chen, Z., Baudier, R.L., Anderson, A.H., Fonseca, V.A., Mauvais-Jarvis, F. Early Menopause and Cardiovascular Disease Risk in Women with or without Type 2 Diabetes: A Pooled Analysis of 9,374 postmenopausal women. Diabetes Care. 2021 Nov;44(11):25642572.

Yoshida, Y., Shi, L., Fonseca, V.A., et al. Patientspecific factors associated with the use of

Research Endocrinology

diabetes self-management education and support programs in Louisiana. BMJ Open Diabetes Res Care. 2021 Dec;9(Suppl 1):e002136. doi: 10.1136/bmjdrc-2021-002136.

Phillippi S, Thomas CL, Yoshida Y, Afaneh H. Holistic representation in juvenile defense: An evaluation of a multidisciplinary children’s defense team. Behav Sci Law. 2021;1–18.

Yoshida, Y., Brown, M.I., Gillet, S.A., Zu, Y., Wilson, S., Ahmed, S., Tirualasetty, S. ,Lovre, D., Krousel-Wood, M., Denson, J.L., Mauvais-Jarvis, F. Sex-based clinical characteristics and outcomes in patients hospitalized for COVID-19 in New Orleans. Biol Sex Differ 12, 20 (2021).

Lectures

Yoshida, Y. Role of prediabetes and undiagnosed diabetes in women’s excessive cardiovascular disease. November 2022 (one of the three podium speakers among over 50 BIRCWH scholars in the U.S.).

Yoshida, Y. Sex differences in risk of cardiovascular disease associated with diabetes. Louisiana Lagniappe Series. Louisiana Clinical & Translational Science Center (LA CaTS). June 16, 2022

JOHN W. DEMING DEPARTMENT OF MEDICINE Charitable

Giving

The John W. Deming Department of Medicine is positioned to play a key role in transforming healthcare within our community and beyond. Through your support, the department continues to expand and build upon our mission of providing world-class education, cutting edge research, and outstanding patient care.

To advance this mission, the philanthropic support of individuals is critical. You can make an immediate impact with gifts of cash, stock and other assets. You can also help sustain and enrich academic excellence and advance research with future gifts from your estate. Philanthropic giving within the department is primarily directed at the following priorities:

· Research: Support our residents, fellows and faculty as they continue to lead in interdisciplinary, groundbreaking research.

· Faculty Support: Recognize the talent and expertise of our faculty, those in the early stages of their academic and research careers as well as our established faculty members.

· Fellowship/Resident Support: Provide meaningful training and research opportunities for our residents and fellows.

The John W. Deming Department of Medicine gratefully accepts gifts that will further the school’s mission of research, education, and patient care. Your gift will have a lasting impact on the future of science and medicine.

We invite you to support the department’s outstanding research, patient care and medical training and education. There are many ways to support our mission and to build a better future for our department, school, community, and world.

To learn more about making a gift to the John W. Deming Department of Medicine contact: Holly Gulden Associate Vice President of Advancement Executive Director of Development for School of Medicine hgulden@tulane.edu

“The reason we established the Bruce and Sherry Healey Faculty Research, Teaching, and Service Endowed Fund is quite simple – the school of medicine provided me and many family members with an excellent education; and for that, we are truly grateful.”

Sherry and Bruce Healey, MD

Gastroenterology and Hepatology

Martin Moehlen, MD, MPH Associate Professor of Medicine & Surgery Interim Section Chief

Director, GI & Hepatology Research, Program Director, GI Fellowship Section of Gastroenterology & Hepatology

The Section of Gastroenterology and Hepatology has a tradition of major contributions in clinical and basic science research, training the next generation of gastroenterology fellows for academic and clinical careers, and providing personal care for patients with complex gastrointestinal and liver diseases.

Faculty are individuals with expertise in general gastroenterology, hepatology (including liver transplant), advanced therapeutic endoscopy, inflammatory bowel disease, neuro gastroenterology & motility, and colorectal cancer genetics. The Section continues to serve New Orleans with their expertise and continue to grow in faculty in the Department.

RESEARCH ACTIVITIES

Industry sponsored clinical trials support much of the Section’s ongoing research. The main researchers are

Moehlen, MD, MPH Associate Professor

EDUCATIONAL ACTIVITIES

The training program in gastroenterology at Tulane is a three-year Accreditation Council for Graduate Medical Education (ACGME)-approved subspecialty program leading to competence in the independent practice of general gastroenterology. The curriculum follows guidelines for GI training set down by the American Board of Internal Medicine (ABIM). Trainees rotate among three main sites, including Tulane Medical Center, University Medical Center LCMC Health, and the Southeast Louisiana Veterans Affairs Health.

The faculty of the Section of Gastroenterology & Hepatology are devoted to the training of our fellows. Fellows engage within a full spectrum of general gastroenterology and hepatology. The mentorship program pairs each fellow with a faculty member who can guide the fellow’s career. Fellows treat a diverse patient population in demographics (race, religion, socio-economic status) and diversity and severity of the disease.

Tulane is a tertiary center for hepatology/liver transplantation, advanced endoscopy, and motility disorders, attracting patients throughout Louisiana and southern Mississippi, Alabama, the Florida panhandle, and Latin America. Clinical activities are conducted at Tulane University Medical Center, University Medical Center LCMC Health, and the Southeast Louisiana Veterans Affairs Health.

Martin

Fredric Regenstein, MD Professor

Solange Abdulnour Nakhoul, PhD, AGAF Associate Professor

Gastroenterology and Hepatology

AWARDS & ACCOMPLISHMENTS

Fredric Regenstein, MD

Castle Connolly Top Doctors 2022 Rebekah H. Lemann, MD

Castle Connolly Top Doctors 2022

Martin Moehlen, MD

Castle Connolly Top Doctors 2022

FACULTY

Martin William Moehlen, MD Associate Professor

Fredric G. Regenstein, MD Professor

Solange Abdulnour-Nakhoul, PhD, AGAF Associate Professor Research

Robert J. Richard, MD Associate Professor

Brian Ting, MD Assistant Professor

ADJUNCT FACULTY

Daniel Raines, MD

Howard Brenner, MD

Vernon Carriere, MD

Julie C Guider, MD

Brett Hymel, MD

Shantiprakas Kedia, MD

Abdul M. Khan, MD

STAFF

Jean Paul Lefort Section Administrator

Margaret D. Rabito, RN Research Nurse

Elaine C. Boos, RN Research Nurse

Richard Awtrey, MD Castle Connolly Top Doctors 2022 Rebekah H. Lemann, MD Exceptional Women in Medicine 2021, 2022

Benjamin A. Guider, MD Assistant Professor

Kaitlin Occhipinti, MD Assistant Professor

Lauri Frances Hengl, NP Instructor

Ai Riza Koksal, MD Postdoctoral Fellow

Sarath V. Krishnan, MD

Rebekah H. Lemann, MD

James D. Lilly, MD Mark Marino, MD Herbert K. Mayer,MD Scott D. Pollack, MD Sanjeeva Reddy, MD

Gary Reiss, MD

Charles, Schibler, MD

David Silvers, MD

Robin Staudinger, MD Rian Tanenbaum, MD Mark Wegmann, MD

Clarissa Koederitz

Graduate Medical Education Program Administrator II Anna Hero

Clinical Protocol Technician

Impaired Authophagy Response in Hepatocellular Carcinomas Enriches Glypican-3 in Exosomes, Not in the Microvesicles. Koksal AR, Thevenot P, Aydin Y, Nunez K, Sandow T, Widmer K, Nayak L, Scott J, Delk M, Moehlen MW, Cohen AJ, Dash S. J Hepatocell Carcinoma. 2022 Sep 7;9:959-972. doi: 10.2147/JHC.S376210. eCollection 2022.

Emerging Treatment Strategies for Patients With Primary Biliary Cholangitis. Moehlen MW. Gastroenterol Hepatol (N Y), 2021 Dec;17(12):558-6.

Geographic Variation in Colorectal Cancer Icidence Among Asian Americans: A Population-Based Analysis 2006-2016. Wang CP, Lin JJ, Shah SC, Kim MK, Montminy EM, Rustgi SD, Karlitz JJ, Itzkowitz SH. Clin Gastroenterol Hepatol. 2022 Feb 3:S1542-3565(22)00080-5. doi: 10.1016/j.cgh.2022.01.026.

Shifting in the Proportion of Distant Stage Early-Onset Colorectal Adenocarcinoma in the United States. Montminy EM, Zhou M, Maniscalco L, Heda R, Kim MK, Patel SG, Wu XC, Itzkowitz SH, Karlitz JJ. Cancer Epidemiol Biomarkers Prev. 2022 Feb;31(2):334-341. doi: 10.1158/10559965.EPI-21-00611. Epub 2022 Jan 26.

Spectrum of Advanced Colorectal Neoplasia and Anticipated Yield of Average-Risk Screening in Veterans Under Age 50. Yen T, Scolaro J, Montminy E, Karlitz JJ, Wani S, Patel SG. Clin Gastroenterol Hepatol. 2021 Nov 18:S1542-3565(21)01229-5. Doi: 10.1016/j.cgh.2021.11.017.

Ussing Chamber Methods to Study the Esophageal Epithelial Barrier. Abdulnour-Nakhoul SM, Nakhoul NL. Methods Mol Biol. 2021;2367:215-233.

doi: 10.1007/7651_2020_324.

The Effects of Co‐Expression of Rhbg with Human CA‐IV on NH 3 /NH 4 + and CO 2 Transport , Zhou, He & Abdulnour-Nakhoul, Solange & Nakhoul, Nazih. The FASEB Journal 35: 10.1096/fasebj.2021.35.S1.03649

May 2021

Trends in the Incidence of Early-Onset Colorectal Adenocarcinoma Among Black and White US Residents Aged 40 to 49 Years, 2000-2017. Montminy EM, Zhou M, Maniscalco L, Penrose H, Yen T, Patel SG, Wu XC, Karlitz JJ. JAMA Netw Open. 2021 Nov 1;4(11):e2130433. doi: 10.1001/ jamanetworkopen.2021.30433.

Multicenter, Double-Blind, Randomized Trial of Emricasan in Hepatitis C-Treated Liver Transplant Recipients With Residual Fibrosis or Cirrhosis. Weinberg EM, Curry MP, Frenette CT, Regenstein FG, Schiff ER, Goodman ZD, Robinson JM, Chan JL, Imperial JC, Reddy KR. Liver Transpl. 2021 Apr;27(4):568-579. doi: 10.1002/ lt.25934. Epub 2020 Dec 29. PMID: 33164276 Clinical Trial.

Extracellular Vesicle Release Promotes Viral Replication during Persistent HCV Infection. Aydin Y, Koksal AR, Reddy V, Lin D, Osman H, Heidari Z, Rhadhi SM, Wimley WC, Parsi MA, Dash S. Cells. 2021 Apr 22;10(5):984. doi: 10.3390/cells10050984. PMID: 33922397

Adenocarcinomas, as opposed to carcinoids, are primarily driving increases in early-onset colorectal cancer rates. Karlitz JJ, Montminy EM, Itzkowitz SH. Gastroenterology. 2021 Mar 19:S0016-5085(21)00532-1. doi: 10.1053/j.gastro.2021.03.024. Online ahead of print. PMID: 33753101 No abstract available.

Publications Gastroenterology

Contributions of Adenocarcinoma and Carcinoid Tumors to Early-Onset Colorectal Cancer Incidence Rates in the United States. Montminy EM, Zhou M, Maniscalco L, Abualkhair W, Kim MK, Siegel RL, Wu XC, Itzkowitz SH, Karlitz JJ. Ann Intern Med. 2021 Feb;174(2):157-166. doi: 10.7326/ M20-0068. Epub 2020 Dec 15. PMID: 33315473

Background and Evaluation of Hypercoagulability. Gish RG, Regenstein FG. Gastroenterol Hepatol (N Y). 2021 Jan;17(1 Suppl 1):3-10. PMID: 34135698 Free PMC article. No abstract available.

Feasibility of Utilizing PREMM Score for Lynch Syndrome Identification in an Urban, Minority Patient Population. Adviento B, Conner M, Sarkisian A, Walano N, Andersson H, Karlitz J. J Prim Care Community Health. 2021 Jan-Dec;12:21501327211020973. doi: 10.1177/21501327211020973. PMID: 34053368

Artificial intelligence in gastrointestinal endoscopy. Pannala R, Krishnan K, Melson J, Parsi MA, Schulman AR, Sullivan S, Trikudanathan G, Trindade AJ, Watson RR, Maple JT, Lichtenstein DR. VideoGIE. 2020 Nov 9;5(12):598613. doi: 10.1016/j.vgie.2020.08.013. eCollection 2020 Dec. PMID: 33319126 Free PMC article.

Screening for Colorectal Cancer. Montminy EM, Jang A, Conner M, Karlitz JJ. Med Clin North Am. 2020 Nov;104(6):1023-1036. doi: 10.1016/j. mcna.2020.08.004. PMID: 33099448 Review.

A Rare Cause of Recurrent Abdominal Pain and Chronic Diarrhea, Patton, Grant; Ghazala, Sehem; Medvedev, Sabeen The American Journal of Gastroenterology: October 2020 Volume 115 - Issue - p S874 doi:

Publications

From Small Cell Neuroendocrine Carcinoma of the Lung Basilio, Carlo; Locklear, Cameron; Hefler, Henry. The American Journal of Gastroenterology. 115:S1531, October 2020.

General Internal Medicine and Geriartrics and Palliative Medicine

Geraldine Ménard, MD, FACP, FHM

Associate Professor Chief

Section of General Internal Medicine and Geriatric Director of Hospitalist & Consultative Medicine

Vice Chair, Clinical Affairs Deming Department of Medicine

GENERAL INTERNAL MEDICINE AND GERIATRICS AND PALLIATIVE MEDICINE

The Tulane Section of General Internal Medicine, Geriatrics, and Palliative Medicine Section is part of an institution with a proud and distinguished history of providing care for varied populations around the globe, advancing medical knowledge, and training the next generation of physicians. Tulane’s General Internal Medicine Section has 58 full and part-time faculty members involved in ambulatory medicine, geriatrics, hospital medicine, medicine-pediatrics, palliative care, and preventative health care. Our physicians are passionate clinician-educators, who promote life-long learning and mentorship of our students, residents, and fellows at three affiliated medical centers: University Medical Center LCMC Health, Southeast Louisiana Veterans Affairs Health, Tulane Medical Center, and various community sites throughout New Orleans. Through educational and curricular innovations, our Section faculty are at the table and leading change initiatives to inspire the next generation of physicians and elevate healthcare in New Orleans and our surrounding communities. Section faculty are healthcare leaders within the department, school, region and nationally advocating for quality improvements, patient safety, social justice, and equality in healthcare for our patients and learners.

MISSION

Our missions are to use evidence-based medicine to provide the highest quality, patient-centered care; Educate our medical students and residents in the practice of evidence-based medicine, professionalism, and humanism; Grow and respect the diversity of our faculty members in their academic endeavors of the School of Medicine’s three missions-clinical, educational, and research have maintained and expanded our devotion to caring for underserved populations.

CLINICAL ACTIVITIES

The General Internal Medicine, Geriatrics, and Palliative Medicine faculty practice at the three New Orleans inner-city hospitals. Faculty practice at several ambulatory clinic sites including Tulane’s Living Well Clinics at Uptown Square and Downtown, Tulane’s Internal Medicine Practice-Downtown, Tulane’s Lakeside Multi-Specialty Clinic, Tulane’s Multispecialty Clinic at Uptown Square, and the Tulane Total Health Clinic. In addition, the Section has affiliations with St. Margaret’s Nursing Home and Heart of Hospice.

St. Margaret’s Nursing Home is our nursing home partner. Dr. Jay St. John serves as the Medical Director. Faculty and nurse practitioners teach residents and medical students on geriatrics related health issues, including cognition assessments, mobility, frailty, chronic illnesses and quality and operations of long-term care facilities. Several residents maintain a continuity panel of patients at St. Margaret’s shared with their faculty preceptor.

Heart of Hospice is the hospice partner for our Hospice and Palliative Medicine Fellowship. Fellows learn hospice medicine with Heart of Hospice through hands-on participation in their daily care team

General Internal Medicine and Geriartrics and

Palliative Medicine

operations, participating in interdisciplinary care team meetings, learning about the hospice benefit, and leading patient visits. The Heart of Hospice Foundation provides funding for fellow rotations, programmatic support for educational and program-building activities, and training sessions for the fellows on home hospice visits.

Tulane Connected Care specializes in caring for the most vulnerable patients – physically frail, elderly people with complex, chronic health issues. Dr. Ricardo Febry leads a team of physicians and nurse practitioners in a comprehensive care model designed for the elderly’s convenience and comfort. Primary care is delivered by a team of physicians, nurse practitioners, and other clinical experts at the patient’s location – whether it’s in a home, assisting living center, skilled nursing facility, nursing home or other long-term care facilities. The team also coordinates with emergency care physicians and hospitalists if inpatient admission is required.

LEADERSHIP

Deepa Bhatnagar, MD

Internal Medicine Residency Program Director

Abigail Byrne, MD

Tulane Internal Medicine Clerkship Director

Chayan Chakraborti, MD

Associate Dean for Medical Education and Academic Affairs

Sarah Cossich, MD

Tulane Associate Chief for Inpatient Services

Jessica DeBord, MD

Clerkship Director, Foundations in Medicine

Tulane Medicine/Pediatrics residency Program Director

Marcia Glass, M

Tulane Hospice and Palliative Medicine Program Director

Irene Grundy, MD

Chief Academic Officer, Southeast Louisiana Veterans Affairs Health

Michelle Guidry, MD

Chief of Hospital Medicine, Southeast Louisiana Veterans Affairs Health

Jacey Jones, MD

Clerkship Director of Clinical Diagnosis

Lumie Kawasaki, MD

Chief of Geriatrics, Southeast Louisiana Veterans Affairs Health

Michael Landry, MD

Chief of Medicine, Southeast Louisiana Veterans Affairs Health

Brandon Mauldin, MD

Tulane Medical Center Chief Medical Officer

Sonia Malhotra, MD

University Medical Center-New Orleans Palliative Medicine Medical Director

Tony Marsh, MD Chief of Ambulatory, Southeast Louisiana Veterans Affairs Health

Cait Martin-Klinger, MD

Assistant Chief of Staff, Southeast Louisiana Veterans Affairs Health Marlowe Maylin, MD

Tulane Medical Center Hospital Medical Director Marlowe Maylin, MD

Tulane Medical Center Medical Executive Committee, Member at Large

Geraldine Menard MD Vice Chair-Clinical Affairs, Tulane Department of Medicine

Geraldine Menard, MD

University Medical Center-New Orleans, Medical Executive Committee Member at Large Tulane School of Medicine Wellness Committee Co-Chair

Robert Miller, MD

Site Director, Southeast Veterans Affairs Hospital and System

Celeste Newby, MD

Tulane Acting Internship Clerkship Director ACP Louisiana Chapter Health Policy Chair

Helen Pope, MD

Tulane Student Run Clinics Faculty Advisor

Ben Rothwell Tulane Simulation Center Co-Director

General Internal Medicine and Geriartrics and Palliative Medicine

Dale Shamburger, MD

University Medical Center-New Orleans Co-Chief Academic Officer

Luke Taggart, MD

Site Director, Southeast Veterans Affairs Hospital and System Isis Smith, MD Curriculum Director for Equity, Diversity, and Inclusion

RESEARCH

David Spruill, MD

University Medical Center-New Orleans-Case Management Physician Medical Director

Luke Taggart, MD Site Director, Southeast Louisiana Veterans Affairs Health

The Section of General Internal Medicine and Geriatrics has a solid research foundation and embraces the growth and expansion of our research initiatives and programs. Faculty receive funding from several agencies such as the Health Resources and Services Administration, Robert Wood Johnson Foundation, Louisiana Public Health Institute, and the Agency for Healthcare Research and Quality.

Research faculty collaborate with other faculty from the Departments of Epidemiology, Pediatrics, Oncology, Tulane School of Public Health, and RAND Gulf States Policy Institute. Our most recently funded partnership with University of California-Irvine on expanding the primary work force in geriatrics and disaster management has led to the successful approval of the Geriatrics fellowship program this year and collective implementation of best practices in disaster planning, particularly surrounding our elderly patients.

EDUCATIONAL ACTIVITIES

Our academic hospitalists and ambulatory clinicians are the primary educators of Tulane medical students during their third- and fourth- year core Medicine clerkship and acting internship as well as 100+ internal medicine residents at our three affiliated hospitals. Faculty teach didactic lectures, interactive small group sessions, and practice simulation sessions in patient safety within newly remodeled space at the Murphy Building downtown, centrally located near the primary clinical sites.

The Hospice and Palliative Medicine fellowship program launched in 2019 and has been highly successful! It is currently the only Hospice and Palliative Medicine fellowship program in the state of Louisiana. Hospice and Palliative Medicine Fellowship is one where there may be many great palliative fellowship programs in the US, but none quite like Tulane HPM. Nowhere else will you find the combination of educational innovation, patient diversity, research excellence, career advancement, and life fulfillment. We are the first Health Policy Management (HPM) program accredited in Louisiana. We bring together a diverse group of palliative medicine faculty from the University of Alabama, MD Anderson, University of Pittsburgh, Harvard University, and the University of California, San Francisco.

We provide in-patient and outpatient palliative services at University Medical Center LCMC Health, a safetynet hospital and Level 1 trauma center in downtown New Orleans, and the Southeast Louisiana Veterans Affairs Health across the street. We also partner with Heart of Hospice to provide the full range of required experiences for HPM fellows. The program is unique in combining a classical, ACGME-approved palliative curriculum with integrative and alternative medicine, narrative medicine, addiction medicine, resilience training, prison advocacy, and international palliative rotations in partnership with Harvard and UCSF.

The Geriatrics fellowship program, newly approved in 2021, has begun with the recruitment of additional geriatrics faculty with plans for our first fellowship match in Spring of 2023. We are thrilled to see the return of Geriatrics fellowship training to Tulane and aspire to have ambitious growth and continued partnership with St. Margaret’s Nursing Home and Tulane Connected Care, and other community partners. We are strategically looking ahead towards offering combined dual fellowship program of Hospice and Palliative Medicine and Geriatrics in the future.

General Internal Medicine and Geriartrics and Palliative Medicine

AWARDS & ACCOMPLISHMENTS

Kristen Bateman, MD

Best Attending by the Internal Medicine Residency for 2020-2021.

Department of Medicine Teaching Award for 2021-2022

Chayan Chakraborti, MD 2021 Tulane School of Medicine Faculty Mentorship Award

Chair, AAIM Medical Education Research Committee

Associate editor for IM, AAMC MedEdPORTAL Councilor, ACP La Chapter Chair, Albert Schweitzer Foundation Fellowship La chapter

Test Development committee member, USMLE Test Development committee member, NBME, IM group

Sarah Cossich, MD

University Medical Center New Orleans LCMC Health Physician Leadership Award for 2021-22 Michelle Christopher, MD

University Medical Center New Orleans LCMC Health Best New Physician Award 2020-2021. Hospice and Palliative Medicine Best Attending, 2021-2022

Vanessa Durbin Department of Medicine Clinical Support Award for 2021-2022

Ricardo Febry, MD Tech Star in Healthcare Award for 2022 given by Zoho Corp for TeleMD360

Marcia Glass, MD Vice Chair of Tulane School of Medicine Faculty 2020-2021

Catherine Jones, MD

2021 Tulane School of Medicine Teaching Scholar

Jacey Jones, MD Tulane Curriculum Committee 2020-2021

2022 New Orleans Healthcare Heroes by City Business magazine

Callie Linden, MD

University Medical Center New Orleans LCMC Best Health Clinic Physician Award 2020-2021

Sonia Malhotra, MD

American Academy of Hospice and Palliative Medicine (AAHPM): Co-Chair, Annual Board Review Course (20202023), Co-Chair, Diversity/Equity/Inclusion Council (2022-2023)

Emerging Leaders Award Center to Advance Palliative Care (CAPC): Faculty for Palliative Medicine Program Development & Expansion

Louisiana Governor’s Statewide Council on Palliative Medicine, Appointed Position (20192022)

Tulane University: Certified Coach for the Anti-Racism Leadership Institute

Faculty Advisor, Racial & Social Justice in Medical Education Committee Faculty Advisor, SLAM Coalition (2019-2021)

University Medical Center: Physician Lead, Schwartz Rounds New Orleans Regional Leadership Institute: Member of the Board

Faculty Champion for Health Equity - University Medical Center New Orleans LCMC Health, 2022

American Heart Association Women of Impact, 2022

Tulane Anti-Racism Cohort Graduation Speaker, 2021

Arnold Gold Foundation Leonard Tow Humanism Award - 2021

NRC Excellence in Human Understanding Award Finalist, 2021

Danielle Metz

Tulane DOM Departmental Excellence in Clinical Support for her work as a community health worker for formerly incarcerated patients

General Internal Medicine and Geriartrics and Palliative Medicine

Anjali Niyogi, MD

Tulane’s “Heroes and Helpers” for her work on “Letters from the Porch: New Orleans Serenades its Medical Community

2021 School of Medicine Humanitarian and Community Outreach Award Celeste Newby, MD

Best Inpatient Attending by the Internal Medicine residency for 2021-2022.

ACP Louisiana Chapter, Chair- Health and Public Policy

ACP Louisiana Chapter, Co-Chair-Early Career Physicians

LEAHP alumni peer mentor for current LEAHP scholars-SGIM

AI clerkship director-Tulane SOM

APD IM residency program, Tulane University

Advocacy Pathway Advisor, IM residency program, Tulane University

Dale Shamburger, MD

University Medical Center New Orleans LCMC Health Quality Award for 2021-22

Isis Smith, MD

Curriculum Director for Equity, Diversity, and Inclusion for the School of Medicine

Erica Tate, MD

Best Ambulatory Attending by the Internal Medicine residency for 2021-2022.

2021, 2022 Exceptional Women in Medicine

2022 School of Medicine Faculty Recognition Award for Diversity and Inclusion

ADVOCACY

Dale Shamburger, MD

University Medical Center New Orleans LCMC Health Quality Award for 2021-22

2020-2021 Castle Connolly Top Doctors

Terry Cummings, MD, Clinical Associate Professor of Medicine and Pediatrics

Rachana Sus, MD, MPH Assistant Professor

Erica Tate, MD Assistant Professor

2021-2022 Castle Connolly Top Doctors

Terry Cummings, MD Clinical Associate Professor of Medicine and Pediatrics

Rachana Sus, MD, MPH Assistant Professor

Marlowe Maylin, MD Assistant Professor

Erica Tate, MD Assistant Professor Isis Smith, MD Assistant Professor

Jon Gugel, MD Assistant Professor

Sonia Malhotra, MD Associate Professor

The Brinton Family Health & Healing Center opened in April 2012 at the Ruth U. Fertel/Tulane Community Health Center benefiting thousands of New Orleanians living in the Tremé neighborhood bordering the historic French Quarter. The mission of the Brinton Family Health & Healing Center has been to promote health and connection of community resources to those in need through in-clinic and community events and programs, acting as a liaison between the clinic, patients, and community, and coordinating volunteer and internship opportunities for future leaders in medicine and public health.

Our community health workers specialize in specific community populations. Fernando Sosa is our Latinx Community Health Worker who helps Latinx patients and community members navigate the health- care system and connects them with community resources. Danielle Metz focuses on formerly incarcerated patients. Danielle connects with patients within 72 hours of being released from prison when patients are the most vulnerable to do a social intake and connect them with much-needed resources, including doctors, Medicaid or insurance enrollment, peer support counseling, and more.

General Internal Medicine and Geriartrics and Palliative Medicine

PROFESSIONAL SOCIETIES

The Section was honored to have two faculty members elected to leadership roles within the SOM

Marcia Glass, MD was named Vice Chair of the Tulane SOM General Faculty

Chayan Chakraborti, MD

Chair, AAIM Medical Education Research Committee

Associate editor for IM, AAMC MedEdPORTAL Councilor, ACP La Chapter Chair, Albert Schweitzer Foundation Fellowship La chapter Test Development committee member, USMLE Test Development committee member, NBME, IM group

Michelle Guidry, MD

VA Hospitalist Field Advisory Board Lead Hospitalist, VISN 16

Michael Landry, MD VA Chiefs of Medicine Field Advisory Board LEAD mentor, SGIM Medical Director, Louisiana Pulmonary Diseases Camp and Camp Pelican NBME Step 3 Clinical Case Scenario reviewer

FACULTY

Kristi Alcina, APRN, FNP Instructor

Dominique Anwar, MD Associate Professor Adjunct

Meredith M. Barr, MD Assistant Professor

Kristin Bateman, MD

Assistant Professor, Associate Program Director, Internal Medicine

Jacey Jones, MD was named to the Tulane SOM Curriculum Committee

Celeste Newby, MD

ACP Louisiana Chapter, Chair- Health and Public Policy ACP Louisiana Chapter, Co-Chair-Early Career Physicians LEAHP alumni peer mentor for current LEAHP scholars-SGIM

Sonia Malhotra, MD

American Academy of Hospice and Palliative Medicine (AAHPM)

Co-Chair, Annual Board Review Course (20202023) Co-Chair, Diversity/Equity/Inclusion Council (2022-2023)

Emerging Leaders Award

Lydia Bazzano, MD, PhD

Professor in Nutrition Research Director, Tulane Center for Lifespan Epidemiology Research

Deepa Bhatnagar, MD

Associate Professor of Medicine & Pediatrics Program Director, Internal Medicine Residency Program

Daniel Brady, MD Instructor

Rebecca Burke, MD

Assistant Professor Abigail Byrne, MD Instructor

Pete Caldwell, MD Assistant Professor Adjunct Anne Jacob Carrere, MD Assistant Professor

Chayan Chakraborti, MD, FACP, FHM

Professor of Medicine Associate Dean for Medical Education and Academic Affairs

Michelle Christopher, MD Assistant Professor

Amanda Cooke, MD Assistant Professor

Jan Cooper, MD Associate Professor Adjunct

Sarah Cossich, MD Assistant Professor

Lisa Craft, APRN, MN, CS Instructor

Terry Cummings, MD Associate Professor of Medicine & Pediatrics Senior Advisor

Cabrina Ridley-Davis, NP Instructor

Jessica DeBord, MD, MPH

Assistant Professor of Medicine & Pediatrics Director of Foundations in Medicine, Interim Director, Tulane Internal Medicine-Pediatrics Residency Program

Monica Dhand, MD Assistant Professor Anne Favret, APRN, FNP-BC, ACHPN Instructor

Ricardo Febry, MSc, MD Assistant Professor

Domnica Fotino, MD, MPH Assistant Professor

William Gilbert, MD Assistant Professor

Michael Gillette, MD Clinical Instructor Co- Director Resident Initiative in Global Health at Tulane Connie Gistand, MD MPH Assistant Professor

General

Internal Medicine and Geriartrics and Palliative Medicine

Marcia Glass, MD

Associate Professor Program Director, Hospice and Palliative Medicine Fellowship Shekinah Gleason, MSN, APRN, FNP-C Instructor

Irene Grundy, MD, MS Assistant Professor, Assistant Chief of Staff of Education for Veterans Affairs

Jonathan Gugel, MD, MPH Assistant Professor Advisor TUMG Population Health

Michelle Guidry, MD Associate Professor Hospital Medicine Section Chief, Veterans Affairs

Mahnur Haider, MBBS Assistant Professor

Joshua Huddleston, MD Instructor

M. Matias Iberico, MD, MPH Assistant Professor Co-Director Resident Initiative in Global Health at Tulane S. Michal Jazwinski, PhD John W. Deming, MD Regents Chair in Aging, Director, Tulane Center for Aging, Professor and Biochemistry

Jacey Jones, MD Assistant Professor Clinical Diagnosis Clerkship Director

Catherine Jones, MD Associate Professor

Margaret Kala, MD Assistant Professor

Naomi Karlen, MD Instructor

Lumie Kawasaki, MD, MBA

Associate Professor Chief of Geriatrics at Southeast Louisiana Health Care, Veterans Affairs

P. Adam Kelly, PhD, MBA Research Associate Professor

Danielle King, MD Assistant Professor Kristen Koehl, NP Instructor

Michael Landry, MD, MSc

Associate Professor Chief of Medicine and Chief of General Internal Medicine at Southeast Louisiana Health Care, Veterans Affairs

Alexandra Leigh, MD Assistant Professor Chief for Hospice and Palliative Care, Southeast Louisiana Health Care, Veterans Affairs

Callie Linden, MD Assistant Professor Hospice & Palliative Medicine Director

Vy Anh Mai, MD, MS Assistant Professor of Medicine & Pediatrics Associate Program Director, Internal Med-Peds Residency

Sonia Malhotra, MD, MS, FAAP

Associate Professor Internal Medicine & Pediatrics Director, Palliative Medicine University Medical Center LCMC Health & Tulane SOM, Associate Program Director, Internal Med-Peds Residency

Anthony Marsh, MD Assistant Professor Associate Program Director Internal Medicine

General Internal Medicine and Geriartrics and Palliative Medicine

Brandon Mauldin, MD, MHS

Assistant Professor Chief Medical Officer Tulane Medical Center

Marlowe M. Maylin, MD Assistant Professor Hospitalist Medical Director Tulane Medical Center

Geraldine Ménard, MD, FACP, FHM

Associate Professor Chief, Section of General Internal Medicine and Geriatrics, Director of Hospitalist & Consultative Medicine

Robert Miller, MD Assistant Professor Senior Associate Program Director, Internal Medicine

Paul Musgrave, MD Assistant Professor

Celeste Newby, MD, PhD Assistant Professor Acting Internship Clerkship Director

Anjali Niyogi, MD, MPH Associate Professor Internal Medicine & Pediatrics Co-Director, RIGHT Program (Resident Initiative in Global Health at Tulane), Adjunct Assistant Professor Tropical Medicine

Jonathan Orner, MD Instructor

Leah Parker, APRN, FNP Instructor

STAFF

Vanessa Durbin

Senior Department Administrator

Teena Geiger

Graduate Medical Education Program Administrator II

Harsh Patel, MD Instructor

Helen Pope, MD Instructor

Justin Rabon, MD Instructor

Peter Reynaud, MD, MPH Assistant Professor IM Hospitalist, Tulane Cabrina Riley-Davis, NP Instructor

Benjamin Rothwell, MD Clinical Assistant Professor

Sarah Sanders, MD Assistant Professor Ryan S. Satovsky, MD Assistant Professor

C. Dale Shamburger, MD Assistant Professor Academic Quality Officer, University Medical Center

Michele Simoneaux, MD Assistant Professor Medicine & Pediatrics

Isis Smith, MD Assistant Professor Director, Community Health Clerkship

Ernest Sneed Jr., MD Assistant Professor

David Spruill, MD Assistant Professor

Lead Hospitalist, University Medical Center LCMC Health

H. Leighton Stweard Professor in Nutrition Research Director, Tulane Center for Lifespan Epidemiology Research

Rachana Sus, MD, MPH Assistant Professor

Joey Swisher, MD Instructor

Erica Tate, MD Assistant Professor

Associate Program Director, Internal Medicine Residency Program

Nick Tolat, MD Instructor

Aldo Torres-Ortiz, MD Assistant Professor

Gala True, PhD Associate Professor Adjunct

Kristen Valliant, MD Assistant Professor

Ashley Wennerstrom, PhD, MPH Associate Professor Adjunct

Jeffrey Wiese, MD, MHM, FACP Professor

Annie Yeh, MD Assistant Professor Tara Zaabel, APRN, FNP Instructor

Lesley Bertrand GIM Program Coordinator Siera Swan

GIM/IMR Schedule and Evaluations Coordinator

Danielle Metz

Community Worker for the FIT Program

Fernando Sosa Community Health Worker

Publications

General Internal Medicine and Palliative Medicine

Anjali Niyogi. Asylum Medicine: A Clinician’s Guide, 2022

Anjali Niyogi, MD. Promoting Health Equity and Criminal Justice Reform: The Louisiana Experience AJPH

Anjali Niyogi, MD. Promoting Health Equity and Criminal Justice Reform: The Louisiana Experience. American Journal of Public Health

Anjali Niyogi, MD. A 23-Year-Old Man with Multisystem Inflammatory Syndrome After Mild COVID-19. Journal of Investigative Medicine High Yield Case Reports.

Kiruba Vembu, MD. Bringing It Home: Point of Care Ultrasound in the Home Hospice Setting (poster) Tulane Scholarship Day 2020 Kiruba Vembu, MD. The Diversity of Grief in Louisiana and Mississippi (poster) LMHPCO Virtual Bereavement Seminar 2020

Jonathan McCall, MD. Predictors of functional dependence after COVID-19: A retrospective examination among veterans (poster). American Journal of Physical Medicine & Rehabilitation

Jonathan McCall, MD. A Case Report of Covid-19 in New Orleans, Louisiana: Highlighting the Complexities of Prognostication in a Critically Ill Patient.

Palliative Medicine Reports

Marcia Glass, MD. A Case Report of Covid-19 in New Orleans, Louisiana: Highlighting the Complexities of Prognostication in a Critically Ill Patient.

Palliative Medicine Reports

Marcia Glass, MD. A Field Manual for Palliative Care in Humanitarian Crisis. Oxford University Press

Mahnur Haider, MD. Retrospective observational study of temporal trends and out-comes of hepatitis B screening in patients receiving rituximab.

BMJ Open

Mahnur Haider, MD. Clinical Risk Prediction model for neoadjuvant therapy in resectable esophageal adenocarcinoma.

Journal of Clinical Gastroenterology

Kristen Bateman, MD. A Case of Pseudothrombotic Microangiopathy Associated with Pernicious Anemia.

Journal of General Internal Medicine

Michelle Christopher, MD. Make the Implicit

Explicit: Measuring Perceptions of Gender Bias and Creating a Gender Bias Curriculum for Internal Medicine Residents. Advances in Medical Education and Practice

Sonia Malhotra, MD. Development and Validation of the Palliative Care Attitudes Scale (PCAS-9) A Measure of Patient Attitudes Toward Palliative Care.

Journal of Palliative and System Management

Jessica Debord, MD. Clinical Pathway for Vaso-Occlusive Pain Reduces Hospital Admissions.Journal for Healthcare Quality

Matias Iberico, MD. SARS-CoV-2 serosurveys in low-income and middle-income countries. The Lancet

Matias Iberico, MD. Early Lessons from Launching and Innovative Community Health Household Model Across 3 Country Contexts. Global Health: Science and Practice

Harsh Patel, MD. Inappropriate Continuation of Acid-Suppression Medication and Bronchodilators on Discharge from ICU. CHEST Annual Meeting

Harsh Patel, MD. Unneeded Meds at Discharge Could Cause Harm Medscape

Celeste Newby, MD. Reviewing Block Grants for Medicaid: Tenncare III. Health Policy Corner

Geraldine Ménard, MD. A 23- Year-Old Man with Multisystem Inflammatory Syndrome

After Mild COVID-19. Journal of Investigative Medicine High Yield Case Reports

Dana Muhlfelder, MD. Grief Communications in a COVID World.

LMHPCO Virtual Bereavement Seminar 2020

Alexandra Leigh, MD. Predictors of functional dependence after COVID-19: A retrospective examination among veterans.

American Journal of Physical Medicine & Rehabilitation

Rebecca Burke, MD. Predictors of functional dependence after COVID-19: A retrospective examination among veterans. American Journal of Physical Medicine & Rehabilitation

Jonathan Gugel, MD. Weight Loss in Underserved Patients -- A ClusterRandomized Trial. New England Journal of Medicine

Marcia Glass, MD. Global Palliative Care Education in the Time of COVID-19.

Journal of Pain and Symptom Management

Michelle Christopher, MD, Sonia Malhotra, MD. Prioritizing in Palliative Medicine: Why Quality of Life Suffers with Racism. Pallimed Michael Gillette, MD. The Grace of Humility. ACP Hospitalis

Hematology & Medical Oncology

Cindy Leissinger, MD Professor of Medicine, Pediatrics & Pathology Chief Section of Hematology & Medical Oncology

Founded over 50 years ago, the Section of Hematology and Oncology has a rich history as an active training program for generations of hematologists/oncologists. Through close affiliation with three hospitals, including the Tulane Medical Center, the Southeast Louisiana Veterans Affairs Health, and the University Medical Center of Louisiana at New Orleans LCMC Health. Tulane hematologists/ oncologists and trainees see patients referred throughout the southeast with a wide array of disorders. The section faculty members possess notable expertise in hematology, oncology, and bone marrow transplantation.

Section programs in benign hematology include the Louisiana Center for Bleeding and Clotting Disorders, the only federally funded center in the state providing expert care and cutting-edge research for patients of all ages suffering from hemophilia and other coagulation disorders. In addition, the Adult Sickle Cell Day Program is pioneering effective management strategies and clinical research studies for patients with sickle disorders.

The oncology programs are closely linked with the Tulane Cancer Center, which is dedicated to a comprehensive, disease-specific, team approach to the care of cancer patients. Comprehensive clinics with associated multi-disciplinary tumor conferences are held for patients that have breast cancer, otolaryngologic malignancies, genitourinary cancer, and hematologic malignancies. Programs in hematologic malignancies and prostate cancer are both led by internationally known faculty and attract patients from around the country.

With a growing base of clinical and research faculty, the Section enjoys an excellent regional and national reputation as a center of specialized, comprehensive patient care and an emerging leader in research in many areas. While some faculty members engage in basic scientific research, all are deeply involved in translational research in a concerted effort to deliver expert care from bench to bedside.

EDUCATIONAL ACTIVITY

The Tulane University Hematology-Oncology Fellowship program is a 3-year Accreditation Council for Graduate Medical Education (ACGME) accredited training program that includes nine fellows. The training goal is to focus on forming great clinicians who can be board-certified and practice in hematology and Oncology. The program offers a diverse patient population in a culturally rich city. Tulane hosts a strong bone marrow transplant program and a hemophilia and bleeding disorders center. There are nationally recognized faculty expertise in genitourinary malignancies, malignant hematology, and breast cancer. In addition, the program also encourages fellows to be involved in research activities. Our graduating fellows have excelled in both private practices and academic institutions.

BONE MARROW TRANSPLANT

Despite the challenges forced on the program by the COVID pandemic, the Bone Marrow Transplant (BMT) Program maintained full academic and clinical activity. The BMT Program is active in autologous and allogeneic transplantation and approved for unrelated stem cell transplantation. The program draws referrals from surrounding states and is active in both clinical and translational research trials. The program has 33 open clinical trials to which patients are enrolled (including pharma trials, investigator-initiated trials, and national cooperative group studies).

SURVIVAL CLINICAL DATA 2021

2021

6

Hematology & Medical Oncology

FACULTY

Pedro C. Barata, MD, MSc Associate Professor

Matthew Burow, PhD Associate Professor Assistant Chair of Research

R. Keith Byram, FNP-BC, MSN Instructor of Clinical Medicine Bridgette Collins-Burow, MD Associate Professor

Chancellor Donald, MD Assistant Professor University Medical Center LCMC Health Cancer Management Medical Director

Daniel Garrett, MD Assistant Professor Director of Health Initiatives LA Center for Bleeding & Clotting Disorders

Maissaa Janbain, MD Associate Professor Associate Director LA Center for Bleeding and Clotting Disorders

Jodi Layton, MD Assistant Professor

Cindy Leissinger, MD Professor

Pediatrics & Pathology Chief, Section of Hematology & Medical Oncology Director, LA Center for Bleeding and Clotting Disorders

Brian Lewis, MD, MPH

Assistant Professor Associate Director, Hematology/Oncology Fellowship Program

STAFF

Angelique Smith, MBA Senior Administrator

Laurie Ray, FNP Douglas Rovira, MD, FACP Assistant Professor Nakhle Saba, MD Associate Professor Hana Safah, MD Professor Director, Bone Marrow Transplant Program

A. Oliver Sartor, MD Professor Medical Director, Tulane Cancer Center C. E. Bernadine Laborde Professor of Cancer Research

Mark Sides, MD, PhD Assistant Professor

Francisco Socola, MD Assistant Professor

Christopher R. Trevino, MD Assistant Professor Adjunct Assistant Professor of Neurology Evangelos Triantaphyllou, PhD Adjunct Associate Professor Nancy Vander Velde, MD Associate Professor Director, Hematolog/Oncology Fellowship Program Chief, Hematology and Oncology at Southeast Louisiana Veterans Healthcare System

Barbara Lassalle Executive Secretary

Katy Smith

Graduate Medical Education Program Administrator I

Hematology & Medical Oncology

Louisiana Center for Bleeding & Clotting Disorders Staff

Erin

Kavanagh, MBA Administrative Operations Manager

Dionne Richard Project Assistant

René

Mire, MBA 340(B) Senior Accountant

Sandra Chiasson Project Assistant

Terry Bell Administrative Secretary

A smartphone-read ultrasensitive and quantitative saliva test for COVID-19. Ning B, Yu T, Zhang S, Huang Z, Tian D, Lin Z, Niu A, Golden N, Hensley K, Threeton B, Lyon CJ, Yin XM, Roy CJ, Saba NS, Rappaport J, Wei Q, Hu TY.Sci Adv. 2021 Jan 8;7(2):eabe3703. doi: 10.1126/sciadv.abe3703. Print 2021 Jan.

PMID: 33310733 Free PMC article.

The prognostic implications of tetraploidy/ near-Tetraploidy in acute myeloid leukemia: a case series and systematic review of the literature.

Xie J, Nachabe A, Hathaway LJ, Farah B, Berbari B, Li Y, Brown TC, Schmid JL, Socola F, Saba NS, Safah H.Leuk Lymphoma. 2021 Jan;62(1):203-210. doi: 10.1080/10428194.2020.1817435. Epub 2020 Sep 29.PMID: 32993375 Review.

The utility of hyperbaric oxygen therapy in post-transplant cyclophosphamide-induced hemorrhagic cystitis: a case report and review of the literature.

Ibrahim M, Bhyravabhotla K, Khalaf B, Van Meter K, Saba NS, Safah H, Socola F.J Med Case Rep. 2021 Jan 4;15(1):1. doi: 10.1186/ s13256-020-02580-w.PMID: 33397476 Free PMC article. Review.

Reinfection versus failure of viral clearance in a COVID-19 patient with hematologic malignancy.

Ibrahim M, Vegel A, Niu A, Panse K, Chen R, Safah H, Socola F, Luk A, Saba NS.Leuk Res. 2021 Feb;101:106514. doi: 10.1016/j. leukres.2021.106514. Epub 2021 Jan 20.PMID: 33524639 Free PMC article. No abstract available.

Sensitive tracking of circulating viral RNA through all stages of SARS-CoV-2 infection. Huang Z, Ning B, Yang HS, Youngquist BM, Niu A, Lyon CJ, Beddingfield BJ, Fears AC, Monk CH, Murrell AE, Bilton SJ, Linhuber JP, Norton EB, Dietrich ML, Yee J, Lai W, Scott JW, Yin XM, Rappaport J, Robinson JE, Saba NS, Roy CJ, Zwezdaryk KJ, Zhao Z, Hu TY.J Clin Invest. 2021 Apr 1;131(7):e146031. doi: 10.1172/JCI146031.PMID: 33561010

Publications

Hematology & Medical Oncology

Free PMC article. Clinical Trial.

Successful treatment of “accelerated” chronic lymphocytic leukemia with single agent ibrutinib: A report of two cases.

Xie J, Jang A, Vegel A, Hajja Y, Mouawad Y, Baghian A, Berbari B, Schmid JL, Socola F, Safah H, Saba NS.Leuk Res Rep. 2021 May 17;15:100247. doi: 10.1016/j.lrr.2021.100247. eCollection 2021.PMID: 34040961 Free PMC article.

Frequency of infusion-related reactions with CPX-351 treatment in an observational study in adults with newly diagnosed therapy-related AML or AML with myelodysplasia-related changes (AML-MRC).

Jacoby MA, Finn L, Emadi A, Saba NS, Powell BL, Seiter K, Garcia R, Faderl S, Male HJ.Leuk Lymphoma. 2021 May 11:1-4. doi: 10.1080/10428194.2021.1919668. Online

ahead of print. PMID: 33974493 No abstract available.

Safety and efficacy of COVID-19 convalescent plasma in severe pulmonary disease: A report of 17 patients.

Pal P, Ibrahim M, Niu A, Zwezdaryk KJ, Tatje E, Robinson WR 4th, Ko L, Satyavarapu I, Jones WE, Nachabe A, Luk A, Mushatt DM, Halvorson K, Denson JL, Smith CC 3rd, Simeone F, Davis G, Gill SK, McDougal A, Vigh AS, Peterson TG, Ning B, Hu T, Socola F, Robinson J, Safah H, Saba NS.Transfus Med. 2021 Jun;31(3):217-220. doi: 10.1111/ tme.12729. Epub 2020 Oct 19.PMID: 33073895 No abstract available.

Treatment of myeloid sarcoma without bone marrow involvement with gemtuzumab ozogamicin-containing regimen.

Ibrahim M, Chen R, Vegel A, Panse K, Bhyravabhotla K, Harris K, Craig R, Safah H, Saba NS, Socola F.Leuk Res. 2021 Jul;106:106583. doi: 10.1016/j. leukres.2021.106583. Epub 2021 Apr 22.PMID: 33906021 No abstract available.

High mortality with High false negative rate: COVID-19 infection in patients with

hematologic malignancies.

Niu A, Ning B, Socola F, Safah H, Reynolds T, Ibrahim M, Safa F, Alfonso T, Luk A, Mushatt DM, Hu T, Saba NS.Leuk Res. 2021 Jul;106:106582. doi: 10.1016/j. leukres.2021.106582. Epub 2021 Apr 24.PMID: 33933714 Free PMC article. No abstract available.

Suarez-Martinez AD, Sole-Gras M, Dykes SS, Wakefield ZR, Bauer K, Majbour D, Bundy A, Pampo C, Burow ME, Siemann DW, Huang Y, Murfee WL Bioprinting on Live Tissue for Investigating Cancer Cell Dynamics. Tissue Eng Part A. 2021 Apr;27(7-8):438-453. doi: 10.1089/ten.TEA.2020.0190. PMID: 33059528

Bhatt AB, Patel S, Matossian MD, Ucar DA, Miele L, Burow ME, Flaherty PT, Cavanaugh JE. Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling. Biomolecules. 2021 Jan 29;11(2):183. doi: 10.3390/biom11020183. PMID: 33572742 Free PMC article. Review. Matossian MD, Wells CI, Zuercher WJ, Collins-Burow BM, Drewry DH, Burow ME. Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review. Curr Med Chem. 2021;28(30):6096-6109. doi: 10.2174/09298 67328666210322101749. PMID: 33749548

Review. Matossian MD, Elliott S, Rhodes LV, Martin EC, Hoang VT, Burks HE, Zuercher WJ, Drewry DH, Collins-Burow BM, Burow ME. Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells. Oncol Lett. 2021 May;21(5):380. doi: 10.3892/ ol.2021.12641. Epub 2021 Mar 16. PMID: 33777204 Free PMC article.

Gurrala R, Byrne CE, Brown LM, Tiongco RFP, Matossian MD, Savoie JJ, CollinsBurow BM, Burow ME, Martin EC, Lau FH. Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in

::

Publications Hematology & Medical Oncology

Primary Human Breast Tissue. Front Bioeng Biotechnol. 2021 Mar 15;9:618448. doi: 10.3389/fbioe.2021.618448. eCollection 2021.

Matossian MD, Hoang VT, Burks HE, La J, Elliott S, Brock C, Rusch DB, Buechlein A, Nephew KP, Bhatt A, Cavanaugh JE, Flaherty PT, Collins-Burow BM, Burow ME.Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer. Oncoscience. 2021 May 18;8:64-71. doi: 10.18632/oncoscience.535. eCollection 2021.

PMID: 34026925

Nguyen K, Rivera A, Alzoubi M, Wathieu H, Dong S, Yousefi H, Matossian M, Alahari S, Drewry D, Burow M, Collins-Burow B. Evaluation of liver kinase B1 downstream signaling expression in various breast cancers and relapse free survival after systemic chemotherapy treatment. Oncotarget. 2021 May 25;12(11):1110-1115. doi: 10.18632/ oncotarget.27929. PMID: 34084284 Free PMC article. Review.

Brown LM, Hebert KL, Gurrala RR, Byrne CE, Burow M, Martin EC, Lau FH. Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System. J Vis Exp. 2021 Apr 23;(170). doi: 10.3791/62009. PMID: 33970144

Byrne CE, Decombe JB, Bingham GC, Remont J, Miller LG, Khalif L, King CT, Hamel K, Bunnell BA, Burow ME, Martin EC. Evaluation of Extracellular Matrix Composition to Improve Breast Cancer Modeling. Tissue Eng Part A. 2021 Apr;27(78):500-511. doi: 10.1089/ten.TEA.2020.0364. PMID: 33797977

Nguyen, K., Mills P.O., Blair, R., CollinsBurow, B.M., Burow, M.E., 2022. Old Disease in a Young Mouse: Case Report for Lymphocytic Leukemia in an 11-WeekOld Female SCID/Beige Mouse. Journal of Veterinary Science & Medical Diagnosis, DOI: 10.4172/2325-9590.306

Nguyen K, McConnell E, Edwards O, Collins-Burow BM, Burow ME. GD2+ cancer

stem cells in triple negative breast cancer: mechanisms of resistance to breast cancer therapies. Cancer Drug Resist 2022;5:721-6. https://dx.doi.org/10.20517/cdr.2022.30.

Nguyen, K., Rivera, A., Alzoubi, M., Wathieu, H., Dong, S., Yousefi, H., Matossian, M., Alahari, S., Drewry, D., Burow, M. and CollinsBurow, B., 2021. Evaluation of liver kinase B1 downstream signaling expression in various breast cancers and relapse free survival after systemic chemotherapy treatment. Oncotarget, 12(11), p.1110.

The effect of obesity on adipose-derived stromal cells and adipose tissue and their impact on cancer. Bunnell BA, Martin EC, Matossian MD, Brock CK, Nguyen K, CollinsBurow B, Burow ME.Cancer Metastasis Rev. 2022 Aug 24. doi: 10.1007/s10555-022-100631. Online ahead of print.PMID: 35999486 Ceritinib is a novel triple negative breast cancer therapeutic agent. Dong S, Yousefi H, Savage IV, Okpechi SC, Wright MK, Matossian MD, Collins-Burow BM, Burow ME, Alahari SK.Mol Cancer. 2022 Jun 29;21(1):138. doi: 10.1186/s12943-022-01601-0.PMID: 35768871

Liver Kinase B1 Regulates Remodeling of the Tumor Microenvironment in Triple-Negative Breast Cancer. King CT, Matossian MD, Savoie JJ, Nguyen K, Wright MK, Byrne CE, Elliott S, Burks HE, Bratton MR, Pashos NC, Bunnell BA, Burow ME, Collins-Burow BM, Martin EC.Front Mol Biosci. 2022 Jun 8;9:847505. doi: 10.3389/fmolb.2022.847505. eCollection 2022.PMID: 35755802

Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations. Nguyen K, Yousefi H, Cheng T, Magrath J, Hartono AB, Alzoubi M, Hebert K, Brock CK, Wright MK, Byrne CE, Rivera A, Okpechi SC, Matossian MD, Wathieu H, Elliott S, Mondrinos MJ, Lee SB, Collins-Burow BM, Alahari SK, Drewry DH, Burow ME.Front Biosci (Landmark Ed). 2022 Jun 17;27(6):196. doi: 10.31083/j.fbl2706196.PMID: 35748272 Review.

The role of MEK1/2 and MEK5 in melatoninmediated actions on osteoblastogenesis,

osteoclastogenesis, bone microarchitecture, biomechanics, and bone formation. Munmun F, Mohiuddin OA, Hoang VT, Burow ME, Bunnell BA, Sola VM, Carpentieri AR, WittEnderby PA.J Pineal Res. 2022 Jun 8:e12814. doi: 10.1111/jpi.12814. Online ahead of print. PMID: 35674448

MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types. Nguyen K, Tran MN, Rivera A, Cheng T, Windsor GO, Chabot AB, Cavanaugh JE, Collins-Burow BM, Lee SB, Drewry DH, Flaherty PT, Burow ME.Front Biosci (Landmark Ed). 2022 May 23;27(5):167. doi: 10.31083/j.fbl2705167.PMID: 35638434 Review. Breast Cancer-Stromal Interactions: AdiposeDerived Stromal/Stem Cell Age and Cancer Subtype Mediated Remodeling. Hamel KM, King CT, Cavalier MB, Liimatta KQ, Rozanski GL, King TA, Lam M, Bingham GC, Byrne CE, Xing D, Collins-Burow BM, Burow ME, Belgodere JA, Bratton MR, Bunnell BA, Martin EC.Stem Cells Dev. 2022 Jul 12. doi: 10.1089/scd.2021.0279. Online ahead of print. PMID: 35579936

Salt-Inducible Kinase 1 is a potential therapeutic target in Desmoplastic Small Round Cell Tumor. Hartono AB, Kang HJ, Shi L, Phipps W, Ungerleider N, Giardina A, Chen W, Spraggon L, Somwar R, Moroz K, Drewry DH, Burow ME, Flemington E, Ladanyi M, Lee SB.Oncogenesis. 2022 Apr 20;11(1):18. doi: 10.1038/s41389-022-00395-6.PMID: 35443736

Glyceollins Trigger Anti-Proliferative Effects in Hormone-Dependent Aromatase-InhibitorResistant Breast Cancer Cells through the Induction of Apoptosis. Walker RR, Patel JR, Gupta A, Davidson AM, Williams CC, Payton-Stewart F, Boué SM, Burow ME, Khupse R, Tilghman SL.Int J Mol Sci. 2022 Mar 7;23(5):2887. doi: 10.3390/ijms23052887. PMID: 35270029

Multifunctional profiling of triple-negative breast cancer patient-derived tumoroids for disease modeling. Cromwell EF, Sirenko O,

John W. Deming Department of Medicine

Publications

Hematology & Medical Oncology

Nikolov E, Hammer M, Brock CK, Matossian MD, Alzoubi MS, Collins-Burow BM, Burow ME.SLAS Discov. 2022 Apr;27(3):191-200. doi: 10.1016/j.slasd.2022.01.006. Epub 2022 Feb 4.PMID: 35124274

Role of Nischarin in the pathology of diseases: a special emphasis on breast cancer. Okpechi SC, Yousefi H, Nguyen K, Cheng T, Alahari NV, Collins-Burow B, Burow ME, Alahari SK.Oncogene. 2022 Feb;41(8):1079-1086. doi: 10.1038/s41388-021-02150-4. Epub 2022 Jan 22.PMID: 35064214 Review.

A Role for Adipocytes and Adipose Stem Cells in the Breast Tumor Microenvironment and Regenerative Medicine. Brock CK, Hebert KL, Artiles M, Wright MK, Cheng T, Windsor GO, Nguyen K, Alzoubi MS, Collins-Burow BM, Martin EC, Lau FH, Bunnell BA, Burow ME.Front Physiol. 2021 Nov 29;12:751239. doi: 10.3389/fphys.2021.751239. eCollection 2021.PMID: 34912237

In-depth characterization of a new patientderived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types. Matossian MD, Chang T, Wright MK, Burks HE, Elliott S, Sabol RA, Wathieu H, Windsor GO, Alzoubi MS, King CT, Bursavich JB, Ham AM, Savoie JJ, Nguyen K, Baddoo M, Flemington E, Sirenko O, Cromwell EF, Hebert KL, Lau F, Izadpanah R, Brown H, Sinha S, Zabaleta J, Riker AI, Moroz K, Miele L, Zea AH, Ochoa A, Bunnell BA, Collins-Burow BM, Martin EC, Burow ME.Clin Transl Oncol. 2022 Jan;24(1):127144. doi: 10.1007/s12094-021-02677-8. Epub 2021 Aug 9.PMID: 34370182

ZEB2 regulates endocrine therapy sensitivity and metastasis in luminal a breast cancer cells through a non-canonical mechanism. Burks HE, Matossian MD, Rhodes LV, Phamduy T, Elliott S, Buechlein A, Rusch DB, Miller DFB, Nephew KP, Chrisey D, Collins-Burow BM, Burow ME.Breast Cancer Res Treat. 2021 Aug;189(1):25-37. doi: 10.1007/s10549-02106256-x. Epub 2021 Jul 6.PMID: 34231077

Constitutive activation of MEK5 promotes a mesenchymal and migratory cell phenotype in triple negative breast cancer. Matossian MD, Hoang VT, Burks HE, La J, Elliott S, Brock C, Rusch DB, Buechlein A, Nephew KP, Bhatt A, Cavanaugh JE, Flaherty PT, Collins-Burow BM, Burow ME.Oncoscience. 2021 May 18;8:64-71. doi: 10.18632/oncoscience.535. eCollection 2021.PMID: 34026925

Dual inhibition of MEK1/2 and MEK5 suppresses the EMT/migration axis in triple-negative breast cancer through FRA-1 regulation. Hoang VT, Matossian MD, La J, Hoang K, Ucar DA, Elliott S, Burks HE, Wright TD, Patel S, Bhatt A, Phamduy T, Chrisey D, Buechlein A, Rusch DB, Nephew KP, Anbalagan M, Rowan B, Cavanaugh JE, Flaherty PT, Miele L, Collins-Burow BM, Burow ME.J Cell Biochem. 2021 Aug;122(8):835-850. doi: 10.1002/jcb.29916. Epub 2021 Apr 20.PMID: 33876843

Evaluation of Extracellular Matrix Composition to Improve Breast Cancer Modeling. Byrne CE, Decombe JB, Bingham GC, Remont J, Miller LG, Khalif L, King CT, Hamel K, Bunnell BA, Burow ME, Martin EC.Tissue Eng Part A. 2021 Apr;27(7-8):500511. doi: 10.1089/ten.TEA.2020.0364.PMID: 33797977

Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue. Gurrala R, Byrne CE, Brown LM, Tiongco RFP, Matossian MD, Savoie JJ, Collins-Burow BM, Burow ME, Martin EC, Lau FH.Front Bioeng Biotechnol. 2021 Mar 15;9:618448. doi: 10.3389/fbioe.2021.618448. eCollection 2021. PMID: 33791282

Taza F, Holler AE, Fu W, Wang H, Adra N, Albany C, Ashkar R, Cheng HH, Sokolova AO, Agarwal N, Kessel A, Bryce A, Nafissi N, Barata P, Sartor AO, Bastos D, Smaletz O, Berchuck JE, Taplin ME, Aggarwal R, Sternberg CN, Vlachostergios PJ, Alva AS, Su C, Marshall CH, Antonarakis ES. Differential Activity of PARP Inhibitors in BRCA1Versus BRCA2-Altered Metastatic Castration-

Plym A, Dióssy M, Szallasi Z, Sartor O, Silberstein J, Powell IJ, Rebbeck TR, Penney KL, Mucci LA, Pomerantz MM, Kibel AS. DNA Repair Pathways and Their Association With Liu S, Zhang B, Rowan BG, Jazwinski SM, Abdel-Mageed AB, Steele C, Wang AR, Sartor O, Niu T, Zhang Q. A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study. Front Mol Biosci. 2021 Jun 3;8:696537. doi: 10.3389/fmolb.2021.696537. PMID: 34150854; PMCID: PMC8211560. Lin E, Hahn AW, Nussenzveig RH, Wesolowski S, Sayegh N, Maughan BL, McFarland T, Rathi N, Sirohi D, Sonpavde G, Swami U, Kohli M, Rich T, Sartor O, Yandell M, Agarwal N. Identification of Somatic Gene Signatures in Circulating Cell-Free DNA Associated with Disease Progression in Metastatic Prostate Cancer by a Novel Machine Learning Platform. Oncologist. 2021 Jun 22. doi: 10.1002/onco.13869. Epub ahead of print. PMID: 34157173. Sartor AO, la Fougère C, Essler M, Ezziddin S, Kramer G, Elllinger J, Nordquist L, Sylvester J, Paganelli G, Peer A, Bögemann M, Meltzer J, Sandström P, Verholen F, Song DY. Lutetium177-prostate-specific membrane antigen ligand following radium-223 treatment in men with bone-metastatic castration-resistant prostate cancer: real-world clinical experience. J Nucl Med. 2021 Jun 24:jnumed.121.262240. doi: 10.2967/jnumed.121.262240. Epub ahead of print. PMID: 34168015.

Ledet EM, Sartor O. Letter to the Editor: “Family history and pathogenic/likely pathogenic germline variants in prostate cancer patients”. Prostate. 2021 Nov;81(15):12621263. doi: 10.1002/pros.24221. Epub 2021 Aug 31. PMID: 34464469.

Sartor AO. PSMA-targeted radiotherapy in metastatic castration-resistant prostate cancer. Clin Adv Hematol Oncol. 2021 Aug;19(8):494-496. PMID: 34411067.

Sokolova AO, Marshall CH, Lozano R, Gulati R, Ledet EM, De Sarkar N, Grivas P, Higano CS, Montgomery B, Nelson PS, Olmos D, Sokolov V, Schweizer MT, Yezefski TA, Yu

Publications Hematology & Medical Oncology

EY, Paller CJ, Sartor O, Castro E, Antonarakis ES, Cheng HH. Efficacy of systemic therapies in men with metastatic castration resistant prostate cancer harboring germline ATM versus BRCA2 mutations. Prostate. 2021 Sep 13. doi: 10.1002/pros.24236. Epub ahead of print. PMID: 34516663.

Maxwell KN, Cheng HH, Powers J, Gulati R, Ledet EM, Morrison C, Le A, Hausler R, Stopfer J, Hyman S, Kohlmann W, Naumer A, Vagher J, Greenberg SE, Naylor L, Laurino M, Konnick EQ, Shirts BH, AlDubayan SH, Van Allen EM, Nguyen B, Vijai J, Abida W, Carlo MI, Dubard-Gault M, Lee DJ, Maese LD, Mandelker D, Montgomery B, Morris MJ, Nicolosi P, Nussbaum RL, Schwartz LE, Stadler Z, Garber JE, Offit K, Schiffman JD, Nelson PS, Sartor O, Walsh MF, Pritchard CC. Inherited TP53 Variants and Risk of Prostate Cancer. Eur Urol. 2021 Dec 1:S0302-2838(21)02139-4. doi: 10.1016/j. eururo.2021.10.036. Epub ahead of print. PMID: 34863587. Sartor O, Morris MJ, Kraus BJ. Lutetium-177PSMA-617 for Prostate Cancer. Reply. N Engl J Med. 2021 Dec 23;385(26):2495-2496. doi: 10.1056/NEJMc2116647. PMID: 34936754. Huang S, Cao B, Wang J, Zhang Y, Ledet E, Sartor O, Xiong Y, Zeng SX, Lu H. Cancerderived C-terminus-extended p53 mutation confers dominant-negative effect on its wildtype counterpart. J Mol Cell Biol. 2021 Dec 16:mjab078. doi: 10.1093/jmcb/mjab078. Epub ahead of print. PMID: 34918105. Plym A, Dióssy M, Szallasi Z, Sartor O, Silberstein J, Powell IJ, Rebbeck TR, Penney KL, Mucci LA, Pomerantz MM, Kibel AS. DNA Repair Pathways and Their Association With

Lethal Prostate Cancer in African American and European American Men. JNCI Cancer Spectr. 2021 Dec 27;6(1):pkab097. doi: 10.1093/jncics/pkab097. PMID: 35079693; PMCID: PMC8784166.

Vogl UM, Beer TM, Davis ID, Shore ND, Sweeney CJ, Ost P, Attard G, Bossi A, de Bono

J, Drake CG, Efstathiou E, Fanti S, Fizazi K, Halabi S, James N, Mottet N, Padhani AR, Roach M, Rubin M, Sartor O, Small E, Smith MR, Soule H, Sydes MR, Tombal B, Omlin A, Gillessen S; APCCC 2019 expert panel.

Lack of consensus identifies important areas for future clinical research: Advanced Prostate Cancer Consensus Conference (APCCC) 2019 findings. Eur J Cancer. 2022 Jan;160:24-60. doi: 10.1016/j.ejca.2021.09.036. Epub 2021 Nov 26. PMID: 34844839.

Sartor O, George D, Tombal B, Agarwal N, Higano CS, Sternberg CN, Miller K, Jiao X, Guo H, Sandström P, Bruno A, Verholen F, Saad F, Shore N. Real-world outcomes of second novel hormonal therapy or radium-223 following first novel hormonal therapy for mCRPC. Future Oncol. 2022 Jan;18(1):35-45. doi: 10.2217/fon-2021-0886. Epub 2021 Oct 12. PMID: 34636627.

Turco F, Armstrong A, Attard G, Beer TM, Beltran H, Bjartell A, Bossi A, Briganti A, Bristow RG, Bulbul M, Caffo O, Chi KN, Clarke CS, Clarke N, Davis ID, de Bono J, Duran I, Eeles R, Efstathiou E, Efstathiou J, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, George D, Gleave M, Halabi S, Heinrich D, Higano C, Hofman MS, Hussain M, James N, Jones R, Kanesvaran R, Khauli RB, Klotz L, Leibowitz R, Logothetis C, Maluf F, Millman R, Morgans AK, Morris MJ, Mottet N, Mrabti H, Murphy DG, Murthy V, Oh WK, Ekeke ON, Ost P, O’Sullivan JM, Padhani AR, Parker C, Poon DMC, Pritchard CC, Rabah DM, Rathkopf D, Reiter RE, Rubin M, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Shore N, Skoneczna I, Small E, Smith M, Soule H, Spratt DE, Sternberg CN, Suzuki H, Sweeney C, Sydes MR, Taplin ME, Tilki D, Tombal B, Türkeri L, Uemura H, Uemura H, van Oort I, Yamoah K, Ye D, Zapatero A, Gillessen S, Omlin A. What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021. Eur Urol. 2022 Feb 17:S0302-2838(22)016505. doi: 10.1016/j.eururo.2022.02.010. Epub ahead of print. PMID: 35393158; PMCID: PMC8849852.

Sartor O. Reply: A VISION of ALSYMPCA. J Nucl Med. 2022 Feb;63(2):324-325. doi: 10.2967/jnumed.121.263193. PMID: 35101928.

George DJ, Agarwal N, Sartor O, Sternberg CN, Tombal B, Saad F, Miller K, Constantinovici N, Guo H, Reeves J, Jiao X, Sandström P, Verholen F, Higano CS, Shore N. Real-world patient characteristics associated with survival of 2 years or more after radium-223 treatment for metastatic castration-resistant prostate cancer (EPIX study). Prostate Cancer Prostatic Dis. 2022 Feb 21. doi: 10.1038/s41391-021-00488-0. Epub ahead of print. PMID: 35190653.

Sentana-Lledo D, Sartor O, Balk SP, Einstein DJ. Immune mechanisms behind prostate cancer in men of African ancestry: A review. Prostate. 2022 Mar 7. doi: 10.1002/pros.24333. Epub ahead of print. PMID: 35254710.

Zhang W, Dong Y, Sartor O, Zhang K. Deciphering the Increased Prevalence of TP53 Mutations in Metastatic Prostate Cancer. Cancer Inform. 2022 Apr 2;21:11769351221087046. doi: 10.1177/11769351221087046. PMID: 35392296; PMCID: PMC8980432.

Freeman MN, Jang A, Zhu J, Sanati F, Nandagopal L, Ravindranathan D, Desai A, Phone A, Nussenzveig R, Jaeger E, Caputo SA, Koshkin VS, Swami U, Basu A, Bilen MA, Agarwal N, Sartor O, Burgess EF, Barata PC. Multi-institutional Analysis of the Clinical and Genomic Characteristics of Black Patients with Metastatic Hormone-Sensitive Prostate Cancer. Oncologist. 2022 Mar 11;27(3):220227. doi: 10.1093/oncolo/oyab057. PMID: 35274720; PMCID: PMC8914485.

Hawkey NM, Sartor AO, Morris MJ, Armstrong AJ. Prostate-specific membrane antigen- targeted theranostics: past, present, and future approaches. Clin Adv Hematol Oncol. 2022 Apr;20(4):227-238. PMID: 35389387.

Reyes DK, Trock BJ, Tran PT, Pavlovich CP, Deville C, Allaf ME, Greco SC, Song DY, Bivalacqua TJ, Han M, Partin AW, Sartor

:: John W. Deming Department of Medicine

Publications

Hematology & Medical Oncology

AO, Rowe SP, Pienta KJ. Interim analysis of companion, prospective, phase II, clinical trials assessing the efficacy and safety of multi-modal total eradication therapy in men with synchronous oligometastatic prostate cancer. Med Oncol. 2022 Apr 28;39(5):63. doi: 10.1007/s12032-022-01662-7. PMID: 35478055.

Gillessen S, Armstrong A, Attard G, Beer TM, Beltran H, Bjartell A, Bossi A, Briganti A, Bristow RG, Bulbul M, Caffo O, Chi KN, Clarke CS, Clarke N, Davis ID, de Bono JS, Duran I, Eeles R, Efstathiou E, Efstathiou J, Ekeke ON, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, George D, Gleave M, Halabi S, Heinrich D, Higano C, Hofman MS, Hussain M, James N, Jones R, Kanesvaran R, Khauli RB, Klotz L, Leibowitz R, Logothetis C, Maluf F, Millman R, Morgans AK, Morris MJ, Mottet N, Mrabti H, Murphy DG, Murthy V, Oh WK, Ost P, O’Sullivan JM, Padhani AR, Parker C, Poon DMC, Pritchard CC, Rabah DM, Rathkopf D, Reiter RE, Rubin M, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Shore N, Skoneczna I, Small E, Smith M, Soule H, Spratt DE, Sternberg CN, Suzuki H, Sweeney C, Sydes MR, Taplin ME, Tilki D, Tombal B, Türkeri L, Uemura H, Uemura H, van Oort I, Yamoah K, Ye D, Zapatero A, Omlin A. Management of Patients with Advanced Prostate Cancer: Report from the Advanced Prostate Cancer Consensus Conference 2021. Eur Urol. 2022 Jul;82(1):115-141. doi: 10.1016/j. eururo.2022.04.002. Epub 2022 Apr 18. PMID: 35450732.

Pollack A, Karrison TG, Balogh AG, Gomella LG, Low DA, Bruner DW, Wefel JS, Martin AG, Michalski JM, Angyalfi SJ, Lukka H, Faria SL, Rodrigues GB, Beauchemin MC, Lee RJ, Seaward SA, Allen AM, Monitto DC, Seiferheld W, Sartor O, Feng F, Sandler HM. The addition of androgen deprivation therapy and pelvic lymph node treatment to prostate bed salvage radiotherapy (NRG Oncology/ RTOG 0534 SPPORT): an international, multicentre, randomised phase 3 trial. Lancet. 2022 May 14;399(10338):1886-1901. doi: 10.1016/S0140- 6736(21)01790-6. PMID: 35569466.

Sartor O, Herrmann K. Prostate Cancer Treatment: 177Lu-PSMA-617 Considerations, Concepts, and Limitations. J Nucl Med. 2022 Jun;63(6):823-829. doi: 10.2967/ jnumed.121.262413. PMID: 35649665. Huang S, Cao B, Wang J, Zhang Y, Ledet E, Sartor O, Xiong Y, Zeng SX, Lu H. Cancerderived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart. J Mol Cell Biol. 2022 Mar 29;14(1):mjab078. doi: 10.1093/jmcb/ mjab078. Erratum in: J Mol Cell Biol. 2022 May 25;14(2): PMID: 34918105; PMCID: PMC8964174.

Manogue CE, Chen W, Mazza A, Dang A, Lewis B, Wallis CJD, Layton J, Barata P, Sartor O, Harris KM. Embracing the Practical Aspects of Theranostics With Prostate-Specific Membrane AntigenTargeted Lutetium-177. Pract Radiat Oncol. 2022 Jul-Aug;12(4):300-304. doi: 10.1016/j. prro.2022.01.008. Epub 2022 May 14. PMID: 35717044.

Meisel A, de Wit R, Oudard S, Sartor O, Stenner-Liewen F, Shun Z, Foster M, Ozatilgan A, Eisenberger M, de Bono JS. Neutropenia, neutrophilia, and neutrophillymphocyte ratio as prognostic markers in patients with metastatic castration-resistant prostate cancer. Ther Adv Med Oncol. 2022 Jun 1. PMID: 35677318; PMCID: PMC9168856.

Sartor O. Invited Perspective, Outcome of patients with PSMA-PET/CT screen failure by VISION criteria and treated with 177Lu-PSMA therapy: a multicenter retrospective analysis. J Nucl Med. 2022 May 26:jnumed.122.264128. doi: 10.2967/ jnumed.122.264128. Epub ahead of print. PMID: 35618477.

Lethal Prostate Cancer in African American and European American Men. JNCI Cancer Spectr. 2021 Dec 27;6(1):pkab097. doi: 10.1093/jncics/pkab097. PMID: 35079693; PMCID: PMC8784166.

Vogl UM, Beer TM, Davis ID, Shore ND, Sweeney CJ, Ost P, Attard G, Bossi A, de Bono

J, Drake CG, Efstathiou E, Fanti S, Fizazi K, Halabi S, James N, Mottet N, Padhani AR, Roach M, Rubin M, Sartor O, Small E, Smith MR, Soule H, Sydes MR, Tombal B, Omlin A, Gillessen S; APCCC 2019 expert panel. Lack of consensus identifies important areas for future clinical research: Advanced Prostate Cancer Consensus Conference (APCCC) 2019 findings. Eur J Cancer. 2022 Jan;160:24-60. doi: 10.1016/j.ejca.2021.09.036. Epub 2021 Nov 26. PMID: 34844839.

Sartor O, George D, Tombal B, Agarwal N, Higano CS, Sternberg CN, Miller K, Jiao X, Guo H, Sandström P, Bruno A, Verholen F, Saad F, Shore N. Real-world outcomes of second novel hormonal therapy or radium-223 following first novel hormonal therapy for mCRPC. Future Oncol. 2022 Jan;18(1):35-45. doi: 10.2217/fon-2021-0886. Epub 2021 Oct 12. PMID: 34636627.

Turco F, Armstrong A, Attard G, Beer TM, Beltran H, Bjartell A, Bossi A, Briganti A, Bristow RG, Bulbul M, Caffo O, Chi KN, Clarke CS, Clarke N, Davis ID, de Bono J, Duran I, Eeles R, Efstathiou E, Efstathiou J, Evans CP, Fanti S, Feng FY, Fizazi K, Frydenberg M, George D, Gleave M, Halabi S, Heinrich D, Higano C, Hofman MS, Hussain M, James N, Jones R, Kanesvaran R, Khauli RB, Klotz L, Leibowitz R, Logothetis C, Maluf F, Millman R, Morgans AK, Morris MJ, Mottet N, Mrabti H, Murphy DG, Murthy V, Oh WK, Ekeke ON, Ost P, O’Sullivan JM, Padhani AR, Parker C, Poon DMC, Pritchard CC, Rabah DM, Rathkopf D, Reiter RE, Rubin M, Ryan CJ, Saad F, Sade JP, Sartor O, Scher HI, Shore N, Skoneczna I, Small E, Smith M, Soule H, Spratt DE, Sternberg CN, Suzuki H, Sweeney C, Sydes MR, Taplin ME, Tilki D, Tombal B, Türkeri L, Uemura H, Uemura H, van Oort I, Yamoah K, Ye D, Zapatero A, Gillessen S, Omlin A. What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021. Eur Urol. 2022 Feb 17:S0302-2838(22)016505. doi: 10.1016/j.eururo.2022.02.010. Epub ahead of print. PMID: 35393158; PMCID: PMC8849852.

Publications Hematology & Medical Oncology

Sartor O. Reply: A VISION of ALSYMPCA. J Nucl Med. 2022 Feb;63(2):324-325. doi: 10.2967/jnumed.121.263193. PMID: 35101928.

George DJ, Agarwal N, Sartor O, Sternberg CN, Tombal B, Saad F, Miller K, Constantinovici N, Guo H, Reeves J, Jiao X, Sandström P, Verholen F, Higano CS, Shore N. Real-world patient characteristics associated with survival of 2 years or more after radium-223 treatment for metastatic castration-resistant prostate cancer (EPIX study). Prostate Cancer Prostatic Dis. 2022 Feb 21. doi: 10.1038/s41391-021-00488-0. Epub ahead of print. PMID: 35190653.

Sentana-Lledo D, Sartor O, Balk SP, Einstein DJ. Immune mechanisms behind prostate cancer in men of African ancestry: A review. Prostate. 2022 Mar 7. doi: 10.1002/pros.24333. Epub ahead of print. PMID: 35254710. Zhang W, Dong Y, Sartor O, Zhang K. Deciphering the Increased Prevalence of TP53 Mutations in Metastatic Prostate Cancer. Cancer Inform. 2022 Apr 2;21:11769351221087046. doi: 10.1177/11769351221087046. PMID: 35392296; PMCID: PMC8980432.

458. Freeman MN, Jang A, Zhu J, Sanati F, Nandagopal L, Ravindranathan D, Desai A, Phone A, Nussenzveig R, Jaeger E, Caputo SA, Koshkin VS, Swami U, Basu A, Bilen MA, Agarwal N, Sartor O, Burgess EF, Barata PC. Multi-institutional Analysis of the Clinical and Genomic Characteristics of Black Patients with Metastatic Hormone-Sensitive Prostate Cancer. Oncologist. 2022 Mar 11;27(3):220227. doi: 10.1093/oncolo/oyab057. PMID: 35274720; PMCID: PMC8914485. Liu AJ, Kosiorek HE, Ueberroth BE, Jaeger E, Ledet E, Kendi AT, Tzou K, Quevedo F, Choo R, Moore CN, Ho TH, Singh P, Keole SR, Wong WW, Sartor O, Bryce AH. The impact of genetic aberrations on response to radium-223 treatment for castration-resistant prostate cancer with bone metastases. Prostate. 2022 Jun 2. doi: 10.1002/pros.24375. Epub ahead of print. PMID: 35652618.

Manogue C, Fleming W, Ledet E, Jaeger E, Layton J, Barata P, Lewis B, Sartor O.

Continuous IV Infusion of 5-Flourouracil in Heavily Pretreated Metastatic CastrateResistant Prostate Cancer. Clin Genitourin Cancer. 2022 Jun 26:S1558-7673(22)00139-2. doi: 10.1016/j.clgc.2022.06.014. Epub ahead of print. PMID: 35869001. Fanti S, Briganti A, Emmett L, Fizazi K, Gillessen S, Goffin K, Hadaschik BA, Herrmann K, Kunikowska J, Maurer T, MacLennan S, Mottet N, Murphy DG, Oprea-Lager DE, O’Sullivan JM, Oyen WJG, Rouvière O, Sartor O, Stenzl A, Van Poppel H, Walz J, Witjes W, Bjartell A. EAU-EANM Consensus Statements on the Role of Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Patients with Prostate Cancer and with Respect to [177Lu]Lu-PSMA Radioligand Therapy. Eur Urol Oncol. 2022 Jun 10:S2588- 9311(22)00086-4. doi: 10.1016/j. euo.2022.05.003. Epub ahead of print. PMID: 35697600.

IDELVION: A Comprehensive Review of Clinical Trial and Real-World Data. Escobar M, Mancuso ME, Hermans C, Leissinger C, Seifert W, Li Y, McKeand W, Oldenburg J.J Clin Med. 2022 Feb 18;11(4):1071. doi: 10.3390/jcm11041071.PMID: 35207344

2. Hemophilia A: Strategies for Improving Long-Term Holistic Management, Adherence, and Quality of Life. Escobar MA, Leissinger C, Young G.J Adv Pract Oncol. 2022 May;13(Suppl 3):7-20. doi: 10.6004/ jadpro.2022.13.4.8. Epub 2022 Jun 21.PMID: 35769336

PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with inhibitors. Escobar M, Luck J, Averianov Y, Ducore J, Fernández MFL, Giermasz A, Hart DP, Journeycake J, Kessler C, Leissinger C, Mahlangu J, Martinez LV, Miesbach W, Mitha IH, Quon D, Reding MT, Schved JF, Stasyshyn O, Vilchevska KV, Wang M, Windyga J, Alexander WA, Al-Sabbagh A, Bonzo D, Mitchell IS, Wilkinson TA, Hermans

C.Haemophilia. 2021 Nov;27(6):911-920. doi: 10.1111/hae.14418. Epub 2021 Oct 6.PMID: 34614267

The safety of activated eptacog beta in the management of bleeding episodes and perioperative haemostasis in adult and paediatric haemophilia patients with inhibitors. Escobar M, Castaman G, Boix SB, Callaghan M, de Moerloose P, Ducore J, Hermans C, Journeycake J, Leissinger C, Luck J, Mahlangu J, Miesbach W, Mitha IH, Négrier C, Quon D, Recht M, Schved JF, Shapiro AD, Sidonio R Jr, Srivastava A, Stasyshyn O, Vilchevska KV, Wang M, Young G, Alexander WA, AlSabbagh A, Bonzo D, Macie C, Wilkinson TA, Kessler C.Haemophilia. 2021 Nov;27(6):921931. doi: 10.1111/hae.14419. Epub 2021 Oct 11.PMID: 34636112

Molecular pathogenesis and heterogeneity in type 3 VWD families in U.S. Zimmerman program. Christopherson PA, Haberichter SL, Flood VH, Perry CL, Sadler BE, Bellissimo DB, Di Paola J, Montgomery RR; Zimmerman Program Investigators (incl. C Leissinger) .J Thromb Haemost. 2022 Jul;20(7):15761588. doi: 10.1111/jth.15713. Epub 2022 Apr 6.PMID: 35343054

Donald C, Kahn M. (2022) Platelet Substitutes. In H. Liu (Ed.) Blood Substitutes and Oxygen Biotherapeutics. (pp. 181 - 184). Cham, Switzerland: Springer.

Sun C, Chen Y, Martinez A, Baptista MJ, Pittaluga S, Liu D, Rosebrock D, Gohil SH, Saba NS, Davies-Hill T, Herman SEM, Getz G, Pirooznia M, Wu CJ, Wiestner A. The Immune Microenvironment Shapes Transcriptional and Genetic Heterogeneity in Chronic Lymphocytic Leukemia. Blood Adv. 2022. DOI: doi.org/10.1182/ bloodadvances.2021006941. PubMed PMID: 35358998. Lakhotia R, Melani C, Dunleavy K, Pittaluga S, Saba NS, Lindenberg L, Mena E, Bergvall E, Lucas AN, Jacob AP, Yusko E, Steinberg SM, Jaffe ES, Wiestner A, Wilson WH, Roschewski MJ. Circulating Tumor DNA Predicts Therapeutic

:: John W. Deming Department of Medicine

Publications

Hematology & Medical Oncology

Outcome in Mantle Cell Lymphoma. Blood Adv. 2022. doi: 10.1182/bloodadvances.2021006397. PubMed

PMID: 35143622.

Huang Z, Zhang L, Lyon C, Ning B, Youngquist B, Niu A, Beddingfield B, Maness, Saba NS, Li C, Roy C, Hu T. CRISPRbased Assay Reveals SARS-CoV-2 RNA Dynamic Changes and Redistribution Patterns in Non-Human Primate Model; Emerg Microbes Infect. 2022; 2:1-24. doi: 10.1080/22221751.2022.2038020. PubMed

PMID: 35108153. Murthy HS, Ahn KW, Estrada-Merly N, Alkhateeb HB, Bal S, Kharfan-Dabaja MA, Dholaria B, Foss F, Revised: 04/01/2022 Gowda L, Jagadeesh D, Sauter C, Abid MB, Aljurf M, Awan FT, Bacher U, Badawy SM, Battiwalla M, Bredeson C, Cerny J, Chhabra S, Deol A, Diaz MA, Farhadfar N, Freytes C, Gajewski J, Gandhi MJ, Ganguly S, Grunwald MR, Halter J, Hashmi S, Hildebrandt GC, Inamoto Y, Jimenez-Jimenez AM, Kalaycio M, Kamble R, Krem MM, Lazarus HM, Lazaryan A, Maakaron J, Munshi PN, Munker R, Nazha A, Nishihori T, OIuwole OO, Ortí G, Pan DC, Patel SS, Pawarode A, Rizzieri D, Saba NS, Savani B, Seo S, Ustun C, van der Poel M, Verdonck LF, Wagner JL, Wirk B, Oran B, Nakamura R, Scott B, Saber W. Outcomes of Allogeneic Hematopoietic Cell Transplantation in T-cell Prolymphocytic Leukemia: A Contemporary Analysis from the Center for International Blood and Marrow Transplant Research. Transplant Cell Ther. 2022; S2666-6367(22)00036-7. doi: 10.1016/j. jtct.2022.01.017. PubMed PMID: 35081472. Soleimani A, Navarro A, Liu D, Herman SEM, Chuang SS, Slavutsky I, Narbaitz M, Safah H, Schmieg J, Lefante J, Roschewski M, Wilson WH, Wiestner A, Saba NS*. CD5-negative mantle cell lymphoma: clinicopathologic features of an indolent variant that confers a survival advantage. Leuk Lymphoma. 2021; doi: 10.1080/10428194.2021.2002317. [Epub ahead of print]. PubMed PMID: 34781807. *, Corresponding Author.

Hawkes EA, Phillips T, Budde LE, Santoro A, Saba NS, Roncolato F, Gregory GP, Verhoef G, Offner F, Quero C, Radford J, Giannopoulos K, Stevens D, Thall A, Huang B, Laird AD, Sandner R, Ansell SM. Avelumab in Combination Regimens for Relapsed/ Refractory DLBCL: Results from the Phase Ib JAVELIN DLBCL Study. Target Oncol. 2021;16:761-771. PubMed PMID: 34687398. PMCID: PMC8613117

Xie J, Jang A, Uemura M, Nakazawa S, Calimeri T, Ferreri AJ, Chen SR, Schmid JL, Brown TC, Socola F, Safah H, Saba NS*. Systemic vs. intrathecal central nervous system prophylaxis in primary adrenal/renal diffuse large b-cell LYMPHOMA: A multi-institution retrospective analysis and systematic review. Leuk Res Rep. 2021;16:100263. doi: 10.1016/j. lrr.2021.100263. eCollection 2021. PubMed PMID: 34401320; PubMed Central PMCID: PMC8355911. *, Corresponding Author.

Ning B, Huang Z, Youngquist BM, Scott JW, Niu A, Bojanowski CM, Zwezdaryk KJ, Saba NS, Fan J, Yin XM, Cao J, Lyon CJ, Li CZ, Roy CJ, Hu TY. Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma. Nat Nanotechnol. 2021 Sep;16(9):1039-1044. doi: 10.1038/s41565021-00939-8. Epub 2021 Jul 22. PubMed PMID: 34294909; PMCID: PMC8440422.

Aboueshia M, Hussein MH, Attia AS, Swinford A, Miller P, Omar M, Toraih EA, Saba NS, Safah H, Duchesne J, Kandil E. Cancer and COVID-19: analysis of patient outcomes. Future Oncol. 2021 Jul 15;. doi: 10.2217/fon-2021-0121. [Epub ahead of print] PubMed PMID: 34263660. PMCID: PMC8284249.

Ibrahim M, Chen R, Vegel A, Panse K, Bhyravabhotla K, Harris K, Craig R, Safah H, Saba NS, Socola F. Treatment of myeloid sarcoma without bone marrow involvement with gemtuzumab ozogamicin-containing regimen. Leuk Res. 2021 Jul;106:106583. PubMed PMID: 33906021.

Xie J, Jang A, Vegel A, Hajja Y, Mouawad Y, Baghian A, Berbari B, Schmid JL, Socola F, Safah H, Saba NS*. Successful treatment of “accelerated” chronic lymphocytic leukemia with single agent ibrutinib: A report of two cases. Leuk Res Rep. 2021;15:100247. PubMed PMID: 34040961. PMCID: PMC8144065. *, Corresponding Author.

Awards

John W. Deming Department of Medicine

Awards for Excellence 2020-2021

AWARD FOR EXCELLENCE IN CLINICAL SERVICE

Nereida Parada, MD Associate Professor Director,

Asthma Center of Excellence

Dr. Nereida Parada joined Tulane School of Medicine in 2000. Dr. Parada has spent the past two decades building premier asthma patient care services for Tulane and greater Louisiana. She has improved asthma care at the state level for the past decade as Statewide Asthma Clinical Lead for LSU Health Sciences Services and as the Medical Director for Asthma and COPD Disease Management for the University Medical Center New Orleans. Dr. Parada has worked with medical students and residents to publish the work she has been leading to improve regional and state-wide asthma care. She has been the primary person responsible for teaching state-of-the-art comprehensive asthma care to medical students, residents, and fellows, which undoubtedly contributes to improved asthma management by these physicians who settle in our region and state.

Dr. Parada leadership at Tulane HCA hospital, as Director of the PFT lab and pulmonary rehabilitation program has led to improvements in the supportive care that these high functioning programs provide to our patients. Nereida has been tireless in adding to services that we can provide, including home ventilator management for patients with severe obstructive lung disease. Most recently she has added a refinement to the PFT lab service by introducing high altitude stimulation testing (HAST) to the wealth of high-quality pulmonary diagnostic and treatment options for patients with asthma and COPD. Her dedication to first-rate asthma patient care has now extended to a robust clinical trial program to seek better ways to care for asthma patients going forward. In summary, Dr. Parada is a national asthma program expert, and her dedication and passion has led to excellence in asthma patient care for Tulane, New Orleans, and Louisiana.

AWARD FOR EXCELLENCE IN TEACHING

Kristin Bateman, MD Assistant Professor Associate Program Director General Internal Medicine

Dr. Kristin Bateman joined the Section of GIM in 2016 and has been making her mark as a leader. Dr. Menard nominated Dr. Kristin Bateman, for her dedication to teaching. The reason for her selection is described in her letter: Kristin is one of the IM APDs for the program and has been for several years. She has won the Owl Club a couple of years now and the IM Best Attending from the IM Housestaff, for a couple of years now. She teaches the

Awards

Board Review course for the PGY3s. She quietly does all of this and sort of fly’s under the radar doing all this teaching, but she is really fantastic and I see her white board chalk talk remains after I go into a room and they are so detailed and chock full of such important IM clinical topics. She is so deserving of this award on the Departmental level for her persistent diligence and dedication to our academic mission.

AWARD FOR EXCELLENCE IN RESEARCH

S. Michal Jazwinski, PhD John W. Deming, MD Regents Chair in Aging Director, Center for Aging Professor of Medicine & Biochemistry

Dr. Jazwinski has been active in research and education, focusing on aging and the genetics of aging. S. Michal Jazwinski, PhD, is receiving the Awards for Excellence because of his continued diligence in research. Dr. Jazwinski received his doctoral degree from Stanford University, and completed his postdoctoral training at The Rockefeller University. Dr. Jazwinski’s research focus is on the genetics of aging and biomarker discovery of aging and frailty. Within the past year, he successfully renewed the NIH-funded Centers of Biomedical Research Excellence (COBRE) Phase Ill - Transitional Centers: Mentoring Research Excellence in Aging and Regenerative Medicine. This support from NIH/NIGMS will be instrumental in support of the Tulane Center for Aging for the next 5 years. Michal is an exceptional mentor, scientist, and colleague, and we are fortunate to have him as a member of the Deming Department of Medicine.

AWARD FOR EXCELLENCE IN DEPARTMENTAL SERVICE

Neelam Sikka Senior Administrator I Gastroenterology

Mrs. Neelam Sikka was nominated by Dr. Martin Moehlin for her outstanding support to the Department of Gastroenterology for over 30 years. Dr Martin Moehlin stated in his letter, “Neelam is one of the most kindhearted individuals I have come to know. The matriarch for our Section, selflessly devoted to both the wellbeing and interests of all those within the Section. Always with her office door open, she welcomed all for a chat, whether it be for a moment or for longer, she patiently listened and responded with her heart. She will be missed, but not forgotten. Neelam wrote in her letter of resignation”My journey at Tulane, which started 32 years ago on January 18, 1990 has been very rewarding and I have much to be thankful for. I will cherish my tenure at Tulane for a very long time. I wish Deming Department of Medicine and Gastroenterology section the very best.”

John W. Deming Department of Medicine

AWARD FOR EXCELLENCE IN CLINICAL SUPPORT

Durbin Senior Administrator, III General Internal Medicine

Vanessa Durbin is an MVP when it comes to Awards for Excellence. She has received her second award for Clinical Support for the 2020-2021 Academic year.

Dr. Menard nominated Vanessa for her remarkable commitment to her duties. Dr. Menard stated “for taking on the GOLD service scheduling component and coordinating with 3 different locums service groups to get providers rapidly credentialed and through the system processes at TMC (you know this is a time consuming task!!) and her consistent weekly GOLD email out to the providers for the week. I don’t think everyone realizes just what an undertaking implementing the GOLD team is on a daily basis. There are multiple emails, phone calls between those that are involved on a daily basis”.

Vanessa

Infectious Diseases

David Mushatt, MD, MPH&TM, FIDSA, FACP Professor Chief Section of Infectious Disease

CLINICAL ACTIVITIES

The Section of Adult Infectious Diseases is one of 11 internal medicine subspecialty sections within the Department of Medicine. Our clinical faculty provide infectious diseases outpatient consultations at the Tulane Medical Center Multi-Specialty Clinic, the University Medical Center LCMC Health HIV Outpatient Program (HOP) clinic, and the Southeast Louisiana Veterans Affairs Health. In addition, it sponsors the Ruth Fertel Ryan White HIV / STI Clinic in New Orleans, the Ryan White HIV Clinic / ID Clinic in Alexandria, LA, and has a faculty member at the Wetmore TB Clinic in New Orleans, LA.

The Section also provides inpatient ID Consultation Services at Tulane Medical Center, University Medical Center LCMC, and Southeast Louisiana Veterans Affairs Health A partnership was created with the City of New Orleans’ Office of Public Health 504.net, LA State Health Dept STD Prevention, AIDS Support Organization, and Central Louisiana AIDS Support Services (CLASS).

EDUCATIONAL ACTIVITIES

The mission of the Tulane Adult Infectious Disease Fellowship Program is to create an educational experience that trains fellows to become excellent clinicians, educators, and scientists who are compassionate, socially conscious, and intellectually curious. In addition, promoting the career development of each fellow’s individual goals is a priority. Through a combination of diverse clinical experiences, didactics, scholarly activity, and mentorship, we aim to provide each fellow with mastery of a core set of knowledge and skillsets while providing the flexibility to become leaders in clinical education, clinical practice, public health, or research.

The Fellowship Program is a 2-year (PGY-4 and PGY-5) ACGME accredited fellowship training program with a total of 6 trainees. Fellows rotate on in-patient ID consultation services at Tulane Medical Center, University Medical Center LCMC Health, and the Southeast Louisiana Veterans Affairs Health.

In addition to in-patient consultation services, fellows complete required rotations in microbiology, infection control, antimicrobial stewardship, hospital epidemiology, and infectious transplant disease. During the 2nd year of training, fellows complete a “focus track” to provide additional specialized focus on areas within infectious disease (e.g., HIV & Sexually Transmitted Infections) or with focused career preparation (e.g., Research; Clinician Educator). Second-year fellows also have the option to do additional clinical rotations, electives, graduate courses, including the Diploma Course in Clinical Tropical Medicine and Travelers’ Health in the Dept of Tropical Medicine at the Tulane University School of Public Health and Tropical Medicine, research, and other scholarly pursuits.

RESEARCH ACTIVITIES

The Section of Adult Infectious Diseases participates in a wide range of clinical and epidemiological

Infectious Diseases

research activities. They have had a longstanding interest in HIV/AIDS, mycoses, mycobacteria and tropical medicine. The Section is fortunate to have a number of faculty and colleagues performing bench research, translational and clinical research at the Tulane University School of Public Health and Tropical Medicine, the Department off Microbiology, the Tulane National Primate Research Center, the Pediatric Infectious Diseases Section, as well as in the graduate school on the Uptown campus.

During the 2020-21 and 2021-22 academic years, many of our research faculty pivoted to conducting research on various aspects of the COVID-19 pandemic: new diagnostics; clinical trials of therapeutics such as antivirals, monoclonal antibodies and immune modulators; COVID virology; long COVID; focus on education/messaging of minority populations to enhance uptake of COVID vaccines and participation in clinical research.

ALEXANDRIA INFECTIOUS DISEASES SATELLITE CLINIC

Disease

Tulane Doctors-Alexandria has two simultaneous clinics

Federal Grant funded Ryan White HIV Clinic

Services Offered: Free HIV & STI Testing

HIV Primary Care

Dental Services

Mental Health Services

Medical Case Management Services Insurance and Medication Management

On-site Pharmacy Services thru Tulane Pharmacy 340(B) Program for patient savings

340(B) Funded STI and Prep Clinic

Services Offered: Free HIV & STI Testing

Hep C Treatment

STI Treatment

PreP Treatment and Services

On-site Pharmacy Services thru Tulane Pharmacy 340(B) Program for patient savings

Tulane University has held the Ryan White HIV grant since 1999 and was housed in Huey P Long

Aaron McLemore, MD Medical Director Infectious

Dana Mays, MD Physician Family Practice

Norma S. Porter, DNP, APRN Nurse Practitioner Family Medicine

Infectious Diseases

Medical Center in Pineville. The clinic became a stand alone HIV clinic in 2013 when the charity system ceased.

HIV Clinic follows approximately 600 patients. STI & Prep Clinic has a fluid patient load; treating and then returning to their primary care physicians.

AWARDS & ACCOMPLISHMENTS

John Dwyer, DO 2021 Health Care Heroes Honoree, presented by New Orleans CityBusiness

David Mushatt, MD

Top Doctors 2021, New Orleans Magazine Award for Excellence in Clinical Service

Crystal Zheng, MD Alpha Omega Alpha Honor Medical Society Difference Maker Recognition/ University Medical Center New Orleans LCMC Health

Jeffrey Percak, MD School of Medicine Award of Excellence in Teaching

Dahlene Fusco, MD School of Medicine PSPP Recipient Shared Equipment Grant Recipient Best Poster Post-Covid Description Clinical Research Award University Medical Center New Orleans LCMC Health

Crystal Zheng, MD School of Medicine LA CaTS Roadmap Scholars Award Research, Scholarship & Artistic Achievement Award (SPHTM

David Mushatt, MD President’s Excellence Award Treasure Schwab President’s Excellence Award

John Dwyer, MD Consultant of the Year Award University Medical Center New Orleans LCMC Health

ADVOCACY

John Dwyer, MD Asociación Nuestros Ahijados The GOD’S CHILD Project

Jeffrey Percak, MD Physicians for Human Rights Asylum Network

Crystal Zheng, MD Board Member Stanford Asian Pacific American Alumni Club

Infectious Diseases

FACULTY

Allison Cormier, MD Assistant Professor Medical Director Ryan White Tulane Total Health Clinic

John Dwyer, DO Assistant Professor Assistant Program Director Fellowship Program TMC Antibiotic Stewardship Program

Dahlene Fusco, MD, PhD Assistant Professor

Alfred Luk, MD Assistant Professor Medical Director of Infectious Diseases Bone Marrow and Solid

STAFF

Treasure Schwab Section Administrator

Jacquel Benion Clinic Manager III Suzanne Adams RN Tracy Harrell LPN

Trina JeanJacques Medical Case Manager

Organ Transplant Program

David Mushatt, MD, MPH&TM, FIDSA, FACP Professor Section Chief

Crystal Zheng, MD Instructor

Diversity Lead Erin Boswell, MD Assistant Professor Adjunct Interim Director ID Fellowship Program Edward Swiatlo, MD, PhD

Adira Myers Scientific Research Analyst II

Charlotte Davenport Graduate Medical Education Program Administrator I

James Lewis Health Promotion Specialist

Christian Aldridge Medical Research Technician

Matthew Moreida Medical Research Technician

Associate Professor Adjunct Kyle Widmer, MD Assistant Professor Adjunct Chief, VA ID Division

Philip Yeon, MD, MPH&TM Assistant Professor Adjunct VA Site Director, ID Fellowship

Joshua Katz Medical Research Technician

Keaneagline Mccurdy Medical Office Assistant Alicia Amador Non-Medical Case Manager Maxwell Rubin Laboratory Aide

Cormier AK, Liebenstein TK, Westergaard RP. Treatment and Prevention of HIV Infection. Conn’s Current Therapy 2021.

Johnston, C., Brown, E. R., Stewart, J., Karita, H. C. S., Kissinger, P. J., Dwyer, J., Hosek, S., Oyedele, T., Paasche-Orlow, M. K., Paolino, K., Heller, K. B., Leingang, H., Haugen, H. S., Dong, T. Q., Bershteyn, A., Sridhar, A. R., Poole, J., Noseworthy, P. A., Ackerman, M. J., Morrison, S., Greninger, A. L., Huang, M. L., Jerome, K. R., Wener, M. H., Wald, A., Schiffer, J. T., Celum, C., Chu, H. Y., Barnabas, R. V., Baeten, J. M., COVID-19 Early Treatment Study Team (2021). Hydroxychloroquine with or without azithromycin for treatment of early sars-cov-2 infection among high-risk outpatient adults: a randomized clinical trial. EClinicalMedicine, 33, 100773. https://dx.doi.org/10.1016/j. eclinm.2021.100773

Woodbridge A, Foroushani S, Hopper T, Perez-Chaumont A, Frechtling D, Phillips B, Ngo L, Dwyer J. Closing the supply gap: how a student clinic organization adapted their role during COVID-19 clinical suspension to support frontline providers. Harvard Public Health Review. 2021; 27.

Alkuzweny, Patricia Snarski, Julia Garcia- Diaz, Rona S. Scott, Lilia Melnik, Raphaëlle Klitting, Michelle McGraw, Pedro Belda- Ferre, Peter DeHoff, Shashank Sathe, Clarisse Marotz, Nathan Grubaugh, David J. Nolan, Arnaud C. Drouin, Kaylynn J. Genemaras, Karissa Chao, Sarah Topol, Emily Spencer, Laura Nicholson, Stefan Aigner, Gene W. Yeo, Lauge Farnaes, Charlotte A. Hobbs, Louise C. Laurent, Rob Knight, Emma B. Hodcroft, Kamran Khan, Dahlene N. Fusco, Vaughn S. Cooper, Phillipe Lemey, Lauren Gardner, Susanna L. Lamers, Jeremy P. Kamil, Robert F. Garry, Marc A. Suchard, Kristian G. Andersen. https://www.medrxiv.org/ content/10.1101/2021.02.05.21251235v1

Publications Infectious Diseases

Adverse pregnancy outcomes and Zika antibodies among pregnant women in Thailand between 1997 and 2015 Nicole Ngo-Giang-Huong *, Charline Leroi, Dahlene Fusco, Tim Roy Cressey, Nantawan Wangsaeng, Nicolas Salvadori, Natedao Kongyai, Wasna Sirirungsi, Marc Lallemant, Prasert Auewarakul, Woottichai Khamduang *, Gonzague Jourdain. Accepted: July 9 2021: VIRUSES.

Impact of Zika virus on the human type I interferon osteoimmune response. Arnaud Drouin, Nicholas Wallbillich, Marc Theberge, Sharon Liu, Joshua Katz, Kamela Bellovoda, Scarlett Se Yun Cheon, Frederick Gootkind, Emily Bierman , Jason Zavras, Matthew J Berberich, Marian Kalocsay, Fernando Guastaldi, Nicolas Salvadori, Maria Troulis, Dahlene N Fusco. Cytokine. 2021 Jan;137:155342. PMID: 33130337.

Emergence of an early SARS-CoV-2 epidemic in the United States. Mark Zeller, Karthik Gangavarapu, Catelyn Anderson, Allison R. Smither, John A. Vanchiere, Rebecca Rose, Daniel J. Snyder, Gytis Dudas, Alexander Watts, Nathaniel L. Matteson, Refugio Robles-Sikisaka, Maximilian Marshall, Amy K. Feehan, Gilberto Sabino-Santos Jr, Antoinette R. Bell-Kareem, Laura D. Hughes, Manar

Successful Clearance of 300 Day SARS-CoV-2 Infection in a Subject with B-Cell Depletion Associated Prolonged (B-DEAP) COVID by REGEN-COV Anti-Spike Monoclonal Antibody Cocktail Arnaud C. Drouin 1,*, Marc W. Theberge 2 , Sharon Y. Liu 1, Allison R. Smither 3, Shelby M. Flaherty 1,Mark Zeller 4, Gregory P. Geba 5 , Peter Reynaud 1, W. Benjamin Rothwell 1, Alfred P. Luk 1, Di Tian 6, Matthew L. Boisen 7, Luis M. Branco 7, Kristian G. Andersen 4, James E. Robinson 8, Robert F. Garry 3 and Dahlene N. Fusco. Viruses 2021, 13(7), 1202; https://doi.org /10.3390/v13071202. Received: 24 April 2021 / Revised: 2 June 2021 / Accepted: 16 June 2021 / Published: 23 June 2021

Ibrahim M, Vegel A, Niu A, Panse K, Chen R, Safah H, Socola F, Luk A, Saba NS. Reinfection versus failure of viral clearance in a COVID-19 patient with hematologic malignancy. Leukemia Research. 2021; 101:106514. Doi: 10.1016/j.leukres.2021.106514. Online ahead of print, 2021 Jan 20.

Zheng C, Anthonypillai J, Musominali S, Chaw GF, Paccione G. Community Perceptions of Village Health Workers in Kisoro, Uganda. Annals of Global Health. 2021;87(1):82.

Research Infectious Diseases

John Dwyer, DO, Assistant Professor of Medicine, as Director of the Antimicrobial Stewardship Program at TMC, worked closely with Wes Pierce, PharmD, Josh Denson, MD of Critical Care, Dr. Davis Mushatt and others to devise COVID-19 treatment algorithms and criteria for use of dexamethasone, and novel agents such as remdesivir and tocilizumab. Dr. Dwyer also enrolled study patients into a large prospective clinical trial of hydroxychloroquine, an important study that was published and demonstrated a lack of benefit, thus helping to put this controversial agent to bed.

Alfred Luk, MD, Assistant Professor of Medicine, Director of Bone Marrow and Transplant ID, worked tirelessly to diagnose and treat COVID-19 in his vulnerable, immunocompromised patients. He collaborated with investigators in Heme-Onc to study the role of convalescent plasma in this population, as well as with Heme-Onc and Tony Wu, PhD, to develop a more sensitive CRISPR-based PCR assay for SARS CoV-2. Dr. Luk is also the PI for Tulane Abdominal Transplant Institute (TATI) study which will study the role of transplanting kidneys from HIVpositive donors to HIV-positive recipients.

Dahlene Fusco, MD, PhD, Assistant Professor of Medicine, is a physician scientist who came to Tulane in 2018 with a focus on Dengue and Zika virus. As the pandemic took hold, she quickly pivoted to the new research environment and took the lead as a PI overseeing multiple clinical trials of new agents, including the Regeneron anti-SARS CoV-2 monoclonal antibodies (casivirimab imdevimab), the antiviral agent remdesivir, the IL-6 antagonist sarilivumab, and others. Ever with an eye towards trying to better understand viral pathogenesis, Dr. Fusco was awarded a grant by the CDC for her Clin- Seq-Ser study, which prospectively enrolls newly diagnosed COVID-19 patients to analyze their antibody responses and viral gene sequences. Once it was apparent that many patients recovering from COVID-19 were developing persistent, long-term sequelae, Dr. Fusco established a clinic to evaluate and follow these patients for what has been termed “Long COVID”, a chronic, debilitating condition that affects at least 10% of those who have been infected.

Crystal Zheng, MD, Instructor of Medicine, joined our Section in July 2020 as a physician scientist and was awarded a LaCATS Roadmap Scholarship to study amenorrhea in women who survived Ebola infection in West Africa.

Nephrology and Hypertension

CLINICAL ACTIVITIES

Robert Hoover MD, FASN, FAHA Professor of Medicine & Physiology The Dr. A. Rudolph and Ruth Ryder Huberwald Chair Chief Section of Nephrology & Hypertension

The Section of Nephrology and Hypertension has clinical services at Tulane Medical Center, University Medical Center LCMC Health, and Southeast Louisiana Veterans Affairs Health. Services include procedures, consult service and specialties. Section faculty also serve in several external leadership roles at partner organizations

UMC Resident Supervision

UMC Medical Directorship Fresenius Directorship Dialysis Clinic Inc. (DCI) Directorship

Eric Simon, MD (Tulane)

Adrian Baudy, MD (New Orleans East)

Federico Teran, MD / Lee Hamm, MD (Westbank)

EDUCATIONAL ACTIVITIES

Nephrologists take holistic care of many of their patients, requiring honed general history and physical exam skills, as well as those specific to Nephrology. Tulane fellows train in the art of history and physical examination as part of their in-patient consults, clinics, and dialysis rotations.

Medical knowledge is gained by direct patient contact on clinical rotations, in continuity clinics, and on dialysis shifts. Additionally, there are extensive didactic conferences, including core lectures, journal clubs, case conferences, biopsy conferences, and research conferences.

Tulane Nephrology Fellows develop procedural proficiency by performing temporary dialysis catheter placement, kidney biopsies of native and transplant kidneys, chronic and acute hemodialysis, including continuous therapies, and peritoneal dialysis. Fellows acquire the skills necessary to be effective physicians by expanding medical knowledge, enhancing interpersonal and leadership capabilities, and understanding the principles of ethical care. The program fosters habits for life-long self-education and personal growth.

The Section of Nephrology & Hypertension at Tulane Medical Center, offers a comprehensive accredited two-year nephrology training program. That includes broad clinical experience working through rotations and clinic assignments at area public, private, and government-oper- ated hospitals and clinics and the opportunity to achieve scholastically through research, publications, and teaching experiences.

A strong relationship with the School of Public Health provides research opportunities for epidemiological studies. A Center of Excellence in Hypertension strengthens research conferences and provides

Nephrology and Hypertension

additional research opportunities. A close relationship with Pediatric Nephrology gives fellows access to experts in the field of Pediatric Nephrology. A diverse patient population provides unique clinical opportunities.

RESEARCH ACTIVITIES

Tulane Nephrology research encompasses basic science, clinical studies, and epidemiological studies. The Section collaborates extensively with various other departments and centers, including Epidemiology, Tulane School of Public Health and Tropical Medicine, and the Tulane Hypertension and Renal Center of Excellence, Department of Physiology. Studies include epidemiology and genetics of chronic kidney disease and related cardiovascular diseases, such as hypertension, and various aspects of the pathophysiology of hypertension, angiotensin II injury, and hormones affecting cardiovascular physiology.

RESEARCHERS

Flor Alvarado, MD, MPH Assistant Professor

Vecihi Batuman, MD, FASN Professor

Jing Chen, MD, MMSc, MSc Professor

Kathleen Hering-Smith, MS, PhD, FASN Associate Professor

Robert S. Hoover, MD, FASN, FAHA Professor

Rhea Bhargava, MD Assistant Professor

Nazih L. Nakhoul, PhD Associate Professor

Moh’d Sharshir, MD Assistant Professor

Rohit Upadhyay Post Doctorial

AWARDS & ACCOMPLISHMENTS

Robert S. Hoover, MD

2022 Professionalism Advisory Board Member

Gerald Schluman Invited Lectureship at Vanderbilt University Medical Grand Rounds

The A. Clifford Barger Underrepresented Minority Mentorship Award from American Physiological Society

Federico Teran, MD

2021 Castle Connolly Top Doctors

Arnold Alper, MD

2021 Castle Connolly Top Doctors

Flor Alvarado, MD

Physician-Scientist Pipeline Program School of Medicine

Nephrology and Hypertension

PROFESSIONAL SOCIETIES

Robert S. Hoover, MD

Chair, American Heart Association (AHA) Council on Hypertension SCILL committee Chair, American Society of Nephrology (ASN) Workforce and Training Committee

Member, ASN Task Force on the Future of Nephrology Member, ASN Executive Committee

Vechi Batuman, MD

2015-Present, Councilor, Southern Society of Clinical Investigation

Kathleen Hering-Smith, MS, PhD

Tulane University Department of Physiology Graduate Education Committee 2010-present Tulane University School of Medicine Freezer Farm Committee 2011-present

Tulane University School of Medicine Research Advisory Committee 2014- present Tulane University Senate Elected 2017-2020

SSCI Membership Committee Elected, term 2019-2021

Tulane University Medical School Admissions Committee, Elected term 2018-2021 SSCI Councilor Elected 2018-2021

Chair, APS Renal Section, Elected, 2020-2023

FACULTY

Alper, Arnold Brent Jr. Associate Professor

Alvarado, Flor Assistant Professor Batuman, Vecihi Professor

Baudy, Adrian Joseph IV Assistant Professor Fellowship Program Director Bhargava, Rhea Assistant Professor

STAFF

Weitao Huang

Senior Research Scientist

Mohammed T Islam Medical Research Technician

Chen, Jing Professor

Delima-Mujica, Bruna NP Instructor

Goldvarg-Abud, Inna Instructor

Hering-Smith, Kathleen S Associate Professor

Hoover, Robert S. Professor and Chief Kleinpeter, Myra A Associate Professor

Nakhoul, Nazih L Associate Professor

Sharshir, Mohd A Assistant Professor Simon, Eric Edward Professor

Teran, Federico J Assistant Professor Upadhyay, Rohit Postdoctoral Fellow

Zannatul Nasrin Medical Research Technician

Venicia Stewart Graduate Medical Education Program Administrator I

Stephanie Villagran Senior Section Administrator

Nephrology and Hypertension

Adrian Baudy, MD Nephrology and Hypertension Specialists

Nephrologist and hypertension specialist Adrian Baudy, MD, knows he can’t simply tell his patients to cut out all the salty foods that are contributing to their health issues. The time of year when Louisiana crawfish are available is practically its own season, celebrated alongside the seasons of football, Carnival, and festivals.

Kidney and hypertension patients who like using hot sauce on their foods still need to watch their sodium intake, so he remembered what he learned in his grandfather’s kitchen. “My grandfather would take peppers off the bush and put them in a jar of vinegar,” said Baudy. Baudy started experimenting with different flavors and used his father as a taste tester. They settled on a recipe a week before his father died of sudden cardiac arrest. “I’m always inventing and tinkering, and he told me this is the best idea I’ve ever had,” Baudy said. “When he died, I knew that was kind of a push that I should want to help other people from losing family members early.

“I’m able to help customers from several different countries now, and that’s really a great feeling that you can expand what you can do for people because I can only see so many patients,” said Baudy. “When I can help someone’s uncle or mother or grandparent and I get these emails back from the family, that’s the best way to make a difference.”

Publications

Nephrology and Hypertension

Giusti S, Lin Y, Sogbetun F, Nakhoul N, Liu S, Shi L, Batuman V: The Effect of Proton Pump Inhibitor use on the Course of Kidney Function in Patients with Chronic Kidney Disease Stages G3a to G4. Am J Med Sci 2021.

Sirac C, Batuman V, Sanders PW: The Proximal Tubule Toxicity of Immunoglobulin Light Chains. Kidney Int Rep 2021, 6(5):12251231.

Schrauben SJ, Shou H, Zhang X, Anderson AH, Bonventre JV, Chen J, Coca S, Furth SL, Greenberg JH, Gutierrez OM, Ix JH, Lash JP, Parikh CR, Rebholz CM, Sabbisetti V, Sarnak MJ, Shlipak MG, Waikar SS, Kimmel PL, Vasan RS, Feldman HI, Schelling JR; CKD Biomarkers Consortium and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Association of Multiple Plasma Biomarker Concentrations with Progression of Prevalent Diabetic Kidney Disease: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. J Am Soc Nephrol. 2021 Jan;32(1):115-126. doi: 10.1681/ ASN.2020040487. Epub 2020 Oct 29. PMID: 33122288; PMCID: PMC7894671. Zheng Z, Waikar SS, Schmidt IM, Landis JR, Hsu CY, Shafi T, Feldman HI, Anderson AH, Wilson FP, Chen J, Rincon-Choles H, Ricardo AC, Saab G, Isakova T, Kallem R, Fink JC, Rao PS, Xie D, Yang W; CRIC Study Investigators. Subtyping CKD Patients by Consensus Clustering: The Chronic Renal Insufficiency Cohort (CRIC) Study. J Am Soc Nephrol. 2021 Mar;32(3):639-653. doi: 10.1681/ASN.2020030239. Epub 2021 Jan 18. PMID: 33462081; PMCID: PMC7920178.

Cohen JB, Yang W, Li L, Zhang X, Zheng Z, Orlandi P, Bansal N, Deo R, Lash JP, Rahman M, He J, Shafi T, Chen J, Cohen DL, Matsushita K, Shlipak MG, Wolf M, Go AS, Feldman HI; CRIC Study Investigators. TimeUpdated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2021 May 27:S0272-6386(21)00629-6. doi:

10.1053/j.ajkd.2021.03.021. Epub ahead of print. PMID: 34052355.

Schmidt IM, Srivastava A, Sabbisetti V, McMahon GM, He J, Chen J, Kusek J, Taliercio J, Ricardo AC, Hsu CY, Kimmel PL, Liu KD, Mifflin TE, Nelson RG, Ramachandran VS, Xie D, Zhang X, Palsson R, Stillman IE, Rennke HG, Feldman HI, Bonventre JV, Waikar SS; Chronic Kidney Disease Biomarkers Consortium and the CRIC Study Investigators. Plasma Kidney Injury Molecule 1 in CKD: Findings From the Boston Kidney Biopsy Cohort and CRIC Studies. Am J Kidney Dis. 2021 Jun 24:S0272-6386(21)00694-6. doi: 10.1053/j. ajkd.2021.05.013. Epub ahead of print. PMID: 34175376.

Dorans KS, Bazzano LA, Qi L, He H, Appel LJ, Samet JM, Chen J, Mills KT, Nguyen BT, O’Brien MJ, Uwaifo GI, He J. Lowcarbohydrate dietary pattern on glycemic outcomes trial (ADEPT) among individuals with elevated hemoglobin A1c: study protocol for a randomized controlled trial. Trials. 2021 Feb 1;22(1):108. doi: 10.1186/s13063020-05001-x. PMID: 33522954; PMCID: PMC7848246.

Hall RK, Blumenthal JB, Doerfler RM, Chen J, Diamantidis CJ, Jaar BG, Kusek JW, Kallem K, Leonard MB, Navaneethan SD, Sha D, Sondheimer JH, Wagner LA, Yang W, Zhan M, Fink JC; CRIC Study Investigators. Risk of Potentially Inappropriate Medications in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2021 May 21:S0272-6386(21)00622-3. doi: 10.1053/j. ajkd.2021.03.019. Epub ahead of print. PMID: 34029681.

Kim H, Anderson CA, Hu EA, Zheng Z, Appel LJ, He J, Feldman HI, Anderson AH, Ricardo AC, Bhat Z, Kelly TN, Chen J, Vasan RS, Kimmel PL, Grams ME, Coresh J, Clish CB, Rhee EP, Rebholz CM. Plasma Metabolomic Signatures of Healthy Dietary Patterns in the Chronic Renal Insufficiency Cohort (CRIC) Study. J Nutr. 2021 Jun

30:nxab203. doi: 10.1093/jn/nxab203. Epub ahead of print. PMID: 34195833. Beddhu S, Boucher RE, Sun J, Balu N, Chonchol M, Navaneethan S, Chertow GM, Townsend R, Haley W, Cheung AK, Conroy MB, Raj DS, Xu D, George T, Yunis R, Wei G, Canton G, Bates J, Chen J, Papademetriou V, Punzi H, Wiggers A, Wright JT, Greene T, Yuan C. Chronic kidney disease, atherosclerotic plaque characteristics on carotid magnetic resonance imaging, and cardiovascular outcomes. BMC Nephrol. 2021 Feb 24;22(1):69. doi: 10.1186/s12882021-02260-x. PMID: 33627066; PMCID: PMC7905597.

Toth-Manikowski SM, Yang W, Appel L, Chen J, Deo R, Frydrych A, Krousel-Wood M, Rahman M, Rosas SE, Sha D, Wright J, Daviglus ML, Go AS, Lash JP, Ricardo AC; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Sex Differences in Cardiovascular Outcomes in CKD: Findings From the CRIC Study. Am J Kidney Dis. 2021 Apr 20:S0272-6386(21)00512-6. doi: 10.1053/j.ajkd.2021.01.020. Epub ahead of print. PMID: 33857532.

Razavi AC, Bazzano LA, He J, Krousel-Wood M, Chen J, Fernandez C, Whelton SP, Kelly TN. Early Contributors to Healthy Arterial Aging Versus Premature Atherosclerosis in Young Adults: The Bogalusa Heart Study. J Am Heart Assoc. 2021 Jun 15;10(12):e020774. doi: 10.1161/JAHA.121.020774. Epub 2021 Jun 5. PMID: 34096330.

Zheng X, Shen S, Wang A, Zhu Z, Peng Y, Peng H, Zhong C, Guo D, Xu T, Chen J, Ju Z, Geng D, Zhang Y, He J. Angiopoietin-like protein 4 and clinical outcomes in ischemic stroke patients. Ann Clin Transl Neurol. 2021 Mar;8(3):687-695. doi: 10.1002/acn3.51319. Epub 2021 Feb 22. PMID: 33616301; PMCID: PMC7951112.

Yang P, Zhu Z, Zang Y, Bu X, Xu T, Zhong C, Wang A, Peng H, Guo D, Zheng X, Xu T, Chen J, Zhang Y, He J. Increased Serum Complement C3 Levels Are Associated With

Publications Nephrology and Hypertension

Adverse Clinical Outcomes After Ischemic Stroke. Stroke. 2021 Mar;52(3):868-877. doi: 10.1161/STROKEAHA.120.031715. Epub 2021 Feb 1. PMID: 33517703. Zheng X, Peng Y, Zhong C, Xie X, Wang A, Zhu Z, Xu T, Peng H, Xu T, Wang D, Ju Z, Geng D, Chen J, Liu L, He J, Zhang Y. Systolic Blood Pressure Trajectories After Discharge and Long-Term Clinical Outcomes of Ischemic Stroke. Hypertension. 2021 May 5;77(5):1694-1702. doi: 10.1161/ HYPERTENSIONAHA.120.16881. Epub 2021 Mar 22. PMID: 33745302. He J, Huang JF, Li C, Chen J, Lu X, Chen JC, He H, Li JX, Cao J, Chen CS, Bazzano LA, Hu D, Kelly TN, Gu DF. Sodium Sensitivity, Sodium Resistance, and Incidence of Hypertension: A Longitudinal FollowUp Study of Dietary Sodium Intervention. Hypertension. 2021 Jul;78(1):155-164. doi: 10.1161/HYPERTENSIONAHA.120.16758. Epub 2021 Apr 26. PMID: 33896191; PMCID: PMC8192427.

Upadhya B, Pajewski NM, Rocco MV, Hundley WG, Aurigemma G, Hamilton CA, Bates JT, He J, Chen J, Chonchol M, Glasser SP, Hung AM, Pisoni R, Punzi H, Supiano MA, Toto R, Taylor A, Kitzman DW; SPRINT Research Group. Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART. Hypertension. 2021 May 5;77(5):1571-1580. doi: 10.1161/ HYPERTENSIONAHA.120.16676. Epub 2021 Mar 29. PMID: 33775127; PMCID: PMC8035296. Wright CB, Auchus AP, Lerner A, Ambrosius WT, Ay H, Bates JT, Chen J, Meschia JF, Pancholi S, Papademetriou V, Rastogi A, Sweeney M, Willard JJ, Yee J, Oparil S. Effect of Intensive Versus Standard Blood Pressure Control on Stroke Subtypes. Hypertension. 2021 Apr;77(4):1391-1398. doi: 10.1161/ HYPERTENSIONAHA.120.16027. Epub 2021 Feb 15. PMID: 33583199; PMCID: PMC8224947.

Harries AJ, Lee C, Jones L, Rodriguez R, Davis JA, Boysen-Osborn M, Kashima KJ, Krane NK, Rae G, Kman N, Langsfeld JM, Juarez M. Effects of the COVID-19 Pandemic on Medical Students: A Quantitative Study. BMC Med Educ. 2021 Jan 6;21(1):14. doi: 10.1186/s12909-020-02462-1. PMID: 33407422

Binks AP, LeClair RJ, Willey JM, Brenner JM, Pickering JD, Moore S, Huggett KN, Everling KM, Arnott JA, Croniger CM, Zehle CH, Krane NK, Schwartzstein RM. Changing Medical Education Overnight: The curricular response to COVID-19 of nine medical schools. Teaching and Learning in Medicine, 33(3): 334-42, 2021

B Lee CM, Juarez M, Rae G, Jones L, Rodriguez RM, Davis JA, Boysen-Osborn M, Kashima KJ, Krane NK, Kman N, Langsfeld JM, Harries AJ. Anxiety, PTSD, and stressors in medical students during the initial peak of the COVID-19 pandemic. PLoS One. 2021 Jul 29;16(7):e0255013. doi: 10.1371/journal.pone.0255013. eCollection 2021. PMID: 34324555

Krane NK, Gibson JW. Designing a Course, in 3nd edition of An Introduction to Medical Teaching: The Foundations of Curriculum Design, Delivery, and Assessment Springer, New York 2021. In Press.

Giusti S, Lin Y, Sogbetun F, Nakhoul NL, Liu S, Shi L and Batuman V. The Effect of Proton Pump Inhibitor use on the Development of Metabolic Acidosis and Decline in Kidney Function in Patients with Chronic Kidney Disease Stages G3a to G4. Am J Med Sci. 2021 May 22:S0002-9629(21)00187-7. doi: 10.1016/j.amjms.2021.05.017. Epub ahead of print. PMID: 34033809.

Cholin L, Ashour T, Mehdi A, Taliercio JJ, Daou R, Arrigain S, Schold JD, Thomas G, Nally J, Nakhoul NL, Nakhoul GN. Protonpump inhibitor vs. H2-receptor blocker use and overall risk of CKD progression. BMC Nephrol. 2021 Jul 15;22(1):264. doi: 10.1186/

s12882-021-02449-0. PMID: 34266395; PMCID: PMC8281649.

Abdulnour-Nakhoul SM, Nakhoul NL. Ussing Chamber Methods to Study the Esophageal Epithelial Barrier. Methods Mol Biol. 2021;2367:215-233. doi: 10.1007/7651_2020_324. PMID: 32946026.

Dominique Eladari, Norman P. Curthoys and Nazih L. Nakhoul. Renal Ammonium Ion Production and Transport. In: The Kidney: Physiology and Pathophysiology, 6th edition. (editors: Seldin and Giebisch), Elsevier 2021. In Press. Abdulnour-Nakhoul S and Nakhoul NL.

PERMEABILITY BARRIER: Methods and Protocols. In: Molecular Biology [SpringerNature 2021].

Collapsing glomerulopathy in a patient with COVID-19, Christopher P Larsen, Thomas D Bourne, Jon D Wilson, Osaid Saqqa, Moh’d A Sharshir Kidney international reports, 2020. AKI treated with renal replacement therapy in critically ill patients with COVID-19. S Gupta, SG Coca, L Chan, ML Melamed, SK Brenner, STOP-COVID Investigators Journal of the American Society of Nephrology, 2021. S. Giusti, S. Chazin, P. Vaitla, K. Atiemo, M. Atari, A. Paramesh, H. Jeon, A. Vijay, A. Torres, M. Killackey, R. Thimmisetty, J. Garces, “Observational Study of the Clinical Characteristics and Short-term Outcomes of Kidney Transplant Recipients Diagnosed with Coronavirus-19 Infection (SARs-CoV2) Requiring Hospitalization in New Orleans.” (TOJ-21-0008.R1) accepted for publication in the Ochsner Journal.

Giusti S, Batuman V. ‘Kidney and Pancreas Transplantation for Diabetic Kidney Disease’. Lerma E, Batuman V. Diabetes and Kidney Disease. 2022. Springer. Chapter submitted, undergoing revisions for printing.

Sinha R, Cassol CA, Sharshir MA, Atari MJ, Teran F. Myeloma Kidney and Kappa-Light Chain Crystal-Storing Histiocytosis. Southern

82 :: John W. Deming Department of Medicine

Publications

Nephrology and Hypertension

Society for Clinical Research Annual Meeting 2021. (Abstract 638)

Alzubaidi M, Ambrosy T, Beckrich A, Blaser R, Conlon S, Garg A, Gupta D, Jalandhara N, Loomis S, Przybyla S, Rahman M, Riley J, Simonton L, Singer D, Teran F, Weinstein A (Ed). The Renal Physicians Guide to Nephrology Practice. Your Primary Resource for Efficient and Effective Business Operations. Renal Physicians Association. 2021. 10th Edition.

Gholam MF, Ko B, Ghazi ZM, Hoover RS, Alli AA. The Pharmacological Inhibition of CaMKII Regulates Sodium Chloride Cotransporter Activity in mDCT15 Cells. Biology (Basel). 2021 Dec 16;10(12). doi: 10.3390/biology10121335. PubMed PMID: 34943250; PubMed Central PMCID: PMC8698651.

Benson LN, Liu Y, Wang X, Xiong Y, Rhee SW, Guo Y, Deck KS, Mora CJ, Li LX, Huang L, Andrews JT, Qin Z, Hoover RS, Ko B, Williams RM, Heller DA, Jaimes

EA, Mu S. The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension. Circ Res. 2022 Apr 18;:101161CIRCRESAHA121320373. [Epub ahead of print] PubMed PMID: 35430873

Research

Nephrology and Hypertension

Jing Chen, MD, MMSC, MSC

Professor

Role: Principal Investigator Project: Clinical Center for Prospective Cohort Study of CRI (CRIC IV)

Period of support: 07/01/201806/30/2023

Funding source: NIDDK/NIH (U01DK60963)

Funding level: $3,249,880

Objectives: The major goals of this project are to examine risk factors for the progression of renal disease and development of cardiovascular disease in patients with chronic renal insufficiency.

Principal Investigator: Jiang He, MD, PhD

Role: Co-Investigator and Clinical Core Director

Project: Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases Period of support: 03/10/2016–03/09/2021

Funding source: NIH P20GM109036

Funding level: $11,273,386

Objective: The overall objective of this COBRE application is to increase the quality and quantity of clinical, translational and implementation research in cardiometabolic diseases at Tulane University. This objective will be achieved by establishing a Center of Excellence for Clinical, Translational and Implementation Research in Cardiometabolic Diseases at Tulane University; developing and nurturing successful competitive independent investigators in clinical, translational and implementation research; motivating and facilitating multidisciplinary and interdisciplinary interaction and collaboration in the area of cardiometabolic disease research; and building and expanding

the clinical and community-based research infrastructure at Tulane University and in Louisiana.

Role: Co-Investigator

Project: Comparative Effectiveness of Hypertension Control Programs in the Rural South

Period of support: 09/01/2017–08/30/2023

Funding source: NIH/NHLBI (UH2 HL130723)

Funding level: $10,436,199

Principal Investigator: Jiang He, MD, PhD

Objectives: The overall objective of the proposed study is to test the comparative effectiveness of a patient-centered, comprehensive intervention program, which combines team-based collaborative care using a stepped-care protocol, home blood pressure telemonitoring, and health coaching, compared to standardized usual care for hypertension control in the Rural South.

1UG3HL152373 (Tulloch-Reid/He/Lopez Jaramillo) (NIH) 09/15/2020-08/31/2026

Implementing

and Scaling Up a Team-based Care Strategy for Hypertension Control in Colombia and Jamaica

The overall objective of this study is to test the implementation and effectiveness outcomes of implementing and scaling up a team-based care strategy for hypertension control in Colombia and Jamaica. This study will identify effective, equitable, and sustainable strategies to achieve hypertension control in routine clinical settings and reduce cardiovascular risk in the general population of Latin America and the Caribbean, as well as other low- and middle-income countries.

Role: Co-Investigator

R61 AG068481 (Mills/He/Williamson)

(NIH) 08/01/2020 - 07/31/2025

Effectiveness of Implementing an Intensive Blood Pressure Reduction Intervention on Cognitive Decline in Low-income and Minority Hypertensive Patients

We will test a multifaceted strategy for implementing an intensive blood pressure intervention protocol targeting systolic BP <120 mmHg on cognitive decline in racial minority and low-income hypertensive patients in primary care. The proposed study will generate urgently needed data on effective, adoptable, and equitable intervention strategies to reduce blood pressure-related cognitive decline in lowincome and minority populations.

Role: Co-Investigator

R01DK125782 05/13/2021-03/31/2026 NIH $612,163

Clonal Hematopoiesis of Indeterminate Potential in Chronic Kidney Disease Patients

The major goals of the project are to elucidate the role of clonal hematopoiesis of indeterminate potential (CHIP) in the progression of kidney disease and development of cardiovascular disease (CVD) in chronic kidney disease (CKD) patients. Knowledge gained from this study may contribute novel insights into the biological pathways underlying common CKD sequelae and help to identify CKD patients at high risk for kidney failure and CVD.

Role: Co-Investigator

R01HL157903 04/01/2021-03/31/2024

NIH $494,349

Establishing A New Diagnostic Paradigm for Peripheral Artery Disease among Patients with Chronic Kidney Disease

The overall objective of the proposed study is to identify more accurate cut-points of ABI

Nephrology and Hypertension

and TBI for PAD screening and diagnosis and to develop a novel approach for PAD screening and diagnosis among CKD patients.

Role: Principal Investigator

U01DK060963 (He) (NIH/NIDDK) 08/19/2013-06/30/2023

Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study

The Chronic Renal Insufficiency Cohort (CRIC) Study is a NIDDK-sponsored multicenter prospective cohort study to investigate novel risk factors for the progression of chronic kidney disease, cardiovascular disease, and other related comorbid outcomes among patients with chronic kidney disease. The CRIC study may provide insights into the underlying etiology and information for developing further intervention studies aimed at reducing the total morbidity and mortality burdens among patients with chronic kidney disease.

Role: Principal Investigator

NIH P20GM109036 (He) (NIH/ NIGMS) 03/10/2016–06/30/2022

Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases

The overall objective of this COBRE application is to increase the quality and quantity of clinical, translational and implementation research in cardiometabolic diseases at Tulane University. This objective will be achieved by establishing a Center of Excellence for Clinical, Translational and Implementation Research in Cardiometabolic Diseases at Tulane University; developing and nurturing successful competitive independent investigators in clinical, translational and implementation research; motivating and facilitating multidisciplinary

Research Nephrology

and Hypertension

and interdisciplinary interaction and collaboration in the area of cardiometabolic disease research; and building and expanding the clinical and community-based research infrastructure at Tulane University and in Louisiana.

Role: Clinical Core Director

R01HL133790 (He) (NIH/NHLBI)

07/01/2017 – 06/30/2022

Dissemination and Implementation of the SPRINT Study Findings in Underserved Populations

We propose to conduct an effectivenessimplementation hybrid trial to simultaneously test the effectiveness of a multicomponent intervention for more intensive BP treatment and the feasibility, fidelity, and sustainability of implementing the intervention in underserved patients with hypertension and at high risk for CVD in Louisiana.

Role: Co-Investigator

UG3HL151309 (He) (NIH) 04/01/2020-03/31/2027

Community Health Worker-Led ChurchBased Intervention for Eliminating Cardiovascular Health Disparities in African Americans

The proposed study will utilize an effectiveness-implementation hybrid design to 1) test the effectiveness of a community health worker (CHW)-led church-based multifaceted implementation strategy for improving cardiovascular health over 18 months among African Americans at high risk for ASCVD, and 2) assess the implementation outcomes (acceptability, adaptation, adoption, feasibility, fidelity, penetrance, cost-effectiveness, and sustainability) of the multifaceted strategy simultaneously.

Role: Co-Investigator

R01HL155559 ( Mills) 01/2022-12/2026

A Mechanistic Trial of Dietary Sodium Reduction on Vascular Structure and Function in African American

The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in African Americans with elevated blood pressure or hypertension.

Role: Co-Investigator

P20GM109036 (He) 07/2022-06/2027

Title: Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases

Major Goals: The overall objective of this COBRE application is to increase the quality and quantity of clinical, translational and implementation research in cardiometabolic diseases at Tulane University. This objective will be achieved by establishing a Center of Excellence for Clinical, Translational and Implementation Research in Cardiometabolic Diseases at Tulane University; developing and nurturing successful competitive independent investigators inclinical, translational and implementation research; motivating and facilitating multidisciplinary and interdisciplinary interaction and collaboration in the area of cardiometabolic disease research; and building and expanding the clinical and community-based research infrastructure at Tulane University and in Louisiana.

Role: Clinical core director.

NIH R-01 grant (NIDDK):

of Ammonia and Acid-Base Transport in the Kidney. PI (reviewed in 2019 but not funded. Will be resubmitted in 2020-2021). Tulane SOM Grant: Ammonia Transport and Acid-Base Homeostasis. PI (Funded 2019). NIH (NIDDK and University of Pennsylvania), CRIC study (PI):: The Role of Ammonium Transport in Progression of CKD. PI, 2019 (pending).

Paul Teschan Research Grant (PI): 2019- . Regulation of Ammonia and Acid-Base Transport in the kidney. PI (Funded 20192021). NIH R-01 grant (NIDDK): The role of pH in kidney development. Multi PI (Nakhoul and Yosypiv), 2021 (in preparation). Dialysis Clinic, Inc. entitled, Paul Teschan Research Fund-Ammonium Transport in Acidosis and Chronic Kidney Disease

Pulmonary Diseases, Critical Care and Environmental Medicine

CLINICAL ACTIVITIES

Joseph A. Lasky, MD Professor Chief Section of Pulmonary

Diseases, Critical Care and Environmental Medicine

John W. Deming, MD Endowed Chair in Internal Medicine

The Section of Pulmonary Diseases, Critical Care and Environmental Medicine centers on the belief that the people of the gulf south merit local access to the best possible health care. They teach foundations and innovations in medicine to the doctors of the future. And because they hold dear the obligation to educate bright, inquiring minds, they are dedicated to delivering evidence-based and cutting-edge medicine. The section is devoted to research that will improve health care in the coming years. They are privileged to have made research contributions along the way and look forward to shaping future advancements in health care.

The pulmonary mission is to provide: State-of-the-art patient care, outstanding educational opportunities to students, residents, and fellows, and Innovative and relevant clinical and basic research.

The clinic and training locations are the main three hospitals in the New Orleans area, Tulane Medical Center, University Medical Center LCMC Health, and Southeast Louisiana Veterans Affairs Health. The section’s new clinic, located in Lakeview, has outreach and consults services. They have also have Nurse Practitioners as the Asthma clinic, Cystic Fibrosis Clinic and Pulmonary Fibrosis Clinic to enhance access to patient care needs.

EDUCATIONAL ACTIVITIES

Our Pulmonary and Critical Care Medicine Fellowship program, offers a three-year pulmonary/critical care training experience. During their training, our fellows manage a diverse patient population while rotating through the following facilities:

Tulane Medical Center

University Medical Center LCMC Health

Southeast Louisiana Veterans Affairs Health

Ochsner Clinic Foundation

Current fellowship has 12 Critical Care Pulmonary fellows, and 1 Critical Care Nephrology fellowship. Our fellowship program offers rotations through an accredited sleep lab. Highly selected fellows who chose an academic track and are exceptionally productive in their scholarly efforts, the program offers financial support for a Certificate in Clinical Research course that can be used to obtain a Master of Science subsequently in Clinical Research. This feature was highlighted in the “2015 ATS innovations in fellowship education book”.

Pulmonary Diseases, Critical Care and Environmental Medicine

Individual curriculums are designed based on each fellow’s career goals.

The list include:

Adult Cystic Fibrosis

Adult Sleep Disorders Asthma Disease Management

Interstitial Lung Disease Interventional Pulmonary Critical Care Medicine

In addition to the usual Medical Intensive Care Unit (MICU) and Pulmonary Consultation services, the clinical experience includes rotations through a level 1 trauma unit, a surgical ICU, a Neuro ICU, lung and solid organ transplant units, a pulmonary rehab program, and several electives based on specific interests or career paths. In addition to their continuity clinic, our fellows rotate through various pulmonary clinics that include Lung Nodule, Pulmonary Hypertension, ILD, Lung Transplant, Cystic Fibrosis, and Tuberculosis. A wide variety of procedures are routinely performed, including percutaneous tracheostomies, pleural procedures, and advanced robotic bronchoscopy. Bedside ultrasound is routinely used for diagnostic purposes during our MICU rounds and to guide invasive procedures. Several faculty members are trained in endobronchial ultrasound, and this is commonly used during bronchoscopies when indicated and taught to fellows.

RESEARCH

The section of Pulmonary Diseases, Critical Care & Environmental Medicine has an active research environment. An Eosinophilic Disorder Center allows researchers, patients, and their families to understand the disease and consult for better treating the eosinophil-associated disorders.

This section has 3 NIH grants (1 Program Project, 1 R and 1 K); in addition to foundation and industry sponsored research support. Our patients have the opportunity to enroll into over a dozen clinical trials offered.

RESEARCHERS

Anil Mishra, PhD Professor

Derek Pociask, PhD Assistant Professor

Qinyan Yin, PhD Assistant Professor

Victor J. Thannickal, MD Professor

Joseph A. Lasky, MD Professor

Christine M. Bojanowski, MD Assistant Professor

Joshua Lee Denson, MD, MS Assistant Professor

Shigeki Saito, MD Assistant Professor

Jerry Zifodya, MD, MPH, TM Assistant Professor

The section has multiple grant funding, which helps in the aid of their research. Below are some of our active grants for Pulmonary Disease and Critical Care.

National Institutes of Health

Cystic Fibrosis Foundation

Duke University University of Alabama-Birmingham

University of Michigan

Rutgers University

Society of Critical Care Medicine American Diabetes Association

Ladies Leukemia League, Inc. Chimerix, Inc.

Boehringer Ingelheim Pharmaceuticals Corbus Pharmaceuticals

Pulmonary

Astra Zeneca USA

Vertex Pharmaceuticals

IQVIA

Leidos Biomedical Research, Inc.

AWARDS & ACCOMPLISHMENTS

Joseph Lasky, MD

Castle Connolly Top Doctors 2022

Nereida A. Parada, MD

Castle Connolly Top Doctors 2022

Sandy Ditta, RN

Diseases, Critical Care and Environmental Medicine

Pharmaceutical Product Development Spero Therapeutics, Inc. Medpace, Inc. Mylan

John W. Deming Department of Medicine Excellence Award in Research Support

Christine M. Bojanowski, MD Y1

Physician Scientist Pipeline Program – (PSPP) (Dean)

Joshua Lee Denson, MD Y2

Louisiana Clinical and Translational Sciences Center (LA CaTS)

New Orleans City Business "2021 Health Care Hero"

Jerry Zifodya, MD

Building Interdisciplinary Research in Women’s Health (BIRWCH) program

Shigeki Saito, MD (Y1 of 4) K08

Anil Mishra, MD (Y2 of 5) R01

PHILANTHROPY

Nereida A. Parada, MD $20,000 for the Asthma Center

Howard Kenyon, $105,000 Donated to Joseph Lasky, MD for ILD Research

FACULTY

Ramsy Abdelghani, MD

Assistant Professor

Cesar A. Aguilar-Lopez, MD

Assistant Professor

David Becnel, MD Assistant Professor

Christine Bojanowski, MD Assistant Professor

Tania Boniske, MD Assistant Professor

Joesph DeFraites, NP Nurse Practitioner

Joshua Denson, MD

Assistant Professor

Jennifer FitzGibbons, NP Nurse Practitioner

Himmat Grewal, MD Assistant Professor

Robert Jones, MD Emeritus Professor

Rahul Kamat, MD Assistant Professor

Yasin Khan, MD Assistant Professor

Ross Klingsberg, MD

Associate Professor

Joseph Lasky, MD Professor

Jaime Palomino, MD Associate Professor

Nereida Parada, MD Associate Professor

Shigeki Saito, MD Assistant Professor

Courtney Shappley, MD Assistant Professor

Pulmonary Diseases, Critical Care and Environmental Medicine

Francesco Simeone, MD Associate Professor

Jennifer Stark, NP Nurse Practitioner

Mohammad Tahboub, MD Assistant Professor

POSTDOCTORAL

Sulbha Sharma, PhD Postdoctoral

Supat Thammasitboon, MD Associate Professor

Victor Thannickal, MD Professor

David Weill, MD Professor

Jerry Zifodya, MD Assistant Professor

Chandra Yadavalli, PhD Postdoctoral

STAFF

Sandy Ditta, RN Senior Research Administrator

Charlene Esteves Section Administrator

Chris Glynn, RN Clinical Research Nurse Coordinator

David Maag Information Systems Specialist

Nikki Nguyen, RN Interventional Pulmonary Nurse

Jaclyn Pagliaro, MPH Research Project Manager

Carol Rockwell, RN Clinical Research Nurse Coordinator

Eliza Sheffield, LCSW License Clinical Social Worker

Allison West Graduate Medical Education Program Administrator I Yan Zhuang Medical Research Specialist

Pulmonary Diseases, Critical Care and Environmental Medicine

ACCOMPLISHMENTS

Joseph Lasky, MD, Professor, Chief, John W. Deming, MD Endowed Chair received a twoyear $500,000 grant to explore serum peptide splice variants as a biomarker predictor for progression of pulmonary fibrosis. This research is an extension of our preliminary data showing that specific splicing events are induced during active fibrogenesis. This is a collaborative effort involving the mass spectroscopy capabilities of Dr. Tony Hu’s laboratory and the development of novel beacon aptamers in the laboratory of Dr. Janarthanan Jayawickramarajah (Tulane Department of Chemistry).

The Pulmonary Fibrosis Foundation appointed Dr. Joseph Lasky as Chief Medical Officer. Dr. Lasky brings more than 30 years of experience caring for patients with pulmonary fibrosis.

Himmat Grewal, MD Assistant Professor for received the Rising Star Award at University Medical Center LCMC Health. The honor recognizes Himmat for moving the needle by doing great work to better the health of everyone in our region. This is such a remarkable contribution during his first year as a faculty member in our section.

Dr. Cheng ‘Han’ Chung PGY VI, was selected as the Fellow of the year at University Medical Center LCMC Health!

Ross C. Klingsberg, MD, Associate Professor – Dean Baker Ellithorpe, MD Professorship, Director of Adult Cystic Fibrosis Program received the 2022 Teaching Scholar Award! The Teaching Scholar Award recognizes a full-time faculty member who has demonstrated a significant record of scholarship and exceptional teaching, along with an ongoing commitment to enhancing the quality of teaching and learning at Tulane University School of Medicine. The recipient of the Teaching Scholar Award becomes a member of the Society of Teaching Scholars, one of the most prestigious distinctions that can be acquired by faculty members in the School of Medicine.

Clinical Service Award: Nereida A. Parada, MD, Associate Professor, Director of Tulane Asthma Center has spent the past two decades building premier asthma patient care services for Tulane and greater Louisiana. She has improved asthma care at the state level for the past decade as Statewide Asthma Clinical Lead for LSU Health Sciences Services and as the Medical Director for Asthma and COPD Disease Management for the University Medical Center LCMC Health. Dr. Parada has worked with medical students and residents to publish the work she has been leading to improve regional and state-wide asthma care. She has been the primary person responsible for teaching state-of-the-art comprehensive asthma care to medical students, residents, and fellows, which undoubtedly contributes to improved asthma management by these physicians who settle in our region and state. Her leadership at Tulane HCA hospital, as Director of the PFT lab and pulmonary rehabilitation program has led to improvements in the supportive care that these high functioning programs provide to our patients. Nereida has been tireless in adding to services that we can provide, including home ventilator management for patients with severe obstructive lung disease. Most recently she has added a refinement to the PFT lab service by introducing high altitude stimulation testing

Pulmonary Diseases, Critical Care and Environmental Medicine

(HAST) to the wealth of high-quality pulmonary diagnostic and treatment options for patients with asthma and COPD. Her dedication to first-rate asthma patient care has now extended to a clinical trial program to seek better ways to care for asthma patients going forward.

Shigeki Saito, MD, Assistant Professor, Co- Director Basic / Translational Research proposal entitled “Inhibition of Histone Deacetylase 8 (HDAC8) as a Therapy for Pulmonary Fibrosis” was selected for a Research Scholar Award from the Southern Society of Clinical Investigation (SSCI). Dr. Saito’s research is focused on making inroads into our understanding of the pathobiology and treatment of pulmonary fibrosis.

Christine M. Bojanowski, MD, Assistant Professor, Co-Director, Adult Cystic Fibrosis Program was named a Scholar from the Department of Medicine in the Dean’s Physician-Scientist Pipeline Program (2021-2023). In addition, Dr. Bojanowski is one of two researchers selected from an international pool of applicants to be named a Gilead Sciences Research Scholar in Cystic Fibrosis. The program recognizes and supports emerging early career investigators in several medical fields including hematological malignancies, solid tumors, HIV, liver disease, and anti-fungal research in addition to Cystic Fibrosis.

Dr. Christine Bojanowski was the recipient of a 2-year NIH-sponsored LACaTS Roadmap Scholar Award. Her research focuses on lung immunology and host response to chronic sinopulmonary infections with important pathogens such as Staphylococcus Aureus and Pseudomonas Aeruginosa. Dr. Bojanowski also received the Cystic Fibrosis Foundation Program for Adult Care Excellence (PACE) Award.

Derek Pociask, PhD, Assistant Professor & Jay Kolls, Professor Tulane Scientists Unravel 50-yearold Medical Mystery Behind Toddlers’ Deaths from RSV Vaccine Researchers Dr. Jay Kolls and Derek Pociask have explained why two toddlers died in 1967 after participating in an infamous clinical trial for an experimental vaccine against RSV, the most common cause of pneumonia in children. The children’s deaths, which were one reason scientists pursued the novel MRNA vaccine design against COVID-19 instead of using an inactivated form of the respiratory virus, were a medical mystery for decades — until now.

Anil Mishra, PhD, Professor, Director of Eosinophilic Disorder Center renewed his NIH RO1 This grant is focused on the role of IL-18 in eosinophils associated allergic diseases. His laboratory has first time reported IL-18 active new subset of pathogenic eosinophils that are different from naïve eosinophils that reside in healthy individuals. Most recently, his laboratory has successfully generated IL-18-induced eosinophilic inflammation mediated murine models of pancreatic ductal carcinoma (PDAC) that has a potential to establish diagnostic and therapeutic interventions for PDAC.

Pulmonary Diseases, Critical Care and Environmental Medicine

Jerry Zifodya, MD, MPH, TM, Assistant Professor was selected as an NIH-sponsored BIRCWH Scholar. As a Tulane BIRCWH Scholar, he will be part of a comprehensive research training program that will assist him in becoming a highly trained, culturally competent, independent, interdisciplinary investigator. His research involves sex differences in lung and cardiovascular disease in Sub-Saharan Africa

Joshua Lee Denson, MD, MS, Assistant Professor, Associate Director Pulm/CCM Fellowship Program, Director of Medical Critical Care received a 2-year NIH-sponsored LACaTS Roadmap Scholar Award. His research is focused on ICU health care delivery and transitions of care. In addition, he was awarded grant support from the ADA for his proposal entitled Prognostic biomarkers for severity of disease in SARS CoV-2 and metabolic syndrome.

Publications

Pulmonary Diseases, Critical Care and Environmental Medicine

Becnel D, Abdelghani R, Nanbo A, Avilala J, Li L, Lin Z. Pathogenic Role of Epstein-Barr Virus in Lung Cancers. Viruses. 2021. May 11;13(5): 877. PMID: 34064727.

Avilala J, Becnel D, Abdelghani R, Nanbo A, Kahn J, Li L, Lin Z. Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses. Frontiers in Microbiology. 2021 Apr 20;12:PMID: 33959113.

Cone-Beam Computed Tomography-Guided Electromagnetic Navigation for Peripheral Lung Nodules. Fayez Kheir, Sanket R Thakore, Juan Pablo Uribe Becerra, Mohammad Tahboub, Rahul Kamat, Ramsy Abdelghani, Sebastian Fernandez-Bussy, Upendra R Kaphle, Adnan Majid. Respiration. 2021; 100(1):44-51. Epub 2021 Jan 5. PMID: 33401270.

Becnel D, Abdelghani R, Nanbo A, Avilala J, Li L, Lin Z. Pathogenic Role of Epstein-Barr Virus in Lung Cancers. Viruses. 2021, 13(5): 877.

Avilala J, Becnel D, Abdelghani R, Nanbo A, Kahn J, Li L, Lin Z. Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses. Frontiers in Microbiology. 2021;12:668.

Ning B, Xiao Y, Huang Z, Youngquist BM, Scott JW, Niu A, Bojanowski CM, Zwezdaryk KJ, Saba NS, Fan J, Yin X, Cao J, Lyon CJ, Li C, Roy CJ, Hu TY. Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma. Nature Nanotechnology. 2021. In Press

Moshensky A, Du M, Shin J, Advani I, Gunge D, Mathew D, Alkolla R, Du A, Javier C, Ma L, Tran A, Nguyen N, Olay J, Nilaad S, Ding J, Najhawan M, Watrous JD, Bojanowski CM, Jain M, Christiani DC, and Crotty Alexander LE. Vaping induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex. European Respiratory Journal Open Research. Accepted on April 24, 2021

Chopyk J, Bojanowski CM, Shin J, Moshensky A, Fuentes AL, Bonde SS, Chuki D, Pride DT, Crotty Alexander LE. Compositional differences in the oral microbiome of e-cigarette users. Front Microbiol. 2021 May 31; 12:599664.doi: 10.3389/ fmicb.2021.599664. eCollection 2021. PMID 34135868.

Masso-Silva J, Moshensky A, Shin J, Olay J, Nilaad S, Advani I, Bojanowski CM, Crotty S, Li WT, Ongkeko WM, Singla S, Crotty Alexander LE. Chronic e-cigarette aerosol inhalation alters the immune state of the lungs and increases ACE2 expression, raising concern for altered response and susceptibility to SARS-CoV-2. Front Physiol. 2021 May 31; 12:649604. Doi:10.3389/fphys.2021.649604. eCollection 2021. PMID: 34122126

Cypro A, McGuire C, Rolfsen M, Jones N, Shah N, Cribbs SK, Kaul V, Bojanowski CM, Pedraza I, Lynch L, Guzman L, Larsson E, Crotty Alexander LE. Creation of a Virtual Critical Care Training Forum for International and Local Healthcare Workers Taking Care of Patients with COVID-19. ATS Scholar. 2021 Accepted February 28, 2021

Bojanowski CM, Wilson S, Klingsberg RC. CFTR Modulator Therapy Improves Cystic Fibrosis-Related Diabetes. But How? J Diabetes Complications. 2021 Feb 25; 107887. doi: 10.1016/j.jdiacomp.2021.107887. Epub ahead of print. PMID: 33775536. (Invited)

Ween MP, Moshensky A, Thredgold L, Bastian N, Hamon R, Badiei A, Nguyen PT, Herewane K, JErsmann, Bojanowski CM, Shin J, Reynolds PN, Crotty Alexander LE, Hodge SJ. E-cigarettes and health risks: more to the flavour than just the name. Am J Physiol Lung Cell Mol Physiol. 2021; 320 (4): L600-L614. PMID: 33295836

Heath JK, Wang T, Santhosh L, Denson JL, Holmboe E, Yamakazi K, Clay AS, Carlos WG. Longitudinal Milestone Assessment Extending through Subspecialty Training: The Relationship between ACGME

Internal Medicine Residency Milestones and Subsequent Pulmonary and Critical Care Fellowship Milestones. Academic Medicine 2021 May 18. doi: 10.1097/ ACM.0000000000004165. PMID: 34010863

Dagher L, Shi H, Zhao Y, Wetherbie A, Johnsen E, Sangani D, Nedunchezhian S, Brown M, Miller P, Denson J, Schieffelin J, Marrouche N. New-Onset

Atrial Arrhythmias

Associated With Mortality in Black and White Patients Hospitalized with COVID-19. Pacing Clin Electrophysiol. 2021 Mar 20. doi: 10.1111/pace.14226. Epub ahead of print. PMID: 33742724.

Domecq JP, Lal A, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Harhay MO, Garcia MA, Kaufman M, Danesh V, Cheruku S, Banner-Goodspeed VM, Anderson HL 3rd, Milligan PS, Denson JL, St Hill CA, Dodd KW, Martin GS, Gajic O, Walkey AJ, Kashyap R. Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2021 Jan 28. doi: 10.1097/CCM.0000000000004879. Epub ahead of print. PMID: 33555777.

Manka L, Guntur VP, Denson JL, Dunn RM, Dollin YT, Strand M, Wechsler ME. Efficacy and Safety of Reslizumab in the Treatment of Eosinophilic Granulomatosis with Polyangiitis (EGPA). Ann Allergy Asthma Immunol. 2021 Feb 3:S1081-1206(21)00097-1. doi: 10.1016/j. anai.2021.01.035. Epub ahead of print. PMID: 33548468.

Yoshida Y, Gillet SA, Brown MI, Zu Y, Wilson SM, Ahmed SJ, Tirumalasetty S, Lovre D, Krousel-Wood M, Denson JL, Mauvais-Jarvis F. Clinical characteristics and outcomes in women and men hospitalized for coronavirus disease 2019 in New Orleans. Biol Sex Differ. 2021 Feb 5;12(1):20. doi: 10.1186/s13293021-00359-2. PMID: 33546750; PMCID: PMC7863061.

John W. Deming Department of Medicine

Publications

Pulmonary Diseases, Critical Care and Environmental Medicine

Hoffmann JP, Kolls JK, McCombs JE. Regulation and Function of ILC3s in Pulmonary Infections. Front Immunol. 2021 Apr 23;12:672523.

Schieffelin JS, Norton EB, Kolls JK. What should define a SARS-CoV-2 “breakthrough” infection? J Clin Invest. 2021 Jun 15;131(12):e151186. doi: 10.1172/JCI151186.

Matsunaga Y, Clark T, Wanek AG, Bitoun JP, Gong Q, Good M, Kolls JK. Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in Citrobacter rodentium Infection. J Immunol. 2021 Jan 11:ji2000591.

Dai G, Wanek A, Eddens T, Volden P, Kolls JK. Toward a humanized mouse model of Pneumocystis pneumonia. JCI Insight. 2021 Jan 25;6(2):139573.

Taghavi S, Abdullah S, Duchesne J, Pociask D, Kolls J, Jackson-Weaver O. Interleukin 22 mitigates endothelial glycocalyx shedding after lipopolysaccharide injury. J Trauma Acute Care Surg. 2021 Feb 1;90(2):337-345.

Lin X, Tawch S, Wong HT, Roy S, Gaudino S, Castillo P, Elsegeiny W, Wakabayashi N, Oury TD, Pociask D, Chen K, McLinskey N, Melville P, Syritsyna O, Coyle P, Good M, Awasthi A, Kolls JK, Kumar P. Nrf2 through Aryl Hydrocarbon Receptor Regulates IL-22 Response in CD4+ T Cells. J Immunol. 2021 Apr 1;206(7):1540-1548.

Taghavi S, Jackson-Weaver O, Abdullah S, Goldberg A, Lawicki S, Killackey M, Duchesne J, Pociask D, Steele C, Kolls J. A Comparison of Growth Factors and Cytokines in Fresh Frozen Plasma and Never Frozen Plasma. J Surg Res. 2021 Mar 24;264:51-57. Mulay A, Konda B, Garcia G Jr, Yao C, Beil S, Villalba JM, Koziol C, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR. SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery. Cell Rep. 2021 Apr 13:109055.

Camiolo MJ, Zhou X, Oriss TB, Yan Q, Gorry M, Horne W, Trudeau JB, Scholl K, Chen W, Kolls JK, Ray P, Weisel FJ, Weisel NM, Aghaeepour N, Nadeau K, Wenzel SE, Ray A. High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status. Cell Rep. 2021 Apr 13;35(2):108974.

Dai G, Noell K, Weckbecker G, Kolls JK

Effect of Subcutaneous Anti-CD20. AntibodyMediated B Cell Depletion on Susceptibility to Pneumocystis Infection in Mice. mSphere. 2021 May 5;6(3):e01144-20. doi: 10.1128/ mSphere.01144-20.

Bojanowski CM, Wilson SM, Klingsberg RC. CFTR modulator therapy improves cystic fibrosis-related diabetes. But how? J Diabetes Complications. 2021 Jun;35(6):107887. doi: 10.1016/j.jdiacomp.2021.107887. Epub 2021 Feb 25. PMID: 33775536.

Raahe F, Belperio JA, Fitzgerald J, Gulati M, Hallowell R, Highland KB, Huie TJ, Kim HJ, Kolb M, Lasky JA, Southern BD, Swigris JJ, de Andrade JA. Delphi Consensus Recommendations on Management of Dosing, Adverse Events, and Comorbidities in the Treatment of Idiopathic Pulmonary Fibrosis with Nintedanib. Clin Med Insights Circ Respir Pulm Med. 2021 Mar 30;15:11795484211006050. doi: 10.1177/11795484211006050. eCollection 2021. PMID: 33854398.

Lasky JA, Fuloria J, Morrison ME, Lanier R, Naderer O, Brundage T, Melemed A.Adv Ther. Design and Rationale of a Randomized, Double-Blind, Placebo-Controlled, Phase 2/3 Study Evaluating Dociparstat in Acute Lung Injury Associated with Severe COVID-19. 2021 Jan;38(1):782-791. doi: 10.1007/s12325020-01539-z. Epub 2020 Oct 27. PMID: 33108622 Free PMC article. Clinical Trial.

Cosgrove GP, Lasky JA. A New Piece to Help Solve the Interstitial Lung Disease Diagnostic Puzzle. Am J Respir Crit Care Med. 2021 Jan 15;203(2):158-160. doi: 10.1164/rccm.2020083189ED.PMID: 32926641 Free PMC article. No abstract available.

Hemanth Kumar Kandikattu, Murli Manohar, Sathisha Upparahalli Venkateshaiah, Chandrasekhar Yadavalli, Anil Mishra. Chronic inflammation promotes epithelialmesenchymal transition-mediated malignant phenotypes and lung injury in experimentally induced pancreatitis. Life Sciences, 278, 2021, 119640. PMID: 34048812

Sathisha Upparahalli Venkateshaiah, Madhavi Rayapudi, Hemanth Kumar Kandikattu, Chandra Sekhar Yadavalli, Anil Mishra. Blood mRNA levels of T cells and IgE receptors are novel non-invasive biomarkers for eosinophilic esophagitis (EoE). Clinical Immunology, 227, 2021, 108752 PMID: 33945873

Hemanth Kumar Kandikattu, Sathisha Upparahalli Venkateshaiah, Alok Kumar Verma, Anil Mishra. Tacrolimus (FK506) treatment protects allergen, IL‐5, and IL‐13‐induced mucosal eosinophilia. Immunology, 2021;163(2):220-235. PMID: 33512727

Murli Manohar, Hemanth Kumar Kandikattu, Sathisha Upparahalli Venkateshaiah, Chandra Sekhar Yadavalli & Anil Mishra. Eosinophils in the pathogenesis of pancreatic disorders. Seminars in Semin Immunopathol, 1-12, (2021). PMID: 33783592

Anil Mishra, Hemanth Kumar Kandikattu, Sandeep Kumar, Sathisha Upparahalli Venkateshaiah. An update on available traditional and convalescent plasma (CP) therapies for COVID-19. Int J. Pub. Health Awa. 2021: 4 (1-2) 1-6.

Sathisha Upparahalli Venkateshaiah, Murli Manohar, Hemanth Kumar Kandikattu, Anil Mishra. Experimental Modeling of Eosinophil-Associated Diseases. Methods Mol Biol. 2021;2241:275-291. PMID: 33486743

Long SA, Tahboub MY, Palomino J, Alkhatib AL, Kennedy TP, Caridi J, Lasky JA. Hypercoagulability in ICU Patients With Coronavirus Disease 2019 With Respiratory Failure Results in Increased Prevalence of Venous Thromboembolic Disease. Chest. 2021 Mar;159(3):1208-1211. doi:

Publications

Pulmonary Diseases, Critical Care and Environmental Medicine

10.1016/j.chest.2020.09.081. Epub 2020 Sep 14. PMID: 32941863 earthquake that devastated the city of Port-au-Prince. Parada NA, Hollingsworth H, Crolomes in Asthma UpToDate 2021 Mulay A, Konda B, Garcia G Jr, Yao C, Beil S, Villalba JM, Koziol C, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR. SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery. Cell Rep. 2021 May 4;35(5):109055. doi: 10.1016/j. celrep.2021.109055. Epub 2021 Apr 13.https:// www.sciencedirect.com/science/article/pii/ S2211124721003715?via%3Dihub

Taghavi S, Jackson-Weaver O, Abdullah S, Goldberg A, Lawicki S, Killackey M, Duchesne J, Pociask D, Steele C, Kolls J. A Comparison of Growth Factors and Cytokines in Fresh Frozen Plasma and Never Frozen Plasma. J Surg Res. 2021 Aug;264:51-57. doi: 10.1016/j.jss.2021.02.002. Epub 2021 Mar 24. https://www.sciencedirect.com/science/article/ pii/S0022480421000871?via%3Dihub Lin X, Tawch S, Wong HT, Roy S, Gaudino S, Castillo P, Elsegeiny W, Wakabayashi N, Oury TD, Pociask D, Chen K, McLinskey N, Melville P, Syritsyna O, Coyle P, Good M, Awasthi A, Kolls JK, Kumar P. Nrf2 through Aryl Hydrocarbon Receptor Regulates IL22 Response in CD4+ T Cells. J Immunol. 2021 Apr 1;206(7):1540-1548. doi: 10.4049/ jimmunol.1900656. Epub 2021 Mar 1.https:// www.jimmunol.org/content/206/7/1540.long

Taghavi S, Abdullah S, Duchesne J, Pociask D, Kolls J, Jackson-Weaver O. Interleukin 22 mitigates endothelial glycocalyx shedding after lipopolysaccharide injury. J Trauma Acute Care Surg. 2021 Feb 1;90(2):337-345. doi: 10.1097/ TA.0000000000003019. https://journals. lww.com/jtrauma/Fulltext/2021/02000/ Interleukin_22_mitigates_endothelial_ glycocalyx.18.aspx

Podolanczuk AJ, Wong AW, Saito S, Lasky JA, Ryerson CJ, Eickelberg O. Update in

Interstitial Lung Disease 2020. Am J Respir Crit Care Med. 2021 Apr 9;. doi: 10.1164/ rccm.202103-0559UP. [Epub ahead of print] PubMed PMID: 33835899.

Samant S, Tran H, Uddo R, deBoisblanc BP, Saketkoo LA, Saito S, Helmcke FR, Lammi

MR. Right atrial pressure by handheld ultrasound: Incorporation into pulmonary hypertension management. Annals ATS

Godwin, M.S., K.M. Reeder, J.P. Blackburn, Z. Yu, S. Matalon, A.T. Hastie, D.A. Meyers and C. Steele. The chemokine CX3CL1/fractalkine plays a protective role in the severity of fungal asthma. American Journal of Physiology Lung Cellular and Molecular Physiology 320:L393-L404 (2021).

Mackel, J.J., J.M. Garth, M. Jones, D.A. Ellis, J.P. Blackburn, Z. Yu, S. Matalon, M. Curtiss, F.E. Lund, A. Hastie, D. Meyers and C. Steele. Chitinase 3-like-1 protects airway function despite promoting type 2 inflammation during fungal-associated allergic airway inflammation. American Journal of Physiology Lung Cellular and Molecular Physiology 320:L615-L626 (2021).

Taghavi S, Jackson-Weaver O, Abdullah S, Goldberg A, Lawicki S, Killackey M, Duchesne J, Pociask D, Steele C, Kolls J. A comparison of growth factors and cytokines in fresh frozen plasma and never frozen plasma. Journal of Surgical Research 264:51-57 (2021). Liu S, Zhang B, Rowan BG, Jazwinski SM, Abdel-Mageed AB, Steele C, Wang AR, Sartor O, Niu T, Zhang Q. A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study. Front Mol Biosci. 2021 Jun 3;8:696537

Bone NB, Becker EJ Jr, Husain M, Jiang S, Zmijewska AA, Park DW, Chacko B, DarleyUsmar V, Grégoire M, Tadie JM, Thannickal VJ, Zmijewski JW. AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections. Sci Rep. 2021 Jun 11;11(1):12387. doi: 10.1038/s41598-02190573-0. PMID: 34117280

Thannickal VJ. Myofibroblast Functions in Tissue Repair and Fibrosis: An Introduction. Methods Mol Biol.2021;2299:9-15. doi: 10.1007/978-1-0716-1382-5_2.PMID: 34028732

Goliwas KF, Ashraf HM, Wood AM, Wang Y, Hough KP, Bodduluri S, Athar M, Berry JL, Ponnazhagan S, Thannickal VJ, Deshane JS. Extracellular Vesicle Mediated Tumor-Stromal Crosstalk Within an Engineered Lung Cancer Model. Front Oncol. 2021 Apr 23;11:654922. doi: 10.3389/fonc.2021.654922. eCollection 2021.PMID: 33968758

Jiang C, Liu G, Cai L, Deshane J, Antony V, Thannickal VJ, Liu RM. Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. Am J Pathol. 2021 Jul;191(7):1227-1239. doi: 10.1016/j. ajpath.2021.04.003. Epub 2021 Apr 20.PMID: 33887217

Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AVF, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal VJ, Carter AB, Antony VB. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med. 2021 Mar 17;13(585):eaba2927. doi: 10.1126/scitranslmed.aba2927.PMID: 33731433

Qu J, Yang SZ, Zhu Y, Guo T, Thannickal VJ, Zhou Y. Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice. J Exp Med. 2021 May 3;218(5):e20202033. doi: 10.1084/jem.20202033.PMID: 33688918

Wenger DS, Triplette M, Shahrir S, Akgun KM, Wongtrakool C, Brown ST, Kim JW, Soo Hoo GW, Rodriguez-Barradas MC, Huang L, Feemster LC, Zifodya J, Crothers K, Associations of marijuana with markers of chronic lung disease in people living with HIV, HIV Medicine 2021; 22(2):92-101. doi: 10.1111/hiv.12966. Epub 2020 PMID: 33022830

:: John W. Deming Department of Medicine

Publications

Pulmonary Diseases, Critical Care and Environmental Medicine

Temu TM, Zifodya JS, Polyak SJ, Wagoner J, Wanjalla CN, Masyuko S, Nyabiage J, Kinuthia J, Bloomfield GS, Page S, Farquhar C, Antiretroviral therapy reduces but does not normalize immune and vascular inflammatory markers in adults with chronic HIV infection in Kenya, AIDS 2021; 35(1):45-51. doi: 10.1097/QAD.0000000000002729 PMID: 33055570

Masyuko SJ, Page ST, Polyak SJ, Kinuthia J, Osoti AO, Otieno FC, Kibachio JM, Mogaka JN, Chohan B, Wogner J, Temu TM, Zifodya JS, Otedo A, Nakanjako D, Hughes JP, Farquhar C, HIV Is Associated with Higher Levels of Systemic Inflammation among Kenyan Adults despite Viral Suppression, Clinical Infectious Diseases ciaa1650, DOI: 10.1093/cid/ciaa1650 PMID: 33313687

Zifodya JS, Kreniske J, Schiller I, Kohli M, Dendukuri N, Schumacher SG, Ochodo EA, Haraka F, Pai M, Steingart KR, Horne DJ, Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis, Cochrane Database of Systematic Reviews 2021, Issue 2. Art. No.: CD009593. PMID: 33616229

Temu TM, Wagoner J, Masyuko S, O’Connor A, Zifodya JS, Macharia P, Wanjalla CN, Mogaka JN, Chohan B, Omodi VM, Gervassi AL, Oyugi J, Page ST, Farquhar C, Polyak SJ, Central Obesity is a Contributor to Systemic Inflammation and Monocyte Activation in Virally Suppressed Adults with Chronic HIV in Kenya, AIDS, 2021 Jun 3. doi: 10.1097/ QAD.0000000000002956. Online ahead of print. PMID: 34033591, Accepted:

Zifodya JS, Temu TM, Masyuko S, Nyale G, Nyabiage JM, Nyale G, Kinuthia J, Page S, LaCourse S, Kolls J, Farquhar C, Crothers K, HIV, Pulmonary Infections, and Risk of Chronic Lung Disease among Kenyan Adults, Annals of the American Thoracic Society, Accepted

Awards

The Owl Club at Tulane University School of Medicine is a service organization committed to fostering improved relationships between the medical student body and the faculty to achieve continual improvement of medical education. The club hosts an annual banquet where outstanding teaching awards are given to selected faculty members and departments.

2022 Owl Award Winners

Best Overall Department

John W. Deming Department of Medicine, Chair, Dr. Victor Thannickal, MD

Best Clerkship

Internal Medicine, Dr. Chayan Chakraborti, MD, FACP, FHM

Internal Medicine: Best Resident

Dr. Katherine Peacock, MD

Internal Medicine: Best Attending Physician

Dr. Douglas Rovira, MD, FACP

Pediatrics: Best Resident Dr. Harrison Grieb, MD

Pediatrics: Best Attending Physician

Dr. Nicole Sheldon, MD

Psychiatry: Best Resident Dr. Zakaria Ray, MD

Psychiatry: Best Attending Physician

Dr. James McConville, MD

Division of Biomedical Informatics & Genomics

Hong-Wen Deng, PhD Professor Chief Division of Biomedical Informatic and Genomics

The Division for Biomedical Informatics and Genomics (CBG) mission is to promote research and education in biomedical informatics, computational biology, various omics, drug repurposing, and translational research of human complex diseases/traits with the goal of accelerating the pace of scientific discovery, reducing mortality and morbidity, and improving the quality of human life.

RESEARCH

The Center for Biomedical Informatics and Genomics faculty conduct multi-/inter-disciplinary research with the goal of accelerating the pace of scientific discovery, reducing mortality and morbidity, and improving the quality of life of Americans. One of the primary research interests includes all those areas related to addressing the question: What and how genetic and environmental factors incur a higher risk of, or better protection against, complex diseases, such as osteoporosis, indifferent sex, and ethnic groups. Theoretical (e.g., methodology development in biostatistics/bioinformatics) and empirical (e.g., clinical data collection and wet/dry labs data collection/management/processing/analyses) approaches used. We are most interested in generating, analyzing, and integrating big data of various omics in vivo in humans.

The purpose is to elucidate how DNA variants affect gene expression/regulation, and protein expression/ modification in the form of functional networks/modules/pathways and how the knowledge gained on these molecular mechanisms in humans would translate into better prediction/intervention/precision medicine and drug development/repurposing. CBG faculty have won numerous NIH/NSF grants, including P50 center grant and U19 program grant, and has advised/mentored more than 100 graduate students and faculty. Many of the mentees have become tenured professors winning their grants with their research centers/programs. Some become academic and industrial administrators such as associate deans, department chairs, and vice president of genomics companies. Other important research areas include big data, medical image analyses with integration to multi-omics data, machine learning/deep learning, and electronic health records and omics approaches.

COLLABORATION

The CBG encourages, promotes, and supports interactive and collaborative research in various fields; such as biomedical informatics (especially bioinformatics and image informatics, now expanding to health informatics), biostatistics, health informatics, computational biology, data sciences, human genetics, genomics, and proteomics, epigenomics, metabolomics, metagenomics, metabolomics, drug repurposing, machine learning, and deep learning, and single-cell sequencing-based research.

Division of Biomedical Informatics & Genomics

EDUCATIONAL

The Division offers two programs that promote Masters and PhD

Biomedical Informatics Master’s Program is a four-semester program designed to enrich and improve the credentials of graduates and to prepare them for future careers in biomedical informatics. This will allow them to apply for biomedical informatics analyst, data scientist, or other healthcare-related professions.

Interdisciplinary PhD Program: The Center for Biomedical Informatics and Genomics (CBG) is currently seeking 3-5 current or future students of the PhD Program in Biomedical Sciences to join its multi-disciplinary research team. Interested students may choose a faculty member from the CBG to serve as their main advisor. After completing all course requirements, students will conduct research in the CBG for the duration of the program and receive an annual stipend through the center. The curriculum specific to the CBG is forthcoming and will be open to all students of the interdisciplinary PhD program.

FACULTY

Hong-Wen Deng, PhD Professor Chief Director, Center for Biomedical Informatics & Genomics

David Crosslin, PhD Associate Professor Co-Director, Graduate Program

Hui Shen, PhD Professor Associate Director, Center for Biomedical Informatics & Genomics

Xiaowen (Kevin) Liu, PhD Professor

Yu-Ping Wang, PhD Professor of Biomedical Engineering Tulane Cancer Center Program Member

STAFF

Georgette M. Thompson Administrator

Lan-Juan ( Jean) Zhao, PhD Associate Professor Director

Clinical & Genetic Epidemiology Section

Md Ashad Alam, PhD Instructor Co-Director Graduate Programs - Biomedical Informatics Jonathan Greenbaum, PhD Instructor

Chuan Qiu, MD, PhD Research Assistant Professor

Division

of Biomedical Informatics & Genomics

ACTIVE FUNDING

R01AG061917 Zhao, Qi; Shen, Hui (MPIs) 9/01/2019 – 4/30/2024 NIH

Title: Identification of Metabolomic Profiles for Sarcopenia Traits in Older Whites and Blacks

To use the cutting-edge metabolomics approach (a high-throughput method for testing metabolites in biofluids) to systematically discover novel metabolic pathways for the pathogenesis of sarcopenia.

R01AR069055 Deng, Hong-Wen (PI) 5/8/2017– 3/31/2022 NIH

Title: Decoding Methylation Mediated Epigenomic Contributions to Male Osteoporosis

To identify and characterize DNA methylation mediated epigenomic mechanisms that contribute to variations in BMD and bone quality/strength in males.

U19AG055373 Deng, Hong-Wen (PI) 9/15/2017 – 3/31/2022 NIH Title: Trans-omics Integration of Multi-omics Studies for Male Osteoporosis

To comprehensively investigate male osteoporosis risk factors simultaneously at the genome, transcriptome, and epigenome levels in males, while considering environmental factors.

U19AG055373-05S1 Deng, Hong-Wen (PI) 9/10/2021 – 3/31/2022 NIH

Title: Trans-omics Integration of Multi-omics Studies for Osteoporosis: Administrative Supplement for COVID-19 studies

To identify specific extrinsic (e.g., diet, lifestyle, medication) and intrinsic (e.g., gene expression and serum metabolites) factors contributing to individual variation in COVID-19 susceptibility, severity, and outcomes.

R01AG068232 Zhao, Qi; Johnson, Karen (MPI) 9/30/2021 – 5/31/2026 NIH

Title: Intensive Lifestyle Intervention, Metabolomics, and Risk of Frailty Fracture in Overweight or Obese Patients with Type 2 Diabetes

To identify metabolomic changes which mediate the effect of ILI on the increased risk for frailty fracture in the Look AHEAD trial using a state-of-the-art LC-MS-based metabolomics approach.

Role: Hui Shen (Co-I, subcontract PI), Hong-Wen Deng (Co-I)

R56MH124925 Wang, Yu-Ping (PI) 6/1/2021 – 5/31/2023 NIH

Title: Integration of brain imaging and multi-omics data for improved diagnosis and prediction of mental disorders

The major goals of this project are to incorporate multiscale omics and brain imaging into clinical studies towards a nosology of psychiatric disorders that are biologically defined and to uncover their specific genetic architectures.

R01DK115679 Qi, Lu (PI) 1/1/2018 – 12/31/2021 0.72 calendar NIH

Title: Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet Interventions

To detect novel circulating microRNAs (miRNAs) on whole genome-scale associated with 2-year weight loss in response to diet interventions. Also assess the dietary effects on dynamic changes in miRNAs, the relations between miRNAs and energy balance, and develop multi-omics algorithm to predict weight loss by integrating miRNAs with genomics, metabolomics, biochemical and clinical measures.

Role: Hong-Wen Deng (Co-I)

Division of Biomedical Informatics & Genomics

Xia Owen Liu, PhD

R01 Sun (PI); 01/2018 – 12/2022

NIH/NIGMS

Title: Quantitative proteomics of zebrafish embryos and blastomeres Role: Liu (Subcontract PI)

R01 Wu (PI) 11/2018 – 10/2023 NIH/NIGMS

Title: Quantitative analysis of serum autoantibody repertoires in systemic lupus erythematosus Role: Liu (Subcontract PI)

R01 Liu, Sun, Ning (PIs) 09/2020 – 08/2024

NIH/NIGMS

Title: Computational tools for proteoform identification by top-down data-independent acquisition mass spectrometry

R01 Sun, Hummon, Liu (PIs) 02/2021 – 01/2026

NIH/NCI

Title: Quantitative top-down proteomics of human colorectal cancer cells and tumors

DOE Agarwal (PI) 09/2021 – 08/2023 Title: Quantifying endogenous volatile organic compounds in healthy Role: Liu (Subcontract PI)

Open Philanthropy Gimp (PI) 09/2021 – 08/2023

Title: Protein Sequencing Using a Sub-Nanopore Role: Liu (Subcontract PI)

David Crosslin, PhD

Evolving Our Partnership

Title: The CSER2 Centralized Support Coordinating Center Role: Crosslin (subcontract PI)

5/1/2021 – 6/30/2022

eMERGE IV Northwest 5/1/2021 – 4/30/2025

Title: A partnership to evaluate the use of genomic information in the health care of diverse participants Role: Crosslin (subcontract PI)

Alam, M. A., Qiu, C., Shen, H., Wang, Y. P., & Deng, H. W. (2021). A generalized kernel machine approach to identify higher-order composite effects in multi-view datasets, with application to adolescent brain development and osteoporosis. J Biomed Inform, 120, 103854. doi:10.1016/j.jbi.2021.103854

Chen, W., & Liu, X. (2021). Proteoform Identification by Combining RNA-Seq and Top-Down Mass Spectrometry. J Proteome Res, 20(1), 261-269. doi:10.1021/acs. jproteome.0c00369

Choi, I. K., Jiang, T., Kankara, S. R., Wu, S., & Liu, X. (2021). TopMSV: A Web-Based Tool for Top-Down Mass Spectrometry Data Visualization. J Am Soc Mass Spectrom, 32(6), 1312-1318. doi:10.1021/jasms.0c00460

Feng, G. J., Wei, X. T., Zhang, H., Yang, X. L., Shen, H., Tian, Q., . . . Pei, Y. F. (2021). Identification of pleiotropic loci underlying hip bone mineral density and trunk lean mass. J Hum Genet, 66(3), 251-260. doi:10.1038/ s10038-020-00835-4

Gong, R., Xiao, H. M., Zhang, Y. H., Zhao, Q., Su, K. J., Lin, X., . . . Deng, H. W. (2021). Identification and Functional Characterization of Metabolites for Bone Mass in Peri- and Postmenopausal Chinese Women. J Clin Endocrinol Metab, 106(8), e3159-e3177. doi:10.1210/clinem/dgab146

Gong, Y., Yang, J., Li, X., Zhou, C., Chen, Y., Wang, Z., . . . Deng, H. W. (2021). A systematic dissection of human primary osteoblasts in vivo at single-cell resolution. Aging (Albany NY), 13(16), 20629-20650. doi:10.18632/ aging.203452

Hasan, M. M., Alam, M. A., Shoombuatong, W., Deng, H. W., Manavalan, B., & Kurata, H. (2021). NeuroPred-FRL: an interpretable prediction model for identifying neuropeptide using feature representation learning. Brief Bioinform. doi:10.1093/bib/bbab167

Publications Division of Biomedical Informatics & Genomics

Liu, A., Liu, Y., Su, K. J., Greenbaum, J., Bai, Y., Tian, Q., . . . Shen, H. (2021). A transcriptome-wide association study to detect novel genes for volumetric bone mineral density. Bone, 153, 116106. doi:10.1016/j. bone.2021.116106

Liu, D. Y., Liu, J. C., Liang, S., Meng, X. H., Greenbaum, J., Xiao, H. M., . . . Deng, H. W. (2021). Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics. Pharmaceutics, 13(4). doi:10.3390/ pharmaceutics13040545

Liu, H. M., Lin, X., Meng, X. H., Zhao, Q., Shen, J., Xiao, H. M., & Deng, H. W. (2021). Integrated metagenome and metabolome analyses of blood pressure studies in early postmenopausal Chinese women. J Hypertens, 39(9), 1800-1809. doi:10.1097/ HJH.0000000000002832

Liu, R. K., Lin, X., Wang, Z., Greenbaum, J., Qiu, C., Zeng, C. P., . . . Deng, H. W. (2021). Identification of novel functional CpG-SNPs associated with Type 2 diabetes and birth weight. Aging (Albany NY), 13(7), 1061910658. doi:10.18632/aging.202828

Liu, Y. Q., Liu, Y., Zhang, Q., Xiao, T., & Deng, H. W. (2021). Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis. Calcif Tissue Int, 109(1), 17-31. doi:10.1007/s00223-02100817-4

Lv, C., Huang, H. L., Yi, D. J., Peng, T. L., Tan, H. J., Quan, R. P., . . . Xiao, H. M. (2021). Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in ratsdagger. Biol Reprod, 104(6), 1262-1270. doi:10.1093/biolre/ioab025

Lv, W. Q., Lin, X., Shen, H., Liu, H. M., Qiu, X., Li, B. Y., . . . Deng, H. W. (2021). Human gut microbiome impacts skeletal muscle mass via gut microbial synthesis of the short-chain fatty acid butyrate among healthy menopausal

women. J Cachexia Sarcopenia Muscle

doi:10.1002/jcsm.12788

Meng, X. H., Xiao, H. M., & Deng, H. W. (2021). Combining artificial intelligence: deep learning with Hi-C data to predict the functional effects of non-coding variants. Bioinformatics, 37(10), 1339-1344. doi:10.1093/ bioinformatics/btaa970

Ning, H., Du, Y., Ellis, D., Deng, H. W., Hu, H., Zhao, Y., . . . Feng, H. (2021). Malnutrition and its associated factors among elderly Chinese with physical functional dependency. Public Health Nutr, 24(6), 1404-1414. doi:10.1017/S1368980019005299

Ning, H., Du, Y., Zhao, L. J., Tian, Q., Feng, H., & Deng, H. W. (2021). The mediating effect of skeletal muscle index on the relationship between menarcheal age and bone mineral density in premenopausal women by race/ethnicity. Menopause, 28(10), 1143-1149. doi:10.1097/GME.0000000000001814

Ning, H. T., Du, Y., Zhao, L. J., Tian, Q., Feng, H., & Deng, H. W. (2021). Racial and gender differences in the relationship between sarcopenia and bone mineral density among older adults. Osteoporos Int, 32(5), 841-851. doi:10.1007/s00198-020-05744-y

Peng, C., Liu, F., Su, K. J., Lin, X., Song, Y. Q., Shen, J., . . . Lou, H. L. (2021). Enhanced Identification of Novel Potential Variants for Appendicular Lean Mass by Leveraging Pleiotropy With Bone Mineral Density. Front Immunol, 12, 643894. doi:10.3389/ fimmu.2021.643894

Qiu, X., Liu, Y., Shen, H., Wang, Z., Gong, Y., Yang, J., . . . Deng, H. W. (2021). Single-cell RNA sequencing of human femoral head in vivo. Aging (Albany NY), 13(11), 15595-15619. doi:10.18632/aging.203124

Publications Division of Biomedical Informatics & Genomics

Wang, K. S., Yu, G., Xu, C., Meng, X. H., Zhou, J., Zheng, C., . . . Deng, H. W. (2021). Accurate diagnosis of colorectal cancer based on histopathology images using artificial intelligence. BMC Med, 19(1), 76. doi:10.1186/ s12916-021-01942-5

Wang, S., Gong, Y., Wang, Z., Greenbaum, J., Xiao, H. M., & Deng, H. W. (2021). Cell-specific network analysis of human folliculogenesis reveals network rewiring in antral stage oocytes. J Cell Mol Med, 25(6), 2851-2860. doi:10.1111/jcmm.16315

Wei, X. T., Feng, G. J., Zhang, H., Xu, Q., Ni, J. J., Zhao, M., . . . Pei, Y. F. (2021). Pleiotropic genomic variants at 17q21.31 associated with bone mineral density and body fat mass: a bivariate genome-wide association analysis. Eur J Hum Genet, 29(4), 553-563. doi:10.1038/ s41431-020-00727-3

Wu, C., Bradley, J., Li, Y., Wu, L., & Deng, H. W. (2021). A gene-level methylome-wide association analysis identifies novel Alzheimer’s disease genes. Bioinformatics. doi:10.1093/ bioinformatics/btab045

Wu, C., Wu, L., Wang, J., Lin, L., Li, Y., Lu, Q., & Deng, H. W. (2021). Systematic identification of risk factors and drug repurposing options for Alzheimer’s disease. Alzheimers Dement (N Y), 7(1), e12148. doi:10.1002/trc2.12148

Wu, C., Zhu, J., King, A., Tong, X., Lu, Q., Park, J. Y., . . . Wu, L. (2021). Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi-phased study of prostate cancer. Cancer Commun (Lond). doi:10.1002/cac2.12205

Wu, L. F., Mo, X. B., He, J. H., He, P., Lu, X., Deng, H. W., . . . Lei, S. F. (2021). Integrative lncRNA-mRNA co-expression network analysis identifies novel lncRNA E2F3-IT1 for rheumatoid arthritis. Clin Transl Med, 11(2), e325. doi:10.1002/ctm2.325

Xu, F., Zhang, Q., Wang, L. K., Tang, Q. X., Sun, C. Q., & Deng, H. W. (2021). Estimates of the effects of physical activity on osteoporosis using multivariable Mendelian randomization analysis. Osteoporos Int, 32(7), 1359-1367. doi:10.1007/s00198-020-05786-2

Zeng, Y., He, H., Zhang, L., Zhu, W., Shen, H., Yan, Y. J., & Deng, H. W. (2021). GWAbased pleiotropic analysis identified potential SNPs and genes related to type 2 diabetes and obesity. J Hum Genet, 66(3), 297-306. doi:10.1038/s10038-020-00843-4

Zhang, S., Zhu, D., Jiang, H., Guo, J., & Liu, X. (2021). Sorting a Permutation by Best Short Swaps. Algorithmica(2), 1-27.

Chen, W., & Liu, X. (2021). Proteoform Identification by Combining RNA-Seq and Top-Down Mass Spectrometry. J Proteome Res, 20(1), 261-269. doi:10.1021/acs. jproteome.0c00369

Choi, I. K., Jiang, T., Kankara, S. R., Wu, S., & Liu, X. (2021). TopMSV: A Web-Based Tool for Top-Down Mass Spectrometry Data Visualization. J Am Soc Mass Spectrom, 32(6), 1312-1318. doi:10.1021/jasms.0c00460

Zhang, S., Zhu, D., Jiang, H., Guo, J., & Liu, X. (2021). Sorting a Permutation by Best Short Swaps. Algorithmica(2), 1-27.

Bowen, D. J., Makhnoon, S., Shirts, B. H., Fullerton, S. M., Larson, E., Ralston, J. D., . . . Jarvik, G. P. (2021). What improves the likelihood of people receiving genetic test results communicating to their families about genetic risk? Patient Educ Couns, 104(4), 726731. doi:10.1016/j.pec.2021.01.001

Consortium, E. (2020). Lessons learned from the eMERGE Network: balancing genomics in discovery and practice.

Eric, V., Yi, V., Murdock, D., Kalla, S. E., Wu, T. J., Sabo, A., . . . e, M. C. (2021). Neptune: an environment for the delivery of genomic medicine. Genet Med. doi:10.1038/s41436-02101230-w

Fan, X., Wynn, J., Shang, N., Liu, C., Fedotov, A., Hallquist, M. L. G., . . . Chung, W. K. (2021). Penetrance of Breast Cancer Susceptibility Genes From the eMERGE III Network. JNCI Cancer Spectr, 5(4), pkab044. doi:10.1093/jncics/pkab044

Khan, S. S., Hoell, C., Castillo, L. M., Connolly, J. J., Crosslin, D. R., Chung, W. K., . . . Rasmussen-Torvik, L. J. (2021). Practice Patterns After Return of Rare Variants Associated With Cardiomyopathy in the Electronic Medical Records and Genomics Network. Circ Heart Fail, 14(5), e008155. doi:10.1161/ CIRCHEARTFAILURE.120.008155

Makhnoon, S., Bowen, D. J., Shirts, B. H., Fullerton, S. M., Larson, E. B., Ralston, J. D., . . . Jarvik, G. P. (2021). The FamilyTalk randomized controlled trial: patient-reported outcomes in clinical genetic sequencing for colorectal cancer. Cancer Causes Control, 32(5), 483-492. doi:10.1007/s10552-021-01398-1

Makhnoon, S., Bowen, D. J., Shirts, B. H., Fullerton, S. M., Meischke, H. W., Larson, E. B., . . . Jarvik, G. P. (2021). Relationship between genetic knowledge and familial communication of CRC risk and intent to communicate CRCP genetic information: insights from FamilyTalk eMERGE III. Transl Behav Med, 11(2), 563-572. doi:10.1093/tbm/ ibaa054

Murugan, M., Babb, L. J., Overby Taylor, C., Rasmussen, L. V., Freimuth, R. R., Venner, E., . . . Gibbs, R. A. (2021). Genomic considerations for FHIR(R); eMERGE implementation lessons. J Biomed Inform, 118, 103795. doi:10.1016/j.jbi.2021.103795

Namjou, B., Stanaway, I. B., Lingren, T., Mentch, F. D., Benoit, B., Dikilitas, O., . . . Harley, J. B. (2021). Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants. Int J Obes (Lond), 45(1), 155-169. doi:10.1038/ s41366-020-00675-4

:: John W. Deming Department of Medicine

Palmer, M. R., Kim, D. S., Crosslin, D. R., Stanaway, I. B., Rosenthal, E. A., Carrell, D. S., . . . Jarvik, G. P. (2021). Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network. Genet Epidemiol, 45(1), 4-15. doi:10.1002/gepi.22360

Rosenthal, E. A., Crosslin, D. R., Gordon, A. S., Carrell, D. S., Stanaway, I. B., Larson, E. B., . . . Jarvik, G. P. (2021). Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multiancestry cohort. BMC Med Genomics, 14(1), 11. doi:10.1186/s12920-020-00854-2

Shang, N., Khan, A., Polubriaginof, F., Zanoni, F., Mehl, K., Fasel, D., . . . Kiryluk, K. (2021).

Publications Division of Biomedical Informatics & Genomics

Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies. NPJ Digit Med, 4(1), 70. doi:10.1038/s41746-021-004281

Suri, P., Stanaway, I. B., Zhang, Y., Freidin, M. B., Tsepilov, Y. A., Carrell, D. S., . . . Lee, M. T. (2021). Genome-wide association studies of low back pain and lumbar spinal disorders using electronic health record data identify a locus associated with lumbar spinal stenosis. Pain, 162(8), 2263-2272. doi:10.1097/j. pain.0000000000002221

Thomas, M., Sakoda, L. C., Hoffmeister, M., Rosenthal, E. A., Lee, J. K., van Duijnhoven,

F. J. B., . . . Hsu, L. (2021). Response to Li and Hopper. Am J Hum Genet, 108(3), 527-529. doi:10.1016/j.ajhg.2021.02.003

Verbitsky, M., Krithivasan, P., Batourina, E., Khan, A., Graham, S. E., Marasa, M., . . . Gharavi, A. G. (2021). Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral Reflux. J Am Soc Nephrol doi:10.1681/ASN.2020050681

CENTER FOR AGING

S. Michal Jazwinski, PhD Professor John W. Deming, MD Regents Chair in Aging Director Tulane Center for Aging

The Tulane Center for Aging is dedicated to the enhancement of the quality of life of an aging population through research, education, and innovative approaches to healthcare and community planning and design.

Vision

The Tulane Center for Aging will foster and support the development of research programs across a broad spectrum of disciplines that will provide solutions to the problems associated with aging at the level of the individual, the community, and the population. Special emphasis will be placed on multidisciplinary efforts that harness the extensive resources available at the Uptown and Downtown Campuses and at the Tulane National Primate Research Center. In the process, these efforts will strengthen individual programs, departments, and disciplines throughout Tulane University. They will also contribute to the development of new initiatives. Virtually any area of endeavor at the University becomes a focus for the Center when the dimension of aging is applied. The Tulane Center for Aging will from the outset play a leading role in the strengthening of geriatrics and gerontology training at the University. This will be achieved by coordinating research, training/education, and service efforts. Our long term goal is to create a policy planning think tank that will serve the state and the region.

Research Activities

The Center is funded by NIH and the Brown Foundation. S. Michal Jazwinski, PhD, Sangkyu Kim, PhD, Malwina Czarny-Ratajczak, PhD, Mimi Sammarco, PhD, Md. Abdul Awoal, MS, Md. Mehedi Hasan, PhD and Ahmed Moustafa, PhD are key researchers in the center. There are currently six active grants. This year the Center for aging had Nine publications.

Educational Activities

The Center for Aging has an Interdisciplinary PhD Program in Aging Studies, and participates in the Tulane Medical Student Research Experience.

Faculty Publications

Cherry KE, Elliott EM, Golob EJ, Silva Brown J, Kim S, Jazwinski SM, Strategic Encoding and Retrieval Processes in Verbal Recall among Middle-Aged and Older Adults. Brit J Dev Psych, 39, 252-268 (2021). doi: 10.1111/ bjdp.12349. PMID: 33001487

Walker E, Slisarenko N, Gerrets G, Grasperge B, Mattison J, Kissinger P, Welsh D, Veazey R, Jazwinski SM, Rout N. Dysregulation of IL-17/IL-22 Effector Functions in Blood and Gut Mucosal Gamma Delta T cells Correlates with Increase in Circulating Leaky Gut and Inflammatory Markers during cART-Treated Chronic

SIV Infection in Macaques. Front Immunol. 12, 647398 (2021). doi: 10.3389/fimmu.2021.647398 PMCID: PMC7946846

Kim S, Fuselier, J, Welsh DA, Cherry KE, Myers L, Jazwinski SM. Feature Selection Algorithms Enhance the Accuracy of Frailty Indexes as Measures of Biological Age. J Gerontol A Biol Sci Med Sci. 76, 1347- 1355 (2021). doi: 10.1093/gerona/glab018 PMID: 8277082

Liu S, Zhang B, Rowan BG, Jazwinski SM, Abdel-Mageed AB, Steele C, Wang AR, Sartor O, Niu T, Zhang Q. A Novel Controlled PTEN-Knockout Mouse Model for Prostate Cancer Study. Front. Mol. Biosci. 8, 696537 (2021). doi: 10.3389/fmolb.2021.696537 PMCID: PMC8211560

Merino KM, Jazwinski SM, Rout N. Th17-Type Immunity and Inflammation of Aging. Aging 13, 1337813379 (2021). doi: 10.18632/aging.203119 PMCID: PMC8202903

Ji L, Jazwinski SM, Kim S. Frailty and Biological Age. Ann. Geriatr. Med. Res. 2021. doi: 10.4235/ agmr.21.0080. Online ahead of print. PMCID: 8497950

Tanes C, Walker EM, Slisarenko N, Gerrets GL, Grasperge BF, Qin X, Jazwinski SM, Bushman FD, Bittinger K, Rout N. Gut Microbiome Changes Associated with Epithelial Barrier Damage and Systemic Inflammation during Antiretroviral Therapy of Chronic SIV Infection. Viruses 13, 1567 (2021); doi: 10.3390/v13081567 PMID: 34452432

Hoffseth K, Busse E, Jaramillo J, Simkin J, Lacey M, Sammarco MC. Age-Dependent Changes in Bone Architecture, Patterning, and Biomechanics During Skeletal Regeneration. Frontiers in Cell and Developmental Biology. 2021;9(2874). doi: 10.3389/fcell.2021.749055.

Tower RJ, Busse E, Jaramillo J, Lacey M, Hoffseth K, Guntur AR, Simkin J, Sammarco MC. Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration. Elife. 2022;11. Epub 2022/05/27. doi: 10.7554/eLife.71542. PubMed PMID: 35616636.

Faculty

S. Michal Jazwinski, PhD Professor

Sangkyu Kim, PhD

Assistant Professor Staff

Md. Abdul Awoal Medical Research Specialist

Stephanie Cox Program Manager Md. Mehedi Hasan Postdoctoral Researcher

Kamile Mitkus Program Coordinator

Ahmed Moustafa Postdoctoral Researcher

Anna B. Latoff Bioinformatics Analyst

National Service:

S.M. Jazwinski: Member, Special Emphasis Panel/Scientific Review Group (NIGMS Phase I COBRE) 2021/10 ZGM1 RCB-W (C1), June 22-23, 2021

Presentations:

S.M. Jazwinski: A Glimpse inside the Dynamics of Aging with the Frailty Index, International Centenarian Consortium (ICC 2021), Online Conference, Tokyo, Japan, June 22 – July 3, 2021

Research collaborations:

M. Czarny-Ratajczak: Vinod Dasa, MD (LSUHSC-New Orleans, Dept. of Orthopedics), Asim Abel-Mageed, PhD (Tulane SOM, Dept. of Urology), Wei Chen, MD (Tulane SOM, Dept. of Pathology)

S. Kim: Andrea Zsombok, PhD (Tulane SOM, Dept. of Physiology), Kevin Zwezdaryk, PhD (Tulane SOM, Dept. of Microbiology & Immunology), Kristin S. Miller, PhD (Tulane SSE, Dept. of Biomedical Engineering), Namita Rout, PhD (Tulane National Primate Research Center), Kate Baker, PhD (Tulane National Primate Research Center)

S.M. Jazwinski: Kevin Zwezdaryk, PhD (Tu- lane SOM, Dept. of Microbiology & Immunology), Kristin S. Miller, PhD (Tulane SSE, Dept. of Biomedical Engineering), Victoria Belancio, PhD (Tulane SOM, Dept. of Structural & Cellular Biology), Qiuyang Zhang, PhD (Tulane SOM, Dept. of Structural & Cellular Biology), Wei Chen, MD (Tulane SOM, Dept. of Patholo- gy), Namita Rout, PhD (Tulane National Primate Research Center), Joseph A. Lasky, MD (Tulane SOM, Dept. of Medicine), Demetrius M. Maraganore, MD (Tulane SOM, Dept. of Neurology), Katie Cherry, PhD (LSU A&M, Dept. of Psychology), Gerald P. Schatten (University of Pittsburgh SOM, Magee- Women’s Research Institute)

CENTER FOR TRANSLATIONAL RESEARCH IN INFECTION & INFLAMMATION

Jay Kolls, MD Professor of Medicine & Pediatrics John W Deming Endowed Chair in Internal Medicine Director

Center for Translational Research in Infection and Inflammation Tulane School of Medicine

The core mission of the Center is to conduct transformative research and discovery in tissue infection and inflammation that ultimately reduces disease burden and mortality in patients.

Additionally, the Center serves as a nidus for training in mucosal immunology and genomics to understand host resistance mechanisms to disease. This fundamental knowledge will allow the translation of these finding to patients that suffer from infection and inflammation.

Areas of research include bacterial pneumonia, fungal pneumonia and opportunistic infections, mucosal immunology, cystic fibrosis and single-cell transcriptomics

Research Activities

The center has two key researchers, Jay Kolls, MD and Janet McCombs, MD. They have 7 active funding grants between them both for research.

Jay Kolls, MD

Bechtner Foundation Immunotherapy of KPC Infection Sars-Cov2 (FastGrant)

CD4 T cell Immunity in the Lungs Improved Therapeutics and Diagnostics for Pneumocystis pneumonia eAsia COVID award

Janet McCombs, MD LACATS

The Center works with the following PhD and other students:

Joseph Hoffman, PhD

Postdoctoral

Akhilesh Srivastava, PhD

Postdoctoral

Naoki Iwanaga, MD, PhD

Postdoctoral (former trainee)

Yasuka Matsunaga, PhD Postdoctoral (former trainee)

Kristin Noell, PhD

Postdoctoral (former trainee)

Haoran Yang PhD student, BMS Program

Robert Clark MD/PhD student

Thomas Remcho MD/PhD student

Shakhaowat Hossain PhD student, BMS Program

Ferris Munyonho PhD student, BMS Program

Marjorie Bateman, MD (former trainee)

Shiping Lu PhD student, graduated May 2022

Faculty Jay Kolls, MD Professor

Guixiang Dai, PhD Instructor

Staff

Candice Fisher Operations Manager

Alexander Martin Medical Research Technician

Sequencing Core Staff

Kejing Song, DVM Medical Research Specialist

Haiyan Miller Medical Research Technician

Janet McCombs, PhD Assistant Professor

Dong Lin, PhD Instructor

Dora Pungan Student Worker

Felix Rabito Former Medical Research Technician

MST Shamima Khatun Medical Research Technician Genevieve Pierre Medical Research Technician (term)

Alanna Wanek Medical Research Technician (term)

TULANE RESEARCH INNOVATION FOR ARRHYTHMIA DISCOVERIES (TRIAD)

Nassir Marrouche, MD Professor Director TRIAD & Chief of Electrophysiology

The Tulane Research Innovation for Arrhythmia Discoveries Center (TRIAD Center) is stimulating inter-disciplinary collaborations at Tulane and bringing together experts in the fields of Cardiology, Neurology, advanced cardiac imaging, machine learning, molecular/cellular biology, and clinical research. Our team has already developed stateof-the-art imaging methods using magnetic resonance imaging to accurately assess structural and functional features associated with heart aging and arrhythmias. We are at the forefront of the digital healthcare revolution and are leveraging real-time remote monitoring and big data throughout our research endeavors. Our team is exploring cutting-edge artificial intelligence algorithms to early detect and prevent aging heart tissue. Moreover, TRIAD established an important experimental aging model that allows testing of molecular and mRNA approaches to stop aging. We believe through these tools we can gain unprecedented insights into the aging heart and finally answer the following questions: How does an aging heart lead to arrhythmias and heart disease? How do we prevent the heart from aging?

In the past three years, the TRIAD center accomplished multicenter studies:

DECAAF II

Effect of DrOnedarone on atrial fibrosis progression and atrial fibrillation Recurrence post-Ablation The

EDORA Trial

Tulane iPredict, Prevent Study (TiPP)

Baseline Atrial Fibrosis predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Pilot Study for SAPPORO-AF

The center has been involved in prospective studies. Wearable health data to characterize early and delayed cardiovascular outcomes in COVID-19 patients after discharge – WEAICOR Study- Role: Clinical Research Coordinator/ data maintenance/data built

Atrial Fibrosis progression in sleep apnea patients: A pilot study (PROOF Study)

Three-dimensional assessment of left atrial appendage orifice anatomy using cardiac magnetic resonance imaging ( Coherex)

Correlation Of CoAGulation Biomarkers and Atrial Fibrillation Burden in Patients Post Catheter Ablation: the COAG-AF Pilot Study.

PPG to Predict Ejection Fraction and Other Echographic Data in the General Population: A Cross-Sectional Study

Baseline Atrial Fibrosis predicts Risk for Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Pilot Study for SAPPORO-AF

Atrial Fibrillation Recurrence Rate after Cryoballoon Ablation for Atrial Fibrillation using the KODEX-EPD Mapping System - A Prospective Study

Translational studies is very important to the research the center is doing. These have aided in the growth of the center. Longitudinal assessment of pulse field ablation in porcine using MRI - Investigator initiated study sponsored by Medtronic Inc. Evaluate ICE-based approaches – Collaborative study with Siemens Medical Solutions to evaluate the utility of novel intracardiac echocardiographic based approaches for catheter ablation

Master Service agreement – Collaborative agreement with Biosense Webster Inc for TRIAD to conduct animal and basic science research studies relating to Biosense Weber’s products and/or matters of interest to the company

Equipment Loan agreement – Collaborative agreement with Siemens Healthineers to support ongoing animal research studies at TRIAD with a mobile fluoroscopy C-arm

The Center Started Three New Databases: Characterizing cardiac complications in COVID-19 hospitalized patients: - COVID 19 database

Tulane Research Innovation Arrhythmia Discovery (TRIAD) Database

REACHnet

TRIAD has had the opportunity to go to several conferences to gain knowledge of Atrial Fibrillation techniques. Western Atrial Fibrillation Symposium 2022: the event was organized by the Director of the TRIAD Center, Dr. Marrouche. Three TRIAD Scientists presented their latest findings at the conference in

Park City, UT.

American College of Cardiology Annual Session 2022: TRIAD Scientists presented over 10 abstracts in a poster format in Washington DC.

Venice Arrhythmia 2022: TRIAD Scientist chaired the session of “Digital health for screening, diagnosis, and monitoring of cardiac arrhythmias: what’s the evidence” at Venice Arrhythmia.

Heart Rhythm Society 2022: TRIAD Scientists presented over 9 abstracts at the conference in San Francisco, CA.

Heart Rhythm Society HRX 2022: TRIAD Artificial Intelligence Scientist is looking forward to participating as a faculty in the upcoming HRX to present his latest findings within the Digital Health field while the Research Scientists will be presenting their 3 abstracts in poster format in September 2022, San Diego, CA.

American Heart Association 2022: TRIAD Research Scientists are looking forward to presenting their abstract at the upcoming conference in November 2022, Chicago, IL.

Publications:

Marrouche NF, Dagher L, Wazni O, Akoum N, Mansour M, El Hajjar AH, Bhatnagar A, Hua H; EDORA Investigators. Effect of DrOnedarone on atrial fibrosis progression and atrial fibrillation recurrence postablation: Design of the EDORA randomized clinical trial. J Cardiovasc Electrophysiol. 2021 Dec;32(12):3203-3210. doi: 10.1111/jce.15274. Epub 2021 Nov 2. PMID: 34664772; PMCID: PMC9298087. Mekhael M, Lim CH, El Hajjar AH, Noujaim C, Pottle C, Makan N, Dagher L, Zhang Y, Chouman N, Li DL, Ayoub T, Marrouche N. Studying the Effect of Long COVID-19 Infection on Sleep Quality Using Wearable Health Devices: Observational Study. J Med Internet Res. 2022 Jul 5;24(7):e38000. doi: 10.2196/38000. PMID: 35731968; PMCID: PMC9258734. Ayoub T, El Hajjar AH, Singh Sidhu GD, Bhatnagar A, Zhang Y, Mekhael M, Noujaim C, Dagher L, Pottle C, Marrouche N. Esophageal temperature during atrial fibrillation ablation poorly predicts esophageal injury: An observational study. Heart Rhythm O2. 2021 Nov 5;2(6Part A):570-577. doi: 10.1016/j.hroo.2021.11.002. PMID: 34988501; PMCID: PMC8703177.

El Hajjar AH, Marrouche N. The need to refine selection criteria for catheter ablation in heart failure patients with atrial fibrillation. Europace. 2022 Apr 5;24(4):527-529. doi: 10.1093/europace/euab239. PMID: 34524414. El Hajjar AH, Huang C, Zhang Y, Mekhael M, Noujaim C, Dagher L, Nedunchezhian S, Pottle C, Kholmovski E, Ayoub T, Dhorepatil A, Barakat M, Yamaguchi T, Chelu M, Marrouche N. Acute Lesion Imaging in Predicting Chronic Tissue Injury in the Ventricles. Front Cardiovasc Med. 2022 Jan 28;8:791217. doi: 10.3389/fcvm.2021.791217. PMID: 35155604; PMCID: PMC8831749. Dagher L, Nedunchezhian S, El Hajjar AH, Zhang Y, Deffer O Jr, Russell A, Pottle C, Marrouche N. A cardiovascular clinic patients’ survey to assess challenges and opportunities of digital health adoption during the COVID-19 pandemic. Cardiovasc Digit Health J. 2022 Feb;3(1):31-39. doi: 10.1016/j.cvdhj.2021.10.007. Epub 2021 Nov 18. PMID: 34812430; PMCID: PMC8600804.

El Hajjar AH, Mekhael M, Huang C, Noujaim C, Zhang Y, Kholmovski E, Ayoub T, Lim CH, Marrouche N. Predictors of Lesions Contiguity and Transmurality in Canine Ventricular Models After Catheter Ablation. Front Cardiovasc Med. 2022 Jun 23;9:920539. doi: 10.3389/fcvm.2022.920539. PMID: 35811729; PMCID: PMC9260253.

Sidhu GDS, Ayoub T, El Hajjar AH, Dhorepatil A, Nedunchezian S, Dagher L, Ferdinand K, Marrouche

N. Atrial Fibrillation and Acute Ischemic Stroke: Evaluation of the Contemporary 2018 National Inpatient Sample Database. CJC Open. 2022 Feb 10;4(6):513-519. doi: 10.1016/j.cjco.2022.01.010. PMID: 35734515; PMCID: PMC9207776.

Dagher L, Shi H, Zhao Y, Mitlacher M, Schnupp S, Ajmi I, Forkmann M, Marrouche N, Mahnkopf C. Atrial fibrosis progression in patients with no history of atrial fibrillation. J Cardiovasc Electrophysiol. 2021 Aug;32(8):2140-2147. doi: 10.1111/jce.15140. Epub 2021 Jul 12. PMID: 34191382.

Dagher L, Shi H, Zhao Y, Wetherbie A, Johnsen E, Sangani D, Nedunchezhian S, Brown M, Miller P, Denson J, Schieffelin J, Marrouche N. New-onset atrial arrhythmias associated with mortality in black and white patients hospitalized with COVID-19. Pacing Clin Electrophysiol. 2021 May;44(5):856-864. doi: 10.1111/ pace.14226. Epub 2021 Apr 16. PMID: 33742724; PMCID: PMC8251330.

Brachmann J, Sohns C, Andresen D, Siebels J, Sehner S, Boersma L, Merkely B, Pokushalov E, Sanders P, Schunkert H, Bänsch D, Dagher L, Zhao Y, Mahnkopf C, Wegscheider K, Marrouche NF. Atrial Fibrillation Burden and Clinical Outcomes in Heart Failure: The CASTLE-AF Trial. JACC Clin Electrophysiol. 2021 May;7(5):594-603. doi: 10.1016/j.jacep.2020.11.021. Epub 2021 Feb 24. PMID: 33640355.

Marrouche NF, Greene T, Dean JM, Kholmovski EG, Boer LM, Mansour M, Calkins H, Marchlinski F, Wilber D, Hindricks G, Mahnkopf C, Jais P, Sanders P, Brachmann J, Bax J, Dagher L, Wazni O, Akoum N; DECAAF II Investigators. Efficacy of LGE-MRI-guided fibrosis ablation versus conventional catheter ablation of atrial fibrillation: The DECAAF II trial: Study design. J Cardiovasc Electrophysiol. 2021 Apr;32(4):916-924. doi: 10.1111/jce.14957. Epub 2021 Mar 2. PMID: 33600025.

Dagher L, Marrouche NF. Consumer-tech-provider co-doctoring in the digital age: A neglected TRIAD. Heart Rhythm. 2021 Apr;18(4):499-500. doi: 10.1016/j.hrthm.2020.10.007. Epub 2021 Feb 2. PMID: 33539827. Dagher L, Wanna B, Mikdadi G, Young M, Sohns C, Marrouche NF. High-degree atrioventricular block in COVID-19 hospitalized patients. Europace. 2021 Mar 8;23(3):451-455. doi: 10.1093/europace/euaa333. PMID: 33432349; PMCID: PMC7928988.

Varma N, Marrouche NF, Aguinaga L, Albert CM, Arbelo E, Choi JI, Chung MK, Conte G, Dagher L, Epstein LM, Ghanbari H, Han JK, Heidbuchel H, Huang H, Lakkireddy DR, Ngarmukos T, Russo AM, Saad EB, Saenz Morales LC, Sandau KE, Sridhar ARM, Stecker EC, Varosy PD. HRS/EHRA/APHRS/LAHRS/ ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic. Europace. 2021 Feb 5;23(2):313. doi: 10.1093/europace/euaa187. PMID: 32526011; PMCID: PMC7313983.

The Center has several donors and private grants.

The Brown Foundation/ Foundation Headington Foundation/ Foundation

Sanofi, Inc/ Private

Faculty

Nassir Marrouche, MD, FHRS Professor Executive Director, TRIAD Center

Eoin Donnellan, MD Assistant Professor

Saint Jude/ Private Biosense Webster/ Private Medtronic, Inc/ Private Siemens, Inc/ Private

Coherex Medical Inc /Private Boston Scientific/ Private AtriCure, Inc/ Private

Omar Kreidieh, MD Assistant Professor Monique Young, ACNP-BC, CVNP-BC Instructor

Centers

Staff

Chao Huang, PhD Manager, Animal Research & Development

Jana Haidar

Senior Administrative Program Coordinator

Mario Mekhael, MD Research Scientist I

Charbel Noujaim, MD Research Scientist I

Nour Chouman, MD Research Scientist I

Ala’ Assaf, MD Research Scientist I

Han Feng, PhD Scientific Research Analyst III Chan Ho Lim Application Developer III

Noor Makan, ACRP-CRCC Senior Clinical Research Coordinator

Quintrele Jones Clinical Coordinator I

THE LA CENTER FOR BLEEDING & CLOTTING DISORDERS

Jennifer Borrillo Executive Director

LA Center for Bleeding & Clotting Disorders

Leissinger, MD Director

LA Center for Bleeding & Clotting Disorders

The Louisiana Center for Bleeding and Clotting Disorders (LCBCD) began over 40 years ago and serves patients throughout Louisiana and the deep Gulf South. The Center is dedicated to the care of patients and families affected by disorders of coagulation including:

Hemophilia

Von Willebrand disease

Clotting factor inhibitors

Rare coagulation disorders

Platelet disorders Thrombotic disorders Thrombophilia

The Center serves both pediatric and adult patients using a comprehensive multi-disciplinary care team that provides diagnostic services in addition to full comprehensive care for patients with coagulation disorders. The Center opened its newest full-time clinic location in July 2021 at the Lakeside Medical Office Building in Metairie. In addition, the Center also provides out-patient services at University Medical Center New Orleans LCMC Health and holds outreach clinics in Lafayette and Alexandria for patients who live in other parts of the state. Some of the services provided by our staff include:

Diagnosis, evaluation, and treatment Physical therapy and orthopedic referrals

Social services Nursing services

Cindy

Extensive education programs

Home infusion instruction

Home and school visits

340B Factor Program & Pharmacy

Educational Activities

Genetic testing Age-specific support groups 24 Hour access for emergencies

The Center provides outreach and educational services that include participation with the Louisiana Hemophilia Foundation (LHF) for programs and educational events that includee

Summer Camp for kids with hemophilia and other bleeding disorders

Transition Retreat for teens with bleeding disorders

Family Camp Day Events Adult Couples Retreat

Presentations

Women’s Retreat and Women’s Events Men’s Retreat

Advocacy Legislative Session in Baton Rouge Teen Leadership Programs Support Groups for Community Members

A Survey of Anti-platelet and Anticoagulant Use in Persons With Hemophilia. Janbain M, Escobar M, Hardetsy B, Kessler C, Nugent D, Quon D, Reding M, Walsh C, Sood S. Poster at Hemostasis and Thrombosis Research Society 2021

The importance of genetic testing in diagnosing Von Willebrand’s disease type 2M. Ksayer R, Zakharia K, Christopherson P, Montgomery R, Janbain M. Oral presentation and abstract award at Hemostasis and Thrombosis Research Society 2021

Hemostatic effect of tranexamic acid combined with emicizumab in prophylactic setting in severe hemophilia A: a preclinical study. Dargaud Y, Enjolras N, Janbain M, Bolbos R, Brevet M, Bordet JC.Poster at International Society of Thrombosis and Hemostasis 2021.

“Pregnancy and Bleeding disorders”- Dr. Maissaa Janbain on March 6, 2021 for the Louisiana Hemophilia Foundation Virtual Women’s Retreat

“Thrombophilia and Aging”- Dr Maissaa Janbain on May 2, 2021 to the Great Plains Region Aging Virtual Conference

Presentation “Five Tips for Managing Your Mental Health” by Alfredo Narvaez Jr, MSW LMSW on July 10, 2021 to the National Hemophilia Foundation’s Inhibitor Summit.

Presentation “Introduction to Women & Bleeding Disorders & Hormone Treatment Options” by Dawn Bauer, NP and Dr. Amina Rafique on March 6, 2021 for the Louisiana Hemophilia Foundation Virtual Women’s Retreat

Presentation “The Spectrum of Aging” by Dawn Bauer, NP and Dr. Garrett on May 2, 2021 to the Great Plains Region Aging Virtual Conference

Presentation “Tool Box Scavenger Hunt” by Tulane Hemophilia Treatment Center Nursing staff – Nicole

Reynaud, BSN, RN, Demetra Bryant, RN, Jackie Thompson, RN on June 23, 2021 for Louisiana Hemophilia Foundation at Home (Virtual) Camp.

Presentation “Gueax with the Fleaux: Global Myths” by Tulane’s BFFT Clinic staff - Nicole Reynaud, BSN, RN, Jackie Thompson, RN, Demetra Bryant, RN, Constance Thibodeaux, MSW, LCSW-BACS, Cheryl Sanders, RN on March 5, 2021 for the Louisiana Hemophilia Foundation Virtual Women’s Retreat

Case presentation accepted by National Hemophilia Foundation for 2021 annual meeting regarding patient outreach, coordination of care, and additional resources and services presented by Dr. Garrett, Jackie Thompson, RN and Alfredo Narvaez, MSW.

June 4, 2021 presentation “COVID-19 One Year Later: Real World Insights from an Hemophilia Treatment Center” - Jennifer Borrillo, MSW, LCSW, MBA to 2021 National Hemophilia Foundation Comprehensive Care Sustainability CollaborativeC Advisory Panel Meeting

Amina Rafique, Extramural Invited Grand Rounds Presentation for Department of Pediatrics Loyola University Chicago, titled: “ Improving the management of Patients with Hemophilia A; Role of Facytro and non Factor replacement” , 2021

Amina Rafique, Vinay Krupadev , “ A Case of Concurrent Sickle Cell trait, Alpha Thalassemia, G6PD deficiency in a Pediatric Patient., Journal of Cell Biology: Research and Therapy and annual meeting in Czech Republic, May 2021

Amina Rafique, Vinay Krupadev , “A Case of Pediatric Acquired Factor 12 Deficiency Secondary to COVID-19”, American Society of Pediatric Hematology Oncology, April 2021.

Center Collaboratives

Entered into a Partnership Agreement with the National Hemophilia Foundation (NHF) to be one of two Hemophilia Treatment Centers across the country participating in the Enhancing Health Equity through Hemophilia Treatment Center Program, which will conduct focus groups to gather insight and information on Black/African-American experiences (at that Hemophilia Treatment Center) related to topics such as: quality of care, patient communication and trust, treatment adherence, provider availability, provider linguistic and cultural competency, and bias. Insights will be collected for the purpose of creating patient education materials (print and/or online) that address strategies to overcome common experiences among underserved groups related to disparities in race, ethnicity, religion, or income. Materials will empower underserved patients to address bias, become self-advocates, and address social factors that impede their ability to actively engage in treatment decision making, access to care, and/or communicate with providers.

Access to Care Contract in place with Louisiana Hemophilia Foundation (LHF), Hope Charities, and the University Medical Center Spirit of Charity Foundation, providing financial and logistical support to patients to reduce the barriers to care.

Worked in conjunction with LHF to identify patients and families in need for Thanksgiving and delivered food

and COVID supply boxes to over 40 families. Hemophilia Treatment Center staff helped make deliveries and covered shipping for LHF of boxes to families that deliveries could not be made to in person due to distance.

Worked in conjunction with Louisiana Hemophilia Foundation to identify patients and families in need for Christmas holidays and provided gift cards to over 40 families in need.

Social Worker serves as Great Plains Southwest Region representative for National Hemophilia Foundation.

Physical Therapist serves as the National Hemophilia Foundation Physical Therapist Great Plains Representative.

Administrative Director serves as Hemophilia Treatment Center Louisiana Hemophilia Foundation Board Representative.

IT Manager is an Louisiana Hemophilia Foundation Board Member

Administrative Director is on Board of Directors for Hemophilia Alliance Administrative Director serves on National Hemophilia Foundation Comprehensive Care Sustainability Collaborative Advisory Board

Center Faculty

Jennifer Borrillo, MSW, LSCW, MBA Instructor

Executive Director, LCBCD

Dawn Bravata-Bauer, DNP Instructor

Women’s Health Provider

Chancellor Donald, MD Assistant Professor Hematologist

Daniel Garrett, MD Assistant Professor Primary Care

Elsa Hahn-Treadway, FNP Instructor

Maissaa Janbain, MD Associate Professor Hematologist

Associate Director, LCBCD

Amy Kinzie, DNP Instructor Clinic Director Cindy Leissinger, MD Professor Hematologist Director, LCBCD

Amina Rafique, MD Assistant Professor of Pediatrics Pediatric Hematologist, Associate Director Pediatrics, LCBCD

Center Staff

Hemophilia Nurse Team

Demetra Bryant, RN Hemophilia Nurse Specialist

Robert Meyn, RN Hemophilia Nurse Specialist

Thrombosis/Hematology Nurse Team

Alicia Cole, BSN, RN Nurse Manager

Bleeding and Clotting Disorders

Lakeside Clinic Team

Lynn Aiken, BSN, RN Nurse Specialist

Becky Bonnette Patient Representative

Social Work Team

Nicole Reynaud, RN Nurse Coordinator

Jacqueline Thompson, RN Pharmacy Outreach Nurse

Kimberly Doris, RN Nurse Specialist Bleeding and Clotting Disorders

Ashley Jones Prior Authorization Coordinator

Amy Kinzie, DNP Clinic Director

Anis Mojena Rodriguez

Certified Medical Office Assistant Louis Saubat Clinic Manager

Alfredo Narvaez, LMSW Social Worker Constance Thibodeaux, LCSW Social Work Manager

Physical Therapist

Anita Wood, LPT Kenneth Martin, LPT

Research Team

Melody Benton, MS Administrative Director Clinical Research

Connie Scott, BSN, RN Research Nurse Manager

340b Pharmacy Team

Suzanne Adams, RN Part time Research Nurse

Lisa Cunningham, MSE Sr. Clinical Research Coordinator

Cheryl Sanders, RN Research Nurse

Jennifer Borrillo, MSW, LSCW, MBA Executive Director Pharmacy

Angela Kellum, PharmD Pharmacy Manger

Joshua Bullock Pharmacy Tech

Kevin Tran, PharmD Relief Pharmacist

Administration

Jennifer

Borrillo, MSW, LSCW, MBA Executive Director

Rene Mire, CPA, MBA Senior Accountant

Leilani Perriatt Health Analyst Data

Kavanagh, MBA Sr. Section Administrator Terry Bell Outreach Clinic Manager

Erin

Dionne

Richard Executive Secretary Subodh Pethe Technology & Data Manager

Serena Crawford Marketing and Communication Specialist

CTC CORE LABORATORY

Shanker Japa, MPhil, PhD Associate Professor Director

CTC Core Laboratory

Dr. Shanker Japa is an Associate Professor of Medicine and the Laboratory Director of the Good Laboratory Practice (GLP), International Air Transport Association (IATA), and Internal Quality Assurance Cell (IQAC) compliant Clinical Trials Cooperative (CTC) Core Laboratory. The CTC Core Lab provides services to investigators who conduct basic, translational, and clinical research and is specialized in human specimens’ handling and performing specialty molecular and biomarker assays. In addition, it has the expertise to perform appropriate molecular test validations and verifications for laboratory-developed assays per Clinical Laboratory Improvement Amendments (CLIA), College of American Pathologists (CAP), and other agencies’ requirements.

The CTC Core laboratory offers quality biospecimens processing and aliquot shipping to satellite laboratories for downstream analysis. Dr. Japa’s laboratory also performs routine and specialized biomarker and molecular analyses using PCR, RT-PCR, and multiplex immune assays to generate data for basic science and clinical studies, trials, and grant proposals. Dr. Japa is currently collaborating with several Tulane-led basic and clinical research studies and clinical trials associated with NIH-funded organizations such as ACTG, HPTN, HVTN, PHACS, and CoVPN.

In the past year, the CTC Core lab has extended its services to outside organizations to perform complex biospecimens processing for high-profile clinical trials. The CTC Core lab now directly collaborates with startup-sized and large pharmaceutical companies such as Vaxart, Sanofi Pasteur, and Janssen/Johnson & Johnson, offering mononuclear cell isolations (PBMCs) from both adult and pediatric research subjects. PBMC isolations are performed per internal and study sponsors’ protocols, and robust Quality Control (QC) standards are maintained. The CTC Core lab works closely with local Clinical Research Organizations (CROs) and the major clinical laboratory network Labcorp to facilitate PBMC specimens’ collection and shipping.

DEPARTMENT OF MEDICINE NEUROSCIENCE LABORATORY

James E Zadina, PhD

Director

Neuroscience Laboratory

Southeast Louisiana Veterans Affairs Health Professor

Neuroscience and Pharmacology

The Tulane University/Veterans Affairs Neuroscience Laboratory within the Department of Medicine, directed by James Zadina, PhD., is focused on research in pain, opioids, and opioid use disorder (OUD). This work includes development of new medications for treatment of pain and OUD. The research is supported by 3 grants: 2 from National Institutes of Health and 1 from Southeast Louisiana Veterans Health Care System.

Center for Translational Research in Infection & Inflammation

Dai G, Wanek A, Eddens T, Volden P, Kolls JK. Toward a humanized mouse model of Pneumocystis pneumonia. JCI Insight. 2021 Jan 25;6(2):e139573. doi: 10.1172/jci. insight.139573. PMID: 33491669; PMCID: PMC7934868.

McCombs JE, Kolls JK. Walking down the “IL”: The Newfound Marriage between IL-36 and Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2021 Feb;64(2):153-154. doi: 10.1165/rcmb.20200461ED. PMID: 33202148; PMCID: PMC7874399.

Matsunaga Y, Clark T, Wanek AG, Bitoun JP, Gong Q, Good M, Kolls JK. Intestinal IL-17R Signaling Controls Secretory IgA and Oxidase Balance in Citrobacter rodentium Infection. J Immunol. 2021 Feb 15;206(4):766-775. doi: 10.4049/jimmunol.2000591. Epub 2021 Jan 11. PMID: 33431657.

Lin X, Tawch S, Wong HT, Roy S, Gaudino S, Castillo P, Elsegeiny W, Wakabayashi N, Oury TD, Pociask D, Chen K, McLinskey N, Melville P, Syritsyna O, Coyle P, Good M, Awasthi A, Kolls JK, Kumar P. Nrf2 through Aryl Hydrocarbon Receptor Regulates IL22 Response in CD4+ T Cells. J Immunol. 2021 Apr 1;206(7):1540-1548. doi: 10.4049/ jimmunol.1900656. Epub 2021 Mar 1. PMID: 33648937; PMCID: PMC7987760.

Camiolo MJ, Zhou X, Oriss TB, Yan Q, Gorry M, Horne W, Trudeau JB, Scholl K, Chen W, Kolls JK, Ray P, Weisel FJ, Weisel NM, Aghaeepour N, Nadeau K, Wenzel SE, Ray A. High-dimensional profiling clusters asthma severity by lymphoid and non-lymphoid status. Cell Rep. 2021 Apr 13;35(2):108974. doi: 10.1016/j.celrep.2021.108974. PMID: 33852838; PMCID: PMC8133874. Hoffmann JP, Kolls JK, McCombs JE. Regulation and Function of ILC3s in Pulmonary Infections. Front Immunol. 2021 Apr 23;12:672523. doi: 10.3389/ fimmu.2021.672523. PMID: 33968082; PMCID: PMC8102726.

Mulay A, Konda B, Garcia G Jr, Yao C, Beil S, Villalba JM, Koziol C, Sen C, Purkayastha A, Kolls JK, Pociask DA, Pessina P, de Aja JS, Garcia-de-Alba C, Kim CF, Gomperts B, Arumugaswami V, Stripp BR. SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery. Cell Rep. 2021 May 4;35(5):109055. doi: 10.1016/j. celrep.2021.109055. Epub 2021 Apr 13. PMID: 33905739; PMCID: PMC8043574.

Dai G, Noell K, Weckbecker G, Kolls JK. Effect of Subcutaneous Anti-CD20 AntibodyMediated B Cell Depletion on Susceptibility to Pneumocystis Infection in Mice. mSphere. 2021 May 5;6(3):e01144-20. doi: 10.1128/ mSphere.01144-20. PMID: 33952667; PMCID: PMC8103991.

Schieffelin JS, Norton EB, Kolls JK. What should define a SARS-CoV-2 “breakthrough” infection? J Clin Invest. 2021 Jun 15;131(12):e151186. doi: 10.1172/JCI151186. PMID: 33974565; PMCID: PMC8203469.

Mihi B, Gong Q, Nolan LS, Gale SE, Goree M, Hu E, Lanik WE, Rimer JM, Liu V, Parks OB, Lewis AN, Agrawal P, Laury ML, Kumar P, Huang E, Bidani SS, Luke CJ, Kolls JK, Good M. Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration. Cell Rep Med. 2021 Jun 15;2(6):100320. doi: 10.1016/j. xcrm.2021.100320. PMID: 34195684; PMCID: PMC8233697.

Liu F, Han K, Blair R, Kenst K, Qin Z, Upcin B, Wörsdörfer P, Midkiff CC, Mudd J, Belyaeva E, Milligan NS, Rorison TD, Wagner N, Bodem J, Dölken L, Aktas BH, Vander Heide RS, Yin XM, Kolls JK, Roy CJ, Rappaport J, Ergün S, Qin X. SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro. Front Cell Infect Microbiol. 2021 Jul 6;11:701278. doi: 10.3389/fcimb.2021.701278. PMID: 34307198; PMCID: PMC8292147.

Qin Z, Liu F, Blair R, Wang C, Yang H, Mudd J, Currey JM, Iwanaga N, He J, Mi R, Han K, Midkiff CC, Alam MA, Aktas BH, Heide RSV, Veazey R, Piedimonte G, Maness NJ, Ergün S, Mauvais-Jarvis F, Rappaport J, Kolls JK, Qin X. Endothelial cell infection and dysfunction, immune activation

in severe COVID-19. Theranostics. 2021 Jul 6;11(16):8076-8091. doi: 10.7150/thno.61810. PMID: 34335981; PMCID: PMC8315069.

Li DD, Bechara R, Ramani K, Jawale CV, Li Y, Kolls JK, Gaffen SL, Biswas PS. RTECintrinsic IL-17-driven inflammatory circuit amplifies antibody-induced glomerulonephritis and is constrained by Regnase-1. JCI Insight. 2021 Jul 8;6(13):e147505. doi: 10.1172/jci. insight.147505. PMID: 34236049; PMCID: PMC8410033.

Qadir MMF, Bhondeley M, Beatty W, Gaupp DD, Doyle-Meyers LA, Fischer T, Bandyopadhyay I, Blair RV, Bohm R, Rappaport J, Lazartigues E, Heide RSV, Kolls JK, Qin X, Mauvais-Jarvis F. SARSCoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes. JCI Insight. 2021 Aug 23;6(16):e151551. doi: 10.1172/jci. insight.151551. PMID: 34241597; PMCID: PMC8410013.

Iwanaga N, Chen K, Yang H, Lu S, Hoffmann JP, Wanek A, McCombs JE, Song K, RangelMoreno J, Norton EB, Kolls JK. Vaccine-driven lung TRM cells provide immunity against Klebsiella via fibroblast IL-17R signaling. Sci Immunol. 2021 Sep 10;6(63):eabf1198. doi: 10.1126/sciimmunol.abf1198. Epub 2021 Sep 10. PMID: 34516780.

Lu S, Kolls JK. Early Antibiotics in Cystic Fibrosis: Lessons from the Cystic Fibrosis Pig Model. Am J Respir Crit Care Med. 2021 Sep 15;204(6):626-627. doi: 10.1164/rccm.2021061383ED. PMID: 34343466.

Department of Medicine Neuroscience Laboratory

A VA Merit Review (J. Zadina, PI) entitled “A Novel Analgesic with Reduced Side Effects and Abuse Liability Relative to Morphine, with Potential for Opioid Dependence Therapy”.

An NIH U18 grant (J. Zadina, PI) entitled “Glycosylated Endomorphin Analogs for Treatment of Opioid Use Disorder (OUD)”.

Publications

An NIH UG3/UH3 grant (M. Moore, PI) entitled “Human microphysiological model of afferent nociceptive signaling”

The LA Center for Bleeding & Clotting Disorders

Benton, M., Patel, A.M., Shi, L., Monnette, A., Hong, D., Kruse-Jarres, R. and Raimundo, K. (2021), Assessing patient and caregiver preferences for treatment of haemophilia A: A discrete choice experiment. Haemophilia, 27: e479-e483. https://doi.org/10.1111/hae.14185